Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Determinants of maximal whole-body fat oxidation in elite cross-country skiers : Role of skeletal muscle mitochondria. / Dandanell, Sune; Meinild-Lundby, Anne-Kristine; Andersen, Andreas Breenfeldt; Lang, Paul F; Oberholzer, Laura; Keiser, Stefanie; Robach, Paul; Larsen, Steen; Rønnestad, Bent R; Lundby, Carsten.

In: Scandinavian Journal of Medicine & Science in Sports, Vol. 28, No. 12, 2018, p. 2494-2504.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Dandanell, S, Meinild-Lundby, A-K, Andersen, AB, Lang, PF, Oberholzer, L, Keiser, S, Robach, P, Larsen, S, Rønnestad, BR & Lundby, C 2018, 'Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria', Scandinavian Journal of Medicine & Science in Sports, vol. 28, no. 12, pp. 2494-2504. https://doi.org/10.1111/sms.13298

APA

Dandanell, S., Meinild-Lundby, A-K., Andersen, A. B., Lang, P. F., Oberholzer, L., Keiser, S., ... Lundby, C. (2018). Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria. Scandinavian Journal of Medicine & Science in Sports, 28(12), 2494-2504. https://doi.org/10.1111/sms.13298

Vancouver

Dandanell S, Meinild-Lundby A-K, Andersen AB, Lang PF, Oberholzer L, Keiser S et al. Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria. Scandinavian Journal of Medicine & Science in Sports. 2018;28(12):2494-2504. https://doi.org/10.1111/sms.13298

Author

Dandanell, Sune ; Meinild-Lundby, Anne-Kristine ; Andersen, Andreas Breenfeldt ; Lang, Paul F ; Oberholzer, Laura ; Keiser, Stefanie ; Robach, Paul ; Larsen, Steen ; Rønnestad, Bent R ; Lundby, Carsten. / Determinants of maximal whole-body fat oxidation in elite cross-country skiers : Role of skeletal muscle mitochondria. In: Scandinavian Journal of Medicine & Science in Sports. 2018 ; Vol. 28, No. 12. pp. 2494-2504.

Bibtex

@article{b8593b3e1c7646e9b60ad1013fb6b415,
title = "Determinants of maximal whole-body fat oxidation in elite cross-country skiers: Role of skeletal muscle mitochondria",
abstract = "Elite endurance athletes possess a high capacity for whole-body maximal fat oxidation (MFO). The aim was to investigate the determinants of a high MFO in endurance athletes. The hypotheses were that augmented MFO in endurance athletes is related to concomitantly increments of skeletal muscle mitochondrial volume density (MitoVD ) and mitochondrial fatty acid oxidation (FAOp ), that is, quantitative mitochondrial adaptations as well as intrinsic FAOp per mitochondria, that is, qualitative adaptations. Eight competitive male cross-country skiers and eight untrained controls were compared in the study. A graded exercise test was performed to determine MFO, the intensity where MFO occurs (FatMax ), and V˙O2Max . Skeletal muscle biopsies were obtained to determine MitoVD (electron microscopy), FAOp , and OXPHOSp (high-resolution respirometry). The following were higher (P < 0.05) in endurance athletes compared to controls: MFO (mean [95{\%} confidence intervals]) (0.60 g/min [0.50-0.70] vs 0.32 [0.24-0.39]), FatMax (46{\%} V˙O2Max [44-47] vs 35 [34-37]), V˙ O2Max (71 mL/min/kg [69-72] vs 48 [47-49]), MitoVD (7.8{\%} [7.2-8.5] vs 6.0 [5.3-6.8]), FAOp (34 pmol/s/mg muscle ww [27-40] vs 21 [17-25]), and OXPHOSp (108 pmol/s/mg muscle ww [104-112] vs 69 [68-71]). Intrinsic FAOp (4.0 pmol/s/mg muscle w.w/MitoVD [2.7-5.3] vs 3.3 [2.7-3.9]) and OXPHOSp (14 pmol/s/mg muscle ww/MitoVD [13-15] vs 11 [10-13]) were, however, similar in the endurance athletes and untrained controls. MFO and MitoVD correlated (r2 = 0.504, P < 0.05) in the endurance athletes. A strong correlation between MitoVD and MFO suggests that expansion of MitoVD might be rate-limiting for MFO in the endurance athletes. In contrast, intrinsic mitochondrial changes were not associated with augmented MFO.",
keywords = "The Faculty of Science, Cross-country skiing, Endurance training, Intrinsic mitochondrial function, Mitochondrial fat oxidation, Mitochondrial volume density",
author = "Sune Dandanell and Anne-Kristine Meinild-Lundby and Andersen, {Andreas Breenfeldt} and Lang, {Paul F} and Laura Oberholzer and Stefanie Keiser and Paul Robach and Steen Larsen and R{\o}nnestad, {Bent R} and Carsten Lundby",
note = "(ekstern)",
year = "2018",
doi = "10.1111/sms.13298",
language = "English",
volume = "28",
pages = "2494--2504",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - Determinants of maximal whole-body fat oxidation in elite cross-country skiers

T2 - Role of skeletal muscle mitochondria

AU - Dandanell, Sune

AU - Meinild-Lundby, Anne-Kristine

AU - Andersen, Andreas Breenfeldt

AU - Lang, Paul F

AU - Oberholzer, Laura

AU - Keiser, Stefanie

AU - Robach, Paul

AU - Larsen, Steen

AU - Rønnestad, Bent R

AU - Lundby, Carsten

N1 - (ekstern)

PY - 2018

Y1 - 2018

N2 - Elite endurance athletes possess a high capacity for whole-body maximal fat oxidation (MFO). The aim was to investigate the determinants of a high MFO in endurance athletes. The hypotheses were that augmented MFO in endurance athletes is related to concomitantly increments of skeletal muscle mitochondrial volume density (MitoVD ) and mitochondrial fatty acid oxidation (FAOp ), that is, quantitative mitochondrial adaptations as well as intrinsic FAOp per mitochondria, that is, qualitative adaptations. Eight competitive male cross-country skiers and eight untrained controls were compared in the study. A graded exercise test was performed to determine MFO, the intensity where MFO occurs (FatMax ), and V˙O2Max . Skeletal muscle biopsies were obtained to determine MitoVD (electron microscopy), FAOp , and OXPHOSp (high-resolution respirometry). The following were higher (P < 0.05) in endurance athletes compared to controls: MFO (mean [95% confidence intervals]) (0.60 g/min [0.50-0.70] vs 0.32 [0.24-0.39]), FatMax (46% V˙O2Max [44-47] vs 35 [34-37]), V˙ O2Max (71 mL/min/kg [69-72] vs 48 [47-49]), MitoVD (7.8% [7.2-8.5] vs 6.0 [5.3-6.8]), FAOp (34 pmol/s/mg muscle ww [27-40] vs 21 [17-25]), and OXPHOSp (108 pmol/s/mg muscle ww [104-112] vs 69 [68-71]). Intrinsic FAOp (4.0 pmol/s/mg muscle w.w/MitoVD [2.7-5.3] vs 3.3 [2.7-3.9]) and OXPHOSp (14 pmol/s/mg muscle ww/MitoVD [13-15] vs 11 [10-13]) were, however, similar in the endurance athletes and untrained controls. MFO and MitoVD correlated (r2 = 0.504, P < 0.05) in the endurance athletes. A strong correlation between MitoVD and MFO suggests that expansion of MitoVD might be rate-limiting for MFO in the endurance athletes. In contrast, intrinsic mitochondrial changes were not associated with augmented MFO.

AB - Elite endurance athletes possess a high capacity for whole-body maximal fat oxidation (MFO). The aim was to investigate the determinants of a high MFO in endurance athletes. The hypotheses were that augmented MFO in endurance athletes is related to concomitantly increments of skeletal muscle mitochondrial volume density (MitoVD ) and mitochondrial fatty acid oxidation (FAOp ), that is, quantitative mitochondrial adaptations as well as intrinsic FAOp per mitochondria, that is, qualitative adaptations. Eight competitive male cross-country skiers and eight untrained controls were compared in the study. A graded exercise test was performed to determine MFO, the intensity where MFO occurs (FatMax ), and V˙O2Max . Skeletal muscle biopsies were obtained to determine MitoVD (electron microscopy), FAOp , and OXPHOSp (high-resolution respirometry). The following were higher (P < 0.05) in endurance athletes compared to controls: MFO (mean [95% confidence intervals]) (0.60 g/min [0.50-0.70] vs 0.32 [0.24-0.39]), FatMax (46% V˙O2Max [44-47] vs 35 [34-37]), V˙ O2Max (71 mL/min/kg [69-72] vs 48 [47-49]), MitoVD (7.8% [7.2-8.5] vs 6.0 [5.3-6.8]), FAOp (34 pmol/s/mg muscle ww [27-40] vs 21 [17-25]), and OXPHOSp (108 pmol/s/mg muscle ww [104-112] vs 69 [68-71]). Intrinsic FAOp (4.0 pmol/s/mg muscle w.w/MitoVD [2.7-5.3] vs 3.3 [2.7-3.9]) and OXPHOSp (14 pmol/s/mg muscle ww/MitoVD [13-15] vs 11 [10-13]) were, however, similar in the endurance athletes and untrained controls. MFO and MitoVD correlated (r2 = 0.504, P < 0.05) in the endurance athletes. A strong correlation between MitoVD and MFO suggests that expansion of MitoVD might be rate-limiting for MFO in the endurance athletes. In contrast, intrinsic mitochondrial changes were not associated with augmented MFO.

KW - The Faculty of Science

KW - Cross-country skiing

KW - Endurance training

KW - Intrinsic mitochondrial function

KW - Mitochondrial fat oxidation

KW - Mitochondrial volume density

U2 - 10.1111/sms.13298

DO - 10.1111/sms.13298

M3 - Journal article

VL - 28

SP - 2494

EP - 2504

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

IS - 12

ER -

ID: 203897022