Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
Research output: Contribution to journal › Journal article › Research › peer-review
By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
|Journal||F E B S Letters|
|Number of pages||6|
|Publication status||Published - 1987|
- Animals, Glucagon, Ileum, Insulin, Intestinal Mucosa, Peptides, Swine