Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates

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Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates. / Thøfner, Maria Søndergaard; Stougaard, C. L.; Westrup, Ulrik; Madry, A. A.; Knudsen, C. S.; Berg, H.; Jensen, C. S. E.; Handby, R. M. L.; Gredal, Hanne Birgit; Fredholm, Merete; Berendt, Mette.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 29, No. 1, 2015, p. 243-250.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thøfner, MS, Stougaard, CL, Westrup, U, Madry, AA, Knudsen, CS, Berg, H, Jensen, CSE, Handby, RML, Gredal, HB, Fredholm, M & Berendt, M 2015, 'Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates', Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, vol. 29, no. 1, pp. 243-250. https://doi.org/10.1111/jvim.12475

APA

Thøfner, M. S., Stougaard, C. L., Westrup, U., Madry, A. A., Knudsen, C. S., Berg, H., ... Berendt, M. (2015). Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 29(1), 243-250. https://doi.org/10.1111/jvim.12475

Vancouver

Thøfner MS, Stougaard CL, Westrup U, Madry AA, Knudsen CS, Berg H et al. Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 2015;29(1):243-250. https://doi.org/10.1111/jvim.12475

Author

Thøfner, Maria Søndergaard ; Stougaard, C. L. ; Westrup, Ulrik ; Madry, A. A. ; Knudsen, C. S. ; Berg, H. ; Jensen, C. S. E. ; Handby, R. M. L. ; Gredal, Hanne Birgit ; Fredholm, Merete ; Berendt, Mette. / Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates. In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 2015 ; Vol. 29, No. 1. pp. 243-250.

Bibtex

@article{764122513e6b47a5b99adfb1f98a0c1f,
title = "Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates",
abstract = "BACKGROUND: Syringomyelia (SM) is common in the Cavalier King Charles Spaniel (CKCS). Dogs with syringes express clinical signs or might be clinically silent.OBJECTIVES: To investigate the prevalence and heritability of symptomatic SM, the association between clinical signs and magnetic resonance imaging (MRI) findings, and long-term outcome.ANIMALS: All CKCS registered in the Danish Kennel Club in 2001 (n = 240).METHODS: A cross-sectional questionnaire-based prevalence study validated by telephone interviews and clinically investigated clinical signs of SM. Dogs were 6 years at the time of investigation. A prospective observational litter study including clinical investigations, MRI and 5-year follow-up of symptomatic and asymptomatic siblings. Heritability was estimated based on the scale of liability in the study population and litter cohort.RESULTS: The cross-sectional study estimated a prevalence of symptomatic SM at 15.4{\%} in the population. Thirteen symptomatic and 9 asymptomatic siblings participated in the litter study. Spinal cord syringes were confirmed in 21 of 22 littermates (95{\%}). Syrinx diameter and mean syrinx : spinal cord ratio were significantly correlated with clinical signs (P < .01). Estimated heritability of symptomatic SM was 0.81. Symptomatic SM motivated euthanasia in 20{\%}. Dogs with syringes, which expressed no clinical signs at the age of 6, remained asymptomatic in 14/15 cases (93{\%}).CONCLUSIONS AND CLINICAL IMPORTANCE: The prevalence of symptomatic SM is high and genetics have a high impact on clinical disease expression. Further investigations of factors influencing the outbreak threshold of clinical signs of SM are desirable.",
author = "Th{\o}fner, {Maria S{\o}ndergaard} and Stougaard, {C. L.} and Ulrik Westrup and Madry, {A. A.} and Knudsen, {C. S.} and H. Berg and Jensen, {C. S. E.} and Handby, {R. M. L.} and Gredal, {Hanne Birgit} and Merete Fredholm and Mette Berendt",
note = "Copyright {\circledC} 2014 by the American College of Veterinary Internal Medicine.",
year = "2015",
doi = "10.1111/jvim.12475",
language = "English",
volume = "29",
pages = "243--250",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates

AU - Thøfner, Maria Søndergaard

AU - Stougaard, C. L.

AU - Westrup, Ulrik

AU - Madry, A. A.

AU - Knudsen, C. S.

AU - Berg, H.

AU - Jensen, C. S. E.

AU - Handby, R. M. L.

AU - Gredal, Hanne Birgit

AU - Fredholm, Merete

AU - Berendt, Mette

N1 - Copyright © 2014 by the American College of Veterinary Internal Medicine.

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Syringomyelia (SM) is common in the Cavalier King Charles Spaniel (CKCS). Dogs with syringes express clinical signs or might be clinically silent.OBJECTIVES: To investigate the prevalence and heritability of symptomatic SM, the association between clinical signs and magnetic resonance imaging (MRI) findings, and long-term outcome.ANIMALS: All CKCS registered in the Danish Kennel Club in 2001 (n = 240).METHODS: A cross-sectional questionnaire-based prevalence study validated by telephone interviews and clinically investigated clinical signs of SM. Dogs were 6 years at the time of investigation. A prospective observational litter study including clinical investigations, MRI and 5-year follow-up of symptomatic and asymptomatic siblings. Heritability was estimated based on the scale of liability in the study population and litter cohort.RESULTS: The cross-sectional study estimated a prevalence of symptomatic SM at 15.4% in the population. Thirteen symptomatic and 9 asymptomatic siblings participated in the litter study. Spinal cord syringes were confirmed in 21 of 22 littermates (95%). Syrinx diameter and mean syrinx : spinal cord ratio were significantly correlated with clinical signs (P < .01). Estimated heritability of symptomatic SM was 0.81. Symptomatic SM motivated euthanasia in 20%. Dogs with syringes, which expressed no clinical signs at the age of 6, remained asymptomatic in 14/15 cases (93%).CONCLUSIONS AND CLINICAL IMPORTANCE: The prevalence of symptomatic SM is high and genetics have a high impact on clinical disease expression. Further investigations of factors influencing the outbreak threshold of clinical signs of SM are desirable.

AB - BACKGROUND: Syringomyelia (SM) is common in the Cavalier King Charles Spaniel (CKCS). Dogs with syringes express clinical signs or might be clinically silent.OBJECTIVES: To investigate the prevalence and heritability of symptomatic SM, the association between clinical signs and magnetic resonance imaging (MRI) findings, and long-term outcome.ANIMALS: All CKCS registered in the Danish Kennel Club in 2001 (n = 240).METHODS: A cross-sectional questionnaire-based prevalence study validated by telephone interviews and clinically investigated clinical signs of SM. Dogs were 6 years at the time of investigation. A prospective observational litter study including clinical investigations, MRI and 5-year follow-up of symptomatic and asymptomatic siblings. Heritability was estimated based on the scale of liability in the study population and litter cohort.RESULTS: The cross-sectional study estimated a prevalence of symptomatic SM at 15.4% in the population. Thirteen symptomatic and 9 asymptomatic siblings participated in the litter study. Spinal cord syringes were confirmed in 21 of 22 littermates (95%). Syrinx diameter and mean syrinx : spinal cord ratio were significantly correlated with clinical signs (P < .01). Estimated heritability of symptomatic SM was 0.81. Symptomatic SM motivated euthanasia in 20%. Dogs with syringes, which expressed no clinical signs at the age of 6, remained asymptomatic in 14/15 cases (93%).CONCLUSIONS AND CLINICAL IMPORTANCE: The prevalence of symptomatic SM is high and genetics have a high impact on clinical disease expression. Further investigations of factors influencing the outbreak threshold of clinical signs of SM are desirable.

U2 - 10.1111/jvim.12475

DO - 10.1111/jvim.12475

M3 - Journal article

VL - 29

SP - 243

EP - 250

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 1

ER -

ID: 130328945