New descriptors of T-wave morphology are independent of heart rate

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Mads Peter Andersen, Joel Q Xue, Claus Graff, Jørgen K. Kanters, Egon Toft, Johannes J. Struijk

T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R(2) = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R(2) = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters.
Original languageEnglish
JournalJournal of Electrocardiology
Volume41
Issue number6
Pages (from-to)557-61
Number of pages5
ISSN0022-0736
DOIs
Publication statusPublished - 2008

    Research areas

  • Algorithms, Artifacts, Diagnosis, Computer-Assisted, Electrocardiography, Heart Rate, Humans, Pattern Recognition, Automated, Reproducibility of Results, Sensitivity and Specificity

ID: 33911254