Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

Research output: Contribution to journalJournal articleResearchpeer-review

David Hersi Smith, Ib Jarle Christensen, Niels Frank Jensen, Bo Markussen, Maria Unni Koefoed Rømer, Sune Boris Nygård, Sven Müller, Hans Jørgen Nielsen, Nils Brünner, Kirsten Vang Nielsen

Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).
Original languageEnglish
Article numbere60613
JournalP L o S One
Volume8
Issue number4
Number of pages10
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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