Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals

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Kirsten Salado-Rasmussen, Steen Hoffmann, Susan Cowan, Jørgen Skov Jensen, Thomas Benfield, Jan Gerstoft, Terese Lea Katzenstein

Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.

Original languageEnglish
JournalActa Dermatovenereologica
Volume96
Issue number6
Pages (from-to)807-811
Number of pages5
ISSN0001-5555
DOIs
Publication statusPublished - 2016

    Research areas

  • Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Denmark, Doxycycline, Female, HIV Seropositivity, Humans, Injections, Male, Middle Aged, Penicillins, Retrospective Studies, Syphilis, Treatment Outcome, Comparative Study

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