T(peak)T(end) interval in long QT syndrome

Research output: Contribution to journalJournal articleResearchpeer-review

Jørgen Kim Kanters, Christian Haarmark, Esben Vedel-Larsen, Mads P Andersen, Claus Graff, Johannes J Struijk, Poul Erik Bloch Thomsen, Michael Christiansen, Henrik K Jensen, Egon Toft

BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. METHODS: Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. RESULTS AND CONCLUSION: (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.
Original languageEnglish
JournalJournal of Electrocardiology
Volume41
Issue number6
Pages (from-to)603-8
Number of pages5
ISSN0022-0736
DOIs
Publication statusPublished - 2008

Bibliographical note

Keywords: Adult; Comorbidity; Denmark; Diagnosis, Computer-Assisted; Electrocardiography; Female; Humans; Incidence; Long QT Syndrome; Male; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Syncope

ID: 19793047