Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats. / Liu, Xiaowen; Murali, Sangita G; Holst, Jens Juul; Ney, Denise M.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2008, p. 295:R1794-1802.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Liu, X, Murali, SG, Holst, JJ & Ney, DM 2008, 'Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, pp. 295:R1794-1802. https://doi.org/10.1152/ajpregu.90616.2008

APA

Liu, X., Murali, S. G., Holst, J. J., & Ney, D. M. (2008). Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 295:R1794-1802. https://doi.org/10.1152/ajpregu.90616.2008

Vancouver

Liu X, Murali SG, Holst JJ, Ney DM. Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2008;295:R1794-1802. https://doi.org/10.1152/ajpregu.90616.2008

Author

Liu, Xiaowen ; Murali, Sangita G ; Holst, Jens Juul ; Ney, Denise M. / Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2008 ; pp. 295:R1794-1802.

Bibtex

@article{4df9de50ab4f11ddb5e9000ea68e967b,
title = "Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.",
abstract = "Glucagon-like peptide-2 (GLP-2) is a nutrient-dependent, intestinotrophic hormone derived from posttranslational processing of proglucagon in the distal bowel. GLP-2 is thought to act through indirect mediators, such as insulin-like growth factor I (IGF-I). We investigated if intestinal expression of GLP-2 and IGF-I system components are increased with the mucosal growth induced by enteral nutrient (EN) and/or a low dose of GLP-2 in parentally-fed rats. Rats were randomized to 4 treatment groups using a 2x2 design and maintained with parental nutrition (PN) for 7 days: PN alone, EN, GLP-2, EN+GLP-2, n=7-9. The 2 main treatment effects are: +/-GLP-2 (100 microg/kg body wt/day) and +/-EN (43{\%} of energy needs, day4-6). Combination treatment with EN+GLP-2 induced synergistic intestinal growth in ileum resulting in greater mucosal cellularity, sucrase segmental activity and gain of body weight (ENxGLP-2, p<0.04). In addition, EN+GLP-2 induced a significant 28{\%} increase in plasma concentration of bioactive GLP-2, a significant 102{\%} increase in ileal proglucagon mRNA with no change in ileal dipeptidyl peptidase-IV (DPP-IV) specific activity, and significantly reduced plasma DPP-IV activity compared to GLP-2. This indicates that EN potentiates the intestinotrophic action of GLP-2. Proliferation of enterocytes due to GLP-2 infusion was associated with greater expression of ileal proglucagon, GLP-2 receptor, IGF-I, IGF binding protein-3 mRNAs, and greater IGF-I peptide concentration in ileum (p<0.032). Ileal IGF-I mRNA was positively correlated with expression of proglucagon, GLP-2R, and IGFBP-5 mRNAs (R(2)=0.43-0.56, p<0.0001). Our findings support the hypothesis that IGF-I is one of the downstream mediators of GLP-2 action in a physiological model of intestinal growth. Key words: parenteral nutrition, GLP-2 receptor, IGF binding protein-3 and -5, proglucagon.",
author = "Xiaowen Liu and Murali, {Sangita G} and Holst, {Jens Juul} and Ney, {Denise M}",
year = "2008",
doi = "10.1152/ajpregu.90616.2008",
language = "English",
pages = "295:R1794--1802",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",

}

RIS

TY - JOUR

T1 - Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.

AU - Liu, Xiaowen

AU - Murali, Sangita G

AU - Holst, Jens Juul

AU - Ney, Denise M

PY - 2008

Y1 - 2008

N2 - Glucagon-like peptide-2 (GLP-2) is a nutrient-dependent, intestinotrophic hormone derived from posttranslational processing of proglucagon in the distal bowel. GLP-2 is thought to act through indirect mediators, such as insulin-like growth factor I (IGF-I). We investigated if intestinal expression of GLP-2 and IGF-I system components are increased with the mucosal growth induced by enteral nutrient (EN) and/or a low dose of GLP-2 in parentally-fed rats. Rats were randomized to 4 treatment groups using a 2x2 design and maintained with parental nutrition (PN) for 7 days: PN alone, EN, GLP-2, EN+GLP-2, n=7-9. The 2 main treatment effects are: +/-GLP-2 (100 microg/kg body wt/day) and +/-EN (43% of energy needs, day4-6). Combination treatment with EN+GLP-2 induced synergistic intestinal growth in ileum resulting in greater mucosal cellularity, sucrase segmental activity and gain of body weight (ENxGLP-2, p<0.04). In addition, EN+GLP-2 induced a significant 28% increase in plasma concentration of bioactive GLP-2, a significant 102% increase in ileal proglucagon mRNA with no change in ileal dipeptidyl peptidase-IV (DPP-IV) specific activity, and significantly reduced plasma DPP-IV activity compared to GLP-2. This indicates that EN potentiates the intestinotrophic action of GLP-2. Proliferation of enterocytes due to GLP-2 infusion was associated with greater expression of ileal proglucagon, GLP-2 receptor, IGF-I, IGF binding protein-3 mRNAs, and greater IGF-I peptide concentration in ileum (p<0.032). Ileal IGF-I mRNA was positively correlated with expression of proglucagon, GLP-2R, and IGFBP-5 mRNAs (R(2)=0.43-0.56, p<0.0001). Our findings support the hypothesis that IGF-I is one of the downstream mediators of GLP-2 action in a physiological model of intestinal growth. Key words: parenteral nutrition, GLP-2 receptor, IGF binding protein-3 and -5, proglucagon.

AB - Glucagon-like peptide-2 (GLP-2) is a nutrient-dependent, intestinotrophic hormone derived from posttranslational processing of proglucagon in the distal bowel. GLP-2 is thought to act through indirect mediators, such as insulin-like growth factor I (IGF-I). We investigated if intestinal expression of GLP-2 and IGF-I system components are increased with the mucosal growth induced by enteral nutrient (EN) and/or a low dose of GLP-2 in parentally-fed rats. Rats were randomized to 4 treatment groups using a 2x2 design and maintained with parental nutrition (PN) for 7 days: PN alone, EN, GLP-2, EN+GLP-2, n=7-9. The 2 main treatment effects are: +/-GLP-2 (100 microg/kg body wt/day) and +/-EN (43% of energy needs, day4-6). Combination treatment with EN+GLP-2 induced synergistic intestinal growth in ileum resulting in greater mucosal cellularity, sucrase segmental activity and gain of body weight (ENxGLP-2, p<0.04). In addition, EN+GLP-2 induced a significant 28% increase in plasma concentration of bioactive GLP-2, a significant 102% increase in ileal proglucagon mRNA with no change in ileal dipeptidyl peptidase-IV (DPP-IV) specific activity, and significantly reduced plasma DPP-IV activity compared to GLP-2. This indicates that EN potentiates the intestinotrophic action of GLP-2. Proliferation of enterocytes due to GLP-2 infusion was associated with greater expression of ileal proglucagon, GLP-2 receptor, IGF-I, IGF binding protein-3 mRNAs, and greater IGF-I peptide concentration in ileum (p<0.032). Ileal IGF-I mRNA was positively correlated with expression of proglucagon, GLP-2R, and IGFBP-5 mRNAs (R(2)=0.43-0.56, p<0.0001). Our findings support the hypothesis that IGF-I is one of the downstream mediators of GLP-2 action in a physiological model of intestinal growth. Key words: parenteral nutrition, GLP-2 receptor, IGF binding protein-3 and -5, proglucagon.

U2 - 10.1152/ajpregu.90616.2008

DO - 10.1152/ajpregu.90616.2008

M3 - Journal article

SP - 295:R1794-1802

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

ER -

ID: 8417838