Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities. / Andersen, Ase B; Law, Ian; Ostrowski, Sisse R; Lebech, Anne Mette; Høyer-Hansen, Gunilla; Højgaard, Liselotte; Gerstoft, Jan; Ullum, Henrik; Kjaer, Andreas.

In: Neuroimmunomodulation, Vol. 13, No. 2, 2006, p. 69-75.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Andersen, AB, Law, I, Ostrowski, SR, Lebech, AM, Høyer-Hansen, G, Højgaard, L, Gerstoft, J, Ullum, H & Kjaer, A 2006, 'Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities', Neuroimmunomodulation, vol. 13, no. 2, pp. 69-75. https://doi.org/10.1159/000095222

APA

Andersen, A. B., Law, I., Ostrowski, S. R., Lebech, A. M., Høyer-Hansen, G., Højgaard, L., ... Kjaer, A. (2006). Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities. Neuroimmunomodulation, 13(2), 69-75. https://doi.org/10.1159/000095222

Vancouver

Andersen AB, Law I, Ostrowski SR, Lebech AM, Høyer-Hansen G, Højgaard L et al. Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities. Neuroimmunomodulation. 2006;13(2):69-75. https://doi.org/10.1159/000095222

Author

Andersen, Ase B ; Law, Ian ; Ostrowski, Sisse R ; Lebech, Anne Mette ; Høyer-Hansen, Gunilla ; Højgaard, Liselotte ; Gerstoft, Jan ; Ullum, Henrik ; Kjaer, Andreas. / Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities. In: Neuroimmunomodulation. 2006 ; Vol. 13, No. 2. pp. 69-75.

Bibtex

@article{7d2669805ff111dea8de000ea68e967b,
title = "Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities",
abstract = "OBJECTIVE: It was the aim of this study to determine the prevalence and severity of fatigue among optimally treated HIV patients and to investigate the potential association with systemic inflammation and abnormalities of the distribution of cerebral glucose metabolism. METHODS: A cohort of HIV patients (n = 95), known to be HIV positive for 5 years, on anti-retroviral therapy for a minimum of 3 years and with CD4 counts above 0.2 x 10(9) cells/l, completed a validated fatigue inventory, and plasma was analysed for pro-inflammatory markers including tumour necrosis factor-alpha, interleukin 6 and soluble urokinase receptor (suPAR) levels. The distribution of the regional cerebral metabolic rate of glucose was measured in a sub-group of patients suffering from severe fatigue (n = 9) and a group with no fatigue (n = 7) using fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. RESULTS: Fifteen percent suffered from severe fatigue, but no association with pro-inflammatory markers was found. About 50{\%} of the FDG-PET-scanned patients showed minor abnormalities in the relative cerebral metabolic rate of glucose. These abnormalities were not associated with fatigue but tended to correlate with a short HIV history (p = 0.058), a low CD4 nadir (p = 0.082) and elevated tumour necrosis factor-alpha levels (p = 0.074). CONCLUSION: Fatigue is common among optimally treated HIV patients. FDG-PET-described signs of imminent neurodegeneration among HIV patients who had a low CD4 nadir may illustrate an aspect of HIV neuropathogenicity.",
author = "Andersen, {Ase B} and Ian Law and Ostrowski, {Sisse R} and Lebech, {Anne Mette} and Gunilla H{\o}yer-Hansen and Liselotte H{\o}jgaard and Jan Gerstoft and Henrik Ullum and Andreas Kjaer",
note = "Keywords: AIDS Dementia Complex; Adult; Aged; Anti-Retroviral Agents; CD4 Lymphocyte Count; Cerebral Cortex; Cohort Studies; Comorbidity; Fatigue Syndrome, Chronic; Female; Fluorodeoxyglucose F18; Glucose; HIV Infections; Humans; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Positron-Emission Tomography; Questionnaires; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tumor Necrosis Factor-alpha",
year = "2006",
doi = "10.1159/000095222",
language = "English",
volume = "13",
pages = "69--75",
journal = "Neuroimmunomodulation",
issn = "1021-7401",
publisher = "S Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities

AU - Andersen, Ase B

AU - Law, Ian

AU - Ostrowski, Sisse R

AU - Lebech, Anne Mette

AU - Høyer-Hansen, Gunilla

AU - Højgaard, Liselotte

AU - Gerstoft, Jan

AU - Ullum, Henrik

AU - Kjaer, Andreas

N1 - Keywords: AIDS Dementia Complex; Adult; Aged; Anti-Retroviral Agents; CD4 Lymphocyte Count; Cerebral Cortex; Cohort Studies; Comorbidity; Fatigue Syndrome, Chronic; Female; Fluorodeoxyglucose F18; Glucose; HIV Infections; Humans; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Positron-Emission Tomography; Questionnaires; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tumor Necrosis Factor-alpha

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: It was the aim of this study to determine the prevalence and severity of fatigue among optimally treated HIV patients and to investigate the potential association with systemic inflammation and abnormalities of the distribution of cerebral glucose metabolism. METHODS: A cohort of HIV patients (n = 95), known to be HIV positive for 5 years, on anti-retroviral therapy for a minimum of 3 years and with CD4 counts above 0.2 x 10(9) cells/l, completed a validated fatigue inventory, and plasma was analysed for pro-inflammatory markers including tumour necrosis factor-alpha, interleukin 6 and soluble urokinase receptor (suPAR) levels. The distribution of the regional cerebral metabolic rate of glucose was measured in a sub-group of patients suffering from severe fatigue (n = 9) and a group with no fatigue (n = 7) using fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. RESULTS: Fifteen percent suffered from severe fatigue, but no association with pro-inflammatory markers was found. About 50% of the FDG-PET-scanned patients showed minor abnormalities in the relative cerebral metabolic rate of glucose. These abnormalities were not associated with fatigue but tended to correlate with a short HIV history (p = 0.058), a low CD4 nadir (p = 0.082) and elevated tumour necrosis factor-alpha levels (p = 0.074). CONCLUSION: Fatigue is common among optimally treated HIV patients. FDG-PET-described signs of imminent neurodegeneration among HIV patients who had a low CD4 nadir may illustrate an aspect of HIV neuropathogenicity.

AB - OBJECTIVE: It was the aim of this study to determine the prevalence and severity of fatigue among optimally treated HIV patients and to investigate the potential association with systemic inflammation and abnormalities of the distribution of cerebral glucose metabolism. METHODS: A cohort of HIV patients (n = 95), known to be HIV positive for 5 years, on anti-retroviral therapy for a minimum of 3 years and with CD4 counts above 0.2 x 10(9) cells/l, completed a validated fatigue inventory, and plasma was analysed for pro-inflammatory markers including tumour necrosis factor-alpha, interleukin 6 and soluble urokinase receptor (suPAR) levels. The distribution of the regional cerebral metabolic rate of glucose was measured in a sub-group of patients suffering from severe fatigue (n = 9) and a group with no fatigue (n = 7) using fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. RESULTS: Fifteen percent suffered from severe fatigue, but no association with pro-inflammatory markers was found. About 50% of the FDG-PET-scanned patients showed minor abnormalities in the relative cerebral metabolic rate of glucose. These abnormalities were not associated with fatigue but tended to correlate with a short HIV history (p = 0.058), a low CD4 nadir (p = 0.082) and elevated tumour necrosis factor-alpha levels (p = 0.074). CONCLUSION: Fatigue is common among optimally treated HIV patients. FDG-PET-described signs of imminent neurodegeneration among HIV patients who had a low CD4 nadir may illustrate an aspect of HIV neuropathogenicity.

U2 - 10.1159/000095222

DO - 10.1159/000095222

M3 - Journal article

VL - 13

SP - 69

EP - 75

JO - Neuroimmunomodulation

JF - Neuroimmunomodulation

SN - 1021-7401

IS - 2

ER -

ID: 12796781