Linking Microbiota to Human Diseases: A Systems Biology Perspective

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Linking Microbiota to Human Diseases : A Systems Biology Perspective. / Wu, Hao; Tremaroli, Valentina; Bäckhed, F.

In: Trends in Endocrinology and Metabolism, Vol. 26, No. 12, 06.11.2015, p. 758-70.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Wu, H, Tremaroli, V & Bäckhed, F 2015, 'Linking Microbiota to Human Diseases: A Systems Biology Perspective', Trends in Endocrinology and Metabolism, vol. 26, no. 12, pp. 758-70. https://doi.org/10.1016/j.tem.2015.09.011

APA

Wu, H., Tremaroli, V., & Bäckhed, F. (2015). Linking Microbiota to Human Diseases: A Systems Biology Perspective. Trends in Endocrinology and Metabolism, 26(12), 758-70. https://doi.org/10.1016/j.tem.2015.09.011

Vancouver

Wu H, Tremaroli V, Bäckhed F. Linking Microbiota to Human Diseases: A Systems Biology Perspective. Trends in Endocrinology and Metabolism. 2015 Nov 6;26(12):758-70. https://doi.org/10.1016/j.tem.2015.09.011

Author

Wu, Hao ; Tremaroli, Valentina ; Bäckhed, F. / Linking Microbiota to Human Diseases : A Systems Biology Perspective. In: Trends in Endocrinology and Metabolism. 2015 ; Vol. 26, No. 12. pp. 758-70.

Bibtex

@article{cd60277424eb44e3ab0b73b5a3a3c172,
title = "Linking Microbiota to Human Diseases: A Systems Biology Perspective",
abstract = "The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), and irritable bowel syndrome, and some animal experiments have suggested causality. However, few studies have validated causality in humans and the underlying mechanisms remain largely to be elucidated. We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism and may provide testable hypotheses for advancing our current understanding of human-microbiota interaction.",
author = "Hao Wu and Valentina Tremaroli and F B{\"a}ckhed",
note = "Copyright {\circledC} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = "11",
day = "6",
doi = "10.1016/j.tem.2015.09.011",
language = "English",
volume = "26",
pages = "758--70",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Ltd. * Trends Journals",
number = "12",

}

RIS

TY - JOUR

T1 - Linking Microbiota to Human Diseases

T2 - A Systems Biology Perspective

AU - Wu, Hao

AU - Tremaroli, Valentina

AU - Bäckhed, F

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/11/6

Y1 - 2015/11/6

N2 - The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), and irritable bowel syndrome, and some animal experiments have suggested causality. However, few studies have validated causality in humans and the underlying mechanisms remain largely to be elucidated. We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism and may provide testable hypotheses for advancing our current understanding of human-microbiota interaction.

AB - The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), and irritable bowel syndrome, and some animal experiments have suggested causality. However, few studies have validated causality in humans and the underlying mechanisms remain largely to be elucidated. We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism and may provide testable hypotheses for advancing our current understanding of human-microbiota interaction.

U2 - 10.1016/j.tem.2015.09.011

DO - 10.1016/j.tem.2015.09.011

M3 - Review

VL - 26

SP - 758

EP - 770

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 12

ER -

ID: 150712119