Agnete Kirkeby

Agnete Kirkeby

Guest Researcher, Associate professor, group leader, Associate Professor

Member of:

    ORCID: 0000-0001-8203-6901

    Publication year:
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    1 - 42 out of 42Page size: 100
    1. 2024
    2. E-pub ahead of print

      Good Manufacturing Practice–compliant human induced pluripotent stem cells: from bench to putative clinical products

      Novoa, J. J., Westra, I. M., Steeneveld, E., Fonseca Neves, N., Arendzen, C. H., Rajaei, B., Grundeken, E., Yildiz, M., van der Valk, W., Salvador, A., Carlotti, F., Dijkers, P. F., Locher, H., van den Berg, C. W., Raymond, K. I., Kirkeby, A., Mummery, C. L., Rabelink, T. J., Freund, C., Meij, P. & 1 others, Wieles, B., 2024, (E-pub ahead of print) In: Cytotherapy.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2023
    4. Published

      Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease

      Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells

      Rifes, P., Isaksson, M., Rusimbi, Charlotte Nuru, Ramón Santonja, A., Nelander, J., Laurell, T. & Kirkeby, Agnete, 2023, In: Stem Cell Research and Therapy. 14, 1, 354.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD

      Novo Nordisk Cell Therapy R&D, N. N. C. T. R., 2023, In: Cell Stem Cell. 30, 10, p. 1299-1314.e9 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

      Häfner, Sophia Julia, Jansson, Martin David, Altinel, Kübra, Andersen, Kasper Langebjerg, Abay-Nørgaard, Zehra Caldwell, Ménard, Patrice, Fontenas, M., Sørensen, Daniel Madriz, Gay, David Michael, Arendrup, Frederic Schrøder, Tehler, D., Krogh, Nicolai, Nielsen, Henrik, Kraushar, M. L., Kirkeby, Agnete & Lund, Anders H., 2023, In: Developmental Cell. 58, 17, p. 1593-1609.e9

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

      Garza, R., Sharma, Y., Atacho, D. A. M., Thiruvalluvan, Arun, Abu Hamdeh, S., Jönsson, M. E., Horvath, V., Adami, A., Ingelsson, M., Jern, P., Hammell, M. G., Englund, E., Kirkeby, Agnete, Jakobsson, J. & Marklund, N., 2023, In: Cell Reports. 42, 11, 19 p., 113395.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2022
    10. Published

      Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells

      Dubonyte, Ugne, Asenjo-Martinez, A., Werge, Thomas, Lage, K. & Kirkeby, Agnete, 2022, In: Acta Neuropathologica Communications. 10, 1, 20 p., 183.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia

      Elabi, O. F., Pass, R., Sormonta, I., Nolbrant, S., Drummond, N., Kirkeby, Agnete, Kunath, T., Parmar, M. & Lane, E. L., 2022, In: Journal of Parkinson's Disease. 12, 6, p. 1881-1896 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      MSLibrarian: Optimized Predicted Spectral Libraries for Data-Independent Acquisition Proteomics

      Isaksson, M., Karlsson, C., Laurell, T., Kirkeby, Agnete & Heusel, M., 2022, In: Journal of Proteome Research. 21, 2, p. 535–546 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. 2021
    14. Published

      Bringing Advanced Therapies for Parkinson's Disease to the Clinic: The Scientist's Perspective

      Tomishima, M. & Kirkeby, Agnete, 2021, In: Journal of Parkinson's Disease. 11, p. S135-S140 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

    15. Published

      Preclinical assessment of a pluripotent cell therapy for treatment of Parkinson's Disease

      Kirkeby, Agnete, 2021, In: Toxicology Letters. 350, Supplement, p. S37 1 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    16. 2020
    17. Published

      Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

      Tiklová, K., Nolbrant, S., Fiorenzano, A., Björklund, Å. K., Sharma, Y., Heuer, A., Gillberg, L., Hoban, D. B., Cardoso, T., Adler, A. F., Birtele, M., Lundén-Miguel, H., Volakakis, N., Kirkeby, Agnete, Perlmann, T. & Parmar, M., 1 Dec 2020, In: Nature Communications. 11, 1, 11 p., 2434.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells

      Korshunova, Irina, Rhein, S., vsz834, vsz834, Stölting, I., Pfisterer, U., Barta, A., Dmytriyeva, O., Kirkeby, Agnete, Schwaninger, M. & Khodosevich, Konstantin, 2020, In: JCI insight. 5, 4, p. 1-19 e126268.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

      Rifes, P., Isaksson, M., Rathore, Gaurav Singh, Aldrin-Kirk, P., Moller, O. K., Barzaghi, G., Lee, J., Egerod, Kristoffer Lihme, Belmont-Rausch, Dylan Matthew, Parmar, M., Pers, Tune H, Laurell, T. & Kirkeby, Agnete, 2020, In: Nature Biotechnology. 38, p. 1265-1273 9 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    20. 2019
    21. Published

      Parkinson disease and growth factors — is GDNF good enough?

      Kirkeby, Agnete & Barker, R. A., 1 Jun 2019, In: Nature Reviews Neurology. 15, 6, p. 312-314 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    22. 2018
    23. Published

      Report of the international conference on manufacturing and testing of pluripotent stem cells

      Abbot, S., Agbanyo, F., Ahlfors, J-E., Baghbaderani, B. A., Bartido, S., Bharti, K., Burke, C., Carlsson, B., Cavagnaro, J., Creasey, A., Lin, S., DiGiusto, D., Francissen, K., Gaffney, A., Goldring, C., Gorba, T., Griffiths, E., Lubiniecki, A., Vandeputte, J., Hanatani, T. & 23 others, Hayakawa, T., Heki, T., Hoogendoorn, K., Kawamata, S., Kimura, H., Kirkeby, Agnete, Knezevic, I., Lebkowski, J., Lin-Gibson, S., O'Shea, O., Pera, M., Petricciani, J., Pigeau, G., Ratcliffe, A., Sato, Y., Schumann, G. G., Shingleton, W., Stacey, C. G., Sullivan, S., Svendsen, C. N., Trouvin, J., Yuan, B. & Zoon, K., Nov 2018, In: Biologicals. 63, p. 67-83

      Research output: Contribution to journal › Conference article › Research › peer-review

    24. Published

      Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats

      Cardoso, T., Adler, A. F., Mattsson, B., Hoban, D. B., Nolbrant, S., Wahlestedt, J. N., Kirkeby, Agnete, Grealish, S., Björklund, A. & Parmar, M., 1 Sep 2018, In: The Journal of Comparative Neurology. 526, 13, p. 2133-2146

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      A symphony of stem cells in Vienna - looking to the future

      Porrello, E. R. & Kirkeby, Agnete, 8 Jun 2018, In: Development (Cambridge, England). 145, 11, 6 p., 163501.

      Research output: Contribution to journal › Conference article › Research › peer-review

    26. Published

      Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

      Mondal, T., Juvvuna, P. K., Kirkeby, A., Mitra, S., Kosalai, S. T., Traxler, L., Hertwig, F., Wernig-Zorc, S., Miranda, C., Deland, L., Volland, R., Bartenhagen, C., Bartsch, D., Bandaru, S., Engesser, A., Subhash, S., Martinsson, T., Carén, H., Akyürek, L. M., Kurian, L. & 5 others, Kanduri, M., Huarte, M., Kogner, P., Fischer, M. & Kanduri, C., 12 Mar 2018, In: Cancer Cell. 33, 3, p. 417-434.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2017
    28. Published

      IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.

      Lehnen, D., Barral, S., Cardoso, T., Grealish, S., Heuer, A., Smiyakin, A., Kirkeby, Agnete, Kollet, J., Cremer, H., Parmar, M., Bosio, A. & Knoebel, S., Oct 2017, In: Stem Cell Reports. 9, 4, p. 1207-1220 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications.

      Moraghebi, R., Kirkeby, Agnete, Chaves, P., Roenn, R. E., Sitnicka, E., Parmar, M., Larsson, M., Herbst, A. & Woods, N., 25 Aug 2017, In: Stem Cell Research & Therapy. 8, 12 p., 190.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

      Kee, N., Volakakis, N., Kirkeby, Agnete, Dahl, L., Storvall, H., Nolbrant, S., Lahti, L., Bjoerklund, A. K., Gillberg, L., Joodmardi, E., Sandberg, R., Parmar, M. & Perlmann, T., 5 Jan 2017, In: Cell Stem Cell. 20, 1, p. 29-40 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Anatomical and Molecular insight into the developing entorhinal cortex in a large mammalian species, the pig.

      Liu, Y., Peralvo Vidal, Juan Miguel, Thomsen, Preben Dybdahl, Møllgård, Kjeld, Kirkeby, Agnete & Hall, Vanessa Jane, 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research

    32. Published

      Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

      Nolbrant, S., Heuer, A., Parmar, M. & Kirkeby, Agnete, 2017, In: Nature Protocols. 12, 9, p. 1962-1979

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

      Kirkeby, Agnete, Nolbrant, S., Tiklova, K., Heuer, A., Kee, N., Cardoso, T., Ottosson, D. R., Lelos, M. J., Rifes, P., Dunnett, S. B., Grealish, S., Perlmann, T. & Parmar, M., 2017, In: Cell Stem Cell. 20, 1, p. 135-148 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD)

      Kirkeby, Agnete, Parmar, M. & Barker, R. A., 2017, Functional Neural Transplantation IV: Translation to Clinical Application, Part A. Vol. 230. p. 165-190 26 p. (Progress in Brain Research).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    35. 2016
    36. Published

      The stem cell niche finds its true north

      Kirkeby, Agnete, Perlmann, T. & Pereira, C. F., 15 Aug 2016, In: Development (Cambridge). 143, 16, p. 2877-2881 5 p.

      Research output: Contribution to journal › Review › Research › peer-review

    37. HESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation

      Heuer, A., Jönsson, M. E., Pfisterer, U., Kirkeby, Agnete & Parmar, M., 1 Aug 2016, In: Experimental Neurology. 282, p. 78-85 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

      Barker, R. A., Parmar, M., Kirkeby, Agnete, Björklund, A., Thompson, L. & Brundin, P., 30 Mar 2016, In: Journal of Parkinson's Disease. 6, 1, p. 57-63 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    39. 2015
    40. Published

      Comprehensive analysis of microrna expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor

      Jönsson, M. E., Wahlestedt, J. N., Åkerblom, M., Kirkeby, Agnete, Malmevik, J., Brattaas, P. L., Jakobsson, J. & Parmar, M., 23 Sep 2015, In: Development (Cambridge). 142, 18, p. 3166-3177 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

      Grealish, S., Heuer, A., Cardoso, T., Kirkeby, Agnete, Jönsson, M., Johansson, J., Björklund, A., Jakobsson, J. & Parmar, M., 9 Jun 2015, In: Stem Cell Reports. 4, 6, p. 975-983 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. 2014
    43. Published

      Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease

      Grealish, S., Diguet, E., Kirkeby, Agnete, Mattsson, B., Heuer, A., Bramoulle, Y., Van Camp, N., Perrier, A. L., Hantraye, P., Björklund, A. & Parmar, M., 1 Jan 2014, In: Cell Stem Cell. 15, 5, p. 653-665 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. 2013
    45. Published

      Generating regionalized neuronal cells from pluripotency, a step-by-stepprotocol

      Kirkeby, Agnete, Nelander, J. & Parmar, M., 3 Jan 2013, In: Frontiers in Cellular Neuroscience. JANUARY 2013

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. 2012
    47. Published

      Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development

      Kirkeby, Agnete & Parmar, M., 1 Dec 2012, In: Translational Neuroscience. 3, 4, p. 314-319 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

      Kirkeby, Agnete, Grealish, S., Wolf, D. A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O. & Parmar, M., 28 Jun 2012, In: Cell Reports. 1, 6, p. 703-714 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. 2011
    50. Published

      Direct conversion of human fibroblasts to dopaminergic neurons

      Pfisterer, U., Kirkeby, Agnete, Torper, O., Wood, J., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J. & Parmar, M., 21 Jun 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10343-10348 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. 2010
    52. Published

      Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors

      Sachdeva, R., Jönsson, M. E., Nelander, J., Kirkeby, Agnete, Guibentif, C., Gentner, B., Naldini, L., Björklund, A., Parmar, M. & Jakobsson, J., 22 Jun 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11602-11607 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. 2008
    54. Published

      The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

      Leist, M., Bremer, S., Brundin, P., Hescheler, J., Kirkeby, Agnete, Krause, K. H., Pörzgen, P., Pucéat, M., Schmidt, M., Schrattenholz, A., Zak, N. B. & Hentze, H., 1 Dec 2008, In: Altex. 25, 3, p. 163-190 28 p.

      Research output: Contribution to journal › Review › Research › peer-review

    55. Published

      Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits

      Lapchak, P. A., Kirkeby, Agnete, Zivin, J. A. & Sager, T. N., 31 Oct 2008, In: Brain Research. 1238, p. 208-214 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).

      Kirkeby, Agnete, Torup, L., Bochsen, L., Kjalke, M., Abel, K., Theilgaard-Mønch, Kim, Johansson, P. I., Bjørn, S. E., Gerwien, J. & Leist, M., 2008, In: Thrombosis and Haemostasis. 99, 4, p. 720-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. 2007
    58. Published

      Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor

      Kirkeby, Agnete, van Beek, J., Nielsen, J., Leist, M. & Helboe, L., 15 Aug 2007, In: Journal of Neuroscience Methods. 164, 1, p. 50-58 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures

      Montero, M., Poulsen, F. R., Noraberg, J., Kirkeby, Agnete, van Beek, J., Leist, M. & Zimmer, J., 1 Mar 2007, In: Experimental Neurology. 204, 1, p. 106-117 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 172979835