Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics

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Thymus gland size during recovery from complicated severe acute malnutrition : A prospective study of the role of probiotics. / Nabukeera Barungi, Nicolette; Grenov, Benedikte; Friis, Henrik; Lanyero, Betty; Namusoke, Hanifa; Mupere, Ezekiel; Michaelsen, Kim F.; Mølgaard, Christian; Christensen, Vibeke Bak; Rytter, Maren Johanne Heilskov.

In: Paediatrics and international child health, Vol. 39, No. 2, 2019, p. 95-103.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nabukeera Barungi, N, Grenov, B, Friis, H, Lanyero, B, Namusoke, H, Mupere, E, Michaelsen, KF, Mølgaard, C, Christensen, VB & Rytter, MJH 2019, 'Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics', Paediatrics and international child health, vol. 39, no. 2, pp. 95-103. https://doi.org/10.1080/20469047.2018.1535871

APA

Nabukeera Barungi, N., Grenov, B., Friis, H., Lanyero, B., Namusoke, H., Mupere, E., ... Rytter, M. J. H. (2019). Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics. Paediatrics and international child health, 39(2), 95-103. https://doi.org/10.1080/20469047.2018.1535871

Vancouver

Nabukeera Barungi N, Grenov B, Friis H, Lanyero B, Namusoke H, Mupere E et al. Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics. Paediatrics and international child health. 2019;39(2):95-103. https://doi.org/10.1080/20469047.2018.1535871

Author

Nabukeera Barungi, Nicolette ; Grenov, Benedikte ; Friis, Henrik ; Lanyero, Betty ; Namusoke, Hanifa ; Mupere, Ezekiel ; Michaelsen, Kim F. ; Mølgaard, Christian ; Christensen, Vibeke Bak ; Rytter, Maren Johanne Heilskov. / Thymus gland size during recovery from complicated severe acute malnutrition : A prospective study of the role of probiotics. In: Paediatrics and international child health. 2019 ; Vol. 39, No. 2. pp. 95-103.

Bibtex

@article{eabd1461fc0444b99412b720972aec78,
title = "Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics",
abstract = "Background: Children with severe acute malnutrition (SAM) are prone to infections due to immune dysfunction including severe thymus atrophy which recovers during nutritional rehabilitation.Aim: To investigate predictors of thymus size recovery, including probiotics during nutritional rehabilitation of children admitted with complicated SAM.Methods: In this prospective study nested in a randomized controlled trial, children 6-59 months admitted with SAM received standard care and either probiotics or placebo during hospitalization until 8 weeks post-discharge. Thymus size was measured using ultrasound at admission, discharge, 8 weeks post-discharge and among 27 community controls. Predictors of thymus size recovery were assessed using linear regression.Results: Among 388 children with SAM, mean (SD) thymus size was 1.06 cm2 (0.41), 1.24 cm2 (0.48), 2.85 cm2 (1.07) and 4.2 cm2 (0.93) at admission, discharge, follow-up and in the healthy controls respectively (p < 0.05).Probiotics did not affect thymus recovery. During both inpatient therapeutic care (ITC) and outpatient therapeutic care (OTC), thymus recovery correlated positively with anthropometry but negatively with caregiver-perceived illness severity and Haemoglobin <8 g/dl. Negative predictors of thymus recovery during ITC included grade 3 oedema (β -0.13, 95{\%}CI -0.25; -0.01), dermatosis (β -0.21, 95{\%}CI -0.41; -0.01), C-reactive protein (CRP) >15mg/L (β -0.13, 95{\%}CI -0.25; -0.02) and neutrophils (β -0.01, 95{\%}CI -0.02; -0.002). During OTC, HIV negatively predicted thymus recovery.Conclusion: Children with SAM failed to regain thymus size at 8 weeks post-discharge. Probiotics did not predict thymus recovery during nutritional rehabilitation. More research is needed to find interventions which can accelerate immune recovery.",
keywords = "The Faculty of Science, Probiotics, Severe malnutrition, Thymus recovery",
author = "{Nabukeera Barungi}, Nicolette and Benedikte Grenov and Henrik Friis and Betty Lanyero and Hanifa Namusoke and Ezekiel Mupere and Michaelsen, {Kim F.} and Christian M{\o}lgaard and Christensen, {Vibeke Bak} and Rytter, {Maren Johanne Heilskov}",
note = "CURIS 2019 NEXS 192",
year = "2019",
doi = "10.1080/20469047.2018.1535871",
language = "English",
volume = "39",
pages = "95--103",
journal = "Paediatrics and international child health",
issn = "2046-9047",
publisher = "Maney Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - Thymus gland size during recovery from complicated severe acute malnutrition

T2 - A prospective study of the role of probiotics

AU - Nabukeera Barungi, Nicolette

AU - Grenov, Benedikte

AU - Friis, Henrik

AU - Lanyero, Betty

AU - Namusoke, Hanifa

AU - Mupere, Ezekiel

AU - Michaelsen, Kim F.

AU - Mølgaard, Christian

AU - Christensen, Vibeke Bak

AU - Rytter, Maren Johanne Heilskov

N1 - CURIS 2019 NEXS 192

PY - 2019

Y1 - 2019

N2 - Background: Children with severe acute malnutrition (SAM) are prone to infections due to immune dysfunction including severe thymus atrophy which recovers during nutritional rehabilitation.Aim: To investigate predictors of thymus size recovery, including probiotics during nutritional rehabilitation of children admitted with complicated SAM.Methods: In this prospective study nested in a randomized controlled trial, children 6-59 months admitted with SAM received standard care and either probiotics or placebo during hospitalization until 8 weeks post-discharge. Thymus size was measured using ultrasound at admission, discharge, 8 weeks post-discharge and among 27 community controls. Predictors of thymus size recovery were assessed using linear regression.Results: Among 388 children with SAM, mean (SD) thymus size was 1.06 cm2 (0.41), 1.24 cm2 (0.48), 2.85 cm2 (1.07) and 4.2 cm2 (0.93) at admission, discharge, follow-up and in the healthy controls respectively (p < 0.05).Probiotics did not affect thymus recovery. During both inpatient therapeutic care (ITC) and outpatient therapeutic care (OTC), thymus recovery correlated positively with anthropometry but negatively with caregiver-perceived illness severity and Haemoglobin <8 g/dl. Negative predictors of thymus recovery during ITC included grade 3 oedema (β -0.13, 95%CI -0.25; -0.01), dermatosis (β -0.21, 95%CI -0.41; -0.01), C-reactive protein (CRP) >15mg/L (β -0.13, 95%CI -0.25; -0.02) and neutrophils (β -0.01, 95%CI -0.02; -0.002). During OTC, HIV negatively predicted thymus recovery.Conclusion: Children with SAM failed to regain thymus size at 8 weeks post-discharge. Probiotics did not predict thymus recovery during nutritional rehabilitation. More research is needed to find interventions which can accelerate immune recovery.

AB - Background: Children with severe acute malnutrition (SAM) are prone to infections due to immune dysfunction including severe thymus atrophy which recovers during nutritional rehabilitation.Aim: To investigate predictors of thymus size recovery, including probiotics during nutritional rehabilitation of children admitted with complicated SAM.Methods: In this prospective study nested in a randomized controlled trial, children 6-59 months admitted with SAM received standard care and either probiotics or placebo during hospitalization until 8 weeks post-discharge. Thymus size was measured using ultrasound at admission, discharge, 8 weeks post-discharge and among 27 community controls. Predictors of thymus size recovery were assessed using linear regression.Results: Among 388 children with SAM, mean (SD) thymus size was 1.06 cm2 (0.41), 1.24 cm2 (0.48), 2.85 cm2 (1.07) and 4.2 cm2 (0.93) at admission, discharge, follow-up and in the healthy controls respectively (p < 0.05).Probiotics did not affect thymus recovery. During both inpatient therapeutic care (ITC) and outpatient therapeutic care (OTC), thymus recovery correlated positively with anthropometry but negatively with caregiver-perceived illness severity and Haemoglobin <8 g/dl. Negative predictors of thymus recovery during ITC included grade 3 oedema (β -0.13, 95%CI -0.25; -0.01), dermatosis (β -0.21, 95%CI -0.41; -0.01), C-reactive protein (CRP) >15mg/L (β -0.13, 95%CI -0.25; -0.02) and neutrophils (β -0.01, 95%CI -0.02; -0.002). During OTC, HIV negatively predicted thymus recovery.Conclusion: Children with SAM failed to regain thymus size at 8 weeks post-discharge. Probiotics did not predict thymus recovery during nutritional rehabilitation. More research is needed to find interventions which can accelerate immune recovery.

KW - The Faculty of Science

KW - Probiotics

KW - Severe malnutrition

KW - Thymus recovery

U2 - 10.1080/20469047.2018.1535871

DO - 10.1080/20469047.2018.1535871

M3 - Journal article

VL - 39

SP - 95

EP - 103

JO - Paediatrics and international child health

JF - Paediatrics and international child health

SN - 2046-9047

IS - 2

ER -

ID: 204465619