Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise: Role of cGMP signaling

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise : Role of cGMP signaling. / Piil, Peter Kromann; Jørgensen, Tue Smith; Egelund, Jon; Mortensen, Nicolai Rytter; Gliemann, Lasse; Bangsbo, Jens; Hellsten, Ylva; Nyberg, Michael Permin.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 315, No. 2, 2018, p. R274-R283.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Piil, PK, Jørgensen, TS, Egelund, J, Mortensen, NR, Gliemann, L, Bangsbo, J, Hellsten, Y & Nyberg, MP 2018, 'Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise: Role of cGMP signaling', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 315, no. 2, pp. R274-R283. https://doi.org/10.1152/ajpregu.00446.2017

APA

Piil, P. K., Jørgensen, T. S., Egelund, J., Mortensen, N. R., Gliemann, L., Bangsbo, J., ... Nyberg, M. P. (2018). Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise: Role of cGMP signaling. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 315(2), R274-R283. https://doi.org/10.1152/ajpregu.00446.2017

Vancouver

Piil PK, Jørgensen TS, Egelund J, Mortensen NR, Gliemann L, Bangsbo J et al. Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise: Role of cGMP signaling. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2018;315(2):R274-R283. https://doi.org/10.1152/ajpregu.00446.2017

Author

Piil, Peter Kromann ; Jørgensen, Tue Smith ; Egelund, Jon ; Mortensen, Nicolai Rytter ; Gliemann, Lasse ; Bangsbo, Jens ; Hellsten, Ylva ; Nyberg, Michael Permin. / Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise : Role of cGMP signaling. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2018 ; Vol. 315, No. 2. pp. R274-R283.

Bibtex

@article{719cd26714984558b4de2de9681db216,
title = "Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise: Role of cGMP signaling",
abstract = "Aging is associated with slower skeletal muscle O2 uptake (VO2) kinetics; however, the mechanisms underlying this effect of age are unclear. Also, the effects of exercise training in elderly on the initial vascular and metabolic response to exercise remain to be elucidated. We measured leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise engaging the knee-extensor muscles in young (n=15, 25{plus minus}1 years) and older (n=15, 72{plus minus}1 years) subjects before and after a period of aerobic high-intensity exercise training. To enhance cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, the older group had a slower ( P˂0.05) increase in femoral arterial blood flow and leg vascular conductance in the transition from rest to steady state exercise at low- and moderate-intensity compared with the young group. The rate of increase in leg VO2 was, however, similar in the two groups as a result of higher ( P<0.05) a-vO2 difference in the older group. Potentiation of cGMP signaling did not affect the rate of increase in blood flow or VO2 in either group. Exercise training augmented ( P<0.05) the increase in leg vascular conductance and blood flow during the onset of moderate-intensity exercise in both groups without altering VO2. These findings suggest that an age-related reduction in the initial vascular response to low- and moderate-intensity knee-extensor exercise is not limiting for VO2 in older individuals. A lower blood flow response in aging does not appear to be a result of reduced cGMP signaling.",
keywords = "The Faculty of Science, Knee-extensor exercise, Sildenafil, PDE5 inhibition",
author = "Piil, {Peter Kromann} and J{\o}rgensen, {Tue Smith} and Jon Egelund and Mortensen, {Nicolai Rytter} and Lasse Gliemann and Jens Bangsbo and Ylva Hellsten and Nyberg, {Michael Permin}",
note = "CURIS 2018 NEXS 260",
year = "2018",
doi = "10.1152/ajpregu.00446.2017",
language = "English",
volume = "315",
pages = "R274--R283",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Effects of aging and exercise training on leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise

T2 - Role of cGMP signaling

AU - Piil, Peter Kromann

AU - Jørgensen, Tue Smith

AU - Egelund, Jon

AU - Mortensen, Nicolai Rytter

AU - Gliemann, Lasse

AU - Bangsbo, Jens

AU - Hellsten, Ylva

AU - Nyberg, Michael Permin

N1 - CURIS 2018 NEXS 260

PY - 2018

Y1 - 2018

N2 - Aging is associated with slower skeletal muscle O2 uptake (VO2) kinetics; however, the mechanisms underlying this effect of age are unclear. Also, the effects of exercise training in elderly on the initial vascular and metabolic response to exercise remain to be elucidated. We measured leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise engaging the knee-extensor muscles in young (n=15, 25{plus minus}1 years) and older (n=15, 72{plus minus}1 years) subjects before and after a period of aerobic high-intensity exercise training. To enhance cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, the older group had a slower ( P˂0.05) increase in femoral arterial blood flow and leg vascular conductance in the transition from rest to steady state exercise at low- and moderate-intensity compared with the young group. The rate of increase in leg VO2 was, however, similar in the two groups as a result of higher ( P<0.05) a-vO2 difference in the older group. Potentiation of cGMP signaling did not affect the rate of increase in blood flow or VO2 in either group. Exercise training augmented ( P<0.05) the increase in leg vascular conductance and blood flow during the onset of moderate-intensity exercise in both groups without altering VO2. These findings suggest that an age-related reduction in the initial vascular response to low- and moderate-intensity knee-extensor exercise is not limiting for VO2 in older individuals. A lower blood flow response in aging does not appear to be a result of reduced cGMP signaling.

AB - Aging is associated with slower skeletal muscle O2 uptake (VO2) kinetics; however, the mechanisms underlying this effect of age are unclear. Also, the effects of exercise training in elderly on the initial vascular and metabolic response to exercise remain to be elucidated. We measured leg hemodynamics and oxidative metabolism in the transition from rest to steady state exercise engaging the knee-extensor muscles in young (n=15, 25{plus minus}1 years) and older (n=15, 72{plus minus}1 years) subjects before and after a period of aerobic high-intensity exercise training. To enhance cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, the older group had a slower ( P˂0.05) increase in femoral arterial blood flow and leg vascular conductance in the transition from rest to steady state exercise at low- and moderate-intensity compared with the young group. The rate of increase in leg VO2 was, however, similar in the two groups as a result of higher ( P<0.05) a-vO2 difference in the older group. Potentiation of cGMP signaling did not affect the rate of increase in blood flow or VO2 in either group. Exercise training augmented ( P<0.05) the increase in leg vascular conductance and blood flow during the onset of moderate-intensity exercise in both groups without altering VO2. These findings suggest that an age-related reduction in the initial vascular response to low- and moderate-intensity knee-extensor exercise is not limiting for VO2 in older individuals. A lower blood flow response in aging does not appear to be a result of reduced cGMP signaling.

KW - The Faculty of Science

KW - Knee-extensor exercise

KW - Sildenafil

KW - PDE5 inhibition

U2 - 10.1152/ajpregu.00446.2017

DO - 10.1152/ajpregu.00446.2017

M3 - Journal article

VL - 315

SP - R274-R283

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

IS - 2

ER -

ID: 195288142