Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review

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Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs : A systematic review. / Jensen, Anders P. ; Bjørnvad, Charlotte Reinhard.

In: Journal of Veterinary Internal Medicine, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jensen, AP & Bjørnvad, CR 2019, 'Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review', Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvlm.15554

APA

Jensen, A. P., & Bjørnvad, C. R. (2019). Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvlm.15554

Vancouver

Jensen AP, Bjørnvad CR. Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review. Journal of Veterinary Internal Medicine. 2019. https://doi.org/10.1111/jvlm.15554

Author

Jensen, Anders P. ; Bjørnvad, Charlotte Reinhard. / Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs : A systematic review. In: Journal of Veterinary Internal Medicine. 2019.

Bibtex

@article{e9fd237452614991bc801a2e2cb8f49f,
title = "Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review",
abstract = "BackgroundGastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments.ObjectiveTo evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment.MethodsA systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size.ResultsOne hundred sixty‐five studies were identified, of which 17 met the inclusion criteria—12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable.Conclusions and Clinical ImportanceThe current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies.",
author = "Jensen, {Anders P.} and Bj{\o}rnvad, {Charlotte Reinhard}",
year = "2019",
doi = "10.1111/jvlm.15554",
language = "English",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs

T2 - A systematic review

AU - Jensen, Anders P.

AU - Bjørnvad, Charlotte Reinhard

PY - 2019

Y1 - 2019

N2 - BackgroundGastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments.ObjectiveTo evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment.MethodsA systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size.ResultsOne hundred sixty‐five studies were identified, of which 17 met the inclusion criteria—12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable.Conclusions and Clinical ImportanceThe current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies.

AB - BackgroundGastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments.ObjectiveTo evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment.MethodsA systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size.ResultsOne hundred sixty‐five studies were identified, of which 17 met the inclusion criteria—12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable.Conclusions and Clinical ImportanceThe current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies.

U2 - 10.1111/jvlm.15554

DO - 10.1111/jvlm.15554

M3 - Journal article

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

ER -

ID: 224335654