Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. Published

    ß-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. / Egerod, Kristoffer Lihme; Jin, Chunyu; Petersen, Pia Steen; Wierup, Nils; Sundler, Frank; Holst, Birgitte; Schwartz, Thue W.

    In: International Journal of Endocrinology, Vol. 2011, 2011, p. 401258.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    [Leu31, Pro34]neuropeptide Y : a specific Y1 receptor agonist. / Fuhlendorff, J; Gether, U; Aakerlund, L; Langeland-Johansen, N; Thøgersen, H; Melberg, S G; Olsen, U B; Thastrup, Ole; Schwartz, T W.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 1, 1990, p. 182-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    [Fine needle aspiration cytology of mammography screening]. / Engvad, B.; Laenkholm, A.V.; Schwartz, Thue W.; Bak, M.

    In: Ugeskrift for læger, Vol. 171, No. 34, 2009, p. 2379-2382.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase. / Aakerlund, L; Gether, U; Fuhlendorff, J; Schwartz, T W; Thastrup, Ole.

    In: F E B S Letters, Vol. 260, No. 1, 1990, p. 73-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors. / Michel, M.C.; Beck-Sickinger, A.; Cox, Helen; Doods, H.N.; Herzog, H.; Larhammer, D.; Quirion, R.; Schwartz, Thue W.; Westfall, T.

    In: Pharmacological Reviews, No. 50, no. 1, 1998, p. 143-150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Virally encoded chemokines and chemokine receptors in the role of viral infections. / Holst, Peter J; Lüttichau, Hans R; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Contributions to Microbiology, Vol. 10, 2003, p. 232-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Virally encoded 7TM receptors. / Rosenkilde, M M; Waldhoer, M; Lüttichau, H R; Schwartz, T W.

    In: Oncogene, Vol. 20, No. 13, 2001, p. 1582-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Viral leads for chemokine-modulatory drugs. / Lindow, Morten; Lüttichau, Hans Rudolf; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, Vol. 24, No. 3, 2003, p. 126-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Validation of chemokine receptors as drug targets. / Lüttichau, Hans Rudolf; Schwartz, Thue W.

    In: Current Opinion in Drug Discovery & Development, No. 3, no. 5, 2000, p. 610-623.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Unique interaction pattern for a functionally biased ghrelin receptor agonist. / Sivertsen, Bjørn Behrens; Lang, Manja; Frimurer, Thomas M.; Holliday, Nicholas D.; Bach, Anders; Els, Sylvia; Engelstoft, Maja Storm; Petersen, Pia Steen; Madsen, Andreas Nygaard; Schwartz, Thue W.; Beck-Sickinger, Annette G.; Holst, Birgitte.

    In: The Journal of Biological Chemistry, Vol. 286, No. 23, 10.06.2011, p. 20845-20860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis. / Holst, B; Hastrup, H; Raffetseder, U; Martini, L; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 276, No. 23, 2001, p. 19793-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. / Holst, P J; Rosenkilde, M M; Manfra, D; Chen, S C; Wiekowski, M T; Holst, B; Cifire, F; Lipp, M; Schwartz, T W; Lira, S A.

    In: Journal of Clinical Investigation, Vol. 108, No. 12, 2001, p. 1789-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. / Holst, J J; Orskov, C; Nielsen, O V; Schwartz, T W.

    In: F E B S Letters, Vol. 211, No. 2, 1987, p. 169-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells. / Egerod, Kristoffer L; Engelstoft, Maja S; Lund, Mari L; Grunddal, Kaare V; Zhao, Mirabella; Barir-Jensen, Dominique; Nygaard, Eva B; Petersen, Natalia; Holst, Jens J; Schwartz, Thue W.

    In: Endocrinology, Vol. 156, No. 11, 11.2015, p. 3909-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation. / Lindow, Morten; Nansen, Anneline; Bartholdy, Christina; Stryhn, Annette; Hansen, Nils J V; Boesen, Thomas P; Wells, Timothy N C; Schwartz, Thue W; Thomsen, Allan R.

    In: Journal of Virology, Vol. 77, No. 13, 2003, p. 7393-400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The minor binding pocket: a major player in 7TM receptor activation. / Rosenkilde, Mette Marie; Benned-Jensen, Tau; Frimurer, Thomas M.; Schwartz, Thue W.

    In: Trends in Pharmacological Sciences, Vol. 31, No. 12, 2010, p. 567-574.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. / Panaro, Brandon L; Tough, Iain R; Engelstoft, Maja S; Matthews, Robert T; Digby, Gregory J; Møller, Cathrine L; Svendsen, Berit; Gribble, Fiona; Reimann, Frank; Holst, Jens Juul; Holst, Birgitte; Schwartz, Thue W; Cox, Helen M; Cone, Roger D.

    In: Cell Metabolism, Vol. 20, No. 6, 02.12.2014, p. 1018-29.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposis sarcoma. / Jensen, Kristian Kirk; Manfra, D.J.; Grisotto, M.G.; Martin, A.P.; Vassileva, G.; Kelley, K.; Schwartz, Thue W.; Lira, Sergio A.

    In: Journal of Immunology, No. Vol. 174, no. 6, 2005, p. 3686-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. / Jensen, Kristian K; Manfra, Denise J; Grisotto, Marcos G; Martin, Andrea P; Vassileva, Galya; Kelley, Kevin; Schwartz, Thue W; Lira, Sergio A.

    In: Journal of Immunology, Vol. 174, No. 6, 2005, p. 3686-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling. / Fraile-Ramos, A; Kledal, T N; Pelchen-Matthews, A; Bowers, K; Schwartz, T W; Marsh, M.

    In: Molecular Biology of the Cell, Vol. 12, No. 6, 2001, p. 1737-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor. / Lüttichau, H R; Lewis, I C; Gerstoft, J; Schwartz, T W.

    In: European Journal of Immunology, Vol. 31, No. 4, 2001, p. 1217-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus encoded chemokine MC148, inhibits the CCR10 receptor. / Lüttichau, Hans Rudolf; Lewis, I.C.; Gerstoft, J.; Schwartz, Thue W.

    In: European Journal of Immunology, No. 31 (4), 2001, p. 1217-1220.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The first PP supper--Camelot at Bispebjerg. / Schwartz, T W; Verlaege, O.

    In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, Vol. 234, 2001, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The first PP supper - Camelot at Bispebjerg. / Schwartz, Thue W.; Verlaege, O.

    In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, No. vol. 234, 2001, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The dual nature of the NK-1 receptor. / Maggi, C.; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, No. 18, no. 10, 1997, p. 351-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The chemokine system - a major regulator of angiogenesis in health and disease. / Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, No. Vol. 112, 7-8, 2004, p. 481-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis. / Waldhoer, Maria; Casarosa, P.; Rosenkilde, Mette Marie; Smit, M.J.; Leurs, R.; Whistler, J.L.; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. Vol. 278 (21), 2003, p. 19473-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. / Waldhoer, Maria; Casarosa, Paola; Rosenkilde, Mette M; Smit, Martine J; Leurs, Rob; Whistler, Jennifer L; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 278, No. 21, 2003, p. 19473-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. / Rudenko, Olga; Shang, Jin; Munk, Alexander; Ekberg, Jeppe P.; Petersen, Natalia; Engelstoft, Maja S; Egerod, Kristoffer L.; Hjorth, Siv A.; Wu, Margaret; Feng, Yue; Zhou, Yun-Ping; Mokrosinski, Jacek; Thams, Peter; Reimann, Frank; Gribble, Fiona; Rehfeld, Jens F; Holst, Jens J.; Treebak, Jonas T.; Howard, Andrew D; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 19, 2019, p. 49-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor. / Hansen, Louise Valentin; Groenen, Marleen; Nygaard, Rie; Frimurer, Thomas M; Holliday, Nicholas D; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 287, No. 38, 14.09.2012, p. 31973-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration. / Cornelia Peeters, Miriam; Fokkelman, Michiel; Boogaard, Bob; Egerod, Kristoffer L; van de Water, Bob; IJzerman, Ad P; Schwartz, Thue W.

    In: Cellular Signalling, Vol. 27, No. 12, 12.2015, p. 2579-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. / Nygaard, Rie; Nielbo, Steen; Schwartz, Thue W; Poulsen, Flemming M.

    In: Biochemistry, Vol. 45, No. 27, 2006, p. 8350-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The Molecular Diversity of Vagal Afferents Revealed. / Egerod, Kristoffer L.; Schwartz, Thue W.; Gautron, Laurent.

    In: Trends in Neurosciences, Vol. 42, No. 10, 2019, p. 663-666.

    Research output: Contribution to journalEditorialResearchpeer-review

  34. Published

    The MicroRNA Repertoire in Enteroendocrine Cells : Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage. / Knudsen, Lina A; Petersen, Natalia; Schwartz, Thue W; Egerod, Kristoffer L.

    In: Endocrinology, Vol. 156, No. 11, 11.2015, p. 3971-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The HETE Is on FFAR1 and Pancreatic Islet Cells. / Trauelsen, Mette; Lückmann, Michael; Frimurer, Thomas M; Schwartz, Thue W.

    In: Cell Metabolism, Vol. 27, No. 2, 2018, p. 273-275.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins. / Rosenkilde, Mette M; McLean, Katherine A; Holst, Peter J; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 279, No. 31, 2004, p. 32524-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies. / Ditzel, H.J.; Rosenkilde, Mette Marie; Garred, P.; Wang, M.; Pedersen, C.; Burton, D.R.; Schwartz, Thue W.

    In: Proceedings of the National Academy of Science of the United States of America, No. 95, no. 9, 1998, p. 5241-5245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Targeting CXCR4 in HIV Cell-Entry Inhibition. / Steen, Anne; Schwartz, T W; Rosenkilde, M M.

    In: Mini reviews in medicinal chemistry, Vol. 9, No. 14, 2010, p. 1605-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. / Hamid, Y H; Vissing, H; Holst, B; Urhammer, S A; Pyke, C; Hansen, S K; Glümer, C; Borch-Johnsen, K; Jørgensen, T; Schwartz, T W; Pedersen, O; Hansen, T.

    In: Diabetic Medicine, Vol. 22, No. 1, 2005, p. 74-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action. / Lückmann, Michael; Amarandi, Roxana-Maria; Papargyri, Natalia; Jakobsen, Mette H; Christiansen, Elisabeth; Jensen, Lars Juhl; Pui, Aurel; Schwartz, Thue W.; Rosenkilde, Mette Marie; Frimurer, Thomas Michael.

    In: Chemical Biology & Drug Design, Vol. 89, No. 3, 2017, p. 289–296.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1. / Rexen Ulven, Elisabeth; Trauelsen, Mette; Brvar, Matjaz; Lückmann, Michael; Bielefeldt, Line Ø; Jensen, Lisa K I; Schwartz, Thue W; Frimurer, Thomas M.

    In: Scientific Reports, Vol. 8, No. 1, 10010, 2018, p. 1-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Structural biology: Full monty of family B GPCRs. / Schwartz, Thue W; Frimurer, Thomas M.

    In: Nature Chemical Biology, Vol. 13, No. 8, 2017, p. 819-821.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Structural biology: A moving story of receptors. / Schwartz, Thue W; Hubbell, Wayne L.

    In: Nature, Vol. 455, No. 7212, 2008, p. 473-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. / Engelstoft, Maja Storm; Norn, C; Pedersen, Maria Hauge; Holliday, N D; Elster, L; Lehmann, J; Jones, R M; Frimurer, T M; Schwartz, T W.

    In: British Journal of Pharmacology, Vol. 171, No. 24, 12.2014, p. 5774-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor. / Holst, Birgitte; Jensen, Sannah Zoffmann; Elling, Christian E.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 53, no. 1, 1998, p. 166-175.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3. / Nielsen, Søren M.; Elling, Christian E.; Schwartz, Thue W.

    In: European Journal of Biochemistry, No. 251, 1998, p. 217-226.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Single-chain vascular endothelial growth factor variant with antagonist activity. / Boesen, Thomas P; Soni, Bobby; Schwartz, Thue W; Halkier, Torben.

    In: Journal of Biological Chemistry, Vol. 277, No. 43, 2002, p. 40335-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. / McLean, Katherine A; Holst, Peter J; Martini, Lene; Schwartz, Thue W; Rosenkilde, Mette M.

    In: Virology, Vol. 325, No. 2, 2004, p. 241-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. / Engelstoft, Maja S; Park, Won-Mee; Sakata, Ichiro; Kristensen, Line V; Husted, Anna Sofie; Osborne-Lawrence, Sherri; Piper, Paul K; Walker, Angela K; Pedersen, Maria H; Nøhr, Mark K; Pan, Jie; Sinz, Christopher J; Carrington, Paul E; Akiyama, Taro E; Jones, Robert M; Tang, Cong; Ahmed, Kashan; Offermanns, Stefan; Egerod, Kristoffer Lihme; Zigman, Jeffrey M; Schwartz, Thue W.

    In: Molecular Metabolism, Vol. 2, No. 4, 11.2013, p. 376-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: FEBS Letters, No. 441, 1998, p. 209-214.

    Research output: Contribution to journalJournal articleResearchpeer-review

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