Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa)

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Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa). / Makau, Christopher M; Towett, Philemon K; Abelson, Klas S P; Kanui, Titus I.

In: Brain and Behavior, Vol. 4, No. 6, 11.2014, p. 850-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Makau, CM, Towett, PK, Abelson, KSP & Kanui, TI 2014, 'Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa)', Brain and Behavior, vol. 4, no. 6, pp. 850-7. https://doi.org/10.1002/brb3.287

APA

Makau, C. M., Towett, P. K., Abelson, K. S. P., & Kanui, T. I. (2014). Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa). Brain and Behavior, 4(6), 850-7. https://doi.org/10.1002/brb3.287

Vancouver

Makau CM, Towett PK, Abelson KSP, Kanui TI. Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa). Brain and Behavior. 2014 Nov;4(6):850-7. https://doi.org/10.1002/brb3.287

Author

Makau, Christopher M ; Towett, Philemon K ; Abelson, Klas S P ; Kanui, Titus I. / Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa). In: Brain and Behavior. 2014 ; Vol. 4, No. 6. pp. 850-7.

Bibtex

@article{3a3181a5c62040579fd6bedc99e0eb19,
title = "Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa)",
abstract = "BACKGROUND: The role of noradrenergic system in the control of nociception is documented in some vertebrate animals. However, there are no data showing the role of this system on nociception in the marsh terrapins.METHODOLOGY: In this study, the antinociceptive action of intrathecal administration of the α 2-adrenoreceptor agonist clonidine and α 2-adrenoreceptor antagonist yohimbine was evaluated in the African marsh terrapin using the formalin test. The interaction of clonidine and yohimbine was also evaluated.RESULTS: Intrathecal administration of clonidine (37.5 or 65 μg/kg) caused a significant reduction in the mean time spent in pain-related behavior. Yohimbine, at a dose of 25 μg/kg, significantly blocked the effect of clonidine (65 μg/kg). However, administration of yohimbine (40 or 53 μg/kg) caused a significant reduction in the mean time spent in pain-related behavior. Intrathecal administration of yohimbine (53 μg/kg) followed immediately by intrathecal injection of the serotonergic methysergide maleate (20 μg/kg) resulted in a significant reversal of the antinociceptive effect of yohimbine.CONCLUSION: The present study documented the intrathecal administration of drugs in the marsh terrapin, a technique that can be applied in future studies on these animals. The data also suggest the involvement of both α 2-adrenoreceptors and 5HT receptors in the modulation of nociception in testudines.",
author = "Makau, {Christopher M} and Towett, {Philemon K} and Abelson, {Klas S P} and Kanui, {Titus I}",
year = "2014",
month = "11",
doi = "10.1002/brb3.287",
language = "English",
volume = "4",
pages = "850--7",
journal = "Brain and Behavior",
issn = "2162-3279",
publisher = "JohnWiley & Sons Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa)

AU - Makau, Christopher M

AU - Towett, Philemon K

AU - Abelson, Klas S P

AU - Kanui, Titus I

PY - 2014/11

Y1 - 2014/11

N2 - BACKGROUND: The role of noradrenergic system in the control of nociception is documented in some vertebrate animals. However, there are no data showing the role of this system on nociception in the marsh terrapins.METHODOLOGY: In this study, the antinociceptive action of intrathecal administration of the α 2-adrenoreceptor agonist clonidine and α 2-adrenoreceptor antagonist yohimbine was evaluated in the African marsh terrapin using the formalin test. The interaction of clonidine and yohimbine was also evaluated.RESULTS: Intrathecal administration of clonidine (37.5 or 65 μg/kg) caused a significant reduction in the mean time spent in pain-related behavior. Yohimbine, at a dose of 25 μg/kg, significantly blocked the effect of clonidine (65 μg/kg). However, administration of yohimbine (40 or 53 μg/kg) caused a significant reduction in the mean time spent in pain-related behavior. Intrathecal administration of yohimbine (53 μg/kg) followed immediately by intrathecal injection of the serotonergic methysergide maleate (20 μg/kg) resulted in a significant reversal of the antinociceptive effect of yohimbine.CONCLUSION: The present study documented the intrathecal administration of drugs in the marsh terrapin, a technique that can be applied in future studies on these animals. The data also suggest the involvement of both α 2-adrenoreceptors and 5HT receptors in the modulation of nociception in testudines.

AB - BACKGROUND: The role of noradrenergic system in the control of nociception is documented in some vertebrate animals. However, there are no data showing the role of this system on nociception in the marsh terrapins.METHODOLOGY: In this study, the antinociceptive action of intrathecal administration of the α 2-adrenoreceptor agonist clonidine and α 2-adrenoreceptor antagonist yohimbine was evaluated in the African marsh terrapin using the formalin test. The interaction of clonidine and yohimbine was also evaluated.RESULTS: Intrathecal administration of clonidine (37.5 or 65 μg/kg) caused a significant reduction in the mean time spent in pain-related behavior. Yohimbine, at a dose of 25 μg/kg, significantly blocked the effect of clonidine (65 μg/kg). However, administration of yohimbine (40 or 53 μg/kg) caused a significant reduction in the mean time spent in pain-related behavior. Intrathecal administration of yohimbine (53 μg/kg) followed immediately by intrathecal injection of the serotonergic methysergide maleate (20 μg/kg) resulted in a significant reversal of the antinociceptive effect of yohimbine.CONCLUSION: The present study documented the intrathecal administration of drugs in the marsh terrapin, a technique that can be applied in future studies on these animals. The data also suggest the involvement of both α 2-adrenoreceptors and 5HT receptors in the modulation of nociception in testudines.

U2 - 10.1002/brb3.287

DO - 10.1002/brb3.287

M3 - Journal article

VL - 4

SP - 850

EP - 857

JO - Brain and Behavior

JF - Brain and Behavior

SN - 2162-3279

IS - 6

ER -

ID: 137375054