Sedentarism, physical activity, steps, and neurotrophic factors in obese children

Research output: Contribution to journalJournal articleResearchpeer-review

Jose Mora-Gonzalez, Jairo H Migueles, Irene Esteban-Cornejo, Cristina Cadenas-Sanchez, Belén Pastor-Villaescusa, Pablo Molina-García, María Rodriguez-Ayllon, María C Rico, Angel Gil, Concepción M Aguilera, María Victoria Escolano-Margarit, Anne Kær Gejl, Lars Bo Andersen, Andrés Catena, Francisco B Ortega

Purpose: This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors.

Methods: A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant wrist. Estimates of light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were obtained. Steps per daytime, peak 60-, 30-, and 1-min cadence were computed. The time accumulated (min·d) in different cadence bands of steps was also computed from hip accelerometer. Plasma levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin growth factor-1 (IGF-1) were determined by the XMap technology (Luminex IS 100/200 system, Luminex Corporation, Austin, TX).

Results: Light PA, moderate PA, MVPA, and the peak 60-min cadence were positively related with BDNF concentrations (all P < 0.05), and only light PA to VEGF (P = 0.048). No association was observed for IGF-1 (P > 0.05). The associations of light PA with BDNF and VEGF disappeared (all P > 0.05) after performing analyses with nondominant wrist-placement data. However, moderate PA and MVPA remained significantly associated with BDNF (both P < 0.05). The time accumulated in cadence bands of 40 to 59 steps per day and 60 to 79 steps per day (i.e., walking at slow pace) was positively associated with plasma BDNF (all P < 0.05).

Conclusions: In conclusion, PA is positively related to plasma BDNF, whereas no relationship was observed for VEGF or IGF-1. Higher amounts of time spent in slow walking cadence bands could increment BDNF levels. Exercise-based randomized controlled trials in children with overweight/obesity should be carried out to better understand the influence of PA behaviors on the neurotrophic factors.

Original languageEnglish
JournalMedicine and Science in Sports and Exercise
Volume51
Issue number11
Pages (from-to)2325-2333
Number of pages9
ISSN0195-9131
DOIs
Publication statusPublished - 2019
Externally publishedYes

    Research areas

  • Faculty of Science - Accelerometry, BDNF, Cognition, Obesity, Walking, Youth

ID: 229060847