Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery

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Standard

Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery. / Guldstrand, M; Ahrén, B; Näslund, E; Holst, Jens Juul; Adamson, U.

In: Diabetes, Obesity and Metabolism, Vol. 11, No. 11, 2009, p. 1027-33.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Guldstrand, M, Ahrén, B, Näslund, E, Holst, JJ & Adamson, U 2009, 'Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery', Diabetes, Obesity and Metabolism, vol. 11, no. 11, pp. 1027-33. https://doi.org/10.1111/j.1463-1326.2009.01089.x

APA

Guldstrand, M., Ahrén, B., Näslund, E., Holst, J. J., & Adamson, U. (2009). Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery. Diabetes, Obesity and Metabolism, 11(11), 1027-33. https://doi.org/10.1111/j.1463-1326.2009.01089.x

Vancouver

Guldstrand M, Ahrén B, Näslund E, Holst JJ, Adamson U. Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery. Diabetes, Obesity and Metabolism. 2009;11(11):1027-33. https://doi.org/10.1111/j.1463-1326.2009.01089.x

Author

Guldstrand, M ; Ahrén, B ; Näslund, E ; Holst, Jens Juul ; Adamson, U. / Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery. In: Diabetes, Obesity and Metabolism. 2009 ; Vol. 11, No. 11. pp. 1027-33.

Bibtex

@article{d5c40620335311df8ed1000ea68e967b,
title = "Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery",
abstract = "AIM: Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. METHODS: Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m(2)]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. RESULTS: At 1 year after operation, reduction in body weight, actual body weight, fasting glucose or insulin, or the glucose and insulin responses to oral glucose did not differ significantly between the groups. Similarly, fasting GIP and GLP-1 levels did not differ significantly between the groups. In contrast, the GIP and GLP-1 responses to oral glucose were different between the groups in a dissociated pattern. Thus, AUC(GIP) was significantly higher after VBG than after JIB (53 +/- 8 vs. 26 +/- 6 pmol/l/min, p = 0.003). In contrast, AUC(GLP-1) was significantly higher after JIB than after VBG (49 +/- 5 vs. 20 +/- 3 pmol/l/min, p = 0.007). CONCLUSIONS: We conclude that at 1 year after bariatric surgery, the two incretins show dissociated responses in that the GIP secretion is higher after VBG whereas GLP-1 secretion is higher after JIB. This dissociated incretin response is independent from reduction in body weight, glucose tolerance or insulin secretion.",
author = "M Guldstrand and B Ahr{\'e}n and E N{\"a}slund and Holst, {Jens Juul} and U Adamson",
year = "2009",
doi = "10.1111/j.1463-1326.2009.01089.x",
language = "English",
volume = "11",
pages = "1027--33",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery

AU - Guldstrand, M

AU - Ahrén, B

AU - Näslund, E

AU - Holst, Jens Juul

AU - Adamson, U

PY - 2009

Y1 - 2009

N2 - AIM: Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. METHODS: Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m(2)]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. RESULTS: At 1 year after operation, reduction in body weight, actual body weight, fasting glucose or insulin, or the glucose and insulin responses to oral glucose did not differ significantly between the groups. Similarly, fasting GIP and GLP-1 levels did not differ significantly between the groups. In contrast, the GIP and GLP-1 responses to oral glucose were different between the groups in a dissociated pattern. Thus, AUC(GIP) was significantly higher after VBG than after JIB (53 +/- 8 vs. 26 +/- 6 pmol/l/min, p = 0.003). In contrast, AUC(GLP-1) was significantly higher after JIB than after VBG (49 +/- 5 vs. 20 +/- 3 pmol/l/min, p = 0.007). CONCLUSIONS: We conclude that at 1 year after bariatric surgery, the two incretins show dissociated responses in that the GIP secretion is higher after VBG whereas GLP-1 secretion is higher after JIB. This dissociated incretin response is independent from reduction in body weight, glucose tolerance or insulin secretion.

AB - AIM: Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. METHODS: Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m(2)]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. RESULTS: At 1 year after operation, reduction in body weight, actual body weight, fasting glucose or insulin, or the glucose and insulin responses to oral glucose did not differ significantly between the groups. Similarly, fasting GIP and GLP-1 levels did not differ significantly between the groups. In contrast, the GIP and GLP-1 responses to oral glucose were different between the groups in a dissociated pattern. Thus, AUC(GIP) was significantly higher after VBG than after JIB (53 +/- 8 vs. 26 +/- 6 pmol/l/min, p = 0.003). In contrast, AUC(GLP-1) was significantly higher after JIB than after VBG (49 +/- 5 vs. 20 +/- 3 pmol/l/min, p = 0.007). CONCLUSIONS: We conclude that at 1 year after bariatric surgery, the two incretins show dissociated responses in that the GIP secretion is higher after VBG whereas GLP-1 secretion is higher after JIB. This dissociated incretin response is independent from reduction in body weight, glucose tolerance or insulin secretion.

U2 - 10.1111/j.1463-1326.2009.01089.x

DO - 10.1111/j.1463-1326.2009.01089.x

M3 - Journal article

VL - 11

SP - 1027

EP - 1033

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 11

ER -

ID: 18700554