Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence

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Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence. / Grøndahl, V.; Binderup, T.; Langer, S. W.; Petersen, R. H.; Nielsen, K.; Kjaer, A.; Federspiel, B.; Knigge, U.

In: Lung Cancer, Vol. 132, 2019, p. 141-149.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Grøndahl, V, Binderup, T, Langer, SW, Petersen, RH, Nielsen, K, Kjaer, A, Federspiel, B & Knigge, U 2019, 'Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence', Lung Cancer, vol. 132, pp. 141-149. https://doi.org/10.1016/j.lungcan.2019.03.013

APA

Grøndahl, V., Binderup, T., Langer, S. W., Petersen, R. H., Nielsen, K., Kjaer, A., ... Knigge, U. (2019). Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence. Lung Cancer, 132, 141-149. https://doi.org/10.1016/j.lungcan.2019.03.013

Vancouver

Grøndahl V, Binderup T, Langer SW, Petersen RH, Nielsen K, Kjaer A et al. Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence. Lung Cancer. 2019;132:141-149. https://doi.org/10.1016/j.lungcan.2019.03.013

Author

Grøndahl, V. ; Binderup, T. ; Langer, S. W. ; Petersen, R. H. ; Nielsen, K. ; Kjaer, A. ; Federspiel, B. ; Knigge, U. / Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence. In: Lung Cancer. 2019 ; Vol. 132. pp. 141-149.

Bibtex

@article{f3ba0d59891c414e9f63d539da91a79d,
title = "Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence",
abstract = "Background: Bronchopulmonary neuroendocrine tumours are divided into typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung cancer (SCLC). Aim: To thoroughly describe a cohort of 252 patients with TC, AC and LCNEC (SCLC excluded). Material and methods: Collection of data from 252 patients referred to and treated at Rigshospitalet 2008-2016. Data was collected from electronic patient files and our prospective NET database. Statistics were performed in SPSS. Results: 162 (64{\%})had TC, 29 (12{\%})had AC and 61 (24{\%})had LCNEC. Median age at diagnosis was 69 years (range: 19–89)with no difference between genders. Thoraco-abdominal CT was performed in all patients at diagnosis. FDG-PET/CT was performed in 207 (82{\%})at diagnosis and was positive in 95{\%} of the entire cohort, with no difference between tumour types. Synaptophysin was positive in 98{\%}, chromogranin A in 92{\%} and CD56 in 97{\%}. Mean Ki67 index was 5{\%} in TC, 16{\%} in AC and 69{\%} in LCNEC (p < 0.001). Metastatic disease was found in 4{\%} of TC, 27{\%} of AC and 58{\%} of LCNEC at time of initial diagnosis (p < 0.001). In total 179 patients (71{\%})underwent surgical resection; TC: 87{\%}, AC: 72{\%} and LCNEC: 28{\%} (p < 0.001). Of the resected patients, 11 (6{\%})had recurrence. Five-year survival rate was 88{\%} for TC, 63{\%} for AC and 20{\%} for LCNEC. Conclusion: In this comprehensive study of a cohort of 252 patients, one of the largest until date, with TC, AC and LCNEC, the gender distribution showed female predominance with 68{\%}. FDG-PET/CT was positive in 95{\%} of the patients independent of tumour type, which confirms that FDG-PET/CT should be a part of the preoperative work-up for TC, AC and LCNEC. Tumour type was the single most potent independent prognostic factor.",
keywords = "Atypical carcinoid, Bronchial neuroendocrine tumour, Bronchopulmonale tumour, Carcinoid tumour, FDG-PET, Ki67 index, Large cell neuroendocrine tumour, Mitotic count, Neuroendocrine neoplasm, Neuroendocrine tumour, Typical carcinoid",
author = "V. Gr{\o}ndahl and T. Binderup and Langer, {S. W.} and Petersen, {R. H.} and K. Nielsen and A. Kjaer and B. Federspiel and U. Knigge",
note = "Erratum: https://doi.org/10.1016/j.lungcan.2019.07.019",
year = "2019",
doi = "10.1016/j.lungcan.2019.03.013",
language = "English",
volume = "132",
pages = "141--149",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence

AU - Grøndahl, V.

AU - Binderup, T.

AU - Langer, S. W.

AU - Petersen, R. H.

AU - Nielsen, K.

AU - Kjaer, A.

AU - Federspiel, B.

AU - Knigge, U.

N1 - Erratum: https://doi.org/10.1016/j.lungcan.2019.07.019

PY - 2019

Y1 - 2019

N2 - Background: Bronchopulmonary neuroendocrine tumours are divided into typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung cancer (SCLC). Aim: To thoroughly describe a cohort of 252 patients with TC, AC and LCNEC (SCLC excluded). Material and methods: Collection of data from 252 patients referred to and treated at Rigshospitalet 2008-2016. Data was collected from electronic patient files and our prospective NET database. Statistics were performed in SPSS. Results: 162 (64%)had TC, 29 (12%)had AC and 61 (24%)had LCNEC. Median age at diagnosis was 69 years (range: 19–89)with no difference between genders. Thoraco-abdominal CT was performed in all patients at diagnosis. FDG-PET/CT was performed in 207 (82%)at diagnosis and was positive in 95% of the entire cohort, with no difference between tumour types. Synaptophysin was positive in 98%, chromogranin A in 92% and CD56 in 97%. Mean Ki67 index was 5% in TC, 16% in AC and 69% in LCNEC (p < 0.001). Metastatic disease was found in 4% of TC, 27% of AC and 58% of LCNEC at time of initial diagnosis (p < 0.001). In total 179 patients (71%)underwent surgical resection; TC: 87%, AC: 72% and LCNEC: 28% (p < 0.001). Of the resected patients, 11 (6%)had recurrence. Five-year survival rate was 88% for TC, 63% for AC and 20% for LCNEC. Conclusion: In this comprehensive study of a cohort of 252 patients, one of the largest until date, with TC, AC and LCNEC, the gender distribution showed female predominance with 68%. FDG-PET/CT was positive in 95% of the patients independent of tumour type, which confirms that FDG-PET/CT should be a part of the preoperative work-up for TC, AC and LCNEC. Tumour type was the single most potent independent prognostic factor.

AB - Background: Bronchopulmonary neuroendocrine tumours are divided into typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung cancer (SCLC). Aim: To thoroughly describe a cohort of 252 patients with TC, AC and LCNEC (SCLC excluded). Material and methods: Collection of data from 252 patients referred to and treated at Rigshospitalet 2008-2016. Data was collected from electronic patient files and our prospective NET database. Statistics were performed in SPSS. Results: 162 (64%)had TC, 29 (12%)had AC and 61 (24%)had LCNEC. Median age at diagnosis was 69 years (range: 19–89)with no difference between genders. Thoraco-abdominal CT was performed in all patients at diagnosis. FDG-PET/CT was performed in 207 (82%)at diagnosis and was positive in 95% of the entire cohort, with no difference between tumour types. Synaptophysin was positive in 98%, chromogranin A in 92% and CD56 in 97%. Mean Ki67 index was 5% in TC, 16% in AC and 69% in LCNEC (p < 0.001). Metastatic disease was found in 4% of TC, 27% of AC and 58% of LCNEC at time of initial diagnosis (p < 0.001). In total 179 patients (71%)underwent surgical resection; TC: 87%, AC: 72% and LCNEC: 28% (p < 0.001). Of the resected patients, 11 (6%)had recurrence. Five-year survival rate was 88% for TC, 63% for AC and 20% for LCNEC. Conclusion: In this comprehensive study of a cohort of 252 patients, one of the largest until date, with TC, AC and LCNEC, the gender distribution showed female predominance with 68%. FDG-PET/CT was positive in 95% of the patients independent of tumour type, which confirms that FDG-PET/CT should be a part of the preoperative work-up for TC, AC and LCNEC. Tumour type was the single most potent independent prognostic factor.

KW - Atypical carcinoid

KW - Bronchial neuroendocrine tumour

KW - Bronchopulmonale tumour

KW - Carcinoid tumour

KW - FDG-PET

KW - Ki67 index

KW - Large cell neuroendocrine tumour

KW - Mitotic count

KW - Neuroendocrine neoplasm

KW - Neuroendocrine tumour

KW - Typical carcinoid

U2 - 10.1016/j.lungcan.2019.03.013

DO - 10.1016/j.lungcan.2019.03.013

M3 - Journal article

VL - 132

SP - 141

EP - 149

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

ER -

ID: 226258599