A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities. / Bhuiyan, Tanveer A; Graff, Claus; Kanters, Jørgen K; Melgaard, Jacob; Toft, Egon; Kääb, Stefan; Struijk, Johannes J.

In: Clinical Pharmacology and Therapeutics, Vol. 103, No. 6, 2018, p. 1100-1106.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bhuiyan, TA, Graff, C, Kanters, JK, Melgaard, J, Toft, E, Kääb, S & Struijk, JJ 2018, 'A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities', Clinical Pharmacology and Therapeutics, vol. 103, no. 6, pp. 1100-1106. https://doi.org/10.1002/cpt.886

APA

Bhuiyan, T. A., Graff, C., Kanters, J. K., Melgaard, J., Toft, E., Kääb, S., & Struijk, J. J. (2018). A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities. Clinical Pharmacology and Therapeutics, 103(6), 1100-1106. https://doi.org/10.1002/cpt.886

Vancouver

Bhuiyan TA, Graff C, Kanters JK, Melgaard J, Toft E, Kääb S et al. A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities. Clinical Pharmacology and Therapeutics. 2018;103(6):1100-1106. https://doi.org/10.1002/cpt.886

Author

Bhuiyan, Tanveer A ; Graff, Claus ; Kanters, Jørgen K ; Melgaard, Jacob ; Toft, Egon ; Kääb, Stefan ; Struijk, Johannes J. / A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities. In: Clinical Pharmacology and Therapeutics. 2018 ; Vol. 103, No. 6. pp. 1100-1106.

Bibtex

@article{0c0d23ca97b54e598a1fee51a4ad28b6,
title = "A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities",
abstract = "The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.",
author = "Bhuiyan, {Tanveer A} and Claus Graff and Kanters, {J{\o}rgen K} and Jacob Melgaard and Egon Toft and Stefan K{\"a}{\"a}b and Struijk, {Johannes J}",
note = "{\circledC} 2017 American Society for Clinical Pharmacology and Therapeutics.",
year = "2018",
doi = "10.1002/cpt.886",
language = "English",
volume = "103",
pages = "1100--1106",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

AU - Bhuiyan, Tanveer A

AU - Graff, Claus

AU - Kanters, Jørgen K

AU - Melgaard, Jacob

AU - Toft, Egon

AU - Kääb, Stefan

AU - Struijk, Johannes J

N1 - © 2017 American Society for Clinical Pharmacology and Therapeutics.

PY - 2018

Y1 - 2018

N2 - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

AB - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

UR - http://www.scopus.com/inward/record.url?scp=85032187887&partnerID=8YFLogxK

U2 - 10.1002/cpt.886

DO - 10.1002/cpt.886

M3 - Journal article

VL - 103

SP - 1100

EP - 1106

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 6

ER -

ID: 189664609