Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties

Research output: Contribution to journalJournal articleResearchpeer-review

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Of aging mice and men : gait speed decline is a translatable trait, with species-specific underlying properties. / Bair, Woei-Nan; Petr, Michael; Alfaras, Irene; Mitchell, Sarah J; Bernier, Michel; Ferrucci, Luigi; Studenski, Stephanie A; de Cabo, Rafael.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, 14.01.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bair, W-N, Petr, M, Alfaras, I, Mitchell, SJ, Bernier, M, Ferrucci, L, Studenski, SA & de Cabo, R 2019, 'Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties', The journals of gerontology. Series A, Biological sciences and medical sciences. https://doi.org/10.1093/gerona/glz015

APA

Bair, W-N., Petr, M., Alfaras, I., Mitchell, S. J., Bernier, M., Ferrucci, L., ... de Cabo, R. (2019). Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties. The journals of gerontology. Series A, Biological sciences and medical sciences. https://doi.org/10.1093/gerona/glz015

Vancouver

Bair W-N, Petr M, Alfaras I, Mitchell SJ, Bernier M, Ferrucci L et al. Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties. The journals of gerontology. Series A, Biological sciences and medical sciences. 2019 Jan 14. https://doi.org/10.1093/gerona/glz015

Author

Bair, Woei-Nan ; Petr, Michael ; Alfaras, Irene ; Mitchell, Sarah J ; Bernier, Michel ; Ferrucci, Luigi ; Studenski, Stephanie A ; de Cabo, Rafael. / Of aging mice and men : gait speed decline is a translatable trait, with species-specific underlying properties. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2019.

Bibtex

@article{0e138a830aa647f48a8ec1ecdda4ae97,
title = "Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties",
abstract = "In the last two decades, great strides were made in our ability to extend the lifespan of model organisms through dietary and other manipulations. Survival curves provide evidence of altered aging processes but are uninformative on what lead to that increase in lifespan. Longitudinal assessments of health and function during intervention studies could help in the identification of predictive biomarkers for health and survival. Comparable biomarkers of healthspan are necessary to effectively translate interventions into human clinical trials. Gait speed is a well-established predictive biomarker of healthspan in humans for risk of disability, health outcomes and mortality, and is relatively simple to assess non-invasively in rodents. In this study, we assessed and compared gait speed in males from two species (mice and humans), from young adulthood to advanced old age. Although gait speed decreases non-linearly with age in both species, the underlying drivers of this change in gait speed were different, with humans exhibiting a shortened step length, and mice displaying a decrease in cadence. Future longitudinal and interventional studies in mice should examine the predictive value of longitudinal declines in gait speed for health and survival.",
author = "Woei-Nan Bair and Michael Petr and Irene Alfaras and Mitchell, {Sarah J} and Michel Bernier and Luigi Ferrucci and Studenski, {Stephanie A} and {de Cabo}, Rafael",
year = "2019",
month = "1",
day = "14",
doi = "10.1093/gerona/glz015",
language = "English",
journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Of aging mice and men

T2 - gait speed decline is a translatable trait, with species-specific underlying properties

AU - Bair, Woei-Nan

AU - Petr, Michael

AU - Alfaras, Irene

AU - Mitchell, Sarah J

AU - Bernier, Michel

AU - Ferrucci, Luigi

AU - Studenski, Stephanie A

AU - de Cabo, Rafael

PY - 2019/1/14

Y1 - 2019/1/14

N2 - In the last two decades, great strides were made in our ability to extend the lifespan of model organisms through dietary and other manipulations. Survival curves provide evidence of altered aging processes but are uninformative on what lead to that increase in lifespan. Longitudinal assessments of health and function during intervention studies could help in the identification of predictive biomarkers for health and survival. Comparable biomarkers of healthspan are necessary to effectively translate interventions into human clinical trials. Gait speed is a well-established predictive biomarker of healthspan in humans for risk of disability, health outcomes and mortality, and is relatively simple to assess non-invasively in rodents. In this study, we assessed and compared gait speed in males from two species (mice and humans), from young adulthood to advanced old age. Although gait speed decreases non-linearly with age in both species, the underlying drivers of this change in gait speed were different, with humans exhibiting a shortened step length, and mice displaying a decrease in cadence. Future longitudinal and interventional studies in mice should examine the predictive value of longitudinal declines in gait speed for health and survival.

AB - In the last two decades, great strides were made in our ability to extend the lifespan of model organisms through dietary and other manipulations. Survival curves provide evidence of altered aging processes but are uninformative on what lead to that increase in lifespan. Longitudinal assessments of health and function during intervention studies could help in the identification of predictive biomarkers for health and survival. Comparable biomarkers of healthspan are necessary to effectively translate interventions into human clinical trials. Gait speed is a well-established predictive biomarker of healthspan in humans for risk of disability, health outcomes and mortality, and is relatively simple to assess non-invasively in rodents. In this study, we assessed and compared gait speed in males from two species (mice and humans), from young adulthood to advanced old age. Although gait speed decreases non-linearly with age in both species, the underlying drivers of this change in gait speed were different, with humans exhibiting a shortened step length, and mice displaying a decrease in cadence. Future longitudinal and interventional studies in mice should examine the predictive value of longitudinal declines in gait speed for health and survival.

U2 - 10.1093/gerona/glz015

DO - 10.1093/gerona/glz015

M3 - Journal article

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

ER -

ID: 213162436