Brenna Osborne

Brenna Osborne

Assistant Professor, Guest Researcher

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    ORCID: 0000-0002-0197-3010

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    1. Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice

      Bentley, N. L., Fiveash, C. E., Osborne, Brenna, Quek, L., Ogura, M., Inagaki, N., Cooney, G. J., Polly, P., Montgomery, M. K. & Turner, N., Jul 2018, In: Biochemical and Biophysical Research Communications. 503, 3, p. 1349-1355

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

      Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L-J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M-J., Hung, T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, Guarente, L. & Sinclair, D. A., 2018, In: Cell. 173, 1, p. 74-89 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))

      Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L. J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M. J., Hung, T. T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z. & 2 others, Guarente, L. & Sinclair, D. A., 7 Feb 2019, In: Cell. 176, 4, p. 944-945 2 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    4. ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

      Du, X., Zhou, L., Aw, Y. C., Mak, H. Y., Xu, Y., Rae, J., Wang, W., Zadoorian, A., Hancock, S. E., Osborne, Brenna, Chen, X., Wu, J., Turner, N., Parton, R. G., Li, P. & Yang, H., 2020, In: Journal of Cell Biology. e201905162.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

      Du, X., Zhang, Y., Jo, S. R., Liu, X., Qi, Y., Osborne, Brenna, Byrne, F. L., Smith, G. C., Turner, N., Hoehn, K. L., Brown, A. J. & Yang, H., 15 Oct 2015, In: Biochemical Journal. 471, 2, p. 243-253 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research

      Gonzalez-Franquesa, A., Carrasquilla Lopez, G. D., Mamidi, A., Ghiasi, S. M., Juel, H. B., Falk, S., Isidor, M. S., Gillberg, L. M. E., Huang, L. O., Quist, J. S., Knudsen, J. R., Quaranta, R., Tozzi, M., Mikkelsen, R. B., Dall, M., Drag, M. H., Small, L. B., Altıntaş, A., Osborne, B., Modvig, I. M. & 11 others, Husted, Anna Sofie, Brown, E. L., Bak, Emilie Glad, Bastos Peluso, A. A., Finger, Fabian Michael, Grunddal, Kaare Villum, Rupar, K., Henningsen, J. B., Pedersen, M. H., Plucinska, Kaja & Attendees of the Danish Diabetes Academy Winter School 2019, A. O. T. D. D. A. W. S. 2., 2020, In: Acta Physiologica. 229, 2, 5 p., e13455.

      Research output: Contribution to journal › Comment/debate › Research

    7. Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate

      Hayward, B., Molero, J. C., Windmill, K., Sanigorski, A., Weir, J., McRae, N. L., Aston-Mourney, K., Osborne, Brenna, Liao, B., Walder, K. R., Meikle, P. J., Konstantopoulos, N. & Schmitz-Peiffer, C., 2017, In: Experimental and Clinical Endocrinology and Diabetes. 124, 10, p. 602-612 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Nuclear morphology is a deep learning biomarker of cellular senescence

      Heckenbach, Indra John, Mkrtchyan, Garik, Ben Ezra, Michael, Bakula, Daniela Janina, Madsen, Jakob Sture, Nielsen, M. H., Oró, D., Osborne, Brenna, Covarrubias, A. J., Idda, M. L., Gorospe, M., Mortensen, Laust Hvas, Verdin, E., Westendorp, Rudi GJ & Scheibye-Knudsen, Morten, 2022, In: Nature Aging. 2, 8, p. 742-755 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.

      Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira, D. R. A., Osborne, Brenna, Yu, D., Seth, D., Rahman, K., Haber, P., Topaloglu, A., Wang, C., Thomson, S. & Hennessy, A., 2013, In: FEBS Open Bio. 4, 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

      Keijzers, G., Bakula, Daniela Janina, Petr, Michael Angelo, Madsen, N. G. K., Teklu, Amanuel Abraha, Mkrtchyan, Garik, Osborne, Brenna & Scheibye-Knudsen, Morten, 2019, In: International Journal of Molecular Sciences . 20, 1, 15 p., 74.

      Research output: Contribution to journal › Review › Research › peer-review

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    ID: 188144250