Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. 2002
  2. Published

    Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. / Fraile-Ramos, Alberto; Pelchen-Matthews, Annegret; Kledal, Thomas N; Browne, Helena; Schwartz, Thue W; Marsh, Mark.

    In: Traffic - International Journal of Intracellular Transport, Vol. 3, No. 3, 2002, p. 218-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor. / Heding, A; Elling, C E; Schwartz, T W.

    In: Journal of Receptors and Signal Transduction, Vol. 22, No. 1-4, 2002, p. 241-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. / Holst, Birgitte; Elling, Christian E; Schwartz, Thue W.

    In: Journal of Biological Chemistry, Vol. 277, No. 49, 2002, p. 47662-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. / Martini, Lene; Hastrup, Hanne; Holst, Birgitte; Fraile-Ramos, Alberto; Marsh, Mark; Schwartz, Thue W.

    In: Molecular Pharmacology, Vol. 62, No. 1, 2002, p. 30-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Molecular structure and function of 7TM/G-protein coupled receptors. / Schwartz, Thue W.; Holst, Birgitte.

    Textbook of receptor Pharmacology. 2002. p. 65-84.

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  7. Published

    Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. / Waldhoer, Maria; Kledal, Thomas N; Farrell, Helen; Schwartz, Thue W.

    In: Journal of Virology, Vol. 76, No. 16, 2002, p. 8161-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2001
  9. Published

    The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling. / Fraile-Ramos, A; Kledal, T N; Pelchen-Matthews, A; Bowers, K; Schwartz, T W; Marsh, M.

    In: Molecular Biology of the Cell, Vol. 12, No. 6, 2001, p. 1737-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. / Gerlach, Lars-Ole; Skerlj, R.T.; Bridger, G.J.; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. 276 (17), 2001, p. 14153-14160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S; Princen, K; Gerlach, L O; Bridger, G; Henson, G; De Clercq, E; Schwartz, T W; Schols, D.

    In: Molecular Pharmacology, Vol. 60, No. 1, 2001, p. 164-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S.; Princen, K.; Gerlach, Lars-Ole; Bridger, G.; Henson, G.; De Clercq, E.; Schwartz, Thue W.; Schols, D.

    In: Molecular Pharmacology, No. 60 (1), 2001, p. 164-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis. / Holst, B; Hastrup, H; Raffetseder, U; Martini, L; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 276, No. 23, 2001, p. 19793-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. / Holst, P J; Rosenkilde, M M; Manfra, D; Chen, S C; Wiekowski, M T; Holst, B; Cifire, F; Lipp, M; Schwartz, T W; Lira, S A.

    In: Journal of Clinical Investigation, Vol. 108, No. 12, 2001, p. 1789-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering. / Jensen, Kristian Kirk; Martini, Lene; Schwartz, Thue W.

    In: Biochemistry, No. 40 (4), 2001, p. 938-945.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. / Lüttichau, H R; Gerstoft, J; Schwartz, T W.

    In: Journal of Leukocyte Biology, Vol. 70, No. 2, 2001, p. 277-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor. / Lüttichau, H R; Lewis, I C; Gerstoft, J; Schwartz, T W.

    In: European Journal of Immunology, Vol. 31, No. 4, 2001, p. 1217-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus encoded chemokine MC148, inhibits the CCR10 receptor. / Lüttichau, Hans Rudolf; Lewis, I.C.; Gerstoft, J.; Schwartz, Thue W.

    In: European Journal of Immunology, No. 31 (4), 2001, p. 1217-1220.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine. / Mizoue, L S; Sullivan, S K; King, D S; Kledal, T N; Schwartz, T W; Bacon, K B; Handel, T M.

    In: Journal of Biological Chemistry, Vol. 276, No. 36, 2001, p. 33906-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Virally encoded 7TM receptors. / Rosenkilde, M M; Waldhoer, M; Lüttichau, H R; Schwartz, T W.

    In: Oncogene, Vol. 20, No. 13, 2001, p. 1582-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The first PP supper--Camelot at Bispebjerg. / Schwartz, T W; Verlaege, O.

    In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, Vol. 234, 2001, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The first PP supper - Camelot at Bispebjerg. / Schwartz, Thue W.; Verlaege, O.

    In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, No. vol. 234, 2001, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2000
  24. Published

    Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor. / Costa-Neto, C.M.; Miyakawa, A.A.; Oliveira, L.; Hjorth, Siv A.; Schwartz, Thue W.; Paiva, A.C.

    In: British Journal of Pharmacology, No. 130, no. 6, 2000, p. 1263-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Disulfide bridge engineering in the tachykinen NK1 receptor. / Elling, Christian E.; Raffetseder, Ute; Nielsen, Søren M.; Schwartz, Thue W.

    In: Biochemistry, No. 39, no. 4, 2000, p. 667-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor. / Holst, B; Elling, C E; Schwartz, T W.

    In: Molecular Pharmacology, Vol. 58, No. 2, 2000, p. 263-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists. / Larson, D.L.; Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 43, no. 8, 2000, p. 1573-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. / Lüttichau, Hans Rudolf; J., Stine; Boesen, Thomas Peter; Johnsen, A.H.; Chantry, D.; Gerstoft, J.; Schwartz, Thue W.

    In: Journal of Experimental Medicine, No. 191, no. 1, 2000, p. 171-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Validation of chemokine receptors as drug targets. / Lüttichau, Hans Rudolf; Schwartz, Thue W.

    In: Current Opinion in Drug Discovery & Development, No. 3, no. 5, 2000, p. 610-623.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74. / Rosenkilde, M M; Kledal, T N; Holst, Peter Johannes; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 275, No. 34, 2000, p. 26309-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. / Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 57, no. 3, 2000, p. 602-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 1999
  33. Published

    Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor. / Elling, C E; Thirstrup, K; Holst, Birgitte; Schwartz, T W.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 22, 1999, p. 12322-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor. / Elling, Christian E.; Thirstrup, Kenneth; Holst, Birgitte; Schwartz, Thue W.

    In: Proceedings of the National Academy of Science of the United States of America, No. 96, no. 22, 1999, p. 12322-12327.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection. / Klasse, P.J.; Rosenkilde, Mette Marie; Signoret, N.; Pelchen-Matthews, A.; Schwartz, Thue W.; Marsh, M.

    In: Journal of Virology, No. 73, no. 9, 1999, p. 7453-7466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. / Rosenkilde, M M; Kledal, T N; Bräuner-Osborne, Hans; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 274, No. 2, 08.01.1999, p. 956-961.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 1998
  38. Published

    The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies. / Ditzel, H.J.; Rosenkilde, Mette Marie; Garred, P.; Wang, M.; Pedersen, C.; Burton, D.R.; Schwartz, Thue W.

    In: Proceedings of the National Academy of Science of the United States of America, No. 95, no. 9, 1998, p. 5241-5245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Constitutive activity of glucagon receptor mutants. / Hjorth, Siv A.; Ørskov, Cathrine; Schwartz, Thue W.

    In: Molecular Endocrinology, No. 12, no. 1, 1998, p. 78-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor. / Holst, Birgitte; Jensen, Sannah Zoffmann; Elling, Christian E.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 53, no. 1, 1998, p. 166-175.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors. / Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 41, 1998, p. 4911-4914.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: FEBS Letters, No. 441, 1998, p. 209-214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors. / Michel, M.C.; Beck-Sickinger, A.; Cox, Helen; Doods, H.N.; Herzog, H.; Larhammer, D.; Quirion, R.; Schwartz, Thue W.; Westfall, T.

    In: Pharmacological Reviews, No. 50, no. 1, 1998, p. 143-150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3. / Nielsen, Søren M.; Elling, Christian E.; Schwartz, Thue W.

    In: European Journal of Biochemistry, No. 251, 1998, p. 217-226.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor. / Rosenkilde, M M; Lucibello, M; Holst, B; Schwartz, T W.

    In: FEBS Letters, Vol. 439, No. 1-2, 1998, p. 35-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Principles of Agonism - Undressing Efficacy. / Schwartz, Thue W.; Ijzermann, A.P.

    In: TIPS - Trends in Pharmacological Sciences, No. 19, no. 11, 1998, p. 433-436.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Differential regulation of CXCR4 and CCR5 endocytosis. / Signoret, N.; Rosenkilde, Mette Marie; Klasse, P.J.; Schwartz, Thue W.; Malim, M.H.; Hoxie, J.A.; Marsh, M.

    In: Journal of Cell Science, No. 111, no. 18, 1998, p. 2819-2830.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 1997
  49. Published

    Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors. / Elling, Christian E.; Thirstrup, Kenneth; Nielsen, Søren M.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Structure, No. 2, no. 4, 1997, p. 76-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors. / Elling, Christian E.; Thirstrup, Kenneth; Nielsen, Søren M.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Annals of the New York Academy of Sciences, No. 814, 1997, p. 142-151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Coulin, F.; Simmons, G.; Johnsen, A.H.; Alouani, S.; Schwartz, Thue W.; Poucer, C.A.; Lüttichau, H.R.; Gerstoft, J.; Clapham, P.R.; Clark-Lewis, I.; Wells, T.N.C.

    In: Kexue (Shanghai), No. 277, 1997, p. 1656-1659.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The dual nature of the NK-1 receptor. / Maggi, C.; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, No. 18, no. 10, 1997, p. 351-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Den normale hjerne : Ny viden på flere fronter. / Pakkenberg, Bente; Gundersen, Hans Jørgen G.; Mortensen, Erik Lykke; Lauritzen, Martin J.; Jeune, Bernard; Regeur, Lisbeth; West, Mark J.; Schwartz, Thue W.

    In: Ugeskrift for Laeger, Vol. 159, No. 6, 01.12.1997, p. 723-727.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Dual agonistic and antagonistic proberty of non-peptide angiotensin AT1 ligands: Susceptibility to receptor mutations. / Perlman, Signe; Costa-Neto, C.M.; Miyakawa, A.A.; Schambye, Hans T.; Hjorth, Siv A.; Paiva, A.C.; Rivero, R.A.; Greenlee, W.J.; Schwartz, Thue W.

    In: Molecular Pharmaceutics, No. 51, no. 2, 1997, p. 301-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion. / Schwartz, Thue W.

    In: Ugeskrift for læger, No. 159, 1997, p. 1239-1245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    How receptor mutagenesis may confirm or confuse receptor classification. / Schwartz, Thue W.; Perlman, Signe; Rosenkilde, Mette Marie; Hjorth, Siv A.

    In: Annals of the New York Academy of Sciences, No. 817, 1997, p. 71-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 11601