Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. / Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Baker, Jenna; Chen, Guanjie; Aschard, Hugues; Bartz, Traci M; Ding, Jingzhong; Dorajoo, Rajkumar; Manning, Alisa K; Rankinen, Tuomo; Smith, Albert V; Tajuddin, Salman M; Zhao, Wei; Graff, Mariaelisa; Alver, Maris; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Goel, Anuj; Hagemeijer, Yanick; Harris, Sarah E; Hartwig, Fernando P; Zhao, Jing Hua; Christensen, Kaare; Kilpeläinen, Tuomas O; Wang, Jun-Sing; Loos, Ruth J F; COGENT-Kidney Consortium.

In: Nature Genetics, Vol. 51, No. 4, 04.2019, p. 636-648.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bentley, AR, Sung, YJ, Brown, MR, Winkler, TW, Kraja, AT, Ntalla, I, Schwander, K, Chasman, DI, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, TM, Ding, J, Dorajoo, R, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, Zhao, JH, Christensen, K, Kilpeläinen, TO, Wang, J-S, Loos, RJF & COGENT-Kidney Consortium 2019, 'Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids', Nature Genetics, vol. 51, no. 4, pp. 636-648. https://doi.org/10.1038/s41588-019-0378-y

APA

Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., ... COGENT-Kidney Consortium (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51(4), 636-648. https://doi.org/10.1038/s41588-019-0378-y

Vancouver

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics. 2019 Apr;51(4):636-648. https://doi.org/10.1038/s41588-019-0378-y

Author

Bentley, Amy R ; Sung, Yun J ; Brown, Michael R ; Winkler, Thomas W ; Kraja, Aldi T ; Ntalla, Ioanna ; Schwander, Karen ; Chasman, Daniel I ; Lim, Elise ; Deng, Xuan ; Guo, Xiuqing ; Liu, Jingmin ; Lu, Yingchang ; Cheng, Ching-Yu ; Sim, Xueling ; Vojinovic, Dina ; Huffman, Jennifer E ; Musani, Solomon K ; Li, Changwei ; Feitosa, Mary F ; Richard, Melissa A ; Noordam, Raymond ; Baker, Jenna ; Chen, Guanjie ; Aschard, Hugues ; Bartz, Traci M ; Ding, Jingzhong ; Dorajoo, Rajkumar ; Manning, Alisa K ; Rankinen, Tuomo ; Smith, Albert V ; Tajuddin, Salman M ; Zhao, Wei ; Graff, Mariaelisa ; Alver, Maris ; Boissel, Mathilde ; Chai, Jin Fang ; Chen, Xu ; Divers, Jasmin ; Evangelou, Evangelos ; Gao, Chuan ; Goel, Anuj ; Hagemeijer, Yanick ; Harris, Sarah E ; Hartwig, Fernando P ; Zhao, Jing Hua ; Christensen, Kaare ; Kilpeläinen, Tuomas O ; Wang, Jun-Sing ; Loos, Ruth J F ; COGENT-Kidney Consortium. / Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. In: Nature Genetics. 2019 ; Vol. 51, No. 4. pp. 636-648.

Bibtex

@article{50ba04f033034eb0b4f5f1d93c582fa4,
title = "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids",
abstract = "The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study/methods, Genotype, Humans, Life Style, Linkage Disequilibrium/genetics, Lipids/blood, Male, Middle Aged, Smoking/blood, Young Adult",
author = "Bentley, {Amy R} and Sung, {Yun J} and Brown, {Michael R} and Winkler, {Thomas W} and Kraja, {Aldi T} and Ioanna Ntalla and Karen Schwander and Chasman, {Daniel I} and Elise Lim and Xuan Deng and Xiuqing Guo and Jingmin Liu and Yingchang Lu and Ching-Yu Cheng and Xueling Sim and Dina Vojinovic and Huffman, {Jennifer E} and Musani, {Solomon K} and Changwei Li and Feitosa, {Mary F} and Richard, {Melissa A} and Raymond Noordam and Jenna Baker and Guanjie Chen and Hugues Aschard and Bartz, {Traci M} and Jingzhong Ding and Rajkumar Dorajoo and Manning, {Alisa K} and Tuomo Rankinen and Smith, {Albert V} and Tajuddin, {Salman M} and Wei Zhao and Mariaelisa Graff and Maris Alver and Mathilde Boissel and Chai, {Jin Fang} and Xu Chen and Jasmin Divers and Evangelos Evangelou and Chuan Gao and Anuj Goel and Yanick Hagemeijer and Harris, {Sarah E} and Hartwig, {Fernando P} and Zhao, {Jing Hua} and Kaare Christensen and Kilpel{\"a}inen, {Tuomas O} and Jun-Sing Wang and Loos, {Ruth J F} and {COGENT-Kidney Consortium}",
year = "2019",
month = "4",
doi = "10.1038/s41588-019-0378-y",
language = "English",
volume = "51",
pages = "636--648",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

AU - Bentley, Amy R

AU - Sung, Yun J

AU - Brown, Michael R

AU - Winkler, Thomas W

AU - Kraja, Aldi T

AU - Ntalla, Ioanna

AU - Schwander, Karen

AU - Chasman, Daniel I

AU - Lim, Elise

AU - Deng, Xuan

AU - Guo, Xiuqing

AU - Liu, Jingmin

AU - Lu, Yingchang

AU - Cheng, Ching-Yu

AU - Sim, Xueling

AU - Vojinovic, Dina

AU - Huffman, Jennifer E

AU - Musani, Solomon K

AU - Li, Changwei

AU - Feitosa, Mary F

AU - Richard, Melissa A

AU - Noordam, Raymond

AU - Baker, Jenna

AU - Chen, Guanjie

AU - Aschard, Hugues

AU - Bartz, Traci M

AU - Ding, Jingzhong

AU - Dorajoo, Rajkumar

AU - Manning, Alisa K

AU - Rankinen, Tuomo

AU - Smith, Albert V

AU - Tajuddin, Salman M

AU - Zhao, Wei

AU - Graff, Mariaelisa

AU - Alver, Maris

AU - Boissel, Mathilde

AU - Chai, Jin Fang

AU - Chen, Xu

AU - Divers, Jasmin

AU - Evangelou, Evangelos

AU - Gao, Chuan

AU - Goel, Anuj

AU - Hagemeijer, Yanick

AU - Harris, Sarah E

AU - Hartwig, Fernando P

AU - Zhao, Jing Hua

AU - Christensen, Kaare

AU - Kilpeläinen, Tuomas O

AU - Wang, Jun-Sing

AU - Loos, Ruth J F

AU - COGENT-Kidney Consortium

PY - 2019/4

Y1 - 2019/4

N2 - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

AB - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Genome-Wide Association Study/methods

KW - Genotype

KW - Humans

KW - Life Style

KW - Linkage Disequilibrium/genetics

KW - Lipids/blood

KW - Male

KW - Middle Aged

KW - Smoking/blood

KW - Young Adult

U2 - 10.1038/s41588-019-0378-y

DO - 10.1038/s41588-019-0378-y

M3 - Journal article

VL - 51

SP - 636

EP - 648

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 4

ER -

ID: 216917745