Impaired blood supply in the colonic anastomosis in mice compromises healing

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Impaired blood supply in the colonic anastomosis in mice compromises healing. / Pommergaard, Hans-Christian; Achiam, Michael Patrick; Burcharth, Jakob; Rosenberg, Jacob.

In: International Surgery, Vol. 100, No. 1, 01.2015, p. 70-6.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pommergaard, H-C, Achiam, MP, Burcharth, J & Rosenberg, J 2015, 'Impaired blood supply in the colonic anastomosis in mice compromises healing', International Surgery, vol. 100, no. 1, pp. 70-6. https://doi.org/10.9738/INTSURG-D-13-00191.1

APA

Pommergaard, H-C., Achiam, M. P., Burcharth, J., & Rosenberg, J. (2015). Impaired blood supply in the colonic anastomosis in mice compromises healing. International Surgery, 100(1), 70-6. https://doi.org/10.9738/INTSURG-D-13-00191.1

Vancouver

Pommergaard H-C, Achiam MP, Burcharth J, Rosenberg J. Impaired blood supply in the colonic anastomosis in mice compromises healing. International Surgery. 2015 Jan;100(1):70-6. https://doi.org/10.9738/INTSURG-D-13-00191.1

Author

Pommergaard, Hans-Christian ; Achiam, Michael Patrick ; Burcharth, Jakob ; Rosenberg, Jacob. / Impaired blood supply in the colonic anastomosis in mice compromises healing. In: International Surgery. 2015 ; Vol. 100, No. 1. pp. 70-6.

Bibtex

@article{6f91c6e77bdc4cda97dca28b34fb7400,
title = "Impaired blood supply in the colonic anastomosis in mice compromises healing",
abstract = "Colon anastomotic leakage has a multifactorial etiology and ischemia is considered one of the most important single factors. However, no existing animal models have established a direct link between ischemia and anastomotic leakage. The aim of this study was to establish a model of colon anastomotic leakage as a result of tissue ischemia. In colon anastomoses of 53 C57BL/6 mice, varying degrees of ischemia were induced. Supplying vessels were divided with bipolar coagulation in order to reduce anastomotic breaking strength and create clinical anastomotic leakage. Breaking strength of all the ischemic anastomoses were significantly lower compared with controls. Increasing ischemia resulted in higher rates of large bowel obstruction without creating anastomotic leakage. Healing was compromised as a result of impaired blood supply. However, clinical leakage was absent. Pure ischemia in otherwise healthy experimental animals may be too simple of an approach to create clinical leakage.",
author = "Hans-Christian Pommergaard and Achiam, {Michael Patrick} and Jakob Burcharth and Jacob Rosenberg",
year = "2015",
month = "1",
doi = "10.9738/INTSURG-D-13-00191.1",
language = "English",
volume = "100",
pages = "70--6",
journal = "International Surgery",
issn = "0020-8868",
publisher = "International College of Surgeons",
number = "1",

}

RIS

TY - JOUR

T1 - Impaired blood supply in the colonic anastomosis in mice compromises healing

AU - Pommergaard, Hans-Christian

AU - Achiam, Michael Patrick

AU - Burcharth, Jakob

AU - Rosenberg, Jacob

PY - 2015/1

Y1 - 2015/1

N2 - Colon anastomotic leakage has a multifactorial etiology and ischemia is considered one of the most important single factors. However, no existing animal models have established a direct link between ischemia and anastomotic leakage. The aim of this study was to establish a model of colon anastomotic leakage as a result of tissue ischemia. In colon anastomoses of 53 C57BL/6 mice, varying degrees of ischemia were induced. Supplying vessels were divided with bipolar coagulation in order to reduce anastomotic breaking strength and create clinical anastomotic leakage. Breaking strength of all the ischemic anastomoses were significantly lower compared with controls. Increasing ischemia resulted in higher rates of large bowel obstruction without creating anastomotic leakage. Healing was compromised as a result of impaired blood supply. However, clinical leakage was absent. Pure ischemia in otherwise healthy experimental animals may be too simple of an approach to create clinical leakage.

AB - Colon anastomotic leakage has a multifactorial etiology and ischemia is considered one of the most important single factors. However, no existing animal models have established a direct link between ischemia and anastomotic leakage. The aim of this study was to establish a model of colon anastomotic leakage as a result of tissue ischemia. In colon anastomoses of 53 C57BL/6 mice, varying degrees of ischemia were induced. Supplying vessels were divided with bipolar coagulation in order to reduce anastomotic breaking strength and create clinical anastomotic leakage. Breaking strength of all the ischemic anastomoses were significantly lower compared with controls. Increasing ischemia resulted in higher rates of large bowel obstruction without creating anastomotic leakage. Healing was compromised as a result of impaired blood supply. However, clinical leakage was absent. Pure ischemia in otherwise healthy experimental animals may be too simple of an approach to create clinical leakage.

U2 - 10.9738/INTSURG-D-13-00191.1

DO - 10.9738/INTSURG-D-13-00191.1

M3 - Journal article

VL - 100

SP - 70

EP - 76

JO - International Surgery

JF - International Surgery

SN - 0020-8868

IS - 1

ER -

ID: 161188573