Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest. / Weeke, Peter; Jensen, Aksel; Folke, Fredrik; Gislason, Gunnar Hilmar; Olesen, Jonas Bjerring; Fosbøl, Emil L; Wissenberg, Mads; Lippert, Freddy K; Christensen, Erika Frischknecht; Nielsen, Søren Loumann; Holm, Ellen; Kanters, Jørgen K.; Poulsen, Henrik Enghusen; Køber, Lars; Torp-Pedersen, Christian.

In: Clinical Pharmacology and Therapeutics, Vol. 96, No. 4, 24.06.2014, p. 490-497.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Weeke, P, Jensen, A, Folke, F, Gislason, GH, Olesen, JB, Fosbøl, EL, Wissenberg, M, Lippert, FK, Christensen, EF, Nielsen, SL, Holm, E, Kanters, JK, Poulsen, HE, Køber, L & Torp-Pedersen, C 2014, 'Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest', Clinical Pharmacology and Therapeutics, vol. 96, no. 4, pp. 490-497. https://doi.org/10.1038/clpt.2014.139

APA

Weeke, P., Jensen, A., Folke, F., Gislason, G. H., Olesen, J. B., Fosbøl, E. L., ... Torp-Pedersen, C. (2014). Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest. Clinical Pharmacology and Therapeutics, 96(4), 490-497. https://doi.org/10.1038/clpt.2014.139

Vancouver

Weeke P, Jensen A, Folke F, Gislason GH, Olesen JB, Fosbøl EL et al. Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest. Clinical Pharmacology and Therapeutics. 2014 Jun 24;96(4):490-497. https://doi.org/10.1038/clpt.2014.139

Author

Weeke, Peter ; Jensen, Aksel ; Folke, Fredrik ; Gislason, Gunnar Hilmar ; Olesen, Jonas Bjerring ; Fosbøl, Emil L ; Wissenberg, Mads ; Lippert, Freddy K ; Christensen, Erika Frischknecht ; Nielsen, Søren Loumann ; Holm, Ellen ; Kanters, Jørgen K. ; Poulsen, Henrik Enghusen ; Køber, Lars ; Torp-Pedersen, Christian. / Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest. In: Clinical Pharmacology and Therapeutics. 2014 ; Vol. 96, No. 4. pp. 490-497.

Bibtex

@article{1d6d6ba724dc458fab798ece4cca3931,
title = "Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest",
abstract = "Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6{\%}) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95{\%} confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.",
author = "Peter Weeke and Aksel Jensen and Fredrik Folke and Gislason, {Gunnar Hilmar} and Olesen, {Jonas Bjerring} and Fosb{\o}l, {Emil L} and Mads Wissenberg and Lippert, {Freddy K} and Christensen, {Erika Frischknecht} and Nielsen, {S{\o}ren Loumann} and Ellen Holm and Kanters, {J{\o}rgen K.} and Poulsen, {Henrik Enghusen} and Lars K{\o}ber and Christian Torp-Pedersen",
year = "2014",
month = "6",
day = "24",
doi = "10.1038/clpt.2014.139",
language = "English",
volume = "96",
pages = "490--497",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "JohnWiley & Sons, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Antipsychotics and Associated Risk of Out-of-Hospital Cardiac Arrest

AU - Weeke, Peter

AU - Jensen, Aksel

AU - Folke, Fredrik

AU - Gislason, Gunnar Hilmar

AU - Olesen, Jonas Bjerring

AU - Fosbøl, Emil L

AU - Wissenberg, Mads

AU - Lippert, Freddy K

AU - Christensen, Erika Frischknecht

AU - Nielsen, Søren Loumann

AU - Holm, Ellen

AU - Kanters, Jørgen K.

AU - Poulsen, Henrik Enghusen

AU - Køber, Lars

AU - Torp-Pedersen, Christian

PY - 2014/6/24

Y1 - 2014/6/24

N2 - Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

AB - Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

U2 - 10.1038/clpt.2014.139

DO - 10.1038/clpt.2014.139

M3 - Journal article

VL - 96

SP - 490

EP - 497

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 4

ER -

ID: 119575720