Brenna Osborne

Brenna Osborne

Assistant Professor, Guest Researcher

Member of:

    ORCID: 0000-0002-0197-3010

    Publication year:
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    1 - 31 out of 31Page size: 50
    1. 2024
    2. Published

      Pharmacological interventions in human aging

      Petr, Michael Angelo, Matiyevskaya, Frida, Osborne, Brenna, Berglind, M., Reves, Simon William Nayberg, Zhang, B., Ben Ezra, Michael, Carmona Marin, Lina Maria, Syadzha, Muhammad Farraz, Mediavilla, M. C., Keijzers, G., Bakula, Daniela Janina, Mkrtchyan, Garik & Scheibye-Knudsen, Morten, 2024, In: Ageing Research Reviews. 95, 14 p., 102213.

      Research output: Contribution to journal › Review › Research › peer-review

    3. 2023
    4. Published

      SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance

      Osborne, Brenna, Wright, L. E., Brandon, A. E., Stuart, E., Small, Lewin Barkla, Hoeks, J., Schrauwen, P., Sinclair, D. A., Montgomery, M. K., Cooney, G. J. & Turner, N., 2023, In: Journal of Endocrinology. 258, 3, 11 p., e220101.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. 2022

    6. Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice

      Osborne, Brenna, Reznick, J., Wright, L. E., Sinclair, D. A., Cooney, G. J. & Turner, N., 2022, In: Biochemical and Biophysical Research Communications. 607, p. 131-137 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Nuclear morphology is a deep learning biomarker of cellular senescence

      Heckenbach, Indra John, Mkrtchyan, Garik, Ben Ezra, Michael, Bakula, Daniela Janina, Madsen, Jakob Sture, Nielsen, M. H., Oró, D., Osborne, Brenna, Covarrubias, A. J., Idda, M. L., Gorospe, M., Mortensen, Laust Hvas, Verdin, E., Westendorp, Rudi GJ & Scheibye-Knudsen, Morten, 2022, In: Nature Aging. 2, 8, p. 742-755 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. 2020

    9. A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

      Xi, C. R., Fazio, A. D., Nadvi, N. A., Patel, K., Xiang, M. S. W., Zhang, H. E., Deshpande, C., Low, J., Wang, X. T., Chen, Y., McMillan, C., Isaacs, A., Osborne, Brenna, Ribeiro, A. J. V. D., McCaughan, G. W., Mackay, J., Church, W. B. & Gorrell, M., Nov 2020, In: Molecules. 5392.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      ARDD 2020: from aging mechanisms to interventions

      Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, Gorbunova, V., Grey, A. D., He, W. W., Hoeijmakers, J., Hoffmann, Eva, Horvath, S., Houtkooper, R. H., Jensen, Majken Karoline, Jensen, M. B., Kane, A., Kassem, Moustapha Saad El-Deen, Keizer, P. D., Kennedy, B., Karsenty, G., Lamming, D. W., Lee, K. F., MacAulay, Nanna, Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, Andreas, Niedernhofer, L., Osborne, Brenna, Pak, H. H., Parkhitko, A., Raimundo, N., Rando, T. A., Rasmussen, Lene Juel, Reis, C., Riedel, C. G., Franco-Romero, A., Schumacher, B., Sinclair, D. A., Suh, Y., Taub, P. R., Toiber, D., Treebak, Jonas Thue, Valenzano, D. R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, Daniela Janina, Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2020, In: Aging. 12, 24, p. 24486-24503 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      New methodologies in ageing research

      Osborne, Brenna, Bakula, Daniela Janina, Ben Ezra, Michael, Dresen, C., Hartmann, E., Kristensen, S. M., Mkrtchyan, Garik, Nielsen, M. H., Petr, Michael Angelo & Scheibye-Knudsen, Morten, 2020, In: Ageing Research Reviews. 62, 11 p., 101094.

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research

      Gonzalez-Franquesa, A., Carrasquilla Lopez, G. D., Mamidi, A., Ghiasi, S. M., Juel, H. B., Falk, S., Isidor, M. S., Gillberg, L. M. E., Huang, L. O., Quist, J. S., Knudsen, J. R., Quaranta, R., Tozzi, M., Mikkelsen, R. B., Dall, M., Drag, M. H., Small, L. B., Altıntaş, A., Osborne, B., Modvig, I. M. & 11 others, Husted, Anna Sofie, Brown, E. L., Bak, Emilie Glad, Bastos Peluso, A. A., Finger, Fabian Michael, Grunddal, Kaare Villum, Rupar, K., Henningsen, J. B., Pedersen, M. H., Plucinska, Kaja & Attendees of the Danish Diabetes Academy Winter School 2019, A. O. T. D. D. A. W. S. 2., 2020, In: Acta Physiologica. 229, 2, 5 p., e13455.

      Research output: Contribution to journal › Comment/debate › Research

    13. ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

      Du, X., Zhou, L., Aw, Y. C., Mak, H. Y., Xu, Y., Rae, J., Wang, W., Zadoorian, A., Hancock, S. E., Osborne, Brenna, Chen, X., Wu, J., Turner, N., Parton, R. G., Li, P. & Yang, H., 2020, In: Journal of Cell Biology. e201905162.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2019

    15. Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells

      Liu, M., Hancock, S. E., Sultani, G., Wilkins, B. P., Ding, E., Osborne, Brenna, Quek, L. & Turner, N., 8 Jun 2019, In: Journal of Clinical Medicine. 8, 6, 822.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

      Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 22 May 2019, In: Oncogene. 38, p. 3824–3842

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))

      Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L. J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M. J., Hung, T. T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, Guarente, L. & Sinclair, D. A., 7 Feb 2019, In: Cell. 176, 4, p. 944-945 2 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    18. Published

      Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

      Keijzers, G., Bakula, Daniela Janina, Petr, Michael Angelo, Madsen, N. G. K., Teklu, Amanuel Abraha, Mkrtchyan, Garik, Osborne, Brenna & Scheibye-Knudsen, Morten, 2019, In: International Journal of Molecular Sciences . 20, 1, 15 p., 74.

      Research output: Contribution to journal › Review › Research › peer-review

    19. Published

      Impact of lifestyle and clinical interventions on mitochondrial function in obesity and type 2 diabetes

      Osborne, Brenna, Brandon, A. E., Smith, G. C. & Turner, N., 2019, Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases. Academic Press, p. 367-397 31 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    20. Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84

      Montgomery, M. K., Osborne, Brenna, Brandon, A. E., O'Reilly, L., Fiveash, C. E., Brown, S. H. J., Wilkins, B. P., Samsudeen, A., Yu, J., Devanapalli, B., Hertzog, A., Tolun, A. A., Kavanagh, T., Cooper, A. A., Mitchell, T. W., Biden, T. J., Smith, N. J., Cooney, G. J. & Turner, N., 2019, In: FASEB Journal. 33, 11, p. 12264-12276

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. 2018

    22. A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

      Turner, N., Lim, X. Y., Toop, H. D., Osborne, B., Brandon, A. E., Taylor, E. N., Fiveash, C. E., Govindaraju, H., Teo, J. D., McEwen, H. P., Couttas, T. A., Butler, S. M., Das, A., Kowalski, G. M., Bruce, C. R., Hoehn, K. L., Fath, T., Schmitz-Peiffer, C., Cooney, G. J., Montgomery, M. K. & 2 others, Morris, J. C. & Don, A. S., Dec 2018, In: Nature Communications. 9, 3165.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice

      Bentley, N. L., Fiveash, C. E., Osborne, Brenna, Quek, L., Ogura, M., Inagaki, N., Cooney, G. J., Polly, P., Montgomery, M. K. & Turner, N., Jul 2018, In: Biochemical and Biophysical Research Communications. 503, 3, p. 1349-1355

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

      Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L-J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M-J., Hung, T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, Guarente, L. & Sinclair, D. A., 2018, In: Cell. 173, 1, p. 74-89 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. 2017

    26. NAD+: A key metabolic regulator with great therapeutic potential

      Sultani, G., Samsudeen, A. F., Osborne, Brenna & Turner, N., 2017, In: Journal of Neuroendocrinology. 29, 10, e12508.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate

      Hayward, B., Molero, J. C., Windmill, K., Sanigorski, A., Weir, J., McRae, N. L., Aston-Mourney, K., Osborne, Brenna, Liao, B., Walder, K. R., Meikle, P. J., Konstantopoulos, N. & Schmitz-Peiffer, C., 2017, In: Experimental and Clinical Endocrinology and Diabetes. 124, 10, p. 602-612 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. 2016
    29. Published

      Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species

      Montgomery, M. K., Brown, S. H. J., Lim, X. Y., Fiveash, C. E., Osborne, Brenna, Bentley, N. L., Braude, J. P., Mitchell, T. W., Coster, A. C. F., Don, A. S., Cooney, G. J., Schmitz-Peiffer, C. & Turner, N., 1 Nov 2016, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1861, 11, p. 1828-1839 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      The role of mitochondrial sirtuins in health and disease

      Osborne, Brenna, Bentley, N. L., Montgomery, M. K. & Turner, N., 1 Nov 2016, In: Free Radical Biology and Medicine. 100, p. 164-174 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    31. Published

      Repurposing Drugs to Target the Diabetes Epidemic

      Turner, N., Zeng, X. Y., Osborne, Brenna, Rogers, S. & Ye, J. M., 1 May 2016, In: Trends in Pharmacological Sciences. 37, 5, p. 379-389 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    32. 2015
    33. Published

      Disparate metabolic response to fructose feeding between different mouse strains

      Montgomery, M. K., Fiveash, C. E., Braude, J. P., Osborne, Brenna, Brown, Stanley, Mitchell, T. W. & Turner, N., 22 Dec 2015, In: Scientific Reports. 5, 18474.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

      Du, X., Zhang, Y., Jo, S. R., Liu, X., Qi, Y., Osborne, Brenna, Byrne, F. L., Smith, G. C., Turner, N., Hoehn, K. L., Brown, A. J. & Yang, H., 15 Oct 2015, In: Biochemical Journal. 471, 2, p. 243-253 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. 2014
    36. Published

      PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis

      Liu, M., Montgomery, M. K., Fiveash, C. E., Osborne, Brenna, Cooney, G. J., Bell-Anderson, K. & Turner, N., 2 Jul 2014, In: Scientific Reports. 4, 5538.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation

      Osborne, Brenna, Yao, T. W., Wang, X. M., Chen, Y., Kotan, L. D., Nadvi, N. A., Herdem, M., McCaughan, G. W., Allen, J. D., Yu, D. M. T., Topaloglu, A. K. & Gorrell, M. D., Jul 2014, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 7, p. 1248-1259 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

      Osborne, Brenna, Cooney, G. J. & Turner, N., Apr 2014, In: Biochimica et Biophysica Acta - General Subjects. 1840, 4, p. 1295-1302 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    39. 2013
    40. Published

      Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle

      Montgomery, M. K., Osborne, Brenna, Brown, S. H. J., Small, Lewin Barkla, Mitchell, T. W., Cooney, G. J. & Turner, N., Dec 2013, In: Journal of Lipid Research. 54, 12, p. 3322-3333 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.

      Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira, D. R. A., Osborne, Brenna, Yu, D., Seth, D., Rahman, K., Haber, P., Topaloglu, A., Wang, C., Thomson, S. & Hennessy, A., 2013, In: FEBS Open Bio. 4, 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. 2010
    43. Published

      The dipeptidyl peptidase IV family in cancer and cell biology.

      Yu, D., Yao, T., Chowdhury, S., Nadvi, N., Osborne, Brenna, Church, W., McCaughan, G. & Gorrell, M. D., Mar 2010, In: FEBS Journal. 277, 5

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 188144250