Birgitte Holst

Birgitte Holst

Professor


  1. Published

    A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

    Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A gut feeling for obesity: 7TM sensors on enteroendocrine cells

    Engelstoft, M. S., Egerod, Kristoffer Lihme, Holst, Birgitte & Schwartz, Thue W., 2008, In: Cell Metabolism. 8, 6, p. 447-9 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)

    Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39

    Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa

    Seidel, M., Jensen, S. M., Healy, D., Dureja, A., Watson, H. J., Holst, Birgitte, Bulik, C. M. & Sjögren, J. M., 2021, In: Nutrients. 13, 2, p. 1-19 19 p., 709.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

    Graae, A., Grarup, Niels, Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, Sabina, Prats Gavalda, Clara, Serup, A. K. L., Birk, Jesper Bratz, Dubail, J., Gillberg, Linn Maria Ellinor, Vienberg, S. G., Nykjær, A., Kiens, Bente, Wojtaszewski, Jørgen F P, Larsen, Steen, Apte, S. S., Häring, H., Vaag, A., Zethelius, B., Pedersen, Oluf Borbye, Treebak, Jonas Thue, Hansen, Torben & Holst, Birgitte, 2019, In: Diabetes. 68, 3, p. 502-514

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting- and ghrelin-mediated food intake

    de Guia, R. M., Hassing, Anna Skab, Ma, T., Plucinska, Kaja, Holst, Birgitte, Gerhart-Hines, Zach, Emanuelli, Brice & Treebak, Jonas Thue, 2021, In: F A S E B Journal. 35, 5, e21450.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes

    Steenberg, V. R., Jensen, S. M., Pedersen, J., Madsen, A. N., Windeloev, J. A., Holst, Birgitte, Quistorff, B., Poulsen, Steen Seier & Holst, Jens Juul, 2016, In: Diabetologia. 59, 2, p. 363-370 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Acylation type determines ghrelin's effects on energy homeostasis in rodents

    Heppner, K., Chaudhary, N., Müller, T. D., Kirchner, H., Habegger, K. M., Ottaway, N., Smiley, D. L., Dimarchi, R., Hofmann, S. M., Woods, S. C., Sivertsen, B. B., Holst, Birgitte, Pfluger, P. T., Perez-Tilve, D. & Tschöp, M. H., Oct 2012, In: Contemporary Endocrinology. 153, 10, p. 4687-95 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors

    Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

    Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese

    Graae, A. S., Hollensted, M., Kloppenborg, J. T., Mahendran, Y., Schnurr, Theresia Maria, Appel, E. V. R., Rask, J., Nielsen, T. R. H., Johansen, M., Linneberg, Allan René, Jørgensen, M. E., Grarup, Niels, Kadarmideen, H. N., Holst, Birgitte, Pedersen, Oluf Borbye, Holm, Jens-Christian & Hansen, Torben, Aug 2018, In: Diabetologia. 61, 8, p. 1769-1779

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor

    Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    An enteroendocrine full package solution

    Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala

    Jensen, M., Ratner, C., Rudenko, Olga, Christiansen, S. H., Skov, Louise Julie, Hundahl, C., Woldbye, David Paul Drucker & Holst, Birgitte, 1 May 2016, In: International Journal of Neuropsychopharmacology. 19, 5, 12 p., pyv123.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

    Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

  17. Published

    Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics

    Park, M., Sivertsen, B. B., Els-Heindl, S., Huber, T., Holst, Birgitte, Beck-Sickinger, A. G., Schwartz, Thue W. & Sakmar, T. P., 19 Nov 2015, In: Chemistry & Biology. 22, 11, p. 1431-1436 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

  18. Published

    C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes

    Kriegbaum, M. C., Jacobsen, B., Fuchtbauer, A., Hansen, Gert Helge, Christensen, I. J., Friis, Carsten, Persson, M., Engelholm, Lars Henning, Madsen, A. N., Di Meo, I., Lund, I. K., Holst, Birgitte, Kjær, Andreas, Laerum, O. D., Fuchtbauer, E. & Ploug, Michael, 12 May 2016, In: Scientific Reports. 6, 25833.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved

    Møller, C. L., Raun, K., Jacobsen, M. L., Pedersen, T. Å., Holst, Birgitte, Conde-Frieboes, K. W. & Wulff, B. S., 20 Jul 2011, In: Molecular and Cellular Endocrinology. 341, 1-2, p. 9-17 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Common structural basis for constitutive activity of the ghrelin receptor family

    Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation

    Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

    Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12322-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor

    Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, no. 22, p. 12322-12327

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

    Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, Rune Ehrenreich, Egerod, Kristoffer Lihme, Nielsen, L. B., Schwartz, Thue W. & Holst, Birgitte, 22 Jul 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Development of potent and proteolytically stable human neuromedin U receptor agonists

    De Prins, A., Martin, C., Van Wanseele, Y., Skov, Louise Julie, Tömböly, C., Tourwé, D., Caveliers, V., Van Eeckhaut, A., Holst, Birgitte, Rosenkilde, Mette, Smolders, I. & Ballet, S., 20 Jan 2018, In: European Journal of Medicinal Chemistry. 144, p. 887-897 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 9886