Abigail Mackey

Abigail Mackey

Clinical Professor

ORCID: 0000-0002-2017-4580

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  1. 2024
  2. Published

    The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults

    Ruple, B. A., Mattingly, M. L., Godwin, J. S., McIntosh, M. C., Kontos, N. J., Agyin-Birikorang, A., Michel, J. M., Plotkin, D. L., Chen, S., Ziegenfuss, T. N., Fruge, A. D., Gladden, L. B., Robinson, A. T., Mobley, C. B., Mackey, Abigail & Roberts, M. D., 30 Apr 2024, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38, 8, p. e23621

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training

    Soendenbroe, C., Karlsen, Anders, Svensson, R. B., Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2024, In: Journal of Cachexia, Sarcopenia and Muscle. 15, 1, p. 306-318 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration

    Højfeldt, Grith Stougaard, Sorenson, T., Gonzales, A., Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 12 Aug 2023, In: Skeletal Muscle. 13, 1, p. 1-14 13.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing

    Karlsen, Anders, Yeung, Ching-Yan Chloé, Schjerling, Peter, Denz, L., Høgsbjerg, Christian, Jakobsen, J. R., Krogsgaard, Michael R., Koch, M., Schiaffino, S., Kjær, Michael & Mackey, Abigail, 2023, In: Journal of Cell Science. 136, 8, 14 p., jcs260913.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Immunohistochemistry, Microscopy, and Image Analysis of Human Muscle Biopsies: Muscle Fiber Denervation as a Working Example

    Soendenbroe, C., Andersen, J. L. & Mackey, Abigail, 2023, Neuromuscular Assessments of Form and Function. Humana Press, p. 145-165 Chapter 9. (Neuromethods, Vol. 204).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  8. Published

    Larger interface area at the human myotendinous junction in type 1 compared to type 2 muscle fibers

    Rithamer Jakobsen, J., Mackey, Abigail, Koch, M., Imhof, T., Hannibal, Jens, Kjær, Michael & Rindom Krogsgaard, M., 2023, In: Scandinavian Journal of Medicine & Science in Sports. 33, 2, p. 136-145 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

    Roberts, M. D., Mccarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, Abigail, Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., Libardi, C. A., Ugrinowitsch, C., Booth, F. W. & Esser, K. A., 2023, In: Physiological Reviews. 103, p. 2679–2757 80 p.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    PCM1 labelling reveals myonuclear and nuclear dynamics in skeletal muscle across species.

    Viggars, M. R., Owens, D. J., Stewart, C., Coirault, C., Mackey, Abigail & Jarvis, J. C., 2023, In: American Journal of Physiology: Cell Physiology. 324, 1, p. C85-C97

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Traumatic muscle injury

    Edouard, P., Reurink, G., Mackey, Abigail, Lieber, R. L., Pizzari, T., Järvinen, T. A. H., Gronwald, T. & Hollander, K., 2023, In: Nature Reviews Disease Primers. 9, 1, 19 p., 56.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2022
  13. Published

    Intramuscular connective tissue content and mechanical properties: Influence of aging and physical activity in mice

    Olesen, A. T., Malchow-møller, L., Bendixen, R. D., Kjær, Michael, Mackey, Abigail, Magnusson, Stig Peter & Svensson, R. B., 1 Jul 2022, In: Experimental Gerontology. p. 111893

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A RANDOMIZED, CROSS-OVER STUDY TO INVESTIGATE THE EFFECT OF WEIGHT-BEARING VS NON-WEIGHT-BEARING EXERCISE AND CARDIOVASCULAR STRESS ON TYPE II COLLAGEN TURNOVER IN PATIENTS WITH KNEE OSTEOARTHRITIS - SERUM BIOMARKER DATA FROM THE EFEX-OA-02 STUDY

    Bjerre-Bastos, J. J., Sejersen, Casper Aastrup, Nielsen, H. B., Boesen, M., Secher, Niels H., Distajo, G., Flood, V., Henrotin, Y., Uebelhoer, M., Mackey, Abigail, Krustrup, P., Kitchen, C. -., Petersen, E. E., Thudium, C. S., Andersen, J. R. & Bihlet, A. R., 2022, In: Osteoarthritis and Cartilage. 30, p. S102-S103 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  15. Published

    Aging is associated with an altered macrophage response during human skeletal muscle regeneration

    Ahmadi, M., Karlsen, Anders, Mehling, J., Soendenbroe, C., Mackey, Abigail & Hyldahl, R. D., 2022, In: Experimental Gerontology. 7 p., 111974.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion

    Bjerre-Bastos, J. J., Sejersen, Casper Aastrup, Bihlet, A. R., Secher, Niels H., Mackey, Abigail, Kitchen, C., Drobinski, P., Thudium, C. S. & Nielsen, H. B., 2022, In: Frontiers in Physiology. 13, 8 p., 948097.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    CHANGES IN PLASMA VOLUME WHEN MEASURING BIOCHEMICAL MARKERS OF JOINT TISSUE TURNOVER IN RELATION TO ACUTE PHYSICAL ACTIVITY

    Bjerre-Bastos, J., Sejersen, C., Nielsen, H. B., Secher, Niels H., Kitchen, C. C., Miller, C. P., Mackey, Abigail & Bihlet, A. R., 2022, In: Annals of the Rheumatic Diseases. 81, p. 1618-1618 1 p., AB0984.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  18. Published

    Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance exercise

    Soendenbroe, C., Flindt Heisterberg, M. F., Schjerling, Peter, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2022, In: American journal of physiology. Cell physiology. 323, p. C159–C169

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Myonuclear addition is associated with sex-specific fiber hypertrophy and occurs in relation to fiber perimeter not cross-sectional area

    Moesgaard, Lukas, Jessen, Søren Kaare, Mackey, Abigail & Hostrup, Morten, 2022, In: Journal of Applied Physiology. 133, 3, p. 732-741 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise

    Jakobsen, J. R., Schjerling, Peter, Kjær, Michael, Mackey, Abigail & Krogsgaard, Michael R., 2022, In: Histochemistry and Cell Biology. 158, p. 49–64

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise

    Soendenbroe, C., Dahl, C. L., Meulengracht, C., Tamáš, M., Svensson, R. B., Schjerling, Peter, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2022, In: The Journal of Physiology. 600, 8, p. 1969-1989

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The proteomic profile of the human myotendinous junction

    Karlsen, Anders, Gonzalez-Franquesa, A., Jakobsen, J. R., Krogsgaard, Michael R., Koch, M., Kjær, Michael, Schiaffino, S., Mackey, Abigail & Deshmukh, Atul Shahaji, 2022, In: iScience. 25, 2, 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2021
  24. Published

    A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study

    Bjerre-Bastos, J. J., Nielsen, H. B., Andersen, J. R., Karsdal, M., Boesen, Mikael Ploug, Mackey, Abigail, Byrjalsen, I., Thudium, C. S. & Bihlet, A. R., 2021, In: European Journal of Applied Physiology. 121, p. 2799–2809 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Adipocytes are present at human and murine myotendinous junctions

    Jakobsen, J. R., Jakobsen, N. R., Mackey, Abigail, Knudsen, A. B., Hannibal, Jens, Koch, M., Kjær, Michael & Krogsgaard, Michael R., 2021, In: Translational Sports Medicine. 4, 2, p. 223-230

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis

    Fridh, M. K., Simonsen, C., Schmidt-andersen, P., Nissen, A. A., Christensen, J. F., Larsen, A., Mackey, Abigail, Larsen, Hanne Bækgaard & Muller, Klaus, 2021, In: Bone Marrow Transplantation. 56, 9, p. 2063–2078

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Collagens in primary frozen shoulder: expression of collagen mRNA isoforms in the different phases of the disease

    Marker, L., Schjerling, P., Mackey, Abigail, Hansen, T., Jakobsen, J., Kjær, Michael & Krogsgaard, Michael R., 2021, In: Rheumatology. 60, 8, p. 3879-3887

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? An exploratory randomized cross-over trial

    Bjerre-bastos, J. J., Nielsen, H. B., Andersen, J. R., Karsdal, M., Bay-jensen, A., Boesen, Mikael Ploug, Mackey, Abigail, Byrjalsen, I. & Bihlet, A. R., 2021, In: Osteoarthritis and Cartilage. 29, 7, p. 986-994

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging

    Søndenbroe, C., Andersen, J. L. & Mackey, Abigail, 2021, In: American journal of physiology. Cell physiology. 321, 2, p. C317-C329

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Mutual stimulatory signaling between human myogenic cells and rat cerebellar neurons

    Tamáš, M., Pankratova, Stanislava, Schjerling, Peter, Soendenbroe, C., Yeung, C. C., Pennisi, C. P., Jakobsen, J. R., Krogsgaard, Michael R., Kjær, Michael & Mackey, Abigail, 2021, In: Physiological Reports. 9, 21, e15077.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    No demonstrable ultrastructural adaptation of the human myotendinous junction to immobilization or 4 weeks of heavy resistance training

    Knudsen, A. B., Mackey, Abigail, Jakobsen, J. R. & Krogsgaard, Michael R., 2021, In: Translational Sports Medicine. 4, 4, p. 431-438

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    RNA-sequencing and immunofluorescence of the myotendinous junction of mature horses and humans

    Jakobsen, J. R., Schjerling, Peter, Svensson, R. B., Buhl, Rikke, Carstensen, Helena, Koch, M., Rindom Krogsgaard, M. R., Kjær, Michael & Mackey, Abigail, 2021, In: American journal of physiology. Cell physiology. 321, p. C453–C470

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Resting in bed - how quickly does the muscle lose its nerve?

    Soendenbroe, C., Mackey, Abigail & Kjær, Michael, 2021, In: The Journal of Physiology. 599, 12, p. 2995-2996

    Research output: Contribution to journal › Editorial › Research

  34. 2020
  35. Published

    What is the impact of acute inflammation on muscle performance in geriatric patients?

    Karlsen, Anders, Mackey, Abigail, Suetta, Charlotte & Kjær, Michael, 1 Jun 2020, In: Experimental Gerontology. 138, 8 p., 111008.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover

    Bjerre-bastos, J. J., Nielsen, H. B., Andersen, J. R., He, Y., Karsdal, M., Bay-jensen, A., Boesen, M., Mackey, Abigail & Bihlet, A. R., 1 Apr 2020, In: Osteoarthritis and Cartilage Open. 2, 8 p., 100060.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Impact of low-volume concurrent strength training distribution on muscular adaptation

    Kilen, Anders, Bay, J., Bejder, Jacob, Andersen, A. B., Bonne, T. C., Larsen, P. D., Carlsen, A., Egelund, J., Nybo, Lars, Mackey, Abigail, Olsen, N. V., Aachmann-Andersen, N. J., Andersen, J. L. & Nordsborg, Nikolai Baastrup, 2020, In: Journal of Science and Medicine in Sport. 23, 10, p. 999-1004 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise

    Søndenbroe, C., Bechshøft, C. J. L., Heisterberg, M. F., Jensen, S. M., Bomme, E., Schjerling, Peter, Karlsen, Anders, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2020, In: Cells. 9, 4, 893.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Macrophage Subpopulations and the Acute Inflammatory Response of Elderly Human Skeletal Muscle to Physiological Resistance Exercise

    Jensen, S. M., Bechshøft, C. J. L., Heisterberg, M. F., Schjerling, P., Andersen, J. L., Kjær, Michael & Mackey, Abigail, 2020, In: Frontiers in Physiology. 11, 15 p., 811.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Neuromuscular Electrical Stimulation Preserves Leg Lean Mass in Geriatric Patients

    Karlsen, Anders, Cullum, C. K., Norheim, K. L., Scheel, F. U., Zinglersen, A. H., Vahlgren, J., Schjerling, P., Kjær, Michael & Mackey, Abigail, 2020, In: Medicine and Science in Sports and Exercise. 52, 4, p. 773-784 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

    Karlsen, Anders, Soendenbroe, C., Malmgaard‐clausen, N. M., Wagener, F., Moeller, C. E., Senhaji, Z., Damberg, K., Andersen, J. L., Schjerling, P., Kjær, Michael & Mackey, Abigail, 2020, In: The FASEB Journal. 34, 5, p. 6418-6436

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts

    Yeung, C. C., Schoof, E. M., Tamáš, M., Mackey, Abigail & Kjær, Michael, 2020, In: Cell Communication and Signaling. 18, 1, 15 p., 177.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2019
  44. Published

    The influence of fibrillin‐1 and physical activity upon tendon tissue morphology and mechanical properties in mice

    Tran, P. H. T., Skrba, T., Wondimu, E., Galatioto, G., Svensson, R. B., Olesen, A. T., Mackey, Abigail, Magnusson, Stig Peter, Ramirez, F. & Kjær, Michael, 1 Nov 2019, In: Physiological Reports. 7, 21, 9 p., e14267 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and non-myogenic cells derived from human skeletal muscle

    Bechshøft, C. J. L., Jensen, S. M., Schjerling, P., Andersen, J. L., Svensson, R. B., Eriksen, C. S., Mkumbuzi, N. S., Kjær, Michael & Mackey, Abigail, Jun 2019, In: American Journal of Physiology: Cell Physiology. 316, 6, p. C898-C912

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with resistance training in 83-94-year-old men and women

    Karlsen, Anders, Bechshøft, R. L., Malmgaard-Clausen, N. M., Andersen, J. L., Schjerling, P., Kjær, Michael & Mackey, Abigail, 3 Mar 2019, In: Acta Physiologica. 227, ja, e13271.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Behandling af akutte muskelskader

    Bayer, M. L., Mackey, Abigail, Magnusson, Stig Peter, Krogsgaard, Michael R. & Kjær, Michael, 18 Feb 2019, In: Ugeskrift for Laeger. 181, 8, 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and nonmyogenic cells derived from human skeletal muscle

    Bechshøft, C. J. L., Jensen, S. M., Schjerling, Peter, Andersen, J. L., Svensson, R. B., Eriksen, C. S., Mkumbuzi, N. S., Kjær, Michael & Mackey, Abigail, 2019, In: American Journal of Physiology: Cell Physiology. 316, p. C898–C912 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Ziegler, A. K., Damgaard, A., Mackey, Abigail, Schjerling, Peter, Magnusson, Stig Peter, Olesen, A. T., Kjær, Michael & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p., 12069.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Integrated method for quantitative morphometry and oxygen transport modeling in striated muscle

    Al-Shammari, A. A., Kissane, R. W. P., Holbek, S., Mackey, Abigail, Andersen, T. R., Gaffney, E. A., Kjær, Michael & Egginton, S., 2019, In: Journal of Applied Physiology. 126, 3, p. 544-557 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Molecular indicators of denervation in ageing human skeletal muscle

    Soendenbroe, C., Heisterberg, M. F., Schjerling, Peter, Karlsen, Anders, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2019, In: Muscle & Nerve. 60, 4, p. 453-463 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Regeneration and remodelling of human skeletal muscle from the cellular perspective

    Mackey, Abigail, 2019, In: Acta Physiologica (Print). 227, p. 29-29

    Research output: Contribution to journal › Conference abstract in journal › Research

  53. Published

    The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation

    Ziegler, A. K., Jensen, S. M., Schjerling, P., Mackey, Abigail, Andersen, J. L. & Kjær, Michael, 2019, In: Experimental Gerontology. 121, p. 19-32

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    The influence of direct and indirect fibroblast cell contact on human myogenic cell behaviour and gene expression in vitro

    Bechshøft, C. J. L., Schjerling, Peter, Kjær, Michael & Mackey, Abigail, 2019, In: Journal of Applied Physiology. 127, 2, p. 342-355

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2018
  56. Published

    Losartan has no additive effect on the response to heavy resistance exercise in human elderly skeletal muscle

    Heisterberg, M. F., Andersen, J. L., Schjerling, Peter, Lund, A., Dalskov, S., Overgård Jønsson, A., Warming, N., Fogelstrøm, M., Kjær, Michael & Mackey, Abigail, Nov 2018, In: Journal of Applied Physiology. 125, 5, p. 1536-1554 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise

    Heisterberg, M. F., Andersen, J. L., Schjerling, P., Bülow, J., Lauersen, J. B., Roeber, H. L., Kjær, Michael & Mackey, Abigail, 1 Feb 2018, In: Medicine and Science in Sports and Exercise. 50, 2, p. 225–235

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 920363