Bone microarchitecture and bone mineral density in multiple sclerosis

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Bone microarchitecture and bone mineral density in multiple sclerosis. / Olsson, A.; Oturai, A.B.; Søndergaard, H. B.; Sellebjerg, F.; Oturai, P. S.

In: Acta Neurologica Scandinavica, Vol. 137, No. 3, 2018, p. 363-369.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Olsson, A, Oturai, AB, Søndergaard, HB, Sellebjerg, F & Oturai, PS 2018, 'Bone microarchitecture and bone mineral density in multiple sclerosis', Acta Neurologica Scandinavica, vol. 137, no. 3, pp. 363-369. https://doi.org/10.1111/ane.12884

APA

Olsson, A., Oturai, A. B., Søndergaard, H. B., Sellebjerg, F., & Oturai, P. S. (2018). Bone microarchitecture and bone mineral density in multiple sclerosis. Acta Neurologica Scandinavica, 137(3), 363-369. https://doi.org/10.1111/ane.12884

Vancouver

Olsson A, Oturai AB, Søndergaard HB, Sellebjerg F, Oturai PS. Bone microarchitecture and bone mineral density in multiple sclerosis. Acta Neurologica Scandinavica. 2018;137(3):363-369. https://doi.org/10.1111/ane.12884

Author

Olsson, A. ; Oturai, A.B. ; Søndergaard, H. B. ; Sellebjerg, F. ; Oturai, P. S. / Bone microarchitecture and bone mineral density in multiple sclerosis. In: Acta Neurologica Scandinavica. 2018 ; Vol. 137, No. 3. pp. 363-369.

Bibtex

@article{b08dc959a3ee4eb0baf869eb7f51530e,
title = "Bone microarchitecture and bone mineral density in multiple sclerosis",
abstract = "BACKGROUND: Multiple sclerosis (MS) patients are at increased risk of reduced bone mineral density (BMD) and fractures. The aetiology of bone loss in MS is unclear. Trabecular bone score (TBS) is a novel analytical tool that provides a measurement of the bone microarchitecture. Decreased TBS predicts increased fracture risk independently of BMD. To date, no studies have investigated TBS in MS patients.OBJECTIVES: To assess bone quality in MS patients by TBS and to evaluate potential risk factors that may affect BMD and TBS in patients with MS.METHODS: Two hundred sixty MS patients were included. TBS was calculated using TBS iNsight software (MediMaps{\circledR} ). Multivariable regression analyses were performed with information on smoking, alcohol, glucocorticoid (GC) treatment, sun exposure, physical activity, vitamin D and BMI.RESULTS: Trabecular bone score was not significantly different from an age-matched reference population. Low TBS was associated with high age (P = .014) and smoking (P = .03). Smoking and physical inactivity were associated with low BMD in spine (P = .034, P = .032). GC treatment was not associated with TBS.CONCLUSION: We could not find altered TBS values among MS patients, suggesting that BMD alone, and not the bone microarchitecture, is affected in MS. However, larger studies are needed to verify these findings and to establish the role of TBS in MS. As in the background population, physical activity and non-smoking habits are associated with better bone health in MS.",
keywords = "Absorptiometry, Photon, Adult, Aged, Bone Density, Bone and Bones/pathology, Female, Humans, Image Interpretation, Computer-Assisted/methods, Male, Middle Aged, Multiple Sclerosis/pathology, Regression Analysis, Risk Factors",
author = "A. Olsson and A.B. Oturai and S{\o}ndergaard, {H. B.} and F. Sellebjerg and Oturai, {P. S.}",
note = "{\circledC} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2018",
doi = "10.1111/ane.12884",
language = "English",
volume = "137",
pages = "363--369",
journal = "Acta Neurologica Scandinavica. Supplementum",
issn = "0065-1427",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Bone microarchitecture and bone mineral density in multiple sclerosis

AU - Olsson, A.

AU - Oturai, A.B.

AU - Søndergaard, H. B.

AU - Sellebjerg, F.

AU - Oturai, P. S.

N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Multiple sclerosis (MS) patients are at increased risk of reduced bone mineral density (BMD) and fractures. The aetiology of bone loss in MS is unclear. Trabecular bone score (TBS) is a novel analytical tool that provides a measurement of the bone microarchitecture. Decreased TBS predicts increased fracture risk independently of BMD. To date, no studies have investigated TBS in MS patients.OBJECTIVES: To assess bone quality in MS patients by TBS and to evaluate potential risk factors that may affect BMD and TBS in patients with MS.METHODS: Two hundred sixty MS patients were included. TBS was calculated using TBS iNsight software (MediMaps® ). Multivariable regression analyses were performed with information on smoking, alcohol, glucocorticoid (GC) treatment, sun exposure, physical activity, vitamin D and BMI.RESULTS: Trabecular bone score was not significantly different from an age-matched reference population. Low TBS was associated with high age (P = .014) and smoking (P = .03). Smoking and physical inactivity were associated with low BMD in spine (P = .034, P = .032). GC treatment was not associated with TBS.CONCLUSION: We could not find altered TBS values among MS patients, suggesting that BMD alone, and not the bone microarchitecture, is affected in MS. However, larger studies are needed to verify these findings and to establish the role of TBS in MS. As in the background population, physical activity and non-smoking habits are associated with better bone health in MS.

AB - BACKGROUND: Multiple sclerosis (MS) patients are at increased risk of reduced bone mineral density (BMD) and fractures. The aetiology of bone loss in MS is unclear. Trabecular bone score (TBS) is a novel analytical tool that provides a measurement of the bone microarchitecture. Decreased TBS predicts increased fracture risk independently of BMD. To date, no studies have investigated TBS in MS patients.OBJECTIVES: To assess bone quality in MS patients by TBS and to evaluate potential risk factors that may affect BMD and TBS in patients with MS.METHODS: Two hundred sixty MS patients were included. TBS was calculated using TBS iNsight software (MediMaps® ). Multivariable regression analyses were performed with information on smoking, alcohol, glucocorticoid (GC) treatment, sun exposure, physical activity, vitamin D and BMI.RESULTS: Trabecular bone score was not significantly different from an age-matched reference population. Low TBS was associated with high age (P = .014) and smoking (P = .03). Smoking and physical inactivity were associated with low BMD in spine (P = .034, P = .032). GC treatment was not associated with TBS.CONCLUSION: We could not find altered TBS values among MS patients, suggesting that BMD alone, and not the bone microarchitecture, is affected in MS. However, larger studies are needed to verify these findings and to establish the role of TBS in MS. As in the background population, physical activity and non-smoking habits are associated with better bone health in MS.

KW - Absorptiometry, Photon

KW - Adult

KW - Aged

KW - Bone Density

KW - Bone and Bones/pathology

KW - Female

KW - Humans

KW - Image Interpretation, Computer-Assisted/methods

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/pathology

KW - Regression Analysis

KW - Risk Factors

U2 - 10.1111/ane.12884

DO - 10.1111/ane.12884

M3 - Journal article

VL - 137

SP - 363

EP - 369

JO - Acta Neurologica Scandinavica. Supplementum

JF - Acta Neurologica Scandinavica. Supplementum

SN - 0065-1427

IS - 3

ER -

ID: 215137846