Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice. / Vesterdal, Lise K; Jantzen, Kim; Sheykhzade, Majid; Roursgaard, Martin; Folkmann, Janne K; Loft, Steffen; Møller, Peter.

In: Nanotoxicology, Vol. 8, No. 1, 14.11.2012, p. 61-71.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vesterdal, LK, Jantzen, K, Sheykhzade, M, Roursgaard, M, Folkmann, JK, Loft, S & Møller, P 2012, 'Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice', Nanotoxicology, vol. 8, no. 1, pp. 61-71. https://doi.org/10.3109/17435390.2012.750385

APA

Vesterdal, L. K., Jantzen, K., Sheykhzade, M., Roursgaard, M., Folkmann, J. K., Loft, S., & Møller, P. (2012). Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice. Nanotoxicology, 8(1), 61-71. https://doi.org/10.3109/17435390.2012.750385

Vancouver

Vesterdal LK, Jantzen K, Sheykhzade M, Roursgaard M, Folkmann JK, Loft S et al. Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice. Nanotoxicology. 2012 Nov 14;8(1):61-71. https://doi.org/10.3109/17435390.2012.750385

Author

Vesterdal, Lise K ; Jantzen, Kim ; Sheykhzade, Majid ; Roursgaard, Martin ; Folkmann, Janne K ; Loft, Steffen ; Møller, Peter. / Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice. In: Nanotoxicology. 2012 ; Vol. 8, No. 1. pp. 61-71.

Bibtex

@article{726f6fc594624bf0ac9195812ae19a94,
title = "Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice",
abstract = "Abstract This study compared the oxidative stress level and vasomotor dysfunction after exposure to urban dust, diesel exhaust particles (DEP) or single-walled carbon nanotubes (SWCNT). DEP and SWCNT increased the production of reactive oxygen species (ROS) in cultured endothelial cells and acellullarly, whereas the exposure to urban dust did not generate ROS. ApoE(-/-) mice, which were exposed twice to 0.5 mg/kg of the particles by intratracheal instillation, had unaltered acetylcholine-elicited vasorelaxation in aorta segments. There was unaltered pulmonary expression level of Vcam-1, Icam-1, Hmox-1 and Ogg1. The levels of oxidatively damaged DNA were unchanged in lung tissue. The exposure to SWCNT significantly increased the expression of Ccl-2 in the lung tissue of the mice. The exposure to DEP and SWCNT was associated with elevated ROS production in cultured cells, whereas intratracheal instillation of the same particles had no effect on biomarkers of pulmonary oxidative stress and dilatory dysfunction in the aorta.",
author = "Vesterdal, {Lise K} and Kim Jantzen and Majid Sheykhzade and Martin Roursgaard and Folkmann, {Janne K} and Steffen Loft and Peter M{\o}ller",
note = "Editor-in-Chief: Prof. H{\aa}kan Wallin 2011 Impact Factor: 5.758 5-Year Impact Factor: 6.781 Eight issues are published per year. ISSN: 1743-5390 (print), 1743-5404 (electronic) Read More: http://informahealthcare.com/nan",
year = "2012",
month = "11",
day = "14",
doi = "10.3109/17435390.2012.750385",
language = "English",
volume = "8",
pages = "61--71",
journal = "Nanotoxicology",
issn = "1743-5390",
publisher = "Informa Healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice

AU - Vesterdal, Lise K

AU - Jantzen, Kim

AU - Sheykhzade, Majid

AU - Roursgaard, Martin

AU - Folkmann, Janne K

AU - Loft, Steffen

AU - Møller, Peter

N1 - Editor-in-Chief: Prof. Håkan Wallin 2011 Impact Factor: 5.758 5-Year Impact Factor: 6.781 Eight issues are published per year. ISSN: 1743-5390 (print), 1743-5404 (electronic) Read More: http://informahealthcare.com/nan

PY - 2012/11/14

Y1 - 2012/11/14

N2 - Abstract This study compared the oxidative stress level and vasomotor dysfunction after exposure to urban dust, diesel exhaust particles (DEP) or single-walled carbon nanotubes (SWCNT). DEP and SWCNT increased the production of reactive oxygen species (ROS) in cultured endothelial cells and acellullarly, whereas the exposure to urban dust did not generate ROS. ApoE(-/-) mice, which were exposed twice to 0.5 mg/kg of the particles by intratracheal instillation, had unaltered acetylcholine-elicited vasorelaxation in aorta segments. There was unaltered pulmonary expression level of Vcam-1, Icam-1, Hmox-1 and Ogg1. The levels of oxidatively damaged DNA were unchanged in lung tissue. The exposure to SWCNT significantly increased the expression of Ccl-2 in the lung tissue of the mice. The exposure to DEP and SWCNT was associated with elevated ROS production in cultured cells, whereas intratracheal instillation of the same particles had no effect on biomarkers of pulmonary oxidative stress and dilatory dysfunction in the aorta.

AB - Abstract This study compared the oxidative stress level and vasomotor dysfunction after exposure to urban dust, diesel exhaust particles (DEP) or single-walled carbon nanotubes (SWCNT). DEP and SWCNT increased the production of reactive oxygen species (ROS) in cultured endothelial cells and acellullarly, whereas the exposure to urban dust did not generate ROS. ApoE(-/-) mice, which were exposed twice to 0.5 mg/kg of the particles by intratracheal instillation, had unaltered acetylcholine-elicited vasorelaxation in aorta segments. There was unaltered pulmonary expression level of Vcam-1, Icam-1, Hmox-1 and Ogg1. The levels of oxidatively damaged DNA were unchanged in lung tissue. The exposure to SWCNT significantly increased the expression of Ccl-2 in the lung tissue of the mice. The exposure to DEP and SWCNT was associated with elevated ROS production in cultured cells, whereas intratracheal instillation of the same particles had no effect on biomarkers of pulmonary oxidative stress and dilatory dysfunction in the aorta.

U2 - 10.3109/17435390.2012.750385

DO - 10.3109/17435390.2012.750385

M3 - Journal article

VL - 8

SP - 61

EP - 71

JO - Nanotoxicology

JF - Nanotoxicology

SN - 1743-5390

IS - 1

ER -

ID: 41898893