Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele

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Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. / Faerch, Kristine; Pilgaard, Kasper; Knop, Filip K; Hansen, Torben; Pedersen, Oluf; Jørgensen, Torben; Holst, Jens J.

In: Diabetes, Obesity and Metabolism Online, Vol. 15, No. 1, 2012, p. 91-95.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Faerch, K, Pilgaard, K, Knop, FK, Hansen, T, Pedersen, O, Jørgensen, T & Holst, JJ 2012, 'Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele', Diabetes, Obesity and Metabolism Online, vol. 15, no. 1, pp. 91-95. https://doi.org/10.1111/j.1463-1326.2012.01675.x

APA

Faerch, K., Pilgaard, K., Knop, F. K., Hansen, T., Pedersen, O., Jørgensen, T., & Holst, J. J. (2012). Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. Diabetes, Obesity and Metabolism Online, 15(1), 91-95. https://doi.org/10.1111/j.1463-1326.2012.01675.x

Vancouver

Faerch K, Pilgaard K, Knop FK, Hansen T, Pedersen O, Jørgensen T et al. Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. Diabetes, Obesity and Metabolism Online. 2012;15(1):91-95. https://doi.org/10.1111/j.1463-1326.2012.01675.x

Author

Faerch, Kristine ; Pilgaard, Kasper ; Knop, Filip K ; Hansen, Torben ; Pedersen, Oluf ; Jørgensen, Torben ; Holst, Jens J. / Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. In: Diabetes, Obesity and Metabolism Online. 2012 ; Vol. 15, No. 1. pp. 91-95.

Bibtex

@article{aec3f52ca15a422d9cda3cc5e13fefbb,
title = "Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele",
abstract = "We characterised 62 non-diabetic, middle-aged, Caucasians with and without the T risk allele of rs7903146 in TCF7L2 with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3-hour oral glucose tolerance test (OGTT), an intravenous glucose tolerance test, and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher HbA(1c) levels (P=0.030), reduced first-phase insulin response (P=0.048), higher peripheral insulin sensitivity (P=0.050) and lower fasting GIP concentrations (P=0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (P=0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon, and GLP-1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP.",
author = "Kristine Faerch and Kasper Pilgaard and Knop, {Filip K} and Torben Hansen and Oluf Pedersen and Torben J{\o}rgensen and Holst, {Jens J}",
note = "{\circledC} 2012 Blackwell Publishing Ltd.",
year = "2012",
doi = "10.1111/j.1463-1326.2012.01675.x",
language = "English",
volume = "15",
pages = "91--95",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele

AU - Faerch, Kristine

AU - Pilgaard, Kasper

AU - Knop, Filip K

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Jørgensen, Torben

AU - Holst, Jens J

N1 - © 2012 Blackwell Publishing Ltd.

PY - 2012

Y1 - 2012

N2 - We characterised 62 non-diabetic, middle-aged, Caucasians with and without the T risk allele of rs7903146 in TCF7L2 with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3-hour oral glucose tolerance test (OGTT), an intravenous glucose tolerance test, and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher HbA(1c) levels (P=0.030), reduced first-phase insulin response (P=0.048), higher peripheral insulin sensitivity (P=0.050) and lower fasting GIP concentrations (P=0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (P=0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon, and GLP-1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP.

AB - We characterised 62 non-diabetic, middle-aged, Caucasians with and without the T risk allele of rs7903146 in TCF7L2 with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3-hour oral glucose tolerance test (OGTT), an intravenous glucose tolerance test, and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher HbA(1c) levels (P=0.030), reduced first-phase insulin response (P=0.048), higher peripheral insulin sensitivity (P=0.050) and lower fasting GIP concentrations (P=0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (P=0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon, and GLP-1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP.

U2 - 10.1111/j.1463-1326.2012.01675.x

DO - 10.1111/j.1463-1326.2012.01675.x

M3 - Journal article

VL - 15

SP - 91

EP - 95

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 1

ER -

ID: 40327055