Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Three-Dimensional Printing of Drug-Eluting Implants : Preparation of an Antimicrobial Polylactide Feedstock Material. / Water, Jorrit Jeroen; Bohr, Adam; Bøtker, Johan Peter; Aho, Johanna; Sandler, Niklas; Nielsen, Hanne Mørck; Rantanen, Jukka.

In: Journal of Pharmaceutical Sciences, 15.01.2015, p. 1099–1107.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Water, JJ, Bohr, A, Bøtker, JP, Aho, J, Sandler, N, Nielsen, HM & Rantanen, J 2015, 'Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material', Journal of Pharmaceutical Sciences, pp. 1099–1107. https://doi.org/10.1002/jps.24305

APA

Water, J. J., Bohr, A., Bøtker, J. P., Aho, J., Sandler, N., Nielsen, H. M., & Rantanen, J. (2015). Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material. Journal of Pharmaceutical Sciences, 1099–1107. https://doi.org/10.1002/jps.24305

Vancouver

Water JJ, Bohr A, Bøtker JP, Aho J, Sandler N, Nielsen HM et al. Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material. Journal of Pharmaceutical Sciences. 2015 Jan 15;1099–1107. https://doi.org/10.1002/jps.24305

Author

Water, Jorrit Jeroen ; Bohr, Adam ; Bøtker, Johan Peter ; Aho, Johanna ; Sandler, Niklas ; Nielsen, Hanne Mørck ; Rantanen, Jukka. / Three-Dimensional Printing of Drug-Eluting Implants : Preparation of an Antimicrobial Polylactide Feedstock Material. In: Journal of Pharmaceutical Sciences. 2015 ; pp. 1099–1107.

Bibtex

@article{02084300de29473e92fee37211eff351,
title = "Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material",
abstract = "The aim of the present work was to investigate the potential of three-dimensional (3D) printing as a manufacturing method for products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30{\%} drug load with and without addition of 5{\%} HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10 × 2 mm). X-ray powder diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug loads. Disks with 30{\%} drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period of 7 days. At 10{\%} drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release.",
author = "Water, {Jorrit Jeroen} and Adam Bohr and B{\o}tker, {Johan Peter} and Johanna Aho and Niklas Sandler and Nielsen, {Hanne M{\o}rck} and Jukka Rantanen",
note = "{\circledC} 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.",
year = "2015",
month = "1",
day = "15",
doi = "10.1002/jps.24305",
language = "English",
pages = "1099–1107",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Three-Dimensional Printing of Drug-Eluting Implants

T2 - Preparation of an Antimicrobial Polylactide Feedstock Material

AU - Water, Jorrit Jeroen

AU - Bohr, Adam

AU - Bøtker, Johan Peter

AU - Aho, Johanna

AU - Sandler, Niklas

AU - Nielsen, Hanne Mørck

AU - Rantanen, Jukka

N1 - © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

PY - 2015/1/15

Y1 - 2015/1/15

N2 - The aim of the present work was to investigate the potential of three-dimensional (3D) printing as a manufacturing method for products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30% drug load with and without addition of 5% HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10 × 2 mm). X-ray powder diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug loads. Disks with 30% drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period of 7 days. At 10% drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release.

AB - The aim of the present work was to investigate the potential of three-dimensional (3D) printing as a manufacturing method for products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30% drug load with and without addition of 5% HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10 × 2 mm). X-ray powder diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug loads. Disks with 30% drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period of 7 days. At 10% drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release.

U2 - 10.1002/jps.24305

DO - 10.1002/jps.24305

M3 - Journal article

SP - 1099

EP - 1107

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

ER -

ID: 130882351