A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Research output: Contribution to journalJournal articleResearchpeer-review

Ruodan Xu, Stanislava Pankratova, Søren Hofman Oliveira Christiansen, David Paul Drucker Woldbye, Anne Højland, Elisabeth Marianne Bock, Vladimir Berezin

rbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.
Original languageEnglish
JournalNeurochemical Research
Volume38
Issue number12
Pages (from-to)2550-8
Number of pages9
ISSN0364-3190
DOIs
Publication statusPublished - 2013

ID: 105608139