Generic GPCR residue numbers - aligning topology maps while minding the gaps

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Generic GPCR residue numbers - aligning topology maps while minding the gaps. / Isberg, Vignir; de Graaf, Chris; Bortolato, Andrea; Cherezov, Vadim; Katritch, Vsevolod; Marshall, Fiona H; Mordalski, Stefan; Pin, Jean-Philippe; Stevens, Raymond C; Vriend, Gerrit; Gloriam, David E.

In: Trends in Pharmacological Sciences, Vol. 36, No. 1, 01.01.2015, p. 22-31.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Isberg, V, de Graaf, C, Bortolato, A, Cherezov, V, Katritch, V, Marshall, FH, Mordalski, S, Pin, J-P, Stevens, RC, Vriend, G & Gloriam, DE 2015, 'Generic GPCR residue numbers - aligning topology maps while minding the gaps' Trends in Pharmacological Sciences, vol. 36, no. 1, pp. 22-31. https://doi.org/10.1016/j.tips.2014.11.001

APA

Isberg, V., de Graaf, C., Bortolato, A., Cherezov, V., Katritch, V., Marshall, F. H., ... Gloriam, D. E. (2015). Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends in Pharmacological Sciences, 36(1), 22-31. https://doi.org/10.1016/j.tips.2014.11.001

Vancouver

Isberg V, de Graaf C, Bortolato A, Cherezov V, Katritch V, Marshall FH et al. Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends in Pharmacological Sciences. 2015 Jan 1;36(1):22-31. https://doi.org/10.1016/j.tips.2014.11.001

Author

Isberg, Vignir ; de Graaf, Chris ; Bortolato, Andrea ; Cherezov, Vadim ; Katritch, Vsevolod ; Marshall, Fiona H ; Mordalski, Stefan ; Pin, Jean-Philippe ; Stevens, Raymond C ; Vriend, Gerrit ; Gloriam, David E. / Generic GPCR residue numbers - aligning topology maps while minding the gaps. In: Trends in Pharmacological Sciences. 2015 ; Vol. 36, No. 1. pp. 22-31.

Bibtex

@article{af5af5c8a03443348c88eced69991f30,
title = "Generic GPCR residue numbers - aligning topology maps while minding the gaps",
abstract = "Generic residue numbers facilitate comparisons of, for example, mutational effects, ligand interactions, and structural motifs. The numbering scheme by Ballesteros and Weinstein for residues within the class A GPCRs (G protein-coupled receptors) has more than 1100 citations, and the recent crystal structures for classes B, C, and F now call for a community consensus in residue numbering within and across these classes. Furthermore, the structural era has uncovered helix bulges and constrictions that offset the generic residue numbers. The use of generic residue numbers depends on convenient access by pharmacologists, chemists, and structural biologists. We review the generic residue numbering schemes for each GPCR class, as well as a complementary structure-based scheme, and provide illustrative examples and GPCR database (GPCRDB) web tools to number any receptor sequence or structure.",
author = "Vignir Isberg and {de Graaf}, Chris and Andrea Bortolato and Vadim Cherezov and Vsevolod Katritch and Marshall, {Fiona H} and Stefan Mordalski and Jean-Philippe Pin and Stevens, {Raymond C} and Gerrit Vriend and Gloriam, {David E}",
note = "Copyright {\circledC} 2014 Elsevier Ltd. All rights reserved.",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.tips.2014.11.001",
language = "English",
volume = "36",
pages = "22--31",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Ltd. * Trends Journals",
number = "1",

}

RIS

TY - JOUR

T1 - Generic GPCR residue numbers - aligning topology maps while minding the gaps

AU - Isberg, Vignir

AU - de Graaf, Chris

AU - Bortolato, Andrea

AU - Cherezov, Vadim

AU - Katritch, Vsevolod

AU - Marshall, Fiona H

AU - Mordalski, Stefan

AU - Pin, Jean-Philippe

AU - Stevens, Raymond C

AU - Vriend, Gerrit

AU - Gloriam, David E

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Generic residue numbers facilitate comparisons of, for example, mutational effects, ligand interactions, and structural motifs. The numbering scheme by Ballesteros and Weinstein for residues within the class A GPCRs (G protein-coupled receptors) has more than 1100 citations, and the recent crystal structures for classes B, C, and F now call for a community consensus in residue numbering within and across these classes. Furthermore, the structural era has uncovered helix bulges and constrictions that offset the generic residue numbers. The use of generic residue numbers depends on convenient access by pharmacologists, chemists, and structural biologists. We review the generic residue numbering schemes for each GPCR class, as well as a complementary structure-based scheme, and provide illustrative examples and GPCR database (GPCRDB) web tools to number any receptor sequence or structure.

AB - Generic residue numbers facilitate comparisons of, for example, mutational effects, ligand interactions, and structural motifs. The numbering scheme by Ballesteros and Weinstein for residues within the class A GPCRs (G protein-coupled receptors) has more than 1100 citations, and the recent crystal structures for classes B, C, and F now call for a community consensus in residue numbering within and across these classes. Furthermore, the structural era has uncovered helix bulges and constrictions that offset the generic residue numbers. The use of generic residue numbers depends on convenient access by pharmacologists, chemists, and structural biologists. We review the generic residue numbering schemes for each GPCR class, as well as a complementary structure-based scheme, and provide illustrative examples and GPCR database (GPCRDB) web tools to number any receptor sequence or structure.

U2 - 10.1016/j.tips.2014.11.001

DO - 10.1016/j.tips.2014.11.001

M3 - Journal article

VL - 36

SP - 22

EP - 31

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 1

ER -

ID: 129538636