2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. / Hansen, Katrine B; Rosenkilde, Mette M; Knop, Filip K; Wellner, Niels; Diep, Thi A; Rehfeld, Jens F; Andersen, Ulrik B; Holst, Jens J; Hansen, Harald S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 9, 2011, p. E1409-17.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hansen, KB, Rosenkilde, MM, Knop, FK, Wellner, N, Diep, TA, Rehfeld, JF, Andersen, UB, Holst, JJ & Hansen, HS 2011, '2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 9, pp. E1409-17. https://doi.org/10.1210/jc.2011-0647

APA

Hansen, K. B., Rosenkilde, M. M., Knop, F. K., Wellner, N., Diep, T. A., Rehfeld, J. F., ... Hansen, H. S. (2011). 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. Journal of Clinical Endocrinology and Metabolism, 96(9), E1409-17. https://doi.org/10.1210/jc.2011-0647

Vancouver

Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF et al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. Journal of Clinical Endocrinology and Metabolism. 2011;96(9):E1409-17. https://doi.org/10.1210/jc.2011-0647

Author

Hansen, Katrine B ; Rosenkilde, Mette M ; Knop, Filip K ; Wellner, Niels ; Diep, Thi A ; Rehfeld, Jens F ; Andersen, Ulrik B ; Holst, Jens J ; Hansen, Harald S. / 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 9. pp. E1409-17.

Bibtex

@article{47b6398f38554b90a482b52c7cafa285,
title = "2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans",
abstract = "Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.",
keywords = "Adult, Blood Glucose, Cyclic AMP, Enteroendocrine Cells, Glucagon-Like Peptide 1, Glycerides, Humans, Male, Oleic Acids, Receptors, G-Protein-Coupled, The Faculty of Pharmaceutical Sciences",
author = "Hansen, {Katrine B} and Rosenkilde, {Mette M} and Knop, {Filip K} and Niels Wellner and Diep, {Thi A} and Rehfeld, {Jens F} and Andersen, {Ulrik B} and Holst, {Jens J} and Hansen, {Harald S.}",
year = "2011",
doi = "10.1210/jc.2011-0647",
language = "English",
volume = "96",
pages = "E1409--17",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

AU - Hansen, Katrine B

AU - Rosenkilde, Mette M

AU - Knop, Filip K

AU - Wellner, Niels

AU - Diep, Thi A

AU - Rehfeld, Jens F

AU - Andersen, Ulrik B

AU - Holst, Jens J

AU - Hansen, Harald S.

PY - 2011

Y1 - 2011

N2 - Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

AB - Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

KW - Adult

KW - Blood Glucose

KW - Cyclic AMP

KW - Enteroendocrine Cells

KW - Glucagon-Like Peptide 1

KW - Glycerides

KW - Humans

KW - Male

KW - Oleic Acids

KW - Receptors, G-Protein-Coupled

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1210/jc.2011-0647

DO - 10.1210/jc.2011-0647

M3 - Journal article

VL - 96

SP - E1409-17

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -

ID: 36082144