Thue W. Schwartz

Thue W. Schwartz

Professor

  • Schwartz Group

    Blegdamsvej 3B, 2200 København N, Maersk Tower, Building: 07-6-85

  • Nutrient and Metabolite Sensing

    Blegdamsvej 3B, Building: 07-6-85

    2200 København N

    Denmark


  1. 1986
  2. Published

    Kredsløbsregulation ved hypovolaemisk shock. / Sander Jensen, K; Secher, Niels H; Rørsgaard, S; Warberg, Jørgen; Astrup, Arne; Christensen, N J; Giese, J; Schwartz, T W; Bie, P.

    In: Ugeskrift for læger, Vol. 148, No. 38, 1986, p. 2383-2387.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 1987
  4. Published

    Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. / Holst, J J; Orskov, C; Nielsen, O V; Schwartz, T W.

    In: F E B S Letters, Vol. 211, No. 2, 1987, p. 169-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 1989
  6. Published

    Release of PYY from pig intestinal mucosa; luminal and neural regulation. / Sheikh, S P; Holst, J J; Orskov, C; Ekman, R; Schwartz, T W.

    In: Regulatory Peptides, Vol. 26, No. 3, 12.1989, p. 253-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 1990
  8. Published

    Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase. / Aakerlund, L; Gether, U; Fuhlendorff, J; Schwartz, T W; Thastrup, Ole.

    In: F E B S Letters, Vol. 260, No. 1, 1990, p. 73-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    [Leu31, Pro34]neuropeptide Y : a specific Y1 receptor agonist. / Fuhlendorff, J; Gether, U; Aakerlund, L; Langeland-Johansen, N; Thøgersen, H; Melberg, S G; Olsen, U B; Thastrup, Ole; Schwartz, T W.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 1, 1990, p. 182-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    C-terminal KDEL-modified cystatin C is retained in transfected CHO cells. / Johansen, Teit Eliot; Vogel, Charlotte Katrine; Schwartz, Thue W.

    In: Biochemical and Biophysical Research Communications, Vol. 172, No. 3, 1990, p. 1384-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 1991
  12. Published

    Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors. / Johansen, Teit Eliot; Schifter, S; Vogel, Charlotte Katrine; Tolstoy, Susanne; Schwartz, Thue W.

    In: Molecular and Cellular Endocrinology, Vol. 82, No. 1, 1991, p. 51-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 1993
  14. Published

    Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides. / Bjørnholm, B; Jørgensen, Flemming Steen; Schwartz, T W.

    In: Biochemistry, Vol. 32, No. 12, 1993, p. 2954-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Regional distribution of putative NPY Y*U1 receptors and neurons expressing Y*U1 mRNA in forebrain areas of the rat central nervous system. / Larsen, Philip J.; Sheikh, Søren P.; Jakobsen, Cherine R.; Schwartz, Thue W.; Mikkelsen, J.D.

    In: European Journal of Neuroscience, No. Vol 5, 1993, p. 1622-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Immunohistochemical and chromatographic Identification of Peptides derived from Proneuropeptide Y in the human frontal Cortex. / Mikkelsen, J.D.; Larsen, Philip J.; Kruse-Larsen, C.; O'Hare, M.M.T.; Schwartz, Thue W.

    In: Brain Research Bulletin, No. 31, 1993, p. 415-425.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 1997
  18. Published

    Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors. / Elling, Christian E.; Thirstrup, Kenneth; Nielsen, Søren M.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Structure, No. 2, no. 4, 1997, p. 76-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors. / Elling, Christian E.; Thirstrup, Kenneth; Nielsen, Søren M.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Annals of the New York Academy of Sciences, No. 814, 1997, p. 142-151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Coulin, F.; Simmons, G.; Johnsen, A.H.; Alouani, S.; Schwartz, Thue W.; Poucer, C.A.; Lüttichau, H.R.; Gerstoft, J.; Clapham, P.R.; Clark-Lewis, I.; Wells, T.N.C.

    In: Kexue (Shanghai), No. 277, 1997, p. 1656-1659.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The dual nature of the NK-1 receptor. / Maggi, C.; Schwartz, Thue W.

    In: TIPS - Trends in Pharmacological Sciences, No. 18, no. 10, 1997, p. 351-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Den normale hjerne : Ny viden på flere fronter. / Pakkenberg, Bente; Gundersen, Hans Jørgen G.; Mortensen, Erik Lykke; Lauritzen, Martin J.; Jeune, Bernard; Regeur, Lisbeth; West, Mark J.; Schwartz, Thue W.

    In: Ugeskrift for Laeger, Vol. 159, No. 6, 01.12.1997, p. 723-727.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Dual agonistic and antagonistic proberty of non-peptide angiotensin AT1 ligands: Susceptibility to receptor mutations. / Perlman, Signe; Costa-Neto, C.M.; Miyakawa, A.A.; Schambye, Hans T.; Hjorth, Siv A.; Paiva, A.C.; Rivero, R.A.; Greenlee, W.J.; Schwartz, Thue W.

    In: Molecular Pharmaceutics, No. 51, no. 2, 1997, p. 301-311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion. / Schwartz, Thue W.

    In: Ugeskrift for læger, No. 159, 1997, p. 1239-1245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    How receptor mutagenesis may confirm or confuse receptor classification. / Schwartz, Thue W.; Perlman, Signe; Rosenkilde, Mette Marie; Hjorth, Siv A.

    In: Annals of the New York Academy of Sciences, No. 817, 1997, p. 71-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4. / Signoret, N.; Oldridge, J.; Pelchen-Matthews, A.; Klasse, P.J.; Tran, T.; Brass, L.F.; Rosenkilde, Mette Marie; Schwartz, Thue W.; Luther, Michael A.; Wells, T.N.C.; Hoxie, J.A.; March, Mark.

    In: Journal of Cell Biology, No. 139, no. 3, 1997, p. 651-664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. / Simmons, G.; Clapham, P.R.; Picard, L.; Offord, R.E.; Rosenkilde, Mette Marie; Schwartz, Thue W.; Buser, R.; Weels, T.N.C.; Proudfoot, A.

    In: Kexue (Shanghai), No. 276, 1997, p. 276-279.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands. / Turcatti, G.; Drozda, S.E.; Chassaing, G.; Schwartz, Thue W.; Chollet, André; Jensen, Sannah Zoffmann; Lowe III, J.A.

    In: Journal of Biological Chemistry, No. 272, no. 34, 1997, p. 21167-21175.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Plagiarism of the host immune system - lessons about chemokine immunology from viruses. / Wells, T.N.C.; Schwartz, Thue W.

    In: Current Opinion in Biotechnology, No. 8, no. 6, 1997, p. 741-748.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 1998
  31. Published

    The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies. / Ditzel, H.J.; Rosenkilde, Mette Marie; Garred, P.; Wang, M.; Pedersen, C.; Burton, D.R.; Schwartz, Thue W.

    In: Proceedings of the National Academy of Science of the United States of America, No. 95, no. 9, 1998, p. 5241-5245.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Constitutive activity of glucagon receptor mutants. / Hjorth, Siv A.; Ørskov, Cathrine; Schwartz, Thue W.

    In: Molecular Endocrinology, No. 12, no. 1, 1998, p. 78-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor. / Holst, Birgitte; Jensen, Sannah Zoffmann; Elling, Christian E.; Hjorth, Siv A.; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 53, no. 1, 1998, p. 166-175.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors. / Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 41, 1998, p. 4911-4914.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28. / Kledal, Thomas N.; Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: FEBS Letters, No. 441, 1998, p. 209-214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors. / Michel, M.C.; Beck-Sickinger, A.; Cox, Helen; Doods, H.N.; Herzog, H.; Larhammer, D.; Quirion, R.; Schwartz, Thue W.; Westfall, T.

    In: Pharmacological Reviews, No. 50, no. 1, 1998, p. 143-150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3. / Nielsen, Søren M.; Elling, Christian E.; Schwartz, Thue W.

    In: European Journal of Biochemistry, No. 251, 1998, p. 217-226.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor. / Rosenkilde, M M; Lucibello, M; Holst, B; Schwartz, T W.

    In: FEBS Letters, Vol. 439, No. 1-2, 1998, p. 35-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Principles of Agonism - Undressing Efficacy. / Schwartz, Thue W.; Ijzermann, A.P.

    In: TIPS - Trends in Pharmacological Sciences, No. 19, no. 11, 1998, p. 433-436.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Differential regulation of CXCR4 and CCR5 endocytosis. / Signoret, N.; Rosenkilde, Mette Marie; Klasse, P.J.; Schwartz, Thue W.; Malim, M.H.; Hoxie, J.A.; Marsh, M.

    In: Journal of Cell Science, No. 111, no. 18, 1998, p. 2819-2830.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 1999
  42. Published

    Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor. / Elling, C E; Thirstrup, K; Holst, Birgitte; Schwartz, T W.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 22, 1999, p. 12322-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor. / Elling, Christian E.; Thirstrup, Kenneth; Holst, Birgitte; Schwartz, Thue W.

    In: Proceedings of the National Academy of Science of the United States of America, No. 96, no. 22, 1999, p. 12322-12327.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection. / Klasse, P.J.; Rosenkilde, Mette Marie; Signoret, N.; Pelchen-Matthews, A.; Schwartz, Thue W.; Marsh, M.

    In: Journal of Virology, No. 73, no. 9, 1999, p. 7453-7466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. / Rosenkilde, M M; Kledal, T N; Bräuner-Osborne, Hans; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 274, No. 2, 08.01.1999, p. 956-961.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2000
  47. Published

    Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor. / Costa-Neto, C.M.; Miyakawa, A.A.; Oliveira, L.; Hjorth, Siv A.; Schwartz, Thue W.; Paiva, A.C.

    In: British Journal of Pharmacology, No. 130, no. 6, 2000, p. 1263-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Disulfide bridge engineering in the tachykinen NK1 receptor. / Elling, Christian E.; Raffetseder, Ute; Nielsen, Søren M.; Schwartz, Thue W.

    In: Biochemistry, No. 39, no. 4, 2000, p. 667-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor. / Holst, B; Elling, C E; Schwartz, T W.

    In: Molecular Pharmacology, Vol. 58, No. 2, 2000, p. 263-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists. / Larson, D.L.; Jones, R.M.; Hjorth, Siv A.; Schwartz, Thue W.; Portoghese, P.S.

    In: Journal of Medicinal Chemistry, No. 43, no. 8, 2000, p. 1573-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. / Lüttichau, Hans Rudolf; J., Stine; Boesen, Thomas Peter; Johnsen, A.H.; Chantry, D.; Gerstoft, J.; Schwartz, Thue W.

    In: Journal of Experimental Medicine, No. 191, no. 1, 2000, p. 171-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Validation of chemokine receptors as drug targets. / Lüttichau, Hans Rudolf; Schwartz, Thue W.

    In: Current Opinion in Drug Discovery & Development, No. 3, no. 5, 2000, p. 610-623.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74. / Rosenkilde, M M; Kledal, T N; Holst, Peter Johannes; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 275, No. 34, 2000, p. 26309-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. / Rosenkilde, Mette Marie; Schwartz, Thue W.

    In: Molecular Pharmacology, No. 57, no. 3, 2000, p. 602-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2001
  56. Published

    The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling. / Fraile-Ramos, A; Kledal, T N; Pelchen-Matthews, A; Bowers, K; Schwartz, T W; Marsh, M.

    In: Molecular Biology of the Cell, Vol. 12, No. 6, 2001, p. 1737-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. / Gerlach, Lars-Ole; Skerlj, R.T.; Bridger, G.J.; Schwartz, Thue W.

    In: Journal of Biological Chemistry, No. 276 (17), 2001, p. 14153-14160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S; Princen, K; Gerlach, L O; Bridger, G; Henson, G; De Clercq, E; Schwartz, T W; Schols, D.

    In: Molecular Pharmacology, Vol. 60, No. 1, 2001, p. 164-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. / Hatse, S.; Princen, K.; Gerlach, Lars-Ole; Bridger, G.; Henson, G.; De Clercq, E.; Schwartz, Thue W.; Schols, D.

    In: Molecular Pharmacology, No. 60 (1), 2001, p. 164-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis. / Holst, B; Hastrup, H; Raffetseder, U; Martini, L; Schwartz, T W.

    In: Journal of Biological Chemistry, Vol. 276, No. 23, 2001, p. 19793-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. / Holst, P J; Rosenkilde, M M; Manfra, D; Chen, S C; Wiekowski, M T; Holst, B; Cifire, F; Lipp, M; Schwartz, T W; Lira, S A.

    In: Journal of Clinical Investigation, Vol. 108, No. 12, 2001, p. 1789-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

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