The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

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The relationship between genetic risk variants with brain structure and function in bipolar disorder : A systematic review of genetic-neuroimaging studies. / Pereira, Licia P; Köhler, Cristiano A; de Sousa, Rafael T; Solmi, Marco; de Freitas, Bárbara P; Fornaro, Michele; Machado-Vieira, Rodrigo; Miskowiak, Kamilla W; Vieta, Eduard; Veronese, Nicola; Stubbs, Brendon; Carvalho, André F.

In: Neuroscience & Biobehavioral Reviews, Vol. 79, 08.2017, p. 87-109.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Pereira, LP, Köhler, CA, de Sousa, RT, Solmi, M, de Freitas, BP, Fornaro, M, Machado-Vieira, R, Miskowiak, KW, Vieta, E, Veronese, N, Stubbs, B & Carvalho, AF 2017, 'The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies', Neuroscience & Biobehavioral Reviews, vol. 79, pp. 87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

APA

Pereira, L. P., Köhler, C. A., de Sousa, R. T., Solmi, M., de Freitas, B. P., Fornaro, M., ... Carvalho, A. F. (2017). The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies. Neuroscience & Biobehavioral Reviews, 79, 87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

Vancouver

Pereira LP, Köhler CA, de Sousa RT, Solmi M, de Freitas BP, Fornaro M et al. The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies. Neuroscience & Biobehavioral Reviews. 2017 Aug;79:87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

Author

Pereira, Licia P ; Köhler, Cristiano A ; de Sousa, Rafael T ; Solmi, Marco ; de Freitas, Bárbara P ; Fornaro, Michele ; Machado-Vieira, Rodrigo ; Miskowiak, Kamilla W ; Vieta, Eduard ; Veronese, Nicola ; Stubbs, Brendon ; Carvalho, André F. / The relationship between genetic risk variants with brain structure and function in bipolar disorder : A systematic review of genetic-neuroimaging studies. In: Neuroscience & Biobehavioral Reviews. 2017 ; Vol. 79. pp. 87-109.

Bibtex

@article{ccd9d944391d43cf8addbdd2bfebaa56,
title = "The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies",
abstract = "Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.",
keywords = "Faculty of Social Sciences, Bipolar disorder, Genetic polymorphisms, Neuroimaging, Magnetic resonance imaging, Functional MRI, Diffusion tensor imagingvoxel based morphometry",
author = "Pereira, {Licia P} and K{\"o}hler, {Cristiano A} and {de Sousa}, {Rafael T} and Marco Solmi and {de Freitas}, {B{\'a}rbara P} and Michele Fornaro and Rodrigo Machado-Vieira and Miskowiak, {Kamilla W} and Eduard Vieta and Nicola Veronese and Brendon Stubbs and Carvalho, {Andr{\'e} F}",
note = "Copyright {\circledC} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = "8",
doi = "10.1016/j.neubiorev.2017.05.002",
language = "English",
volume = "79",
pages = "87--109",
journal = "Neuroscience & Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - The relationship between genetic risk variants with brain structure and function in bipolar disorder

T2 - A systematic review of genetic-neuroimaging studies

AU - Pereira, Licia P

AU - Köhler, Cristiano A

AU - de Sousa, Rafael T

AU - Solmi, Marco

AU - de Freitas, Bárbara P

AU - Fornaro, Michele

AU - Machado-Vieira, Rodrigo

AU - Miskowiak, Kamilla W

AU - Vieta, Eduard

AU - Veronese, Nicola

AU - Stubbs, Brendon

AU - Carvalho, André F

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/8

Y1 - 2017/8

N2 - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

AB - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

KW - Faculty of Social Sciences

KW - Bipolar disorder

KW - Genetic polymorphisms

KW - Neuroimaging

KW - Magnetic resonance imaging

KW - Functional MRI

KW - Diffusion tensor imagingvoxel based morphometry

U2 - 10.1016/j.neubiorev.2017.05.002

DO - 10.1016/j.neubiorev.2017.05.002

M3 - Review

VL - 79

SP - 87

EP - 109

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

SN - 0149-7634

ER -

ID: 184209182