Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study

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Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study. / Drummen, Mathijs; Heinecke, Alexander; Dorenbos, Elke; Vreugdenhil, Anita; Raben, Anne; Westerterp-Plantenga, M S; Adam, Tanja C.

In: Journal of the Neurological Sciences, Vol. 403, 2019, p. 106-111.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Drummen, M, Heinecke, A, Dorenbos, E, Vreugdenhil, A, Raben, A, Westerterp-Plantenga, MS & Adam, TC 2019, 'Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study', Journal of the Neurological Sciences, vol. 403, pp. 106-111. https://doi.org/10.1016/j.jns.2019.06.017

APA

Drummen, M., Heinecke, A., Dorenbos, E., Vreugdenhil, A., Raben, A., Westerterp-Plantenga, M. S., & Adam, T. C. (2019). Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study. Journal of the Neurological Sciences, 403, 106-111. https://doi.org/10.1016/j.jns.2019.06.017

Vancouver

Drummen M, Heinecke A, Dorenbos E, Vreugdenhil A, Raben A, Westerterp-Plantenga MS et al. Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study. Journal of the Neurological Sciences. 2019;403:106-111. https://doi.org/10.1016/j.jns.2019.06.017

Author

Drummen, Mathijs ; Heinecke, Alexander ; Dorenbos, Elke ; Vreugdenhil, Anita ; Raben, Anne ; Westerterp-Plantenga, M S ; Adam, Tanja C. / Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study. In: Journal of the Neurological Sciences. 2019 ; Vol. 403. pp. 106-111.

Bibtex

@article{81ce9e37374f409d830dc3e626a08d50,
title = "Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study",
abstract = "Introduction: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8{\%} of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.Methods: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.Results: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0{\%}, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3{\%}; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.Conclusion: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.Trial registration: The trial is registered with ClinicalTrials.gov, NCT01777893.",
keywords = "The Faculty of Science, MRI, Cortical thickness, Grey matter volume, BMI, Insulin resistance, Weight loss",
author = "Mathijs Drummen and Alexander Heinecke and Elke Dorenbos and Anita Vreugdenhil and Anne Raben and Westerterp-Plantenga, {M S} and Adam, {Tanja C}",
note = "CURIS 2019 NEXS 225 Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
doi = "10.1016/j.jns.2019.06.017",
language = "English",
volume = "403",
pages = "106--111",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study

AU - Drummen, Mathijs

AU - Heinecke, Alexander

AU - Dorenbos, Elke

AU - Vreugdenhil, Anita

AU - Raben, Anne

AU - Westerterp-Plantenga, M S

AU - Adam, Tanja C

N1 - CURIS 2019 NEXS 225 Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Introduction: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.Methods: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.Results: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.Conclusion: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.Trial registration: The trial is registered with ClinicalTrials.gov, NCT01777893.

AB - Introduction: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.Methods: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.Results: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.Conclusion: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.Trial registration: The trial is registered with ClinicalTrials.gov, NCT01777893.

KW - The Faculty of Science

KW - MRI

KW - Cortical thickness

KW - Grey matter volume

KW - BMI

KW - Insulin resistance

KW - Weight loss

U2 - 10.1016/j.jns.2019.06.017

DO - 10.1016/j.jns.2019.06.017

M3 - Journal article

VL - 403

SP - 106

EP - 111

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -

ID: 223572400