No evidence of transmission of chronic lymphocytic leukemia through blood transfusion

Research output: Contribution to journalLetterResearchpeer-review

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No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. / Hjalgrim, Henrik; Rostgaard, Klaus; Vasan, Senthil K; Ullum, Henrik; Erikstrup, Christian; Pedersen, Ole B V; Nielsen, Kaspar Rosengreen; Titlestad, Kjell-Einar; Melbye, Mads; Nyrén, Olof; Edgren, Gustaf.

In: Blood, Vol. 126, No. 17, 22.10.2015, p. 2059-61.

Research output: Contribution to journalLetterResearchpeer-review

Harvard

Hjalgrim, H, Rostgaard, K, Vasan, SK, Ullum, H, Erikstrup, C, Pedersen, OBV, Nielsen, KR, Titlestad, K-E, Melbye, M, Nyrén, O & Edgren, G 2015, 'No evidence of transmission of chronic lymphocytic leukemia through blood transfusion', Blood, vol. 126, no. 17, pp. 2059-61. https://doi.org/10.1182/blood-2015-03-632844

APA

Hjalgrim, H., Rostgaard, K., Vasan, S. K., Ullum, H., Erikstrup, C., Pedersen, O. B. V., ... Edgren, G. (2015). No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. Blood, 126(17), 2059-61. https://doi.org/10.1182/blood-2015-03-632844

Vancouver

Hjalgrim H, Rostgaard K, Vasan SK, Ullum H, Erikstrup C, Pedersen OBV et al. No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. Blood. 2015 Oct 22;126(17):2059-61. https://doi.org/10.1182/blood-2015-03-632844

Author

Hjalgrim, Henrik ; Rostgaard, Klaus ; Vasan, Senthil K ; Ullum, Henrik ; Erikstrup, Christian ; Pedersen, Ole B V ; Nielsen, Kaspar Rosengreen ; Titlestad, Kjell-Einar ; Melbye, Mads ; Nyrén, Olof ; Edgren, Gustaf. / No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. In: Blood. 2015 ; Vol. 126, No. 17. pp. 2059-61.

Bibtex

@article{0c7345bd655a4dd9bcdcbd9dc22287d2,
title = "No evidence of transmission of chronic lymphocytic leukemia through blood transfusion",
abstract = "Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80, 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95{\%} confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.",
keywords = "B-Lymphocytes, Blood Donors, Blood Transfusion, Follow-Up Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocyte Count, Lymphocytosis, Prognosis, Scandinavian and Nordic Countries, Journal Article, Research Support, Non-U.S. Gov't",
author = "Henrik Hjalgrim and Klaus Rostgaard and Vasan, {Senthil K} and Henrik Ullum and Christian Erikstrup and Pedersen, {Ole B V} and Nielsen, {Kaspar Rosengreen} and Kjell-Einar Titlestad and Mads Melbye and Olof Nyr{\'e}n and Gustaf Edgren",
note = "{\circledC} 2015 by The American Society of Hematology.",
year = "2015",
month = "10",
day = "22",
doi = "10.1182/blood-2015-03-632844",
language = "English",
volume = "126",
pages = "2059--61",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "17",

}

RIS

TY - JOUR

T1 - No evidence of transmission of chronic lymphocytic leukemia through blood transfusion

AU - Hjalgrim, Henrik

AU - Rostgaard, Klaus

AU - Vasan, Senthil K

AU - Ullum, Henrik

AU - Erikstrup, Christian

AU - Pedersen, Ole B V

AU - Nielsen, Kaspar Rosengreen

AU - Titlestad, Kjell-Einar

AU - Melbye, Mads

AU - Nyrén, Olof

AU - Edgren, Gustaf

N1 - © 2015 by The American Society of Hematology.

PY - 2015/10/22

Y1 - 2015/10/22

N2 - Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80, 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

AB - Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80, 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

KW - B-Lymphocytes

KW - Blood Donors

KW - Blood Transfusion

KW - Follow-Up Studies

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Lymphocyte Count

KW - Lymphocytosis

KW - Prognosis

KW - Scandinavian and Nordic Countries

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1182/blood-2015-03-632844

DO - 10.1182/blood-2015-03-632844

M3 - Letter

VL - 126

SP - 2059

EP - 2061

JO - Blood

JF - Blood

SN - 0006-4971

IS - 17

ER -

ID: 180570200