Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens

Research output: Contribution to journalJournal articleResearchpeer-review

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Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation : effects of different diet regimens. / Paris, Monique C; Fuller, Peter J; Carstensen, Bendix; Nagy, Eva; Taylor, Russell G; Sourial, Magdy; Holst, Jens Juul; Hartmann, Bolette; Binesm, Julie E.

In: Digestive Diseases and Sciences, Vol. 49, No. 10, 10.2004, p. 1688-95.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Paris, MC, Fuller, PJ, Carstensen, B, Nagy, E, Taylor, RG, Sourial, M, Holst, JJ, Hartmann, B & Binesm, JE 2004, 'Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens', Digestive Diseases and Sciences, vol. 49, no. 10, pp. 1688-95.

APA

Paris, M. C., Fuller, P. J., Carstensen, B., Nagy, E., Taylor, R. G., Sourial, M., ... Binesm, J. E. (2004). Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens. Digestive Diseases and Sciences, 49(10), 1688-95.

Vancouver

Paris MC, Fuller PJ, Carstensen B, Nagy E, Taylor RG, Sourial M et al. Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens. Digestive Diseases and Sciences. 2004 Oct;49(10):1688-95.

Author

Paris, Monique C ; Fuller, Peter J ; Carstensen, Bendix ; Nagy, Eva ; Taylor, Russell G ; Sourial, Magdy ; Holst, Jens Juul ; Hartmann, Bolette ; Binesm, Julie E. / Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation : effects of different diet regimens. In: Digestive Diseases and Sciences. 2004 ; Vol. 49, No. 10. pp. 1688-95.

Bibtex

@article{41487cdc77994453bdd7619e5a2c36a2,
title = "Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens",
abstract = "Adaptation of the residual small bowel following resection is dependent on luminal and humoral factors. We aimed to establish if circulating levels of glucagon-like peptide (GLP-2) change under different dietary regimens following resection and to determine if there is a relationship between plasma GLP-2 levels and markers of intestinal adaptation. Four-week-old piglets underwent a 75{\%} proximal small bowel resection (n = 31) or transection (n = 14). Postoperatively they received either pig chow (n = 14), nonpolymeric (elemental) infant formula (n = 7), or polymeric infant formula alone (n = 8) or supplemented either with fiber (n = 6) or with bovine colostrum protein concentrate (CPC; n = 10) for 8 weeks until sacrifice. Plasma GLP-2 levels were measured at weeks 0, 2, 4, and 8 postoperatively. In addition, end-stage parameters were studied at week 8 including weight gain, ileal villus height, crypt depth, and disaccharidase levels. Plasma GLP-2 levels were higher in resected animals compared to transected animals fed the same diet. Plasma GLP-2 levels were significantly increased in the colostrum protein isolate-supplemented animals following resection compared to all other diet groups. The increase in plasma GLP-2 (pM) was greatest in the first 2 weeks postresection (week 0, 15.5; week 2, 30.9), followed by a plateau at weeks 2 to 4 and a decrease in GLP-2 levels from week 4 to week 8. At week 8, no relationships were found between the plasma GLP-2 levels and the measurements of weight gain, villus height, lactase, sucrase, maltase, crypt depth, or villus/crypt ratio. Plasma GLP-2 levels increase in the first weeks following massive small intestinal resection. The increase in plasma GLP-2 levels was enhanced by supplementation of the diet with CPC. The changes in GLP-2 levels observed in this study may suggest that GLP-2 plays a role in the adaptive response in the intestine following resection in this preclinical model.",
keywords = "Adaptation, Physiological, Animals, Diet, Dietary Supplements, Disease Models, Animal, Energy Intake, Female, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Intestine, Small, Peptides, Postoperative Period, Short Bowel Syndrome, Swine",
author = "Paris, {Monique C} and Fuller, {Peter J} and Bendix Carstensen and Eva Nagy and Taylor, {Russell G} and Magdy Sourial and Holst, {Jens Juul} and Bolette Hartmann and Binesm, {Julie E}",
year = "2004",
month = "10",
language = "English",
volume = "49",
pages = "1688--95",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation

T2 - effects of different diet regimens

AU - Paris, Monique C

AU - Fuller, Peter J

AU - Carstensen, Bendix

AU - Nagy, Eva

AU - Taylor, Russell G

AU - Sourial, Magdy

AU - Holst, Jens Juul

AU - Hartmann, Bolette

AU - Binesm, Julie E

PY - 2004/10

Y1 - 2004/10

N2 - Adaptation of the residual small bowel following resection is dependent on luminal and humoral factors. We aimed to establish if circulating levels of glucagon-like peptide (GLP-2) change under different dietary regimens following resection and to determine if there is a relationship between plasma GLP-2 levels and markers of intestinal adaptation. Four-week-old piglets underwent a 75% proximal small bowel resection (n = 31) or transection (n = 14). Postoperatively they received either pig chow (n = 14), nonpolymeric (elemental) infant formula (n = 7), or polymeric infant formula alone (n = 8) or supplemented either with fiber (n = 6) or with bovine colostrum protein concentrate (CPC; n = 10) for 8 weeks until sacrifice. Plasma GLP-2 levels were measured at weeks 0, 2, 4, and 8 postoperatively. In addition, end-stage parameters were studied at week 8 including weight gain, ileal villus height, crypt depth, and disaccharidase levels. Plasma GLP-2 levels were higher in resected animals compared to transected animals fed the same diet. Plasma GLP-2 levels were significantly increased in the colostrum protein isolate-supplemented animals following resection compared to all other diet groups. The increase in plasma GLP-2 (pM) was greatest in the first 2 weeks postresection (week 0, 15.5; week 2, 30.9), followed by a plateau at weeks 2 to 4 and a decrease in GLP-2 levels from week 4 to week 8. At week 8, no relationships were found between the plasma GLP-2 levels and the measurements of weight gain, villus height, lactase, sucrase, maltase, crypt depth, or villus/crypt ratio. Plasma GLP-2 levels increase in the first weeks following massive small intestinal resection. The increase in plasma GLP-2 levels was enhanced by supplementation of the diet with CPC. The changes in GLP-2 levels observed in this study may suggest that GLP-2 plays a role in the adaptive response in the intestine following resection in this preclinical model.

AB - Adaptation of the residual small bowel following resection is dependent on luminal and humoral factors. We aimed to establish if circulating levels of glucagon-like peptide (GLP-2) change under different dietary regimens following resection and to determine if there is a relationship between plasma GLP-2 levels and markers of intestinal adaptation. Four-week-old piglets underwent a 75% proximal small bowel resection (n = 31) or transection (n = 14). Postoperatively they received either pig chow (n = 14), nonpolymeric (elemental) infant formula (n = 7), or polymeric infant formula alone (n = 8) or supplemented either with fiber (n = 6) or with bovine colostrum protein concentrate (CPC; n = 10) for 8 weeks until sacrifice. Plasma GLP-2 levels were measured at weeks 0, 2, 4, and 8 postoperatively. In addition, end-stage parameters were studied at week 8 including weight gain, ileal villus height, crypt depth, and disaccharidase levels. Plasma GLP-2 levels were higher in resected animals compared to transected animals fed the same diet. Plasma GLP-2 levels were significantly increased in the colostrum protein isolate-supplemented animals following resection compared to all other diet groups. The increase in plasma GLP-2 (pM) was greatest in the first 2 weeks postresection (week 0, 15.5; week 2, 30.9), followed by a plateau at weeks 2 to 4 and a decrease in GLP-2 levels from week 4 to week 8. At week 8, no relationships were found between the plasma GLP-2 levels and the measurements of weight gain, villus height, lactase, sucrase, maltase, crypt depth, or villus/crypt ratio. Plasma GLP-2 levels increase in the first weeks following massive small intestinal resection. The increase in plasma GLP-2 levels was enhanced by supplementation of the diet with CPC. The changes in GLP-2 levels observed in this study may suggest that GLP-2 plays a role in the adaptive response in the intestine following resection in this preclinical model.

KW - Adaptation, Physiological

KW - Animals

KW - Diet

KW - Dietary Supplements

KW - Disease Models, Animal

KW - Energy Intake

KW - Female

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Intestine, Small

KW - Peptides

KW - Postoperative Period

KW - Short Bowel Syndrome

KW - Swine

M3 - Journal article

VL - 49

SP - 1688

EP - 1695

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 10

ER -

ID: 132054045