Birgitte Rahbek Kornum

Birgitte Rahbek Kornum

Guest Researcher, Associate Professor - Promotion Programme


  1. 2024
  2. Published

    The immunopathogenesis of narcolepsy type 1

    Liblau, R. S., Latorre, D., Kornum, Birgitte Rahbek, Dauvilliers, Y. & Mignot, E. J., 2024, In: Nature Reviews Immunology. 24, p. 33-48

    Research output: Contribution to journalReviewpeer-review

  3. Published

    Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice

    Pagh-Berendtsen, Nicolai, Pavlovskyi, A., Flores Téllez, D., Jensen, Christine Egebjerg, Pedersen, Mie Gunni Kolmos, Justinussen, Jessica & Kornum, Birgitte Rahbek, 2024, In: Sleep.

    Research output: Contribution to journalJournal articlepeer-review

  4. 2023
  5. Published

    How hypocretin agonists may improve the quality of wake in narcolepsy

    Justinussen, Jessica, Jensen, Christine Egebjerg & Kornum, Birgitte Rahbek, 2023, In: Trends in Molecular Medicine. 29, 1, p. 61-69 9 p.

    Research output: Contribution to journalReviewpeer-review

  6. Published

    Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice

    Pedersen, Mie Gunni Kolmos, Arribas, A. P., Kornum, Birgitte Rahbek & Justinussen, Jessica, 2023, In: European Journal of Neuroscience. 58, 9, p. 4002-4010 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published
  8. Published
  9. Published

    Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

    Ollila, H. M., Sharon, E., Lin, L., Sinnott-Armstrong, N., Ambati, A., Yogeshwar, S. M., Hillary, R. P., Jolanki, O., Faraco, J., Einen, M., Luo, G., Zhang, J., Han, F., Yan, H., Dong, X. S., Li, J., Zhang, J., Hong, S. C., Kim, T. W., Dauvilliers, Y. & 31 others, Barateau, L., Lammers, G. J., Fronczek, R., Mayer, G., Santamaria, J., Arnulf, I., Knudsen-Heier, S., Bredahl, M. K. L., Thorsby, P. M., Plazzi, G., Pizza, F., Moresco, M., Crowe, C., Van den Eeden, S. K., Lecendreux, M., Bourgin, P., Kanbayashi, T., Martínez-Orozco, F. J., Peraita-Adrados, R., Benetó, A., Montplaisir, J., Desautels, A., Huang, Y. S., Jennum, Poul, Nevsimalova, S., Kemlink, D., Iranzo, A., Overeem, S., Wierzbicka, A., Kornum, Birgitte Rahbek & FinnGen, F., 2023, In: Nature Communications. 14, 1, 13 p., 2709.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published
  11. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls

    Torstensen, E. W., Haubjerg Østerby, N. C., Pizza, F., Plazzi, G., Antelmi, E., Moresco, M., Mignot, E., Jørgensen, Niklas Rye, Christensen, G. L., Wanscher, B., Kornum, Birgitte Rahbek & Jennum, Poul, 2023, In: Sleep Medicine. 101, p. 213-220 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders

    Torstensen, E. W., Haubjerg Østerby, N. C., Kornum, Birgitte Rahbek, Wanscher, B., Mignot, E., Barløse, Mads Christian Johannes & Jennum, Poul, 2023, In: Sleep Medicine. 110, p. 91-98 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

    Viste, R., Follin, L. F., Kornum, Birgitte Rahbek, Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Emerging therapeutic targets for narcolepsy

    Vringer, M. & Kornum, Birgitte Rahbek, 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.

    Research output: Contribution to journalReviewpeer-review

  16. 2022
  17. Published

    Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

    Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, Hall, Vanessa Jane, 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

    Holm, A., Possovre, M. L., Bandarabadi, M., Moseholm, Kristine Frøsig, Justinussen, Jessica, Bozic, I., Lemcke, René, Arribat, Y., Amati, F., Silahtaroglu, Asli, Juventin, M., Adamantidis, A., Tafti, M. & Kornum, Birgitte Rahbek, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Neurobioloy of sleep and circadian disorders

    Kornum, Birgitte Rahbek & Mignot, E., 2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. M. J. Z., C. A. W. & M-F. C. (eds.). 2 ed. Elsevier, p. 635-658 24 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  20. Published

    Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model

    Petersen, Louise Piilgaard, Rose, Laura, Hviid, C. G., Kohlmeier, Kristi Anne & Kornum, Birgitte Rahbek, 2022, In: Sleep. 45, 7, 15 p., zsac058.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients have increased muscle activity during REM and nrem sleep compared with their non-narcoleptic siblings

    Viste, R., Lie, B. A., Kornum, Birgitte Rahbek, Rootwelt, T. & Knudsen-Heier, S., 2022, In: Journal of Sleep Research. 31, Supplement 1, 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  22. 2021
  23. Published

    Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I

    Aegidius, H. M., Kruse, L., Christensen, G. L., Lorentzen, M. P., Jørgensen, Niklas Rye, Moresco, M., Pizza, F., Plazzi, G., Jennum, Poul & Kornum, Birgitte Rahbek, 2021, In: Brain Communications. 3, 2, 13 p., 050.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Narcolepsy Type I as an autoimmune disorder

    Kornum, Birgitte Rahbek, 2021, Handbook of Clinical Neurology. 1 ed. Elsevier, p. 161-172 12 p. (Handbook of Clinical Neurology, Vol. 181).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  25. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Diagnostic value of actigraphy in hypersomnolence disorders

    Torstensen, E. W., Pickering, L., Kornum, Birgitte Rahbek, Wanscher, B., Baandrup, Lone & Jennum, Poul, 2021, In: Sleep Medicine. 85, p. 1-7 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1

    Viste, R., Viken, M. K., Lie, B. A., Juvodden, H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, Birgitte Rahbek & Knudsen-Heier, S., 2021, In: Sleep. 44, 8, 12 p., zsab062.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status

    Viste, R., Lie, B. A., Viken, M. K., Rootwelt, T., Knudsen-Heier, S. & Kornum, Birgitte Rahbek, 2021, In: Sleep Medicine. 85, p. 271-279 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. 2020
  31. Published

    Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

    Bentsen, M. A., Rausch, D. M., Mirzadeh, Z., Muta, K., Scarlett, J. M., Brown, J. M., Herranz-Pérez, V., Baquero, A. F., Thompson, J., Alonge, K. M., Faber, C. L., Kaiyala, K. J., Bennett, C., Pyke, C., Ratner, C., Egerod, K. L., Holst, B., Meek, T. H., Kutlu, B., Zhang, Y. & 9 others, Sparso, T., Grove, K. L., Morton, G. J., Kornum, Birgitte Rahbek, García-Verdugo, J. M., Secher, A., Jorgensen, R., Schwartz, M. W. & Pers, Tune H, 2020, In: Nature Communications. 11, 1, 4458.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published
  33. Published

    Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes

    Hauglund, Natalie Linea, Kusk, P., Kornum, Birgitte Rahbek & Nedergaard, Maiken, 2020, In: Journal of Neuroscience. 40, 11, p. 2371-2380 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Narcolepsy type 1: What have we learned from immunology?

    Kornum, Birgitte Rahbek, 2020, In: Sleep. 43, 10, zsaa055.

    Research output: Contribution to journalReviewpeer-review

  35. Published

    The case for narcolepsy as an autoimmune disease

    Kornum, Birgitte Rahbek & Jennum, Poul, 2020, In: Expert Review of Clinical Immunology. 16, 3, p. 231-233 3 p.

    Research output: Contribution to journalReviewpeer-review

  36. Published

    TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES

    Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628

    Research output: Patent

  37. Published

    Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

    Ægidius, H. M., Veidal, S. S., Feigh, M., Hallenborg, P., Puglia, M., Pers, Tune H, Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K. T. G., 2020, In: Scientific Reports. 10, 1, 12 p., 1148.

    Research output: Contribution to journalJournal articlepeer-review

  38. 2019
  39. Published

    CHARACTERIZATION OF REGULATORY NETWORKS BY MULTI-OMICS COMBINING PROTEOMICS WITH BULK AND SINGLE-CELL RNA SEQUENCING IN A DIET-INDUCED AND BIOPSY-CONFIRMED MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS

    AEgidius, H., Veidal, S., Feigh, M., Puglia, M., Hallenborg, P., Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K., 2019, In: Hepatology. 70, Supplement 1, p. 1278A-1279A 2 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  40. Published

    Unge forskere: S-løftebrud er en katastrofe for universiteterne

    Aguirre, V., Andersen, C., Andersen, P. R., Bjørk, R., Clemmensen, C., Dalsgaard, P., Danbolt, M., Dimke, H., Engberg-Pedersen, A., Feliu, E., Jauffred, L., Jønsson, K., Kornum, B. R., Kropp, K., Laustsen, A., Levisen, C., Lock, N., Lomborg, S., Møller, N. M., Niss, K. & 5 others, Pedersen, B. P., Pristed, B. B., Sørensen, Thomas Just, Ulstrup, S. & Vallgårda, Karen Asta Arnfred, 2019

    Research output: Other contributionCommunication

  41. Published

    Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment

    Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, Birgitte Rahbek, Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmaecher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M. & Dauvilliers, Y., 2019, In: Nature Reviews. Neurology. 15, 9, p. 519-539

    Research output: Contribution to journalReviewpeer-review

  42. Published

    Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations

    Dommer, M. W., Dreisig, K. & Kornum, Birgitte Rahbek, 2019, In: Pharmacological Reports. 71, 5, p. 926-928 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

    Jiang, W., Birtley, J. R., Hung, S. C., Wang, W., Chiou, S. H., Macaubas, C., Kornum, Birgitte Rahbek, Tian, L., Huang, H., Adler, L., Weaver, G., Lu, L., Ilstad-Minnihan, A., Somasundaram, S., Ayyangar, S., Davis, M. M., Stern, L. J. & Mellins, E. D., 2019, In: Nature Communications. 10, 1, 17 p., 5247.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Forstå din søvn: Hvad videnskaben siger om at sove godt, og hvordan du opnår det!

    Kornum, Birgitte Rahbek, 2019, 1 ed. København: Gyldendal. 205 p.

    Research output: Book/ReportBook

  45. Published

    Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system

    Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, Pers, Tune H & Hall, Vanessa Jane, 2019. 45 p.

    Research output: Contribution to conferencePaperCommunication

  46. Published

    CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, Poul, Knudsen, S., Hadrup, S. R. & Kornum, Birgitte Rahbek, 2019, In: Nature Communications. 10, p. 1-12 837.

    Research output: Contribution to journalJournal articlepeer-review

  47. 2018
  48. Published

    Human P2Y11 expression level affects human P2X7 receptor-mediated cell death

    Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, Niels, Jäättelä, M., Skov, Søren & Kornum, Birgitte Rahbek, 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.

    Research output: Contribution to journalJournal articlepeer-review

  49. N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake

    Dreisig, K., Kristensen, N. P., Dommer, M. W., Jørgensen, N. R. & Kornum, Birgitte Rahbek, 2018, In: Purinergic Signalling. 14, 1, p. 83-90 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    DNMT1 regulates expression of MHC class I in post-mitotic neurons

    Gustafsson, J. R., Katsioudi, G., Degn, M., Ejlerskov, P., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 2018, In: Molecular Brain. 11, 1, p. 1-16 16 p., 36.

    Research output: Contribution to journalJournal articlepeer-review

  51. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, Birgitte Rahbek, Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., 2018, In: Sleep Medicine. 44, p. 53-60 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

    Torstensen, E. W., Brinth, L. S., Mehlsen, J., Kornum, Birgitte Rahbek & Jennum, Poul, 2018, In: Danish Medical Journal. 65, 11, 4 p., A5510.

    Research output: Contribution to journalJournal articlepeer-review

  53. Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells

    Zager, A., Brandão, W. N., Margatho, R. O., Cruz, D. S. G., Peron, J. P., Tufik, S., Andersen, M. L., Moresco, M., Pizza, F., Plazzi, G., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 297-305 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor

    Zager, A., Brandão, W. N., Margatho, R. O., Peron, J. P., Tufik, S., Andersen, M. L., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 468-476 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. 2017
  56. Published

    Novel method for evaluation of eye movements in patients with narcolepsy

    Christensen, J. A. E., Kempfner, L., Leonthin, H. L., Hvidtfelt, M., Nikolic, M., Kornum, Birgitte Rahbek & Jennum, Poul, May 2017, In: Sleep Medicine. 33, p. 171-180 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Sleep spindle density in narcolepsy

    Christensen, J. A. E., Nikolic, M., Hvidtfelt, M., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 40-49 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Rare missense mutations in P2RY11 in narcolepsy with cataplexy

    Degn, M., Dauvilliers, Y., Dreisig, K., Lopez, R., Pfister, C., Pradervand, S., Kornum, Birgitte Rahbek & Tafti, M., 1 Jun 2017, In: Brain. 140, 6, p. 1657-1668 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Sleep-wake stability in narcolepsy patients with normal, low and unmeasurable hypocretin levels

    Hansen, M. H., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 1-6 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    The evolutionary conserved microrna MIR-137 regulates gene expression and diurnal rhythm of the wake-promoting hypocretin neuropeptides

    Holm, A., Moseholm, Kristine Frøsig, Justinussen, Jessica, Silahtaroglu, Asli, Adamantidis, A. & Kornum, Birgitte Rahbek, 2017, In: Sleep Medicine. 40, Supplement 1, p. E132-E133 2 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  61. Published

    Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy

    Jennum, Poul, Østergaard Pedersen, L., Czarna Bahl, J. M., Modvig, S., Fog, K., Holm, A., Kornum, Birgitte Rahbek & Gammeltoft, S., 1 Jan 2017, In: Sleep. 40, 1, 9 p., zsw006.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    Narcolepsy

    Kornum, Birgitte Rahbek, Knudsen, S., Ollila, H. M., Pizza, F., Jennum, Poul, Dauvilliers, Y. & Overeem, S., 2017, In: Nature Reviews. Disease Primers. 3, 19 p., 16100.

    Research output: Contribution to journalReviewpeer-review

  63. Published

    Absence of autoreactive CD4(+) T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot

    Kornum, Birgitte Rahbek, Burgdorf, Kristoffer Sølvsten, Holm, A., Ullum, H., Jennum, Poul & Knudsen, S., 2017, In: Journal of Neuroimmunology. 309, p. 7-11 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Genetics of Human Sleep and Sleep Disorders

    Kornum, Birgitte Rahbek, 2017, Handbook of Neurobehavioural Genetics and Phenotyping. Tucci, V. (ed.). 1 ed. New Jersey: Wiley-Blackwell, p. 295-320 26 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  65. Published

    Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2

    Schrölkamp, Maren, Jennum, Poul, Gammeltoft, S., Holm, A., Kornum, Birgitte Rahbek & Knudsen, S., Feb 2017, In: Journal of Clinical Sleep Medicine. 13, 2, p. 235-243 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. 2016
  67. Published

    Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length

    Boddum, K., Hansen, M. H., Jennum, Poul & Kornum, Birgitte Rahbek, 2016, In: PloS one. 11, 3, 13 p., e0151288.

    Research output: Contribution to journalJournal articlepeer-review

  68. Published

    A critical look at the function of the P2Y11 receptor

    Dreisig, K. & Kornum, Birgitte Rahbek, Sep 2016, In: Purinergic Signalling. 12, 3, p. 427-37 11 p.

    Research output: Contribution to journalReviewpeer-review

  69. Published

    Validation of antibodies for neuroanatomical localization of the P2Y receptor in macaque brain

    Dreisig, K., Degn, M., Sund, L., Hadaczek, P., Samaranch, L., San Sebastian, W., Bankiewicz, K. & Kornum, Birgitte Rahbek, Dec 2016, In: Journal of Chemical Neuroanatomy. 78, p. 25-33 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Neurobasal media facilitates increased specificity of siRNA-mediated knockdown in primary cerebellar cultures

    Gustafsson, J. R., Katsioudi, G., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 1 Dec 2016, In: Journal of Neuroscience Methods. 274, p. 116-124 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis

    Jennum, Poul, Kornum, Birgitte Rahbek, Issa, N. M., Gammeltoft, S., Tommerup, Niels, Morling, Niels, Tümer, Asuman Zeynep & Knudsen, S., Aug 2016, In: Neurology: Neuroimmunology & Neuroinflammation. 3, 4, 2 p., e249.

    Research output: Contribution to journalLetterpeer-review

  72. Published

    The European Narcolepsy Network (EU-NN) database

    Khatami, R., Luca, G., Baumann, C. R., Bassetti, C. L., Bruni, O., Canellas, F., Dauvilliers, Y., Del Rio-Villegas, R., Feketeova, E., Ferri, R., Geisler, P., Högl, B., Jennum, P., Kornum, B. R., Lecendreux, M., Martins-da-Silva, A., Mathis, J., Mayer, G., Paiva, T., Partinen, M. & 11 others, Peraita Adrados, R., Plazzi, G., Santamaria, J., Sonka, K., Riha, R., Tafti, M., Wierzbicka, A., Young, P., Lammers, G. J., Overeem, S. & European Narcolepsy Network, E. N. N., Jun 2016, In: Journal of Sleep Research. 25, 3, p. 356-64 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Precipitants of Narcolepsy: Vaccines and Infections

    Kornum, Birgitte Rahbek, 2016, Narcolepsy: A Clinical Guide. 2 ed. Springer, p. 25-33 9 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  74. 2015
  75. Published

    Type 1 narcolepsy: a CD8+ T cell-mediated disease?

    Degn, M. & Kornum, Birgitte Rahbek, Sep 2015, In: Annals of the New York Academy of Sciences. 1351, p. 80-88 9 p.

    Research output: Contribution to journalReviewpeer-review

  76. Published

    EIF3G is associated with narcolepsy across ethnicities

    Holm, A., Lin, L., Faraco, J., Mostafavi, S., Battle, A., Zhu, X., Levinson, D. F., Han, F., Gammeltoft, S., Jennum, Poul, Mignot, E. & Kornum, Birgitte Rahbek, 2015, In: European Journal of Human Genetics. 23, 11, p. 1573-80 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published
  78. Published

    Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset

    Kornum, Birgitte Rahbek, Pizza, F., Knudsen, S., Plazzi, G., Jennum, Poul & Mignot, E., Oct 2015, In: Brain, Behavior, and Immunity. 49, p. 54-8 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Serum cytokine levels in Kleine-Levin syndrome

    Kornum, Birgitte Rahbek, Rico, T., Lin, L., Huang, Y., Arnulf, I., Jennum, Poul & Mignot, E., Aug 2015, In: Sleep Medicine. 16, 8, p. 961-5 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    Sleep Disorders

    Kornum, Birgitte Rahbek & Mignot, E., 1 Jan 2015, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Zigmond, M. J., Rowland, L. P. & Coyle, J. T. (eds.). London: Elsevier Science Inc., p. 585-611 27 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  81. Published

    HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy

    Ollila, H. M., Ravel, J-M., Han, F., Faraco, J., Lin, L., Zheng, X., Plazzi, G., Dauvilliers, Y., Pizza, F., Hong, S-C., Jennum, P., Knudsen, S., Kornum, B. R., Dong, X. S., Yan, H., Hong, H., Coquillard, C., Mahlios, J., Jolanki, O., Einen, M. & 15 others, Arnulf, I., Lavault, S., Högl, B., Frauscher, B., Crowe, C., Partinen, M., Huang, Y. S., Bourgin, P., Vaarala, O., Désautels, A., Montplaisir, J., Mack, S. J., Mindrinos, M., Fernandez-Vina, M. & Mignot, E., 8 Jan 2015, In: American Journal of Human Genetics. 96, 1, p. 136-46 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. 2014
  83. Published

    Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy"

    De la Herrán-Arita, A. K., Kornum, Birgitte Rahbek, Mahlios, J., Jiang, W., Lin, L., Hou, T., Macaubas, C., Einen, M., Plazzi, G., Crowe, C., Newell, E. W., Davis, M. M., Mellins, E. D. & Mignot, E., 30 Jul 2014, In: Science Translational Medicine. 6, 247, 247rt1.

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    miRNA profiles in cerebrospinal fluid from patients with central hypersomnias

    Holm, A., Bang-Berthelsen, C. H., Knudsen, S., Modvig, S., Kornum, Birgitte Rahbek, Gammeltoft, S. & Jennum, Poul, 15 Dec 2014, In: Journal of the Neurological Sciences. 347, 1-2, p. 199-204 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  85. Published

    miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias

    Holm, A., Bang-Berthelsen, C. H., Knudsen, S., Kornum, Birgitte Rahbek, Modvig, S., Jennum, Poul & Gammeltoft, S., Sep 2014, In: Sleep. 37, 9, p. 1525-1533 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    Does autoreactivity have a role in narcolepsy?

    Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., Nov 2014, In: Lancet Neurology. 13, 11, p. 1072-1073 2 p.

    Research output: Contribution to journalJournal articlepeer-review

  87. Published

    Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

    Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., 2014, In: Lancet Neurology. 13, 6, p. 600-13

    Research output: Contribution to journalReviewpeer-review

  88. 2013
  89. Published

    CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy

    De la Herrán-Arita, A. K., Kornum, Birgitte Rahbek, Mahlios, J., Jiang, W., Lin, L., Hou, T., Macaubas, C., Einen, M., Plazzi, G., Crowe, C., Newell, E. W., Davis, M. M., Mellins, E. D. & Mignot, E., 18 Dec 2013, In: Science Translational Medicine. 5, 216, p. 216ra176

    Research output: Contribution to journalJournal articlepeer-review

  90. Published

    ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

    Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., Rico, T. J., Lichtner, P., Dauvilliers, Y., Arnulf, I., Lecendreux, M., Javidi, S., Geisler, P., Mayer, G., Pizza, F., Poli, F., Plazzi, G., Overeem, S., Lammers, G. J., Kemlink, D. & 28 others, Sonka, K., Nevsimalova, S., Rouleau, G., Desautels, A., Montplaisir, J., Frauscher, B., Ehrmann, L., Högl, B., Jennum, Poul, Bourgin, P., Peraita-Adrados, R., Iranzo, A., Bassetti, C., Chen, W., Concannon, P., Thompson, S. D., Damotte, V., Fontaine, B., Breban, M., Gieger, C., Klopp, N., Deloukas, P., Wijmenga, C., Hallmayer, J., Onengut-Gumuscu, S., Rich, S. S., Winkelmann, J. & Mignot, E., 2013, In: P L o S Genetics (Online). 9, 2, 7 p., e1003270.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    Hjernens regulering af søvn

    Gammeltoft, S., Nordvang, A. H. & Kornum, Birgitte Rahbek, 2013, Søvn. Jennum, P. (ed.). 1 ed. København: Munksgaard , p. 39-50 12 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  92. Association mellem narkolepsi og H1N1-influenza

    Kornum, Birgitte Rahbek, Knudsen, S., Gammeltoft, S. & Jennum, Poul, 2013, In: Ugeskrift for Laeger. 175, 12, p. 815

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    5-HT radioligands for human brain imaging with PET and SPECT

    Paterson, L. M., Kornum, Birgitte Rahbek, Nutt, D. J., Pike, V. W. & Knudsen, Gitte Moos, Jan 2013, In: Medicinal Research Reviews. 33, 1, p. 54-111 58 p.

    Research output: Contribution to journalReviewpeer-review

  94. 2012
  95. Published

    Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy

    Andlauer, O., Moore, H., Hong, S., Dauvilliers, Y., Kanbayashi, T., Nishino, S., Han, F., Silber, M. H., Rico, T., Einen, M., Kornum, Birgitte Rahbek, Jennum, Poul, Knudsen, S., Nevsimalova, S., Poli, F., Plazzi, G. & Mignot, E., 2012, In: Sleep. 35, 9, p. 1247-55F

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency

    Knudsen, S., Biering-Sørensen, B., Kornum, Birgitte Rahbek, Petersen, E., Ibsen, J. D., Gammeltoft, S., Mignot, E. & Jennum, Poul, 2012, In: Neurology. 79, 1, p. 102-3 2 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status

    Weiner Lachmi, K., Lin, L., Kornum, Birgitte Rahbek, Rico, T., Lo, B., Aran, A. & Mignot, E., Apr 2012, In: Human Immunology. 73, 4, p. 405-10 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy

    Winkelmann, J., Lin, L., Schormair, B., Kornum, Birgitte Rahbek, Faraco, J., Plazzi, G., Melberg, A., Cornelio, F., Urban, A. E., Pizza, F., Poli, F., Grubert, F., Wieland, T., Graf, E., Hallmayer, J., Strom, T. M. & Mignot, E., 15 May 2012, In: Human Molecular Genetics. 21, 10, p. 2205-10 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. 2011
  100. Published

    An approach for serotonin depletion in pigs: effects on serotonin receptor binding

    Ettrup, A., Kornum, Birgitte Rahbek, Weikop, P. & Knudsen, Gitte Moos, 2011, In: Synapse. 65, 2, p. 136-45 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  101. Published

    Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research

    Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 2011, In: Neuroscience & Biobehavioral Reviews. 35, 3, p. 437-51 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  102. Published

    Common variants in P2RY11 are associated with narcolepsy

    Kornum, B. R., Kawashima, M., Faraco, J., Lin, L., Rico, T. J., Hesselson, S., Axtell, R. C., Kuipers, H., Weiner, K., Hamacher, A., Kassack, M. U., Han, F., Knudsen, S., Li, J., Dong, X., Winkelmann, J., Plazzi, G., Nevsimalova, S., Hong, S-C., Honda, Y. & 30 others, Honda, M., Högl, B., Ton, T. G. N., Montplaisir, J., Bourgin, P., Kemlink, D., Huang, Y., Warby, S., Einen, M., Eshragh, J. L., Miyagawa, T., Desautels, A., Ruppert, E., Hesla, P. E., Poli, F., Pizza, F., Frauscher, B., Jeong, J., Lee, S., Strohl, K. P., Longstreth, W. T., Kvale, M., Dobrovolna, M., Ohayon, M. M., Nepom, G. T., Wichmann, H., Rouleau, G. A., Gieger, C., Levinson, D. F. & Jennum, Poul, Jan 2011, In: Nature Genetics. 43, 1, p. 66-71 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  103. Published

    Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain

    Kornum, Birgitte Rahbek, Faraco, J. & Mignot, E., Dec 2011, In: Current Opinion in Neurobiology. 21, 6, p. 897-903 7 p.

    Research output: Contribution to journalReviewpeer-review

  104. 2010
  105. Published

    Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET

    Ettrup, A., Palner, M., Gillings, N., Santini, M. A., Hansen, M., Kornum, Birgitte Rahbek, Rasmussen, L. K., Någren, K., Madsen, J., Begtrup, M. & Knudsen, Gitte Moos, 1 Nov 2010, In: Journal of Nuclear Medicine. 51, 11, p. 1763-1770

    Research output: Contribution to journalJournal articlepeer-review

  106. Published

    Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain

    Kornum, Birgitte Rahbek, Stott, S. R. W., Mattsson, B., Wisman, L., Ettrup, A., Hermening, S., Knudsen, Gitte Moos & Kirik, D., 1 Mar 2010, In: Experimental Neurology. 222, 1, p. 70-85 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  107. 2009
  108. Published

    Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig

    Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N., Marner, Lisbeth, Andersen, F. & Knudsen, Gitte Moos, 1 Jan 2009, In: Journal of Cerebral Blood Flow and Metabolism. 29, 1, p. 186-96 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  109. Published

    A pig model for studies of serotonergic mechanisms in memory disorders

    Kornum, Birgitte Rahbek, 2009, København: Museum Tusculanum. 69 p.

    Research output: Book/ReportPh.D. thesis

  110. Published

    Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

    Syvanen, S., Lindhe, O., Palner, M., Kornum, Birgitte Rahbek, Rahman, O., Langstrom, B., Knudsen, Gitte Moos & Hammarlund-Udenaes, M., 2009, In: Drug Metabolism and Disposition. 37, 3, p. 635-643 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  111. 2008
  112. Published

    Evaluation of the novel 5-HT4 receptor PET ligand (11C)SB207145 in the Göttingen minnipig

    Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N. M., Marner, L., Andersen, F. & Knudsen, G. M., 2008, In: Comprehensive Medline. 1, p. 186-96 10 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  113. Published

    A novel spatial Delayed Non-Match to Sample (DNMS) task in the Göttingen minipig

    Nielsen, T. R., Kornum, Birgitte Rahbek, Moustgaard, A. C., Gade, A., Lind, N. M. & Knudsen, Gitte Moos, 2008, In: Behavioural Brain Research. p. 93-8 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  114. 2007
  115. Published

    The effect of the inter-phase delay interval in the spontaneous object recognition test for pigs

    Kornum, Birgitte Rahbek, Thygesen, K. S., Nielsen, Thomas Rune, Knudsen, Gitte Moos & Lind, N. M., 6 Aug 2007, In: Behavioural Brain Research. 181, 2, p. 210-7 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  116. 2006
  117. Published

    Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus

    Kornum, Birgitte Rahbek, Weikop, Pia, Moller, A., Ronn, L. C. B., Knudsen, Gitte Moos & Aznar, S., 16 Feb 2006, In: Brain Research. 1073-1074, p. 262-8 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  118. Published

    Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes

    Kornum, Birgitte Rahbek, Licht, C. L., Weikop, P., Knudsen, G. M. & Kleijn, S. A., 9 Jan 2006, In: Neuroscience Letters. 392, 1-2, p. 129-34 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  119. 2003
  120. Published

    The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain

    Aznar, S., Qian, Z., Shah, R., Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 3 Jan 2003, In: Brain Research. 959, 1, p. 58-67 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  121. 2002
  122. Attenuation and scatter correction in myocardial SPET: improved diagnostic accuracy in patients with suspected coronary artery disease.

    Kjaer, A., Cortsen, A., Kornum, Birgitte Rahbek, Hasseldam, Henrik & Hesse, B., 2002, In: European Journal of Nuclear Medicine and Molecular Imaging. 29, 11, p. 1438-42 4 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 143987587