Brenna Osborne

Brenna Osborne

Assistant Professor, Guest Researcher

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    ORCID: 0000-0002-0197-3010

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    1. A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

      Xi, C. R., Fazio, A. D., Nadvi, N. A., Patel, K., Xiang, M. S. W., Zhang, H. E., Deshpande, C., Low, J., Wang, X. T., Chen, Y., McMillan, C., Isaacs, A., Osborne, Brenna, Ribeiro, A. J. V. D., McCaughan, G. W., Mackay, J., Church, W. B. & Gorrell, M., Nov 2020, In: Molecules. 5392.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

      Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 22 May 2019, In: Oncogene. 38, p. 3824–3842

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation

      Osborne, Brenna, Yao, T. W., Wang, X. M., Chen, Y., Kotan, L. D., Nadvi, N. A., Herdem, M., McCaughan, G. W., Allen, J. D., Yu, D. M. T., Topaloglu, A. K. & Gorrell, M. D., Jul 2014, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 7, p. 1248-1259 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

      Turner, N., Lim, X. Y., Toop, H. D., Osborne, B., Brandon, A. E., Taylor, E. N., Fiveash, C. E., Govindaraju, H., Teo, J. D., McEwen, H. P., Couttas, T. A., Butler, S. M., Das, A., Kowalski, G. M., Bruce, C. R., Hoehn, K. L., Fath, T., Schmitz-Peiffer, C., Cooney, G. J., Montgomery, M. K. & 2 others, Morris, J. C. & Don, A. S., Dec 2018, In: Nature Communications. 9, 3165.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      ARDD 2020: from aging mechanisms to interventions

      Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, Gorbunova, V., Grey, A. D., He, W. W., Hoeijmakers, J., Hoffmann, Eva, Horvath, S., Houtkooper, R. H., Jensen, Majken Karoline, Jensen, M. B., Kane, A., Kassem, Moustapha Saad El-Deen, Keizer, P. D., Kennedy, B., Karsenty, G., Lamming, D. W., Lee, K. F., MacAulay, Nanna, Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, Andreas, Niedernhofer, L., Osborne, Brenna, Pak, H. H., Parkhitko, A., Raimundo, N., Rando, T. A., Rasmussen, Lene Juel, Reis, C., Riedel, C. G., Franco-Romero, A., Schumacher, B., Sinclair, D. A., Suh, Y., Taub, P. R., Toiber, D., Treebak, Jonas Thue, Valenzano, D. R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, Daniela Janina, Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2020, In: Aging. 12, 24, p. 24486-24503 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

      Du, X., Zhang, Y., Jo, S. R., Liu, X., Qi, Y., Osborne, Brenna, Byrne, F. L., Smith, G. C., Turner, N., Hoehn, K. L., Brown, A. J. & Yang, H., 15 Oct 2015, In: Biochemical Journal. 471, 2, p. 243-253 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

      Osborne, Brenna, Cooney, G. J. & Turner, N., Apr 2014, In: Biochimica et Biophysica Acta - General Subjects. 1840, 4, p. 1295-1302 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    8. Published

      Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle

      Montgomery, M. K., Osborne, Brenna, Brown, S. H. J., Small, Lewin Barkla, Mitchell, T. W., Cooney, G. J. & Turner, N., Dec 2013, In: Journal of Lipid Research. 54, 12, p. 3322-3333 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Disparate metabolic response to fructose feeding between different mouse strains

      Montgomery, M. K., Fiveash, C. E., Braude, J. P., Osborne, Brenna, Brown, Stanley, Mitchell, T. W. & Turner, N., 22 Dec 2015, In: Scientific Reports. 5, 18474.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))

      Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L. J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M. J., Hung, T. T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, Guarente, L. & Sinclair, D. A., 7 Feb 2019, In: Cell. 176, 4, p. 944-945 2 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

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