Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke

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Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke. / Rathcke, Camilla Noelle; Thomsen, Stine Brinkloev; Linneberg, Allan; Vestergaard, Henrik.

In: P L o S One, Vol. 7, No. 8, 2012, p. e43498.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rathcke, CN, Thomsen, SB, Linneberg, A & Vestergaard, H 2012, 'Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke', P L o S One, vol. 7, no. 8, pp. e43498. https://doi.org/10.1371/journal.pone.0043498

APA

Rathcke, C. N., Thomsen, S. B., Linneberg, A., & Vestergaard, H. (2012). Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke. P L o S One, 7(8), e43498. https://doi.org/10.1371/journal.pone.0043498

Vancouver

Rathcke CN, Thomsen SB, Linneberg A, Vestergaard H. Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke. P L o S One. 2012;7(8):e43498. https://doi.org/10.1371/journal.pone.0043498

Author

Rathcke, Camilla Noelle ; Thomsen, Stine Brinkloev ; Linneberg, Allan ; Vestergaard, Henrik. / Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke. In: P L o S One. 2012 ; Vol. 7, No. 8. pp. e43498.

Bibtex

@article{8634705351084e85a10456aa3d3d228d,
title = "Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke",
abstract = "BACKGROUND: Polymorphisms of CHI3L1 are associated with inter-individual YKL-40 levels and YKL-40 is associated with an increased mortality and is elevated in patients with cardiovascular disease. We investigated the association between single nucleotide polymorphisms (SNPs) of CHI3L1, serum YKL-40 levels and all-cause and cardiovascular mortality and first-time incidence of myocardial infarction, ischemic heart disease (IHD) and stroke. METHODOLOGY/PRINCIPAL FINDINGS: 12 SNPs of CHI3L1 were genotyped and serum YKL-40 was measured in 2656 Danes representative of the general population. Median follow-up period was 15 (0-16) years. Admission data and deaths were ascertained from registers from the Danish National Board of Health. Fourth quartile YKL-40 levels were associated with an increased mortality risk of ischemic stroke (HR 2.44 (1.01-5.88), p = 0.041) and so were homozygotes of the minor allele of rs872129 (HR 9.35 (1.25-69.87, p = 0.022)). Both continuous YKL-40 levels and 4(th) quartile YKL-40 values (>85 ng/ml) were associated with all-cause mortality (HRs 1.22 (95{\%} CI, 1.10-1.35), p85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD. This could be a chance finding but could also elucidate that YKL-40 plays different roles in development of thromboembolisms versus the formation of local thrombosis.",
author = "Rathcke, {Camilla Noelle} and Thomsen, {Stine Brinkloev} and Allan Linneberg and Henrik Vestergaard",
year = "2012",
doi = "10.1371/journal.pone.0043498",
language = "English",
volume = "7",
pages = "e43498",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke

AU - Rathcke, Camilla Noelle

AU - Thomsen, Stine Brinkloev

AU - Linneberg, Allan

AU - Vestergaard, Henrik

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Polymorphisms of CHI3L1 are associated with inter-individual YKL-40 levels and YKL-40 is associated with an increased mortality and is elevated in patients with cardiovascular disease. We investigated the association between single nucleotide polymorphisms (SNPs) of CHI3L1, serum YKL-40 levels and all-cause and cardiovascular mortality and first-time incidence of myocardial infarction, ischemic heart disease (IHD) and stroke. METHODOLOGY/PRINCIPAL FINDINGS: 12 SNPs of CHI3L1 were genotyped and serum YKL-40 was measured in 2656 Danes representative of the general population. Median follow-up period was 15 (0-16) years. Admission data and deaths were ascertained from registers from the Danish National Board of Health. Fourth quartile YKL-40 levels were associated with an increased mortality risk of ischemic stroke (HR 2.44 (1.01-5.88), p = 0.041) and so were homozygotes of the minor allele of rs872129 (HR 9.35 (1.25-69.87, p = 0.022)). Both continuous YKL-40 levels and 4(th) quartile YKL-40 values (>85 ng/ml) were associated with all-cause mortality (HRs 1.22 (95% CI, 1.10-1.35), p85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD. This could be a chance finding but could also elucidate that YKL-40 plays different roles in development of thromboembolisms versus the formation of local thrombosis.

AB - BACKGROUND: Polymorphisms of CHI3L1 are associated with inter-individual YKL-40 levels and YKL-40 is associated with an increased mortality and is elevated in patients with cardiovascular disease. We investigated the association between single nucleotide polymorphisms (SNPs) of CHI3L1, serum YKL-40 levels and all-cause and cardiovascular mortality and first-time incidence of myocardial infarction, ischemic heart disease (IHD) and stroke. METHODOLOGY/PRINCIPAL FINDINGS: 12 SNPs of CHI3L1 were genotyped and serum YKL-40 was measured in 2656 Danes representative of the general population. Median follow-up period was 15 (0-16) years. Admission data and deaths were ascertained from registers from the Danish National Board of Health. Fourth quartile YKL-40 levels were associated with an increased mortality risk of ischemic stroke (HR 2.44 (1.01-5.88), p = 0.041) and so were homozygotes of the minor allele of rs872129 (HR 9.35 (1.25-69.87, p = 0.022)). Both continuous YKL-40 levels and 4(th) quartile YKL-40 values (>85 ng/ml) were associated with all-cause mortality (HRs 1.22 (95% CI, 1.10-1.35), p85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD. This could be a chance finding but could also elucidate that YKL-40 plays different roles in development of thromboembolisms versus the formation of local thrombosis.

U2 - 10.1371/journal.pone.0043498

DO - 10.1371/journal.pone.0043498

M3 - Journal article

VL - 7

SP - e43498

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 8

ER -

ID: 48513209