Morten Grunnet

Morten Grunnet

Affiliate professor


  1. 2019
  2. Published

    Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model. / Lubberding, Anniek F; Sattler, Stefan M; Grunnet, Morten; Sørensen, Ulrik S; Tfelt-Hansen, Jacob; Jespersen, Thomas.

    In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 21, No. 10, 10.2019, p. 1584–1593.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts. / Kirchhoff, Jeppe Egedal; Skarsfeldt, Mark; Muthukumarasamy, Kalai Mangai; Simó-Vicens, Rafel; Bomholtz, Sofia Hammami; Abildgaard, Lea; Jespersen, Thomas; Sørensen, Ulrik S; Grunnet, Morten; Bentzen, Bo Hjorth; Diness, Jonas Goldin.

    In: Frontiers in Pharmacology, Vol. 10, 668, 19.06.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Impact of arrhythmogenic calmodulin variants on small conductance Ca2+-activated K+ (SK3) channels. / Saljic, Arnela; Muthukumarasamy, Kalai Mangai; la Cour, Jonas Marstrand; Boddum, Kim; Grunnet, Morten; Berchtold, Martin Werner; Jespersen, Thomas.

    In: Physiological Reports, Vol. 7, No. 19, e14210, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2018
  6. Published

    Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death. / Richards, Kay L.; Milligan, Carol J.; Richardson, Robert J.; Jancovski, Nikola; Grunnet, Morten; Jacobson, Laura H.; Undheim, Eivind A. B.; Mobli, Mehdi; Chow, Chun Yuen; Herzig, Volker; Csoti, Agota; Panyi, Gyorgy; Reid, Christopher A.; King, Glenn F.; Petrou, Steven.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 34, 21.08.2018, p. E8077-E8085.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Pharmacological rescue of mutated K(v)3.1 ion-channel linked to progressive myoclonus epilepsies. / Munch, Anders Sonne; Saljic, Arnela; Boddum, Kim; Grunnet, Morten; Hougaard, Charlotte; Jespersen, Thomas.

    In: European Journal of Pharmacology, Vol. 833, 2018, p. 255-262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2017
  9. Published

    A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels. / Simo Vicens, Rafel; Kirchhoff, Jeppe Egedal; Dolce , Bernardo ; Abildgaard, Lea; Speerschneider, Tobias; Sørensen, Ulrik Svane; Grunnet, Morten; Diness, Jonas Goldin; Bentzen, Bo Hjorth.

    In: British Journal of Pharmacology, Vol. 174, No. 23, 05.12.2017, p. 4396-4408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Phosphodiesterase 1a inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries. / Khammy, Makhala Michell; Dalsgaard, Thomas; Larsen, Peter Hjørringgaard; Christoffersen, Claus Tornby; Clausen, Dorte; Rasmussen, Lars Kyhn; Folkersen, Lasse; Grunnet, Morten; Kehler, Jan; Aalkjaer, Christian; Nielsen, Jacob.

    In: British Journal of Pharmacology, Vol. 174, No. 22, 11.2017, p. 4186-4198.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs. / Diness, Jonas Goldin; Skibsbye, Lasse; Simó-Vicens, Rafel; Louro Larupa dos Santos, Joana; Lundegaard, Pia Rengtved; Citerni, Carlotta; Sauter, Daniel Rafael Peter; Bomholtz, Sofia Hammami; Svendsen, Jesper Hastrup; Olesen, Søren-Peter; Sørensen, Ulrik S; Jespersen, Thomas; Grunnet, Morten; Bentzen, Bo Hjorth.

    In: Circulation: Arrhythmia and Electrophysiology, Vol. 10, e005125, 10.10.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats. / Laursen, Morten; Beck, Lilliana; Kehler, Jan; Christoffersen, Claus Tornby; Bundgaard, Christoffer; Mogensen, Susie; Mow, Tomas Joachim; Pinilla, Estéfano; Knudsen, Jakob Schöllhammer; Hedegaard, Elise Røge; Grunnet, Morten; Simonsen, Ulf.

    In: British Journal of Pharmacology, Vol. 174, No. 15, 08.2017, p. 2563-2575.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels. / Simo Vicens, Rafel; Sauter, Daniel Rafael Peter; Grunnet, Morten; Diness, Jonas Goldin; Bentzen, Bo Hjorth.

    In: European Journal of Pharmacology, Vol. 803, 15.05.2017, p. 118-123.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Novel negative allosteric modulator inhibits small conductance calcium-activated potassium channels and selectively prolongs atrial refractoriness in conscious pigs. / Simó-Vicens, Rafel; Citerni, Carlotta; Edvardsson, Niels G.; Sørensen, Ulrik Svane; Grunnet, Morten; Diness, Jonas Goldin; Bentzen, Bo Hjorth.

    In: Heart Rhythm, Vol. 14, No. 5 suppl., P-PO02-15, 11.05.2017, p. S149-S150.

    Research output: Contribution to journalConference abstract in journalResearch

  15. 2016
  16. Published

    Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation. / Kirchhoff, Jeppe Egedal; Diness, Jonas Goldin; Abildgaard, Lea; Sheykhzade, Majid; Grunnet, Morten; Jespersen, Thomas.

    In: Pfluegers Archiv, Vol. 468, No. 11, 08.10.2016, p. 1853–1863.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2015
  18. Published

    Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy. / Diness, Jonas G.; Bentzen, Bo H.; S. Sørensen, Ulrik; Grunnet, Morten.

    In: Journal of Cardiovascular Pharmacology, Vol. 66, No. 5, 11.2015, p. 441-448.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. / Skibsbye, Lasse; Wang, Xiaodong; Axelsen, Lene Nygaard; Bomholtz, Sofia Hammami; Nielsen, Morten Schak; Grunnet, Morten; Bentzen, Bo Hjorth; Jespersen, Thomas.

    In: Journal of Cardiovascular Pharmacology, Vol. 66, No. 2, 08.2015, p. 165-176.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation. / Poulet, Claire; Wettwer, Erich; Grunnet, Morten; Jespersen, Thomas; Fabritz, Larissa; Matschke, Klaus; Knaut, Michael; Ravens, Ursula.

    In: PLOS ONE, Vol. 10, No. 6, e0131432, 29.06.2015, p. 1-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family. / Kanters, Jørgen K.; Skibsbye, Lasse; Hedley, Paula L.; Dembic, Maja; Liang, Bo; Hagen, Christian M.; Eschen, Ole; Grunnet, Morten; Christiansen, Michael; Jespersen, Thomas.

    In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 75, No. 8, 2015, p. 699-709.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Common and rare variants in SCN10A modulate the risk of atrial fibrillation. / Jabbari, Javad; Olesen, Morten S.; Yuan, Lei; Nielsen, Jonas B.; Liang, Bo; Macri, Vincenzo; Christophersen, Ingrid E.; Nielsen, Nikolaj; Sajadieh, Ahmad; Ellinor, Patrick T.; Grunnet, Morten; Haunsø, Stig; Holst, Anders G.; Svendsen, Jesper H.; Jespersen, Thomas.

    In: Circulation: Cardiovascular Genetics, Vol. 8, No. 1, 2015, p. 64-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2014
  24. Published

    Cardiac potassium channel subtypes : new roles in repolarization and arrhythmia. / Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter.

    In: Physiological Reviews, Vol. 94, No. 2, 04.2014, p. 609-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome. / Kanters, Jørgen K.; Yuan, Lei; Hedley, Paula L; Stoevring, Birgitte; Jons, Christian; Bloch Thomsen, Poul Erik; Grunnet, Morten; Christiansen, Michael; Jespersen, Thomas.

    In: Circulation Journal, Vol. 78, No. 5, 06.03.2014, p. 1136-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization. / Liang, Bo; Nissen, Jakob D; Laursen, Morten; Wang, Xiaodong; Skibsbye, Lasse; Hearing, Matthew C; Andersen, Martin N; Rasmussen, Hanne B; Wickman, Kevin; Grunnet, Morten; Olesen, Søren-Peter; Jespersen, Thomas.

    In: Cardiovascular Research, Vol. 101, No. 1, 01.01.2014, p. 175-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    BK channel activators and their therapeutic perspectives. / Bentzen, Bo Hjorth; Olesen, Søren-Peter; Rønn, Lars C B; Grunnet, Morten.

    In: Frontiers in Physiology, Vol. 5, 2014, p. 1-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2013
  29. Published

    GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology. / Wang, Xiaodong; Liang, Bo; Skibsbye, Lasse; Olesen, Søren-Peter; Grunnet, Morten; Jespersen, Thomas.

    In: Journal of Cardiovascular Pharmacology, Vol. 62, No. 2, 08.2013, p. 192-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Benzimidazolyl-acetamide derivatives useful as potassium channel modulators. / SØRENSEN, Ulrik Svane; Grunnet, Morten; BENTZEN, Bo Hjorth; Christophersen, Palle; Diness, Jonas Goldin; SKIBSBYE, Lasse; Strøbæk, Dorte.

    2013, Patent.

    Research output: Other contributionResearch

  31. 2012
  32. Published

    Functionally Selective AT(1) Receptor Activation Reduces Ischemia Reperfusion Injury. / Hostrup, Anders; Christensen, Gitte Lund; Bentzen, Bo Hjort; Liang, Bo; Aplin, Mark; Grunnet, Morten; Hansen, Jakob Lerche; Jespersen, Thomas.

    In: Cellular Physiology and Biochemistry, Vol. 30, No. 3, 30.07.2012, p. 642-652.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats. / Bentzen, Bo Hjorth; Grunnet, Morten; Hyveled-Nielsen, Lars; Sundgreen, Claus; lassen, Jørgen Buus; Hansen, Henrik H.

    In: Obesity, 2012.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure. / Nissen, Jakob Dahl; Thomsen, Morten Bækgaard; Bentzen, Bo Hjorth; Diness, Jonas Goldin; Diness, Thomas Goldin; Jespersen, Thomas; Grunnet, Morten.

    In: Journal of Cardiovascular Pharmacology, Vol. 59, No. 2, 2012, p. 142-150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. / Krzystanek, Katarzyna; Rasmussen, Hanne Borger; Grunnet, Morten; Staub, Olivier; Olesen, Søren-Peter; Abriel, Hugues; Jespersen, Thomas.

    In: Heart Rhythm, Vol. 9, No. 3, 2012, p. 440-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts. / Laursen, Morten; Grunnet, Morten; Olesen, Søren-Peter; Jespersen, Thomas; Mow, Tomas.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 64, No. 2, 2012, p. 134-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2011
  38. Published

    Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits. / Bentzen, Bo Hjorth; Bahrke, Sophia; Wu, Kezhong; Larsen, Anders Peter; Odening, Katja E; Franke, Gerlind; Storm vans Gravesande, Karin; Biermann, Jürgen; Peng, Xuwen; Koren, Gideon; Zehender, Manfred; Bode, Christoph; Grunnet, Morten; Brunner, Michael.

    In: Journal of Cardiovascular Pharmacology, Vol. 57, No. 2, 02.2011, p. 223-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Cardiac channelopathies and sudden infant death syndrome. / Tfelt-Hansen, Jacob; Winkel, Bo Gregers; Grunnet, Morten; Jespersen, Thomas.

    In: The Cardiology, Vol. 119, No. 1, 2011, p. 21-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Cardiac ion channels and mechanisms for protection against atrial fibrillation. / Grunnet, Morten; Bentzen, Bo Hjorth; Sørensen, Ulrik S; Diness, Jonas Goldin.

    In: Reviews of Physiology, Biochemistry and Pharmacology, Vol. 162, 2011, p. 1-58.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. / Bentzen, Bo Hjorth; Grunnet, Morten.

    In: Advances in Pharmacological Sciences, Vol. 2011, 2011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Characterization of cardiac repolarization in the Göttingen minipig. / Laursen, Morten; Olesen, Søren-Peter; Grunnet, Morten; Mow, Tomas; Jespersen, Thomas; Jespersen, Thomas.

    In: Journal of Pharmacological and Toxicological Methods, Vol. 63, No. 2, 2011, p. 186-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition. / Diness, Jonas Goldin; Skibsbye, Lasse; Jespersen, Thomas; Bartels, Emil D; Sørensen, Ulrik S; Hansen, Rie S; Grunnet, Morten.

    In: Hypertension, Vol. 57, No. 6, 2011, p. 1129-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state. / Larsen, Anders Peter; Steffensen, Annette Buur; Grunnet, Morten; Olesen, Søren-Peter.

    In: Biophysical Journal, Vol. 101, No. 4, 2011, p. 818-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1. / Andersen, Ann-Dorit; Bentzen, Bo Hjorth; Salling, H.; Klingberg, Henrik; Kanneworff, Morten; Grunnet, Morten; Pedersen, Stine Helene Falsig.

    In: Cellular Physiology and Biochemistry, Vol. 28, No. 1, 2011, p. 13-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca2+-activated K+ channels. / Skibsbye, Lasse; Diness, Jonas; Sørensen, Ulrik S; Hansen, Rie Schultz; Grunnet, Morten.

    In: Journal of Cardiovascular Pharmacology, Vol. 57, No. 6, 2011, p. 672-681.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2010
  48. Published

    Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels. / Larsen, A P; Bentzen, Bo Hjorth; Grunnet, M.

    In: British Journal of Pharmacology, Vol. 161, No. 3, 10.2010, p. 614-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. / Diness, Jonas Goldin; Sørensen, Ulrik S; Nissen, Jakob Dahl; Al-Shahib, Baha; Jespersen, Thomas; Grunnet, Morten; Hansen, Rie Schultz; Jespersen, Thomas.

    In: Circulation. Arrhythmia and electrophysiology, Vol. 3, No. 4, 08.2010, p. 380-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome. / Yang, Yanzong; Yang, Yiqing; Liang, Bo; Liu, Jinqiu; Li, Jun; Grunnet, Morten; Olesen, Søren-Peter; Rasmussen, Hanne B; Ellinor, Patrick T; Gao, Lianjun; Lin, Xiaoping; Li, Li; Wang, Lei; Xiao, Junjie; Liu, Yi; Liu, Ying; Zhang, Shulong; Liang, Dandan; Peng, Luying; Jespersen, Thomas; Chen, Yi-Han.

    In: American Journal of Human Genetics, Vol. 86, No. 6, 2010, p. 872-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2009
  52. Published

    Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury. / Bentzen, Bo Hjorth; Osadchii, Oleg; Jespersen, Thomas; Hansen, Rie Schultz; Olesen, Søren-Peter; Grunnet, Morten.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 457, No. 5, 2009, p. 979-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours. / Poulsen, H.S.; Grunnet, K.; Sorensen, M.; Olsen, P.; Hasselbalch, B.; Nelausen, K.; Kosteljanetz, M.; Lassen, U.

    In: Acta Oncologica, Vol. 48, No. 1, 2009, p. 52-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria. / Aon, Miguel A; Cortassa, Sonia; Wei, An-Chi; Grunnet, Morten; O'Rourke, Brian.

    In: BBA General Subjects, Vol. 1797, No. 1, 2009, p. 71-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Functional properties of human neuronal Kv11 channels. / Einarsen, Karoline; Calloe, Kirstine; Grunnet, Morten; Olesen, Søren-Peter; Schmitt, Nicole.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 458, No. 4, 2009, p. 689-700.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Inherited Cardiac Diseases Caused by Mutations in the Nav1.5 Sodium Channel. / Tfelt-Hansen, Jacob; Winkel, Bo Gregers; Grunnet, Morten; Jespersen, Thomas.

    In: Cardiovascular Electrophysiology, 2009.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Negative Modulation of SK Channels Terminates and Protects Against Atrial Fibrillation in Rat and Guinea Pig Ex Vivo and in vivo Models. / Diness, Jonas Goldin; Schultz Hansen, Rie; Sørensen, Ulrik S; Grunnet, Morten.

    In: Circulation. Supplement, Vol. 2009;120 (18): S712-S712 Suppl. 2., 2009.

    Research output: Contribution to journalConference articleResearchpeer-review

  58. Published

    Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes. / Nissen, Jakob Dahl; Diness, Jonas Goldin; Diness, Thomas Goldin; Hansen, Rie Schultz; Grunnet, Morten; Jespersen, Thomas.

    In: Journal of Cardiovascular Pharmacology, Vol. 54, No. 2, 2009, p. 169-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo. / Bentzen, Bo Hjorth; Andersen, Rune Wederkinck; Olesen, Søren-Peter; Grunnet, Morten; Nardi, Antonio.

    In: NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE, 2009.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. / Soltysinska, Ewa; Olesen, Søren-Peter; Christ, Torsten; Wettwer, Erich; Varró, Andras; Grunnet, Morten; Jespersen, Thomas.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 459, No. 1, 2009, p. 11-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. 2008
  62. Published

    A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. / Calloe, Kirstine; Cordeiro, Jonathan M; Di Diego, José M; Hansen, Rie S; Grunnet, Morten; Olesen, Søren Peter; Antzelevitch, Charles.

    In: Cardiovascular Research, Vol. 81, No. 4, 2008, p. 686-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Antiarrhythmic effect of IKr activation in a cellular model of LQT3. / Diness, Jonas Goldin; Hansen, Rie Schultz; Nissen, Jakob Dahl; Jespersen, Thomas; Grunnet, Morten.

    In: Heart Rhythm, Vol. 6, No. 1, 2008, p. 100-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. / Diness, Thomas G; Yeh, Yung-Hsin; Qi, Xiao Yan; Chartier, Denis; Tsuji, Yukiomi; Hansen, Rie S; Olesen, Søren-Peter; Grunnet, Morten; Nattel, Stanley.

    In: Cardiovascular Research, Vol. 79, No. 1, 2008, p. 61-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function. / Grunnet, M.; Diness, T.G.; Hansen, R.S.; Olesen, Søren-Peter.

    In: Cellular Physiology and Biochemistry, Vol. 22, No. 5-6, 2008, p. 611-624.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current. / Larsen, Anders Peter; Olesen, Søren-Peter; Grunnet, Morten; Jespersen, Thomas.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 456, No. 6, 2008, p. 1137-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model. / Peitersen, Torben; Grunnet, Morten; Benson, Alan P; Holden, Arun V; Holstein-Rathlou, Niels-Henrik; Olesen, Søren-Peter.

    In: Heart Rhythm, Vol. 5, No. 5, 2008, p. 734-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Fetal arrhythmia caused by dysregulation of HERG channels. / Grunnet, Morten.

    In: Heart Rhythm, Vol. 5, No. 4, 2008, p. 562-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. / Hansen, Rie Schultz; Olesen, Søren-Peter; Rønn, Lars Christian B; Grunnet, Morten.

    In: Journal of Cardiovascular Pharmacology, Vol. 52, No. 1, 2008, p. 35-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro. / Fanoe, Søren; Jensen, Gorm Boje; Sjøgren, Per; Korsgaard, Mads P G; Grunnet, Morten; Fanoe, Søren; Jensen, Gorm Boje; Sjøgren, Per; Korsgaard, Mads P G; Grunnet, Morten.

    In: British Journal of Clinical Pharmacology, Vol. 67, No. 2, 2008, p. 172-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Single-copy insertion of transgenes in Caenorhabditis elegans. / Frøkjaer-Jensen, Christian; Davis, M Wayne; Hopkins, Christopher E; Newman, Blake J; Thummel, Jason M; Olesen, Søren-Peter; Grunnet, Morten; Jorgensen, Erik M.

    In: Nature Genetics, Vol. 40, No. 11, 2008, p. 1375-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. 2007
  73. Published

    Activation of ERG2 potassium channels by the diphenylurea NS1643. / Elmedyb, Pernille; Olesen, Søren-Peter; Grunnet, Morten.

    In: Neuropharmacology, Vol. 53, No. 2, 2007, p. 283-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit. / Calloe, Kirstine; Ravn, Lasse Steen; Schmitt, Nicole; Sui, Jin Liang; Duno, Morten; Haunso, Stig; Grunnet, Morten; Svendsen, Jesper Hastrup; Olesen, Søren-Peter.

    In: Biochemical and Biophysical Research Communications, Vol. 364, No. 4, 2007, p. 889-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Inactivation as a new regulatory mechanism for neuronal Kv7 channels. / Jensen, Henrik Sindal; Grunnet, Morten; Olesen, Søren-Peter.

    In: Biophysical Journal, Vol. 92, No. 8, 2007, p. 2747-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes. / Calloe, Kirstine; Nielsen, Morten Schak; Grunnet, Morten; Schmitt, Nicole; Jorgensen, Nanna Koschmieder.

    In: BBA General Subjects, Vol. 1773, No. 6, 2007, p. 764-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Modulation of ERG channels by XE991. / Elmedyb, Pernille; Calloe, Kirstine; Schmitt, Nicole; Hansen, Rie Schultz; Grunnet, Morten; Olesen, Søren-Peter.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 100, No. 5, 2007, p. 316-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients. / Nielsen, Nathalie H; Winkel, Bo G; Kanters, Jørgen K; Schmitt, Nicole; Hofman-Bang, Jacob; Jensen, Henrik S; Bentzen, Bo H; Sigurd, Bjarne; Larsen, Lars Allan; Andersen, Paal S; Kjeldsen, Keld; Grunnet, Morten; Christiansen, Michael; Olesen, Søren-Peter; Haunsø, Stig.

    In: Biochemical and Biophysical Research Communications, Vol. 354, No. 3, 2007, p. 776-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. / Hansen, Rie Schultz; Olesen, Søren-Peter; Grunnet, Morten.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 321, No. 3, 2007, p. 996-1002.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. / Bentzen, Bo Hjorth; Nardi, Antonio; Calloe, Kirstine; Madsen, Lars Siim; Olesen, Søren-Peter; Grunnet, Morten.

    In: Molecular Pharmacology, Vol. 72, No. 4, 2007, p. 1033-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. 2006
  82. Published

    Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]. / Hansen, R.S.; Diness, T.G.; Christ, T.; Wettwer, E.; Ravens, U.; Olesen, Søren-Peter Fuchs; Grunnet, Morten.

    In: Molecular Pharmacology, Vol. 70, No. 4, 2006, p. 1319-1329.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. / Bøttger, Pernille; Hede, Susanne E; Grunnet, Morten; Høyer, Boy; Klaerke, Dan A; Pedersen, Lene.

    In: American Journal of Physiology: Cell Physiology, Vol. 291, No. 6, 2006, p. C1377-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels. / Diness, Thomas Goldin; Hansen, Rie Schultz; Olesen, Søren-Peter; Grunnet, Morten.

    In: Biochemical and Biophysical Research Communications, Vol. 343, No. 4, 2006, p. 1224-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Subtype-specific, bi-component inhibition of SK channels by low internal pH. / Peitersen, Torben; Jespersen, Thomas; Jorgensen, Nanna K; Olesen, Søren-Peter; Grunnet, Morten.

    In: Biochemical and Biophysical Research Communications, Vol. 343, No. 3, 2006, p. 943-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. / Bentzen, Bo Hjorth; Schmitt, Nicole; Calloe, Kirstine; Dalby Brown, William; Grunnet, Morten; Olesen, Søren-Peter.

    In: Neuropharmacology, Vol. 51, No. 6, 2006, p. 1068-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels? / Jespersen, Thomas; Grunnet, Morten; Rasmussen, Hanne B; Jørgensen, Nils B; Jensen, Henrik; Angelo, Kamilla; Olesen, Søren-Peter; Klaerke, Dan A.

    In: Biochemical and Biophysical Research Communications, Vol. 341, No. 4, 2006, p. 979-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. 2005
  89. Published

    Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). / Hansen, Rie Schultz; Diness, Thomas Goldin; Christ, Torsten; Demnitz, Joachim; Ravens, Ursula; Olesen, Søren-Peter; Grunnet, Morten.

    In: Molecular Pharmacology, Vol. 69, No. 1, 2005, p. 266-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome. / Grunnet, Morten; Behr, Elijah Raphael; Calloe, Kirstine; Hofman-Bang, Jacob; Till, Jan; Christiansen, Michael; McKenna, William John; Olesen, Søren-Peter; Schmitt, Nicole.

    In: Heart Rhythm, Vol. 2, No. 11, 2005, p. 1238-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels. / Calloe, Kirstine; Elmedyb, Pernille; Olesen, Søren-Peter; Jorgensen, Nanna K; Grunnet, Morten.

    In: Biophysical Journal, Vol. 89, No. 3, 2005, p. 2159-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Quantification and distribution of big conductance Ca2+-activated K+ channels in kidney epithelia. / Grunnet, Morten; Hay-Schmidt, Anders; Klaerke, Dan A.

    In: BBA General Subjects, Vol. 1714, No. 2, 2005, p. 114-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    The KCNQ1 potassium channel: from gene to physiological function. / Jespersen, Thomas; Grunnet, Morten; Olesen, Søren-Peter.

    In: Physiology, Vol. 20, 2005, p. 408-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics. / Grunnet, Morten; Olesen, Søren-Peter; Klaerke, Dan A; Jespersen, Thomas.

    In: Biochemical and Biophysical Research Communications, Vol. 328, No. 4, 2005, p. 1146-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. 2004
  96. Published

    5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels. / Grunnet, Morten; Jespersen, Thomas; Perrier, Jean-François.

    In: Journal of Neuroscience Research, Vol. 78, No. 6, 2004, p. 845-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif. / Jespersen, Thomas; Rasmussen, Hanne B; Grunnet, Morten; Jensen, Henrik S.; Angelo, Kamilla; Dupuis, Delphine S; Vogel, Lotte K; Jorgensen, Nanna K; Klaerke, Dan A; Olesen, Søren-Peter.

    In: Journal of Cell Science, Vol. 117, No. Pt 19, 2004, p. 4517-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Coassembly of big conductance Ca2+-activated K+ channels and L-type voltage-gated Ca2+ channels in rat brain. / Grunnet, Morten; Kaufmann, Walter A.

    In: Journal of Biological Chemistry, Vol. 279, No. 35, 2004, p. 36445-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Difference in allelic expression of the CLCN1 gene and the possible influence on the myotonia congenita phenotype. / Dunø, Morten; Colding-Jørgensen, Eskild; Grunnet, Morten; Jespersen, Thomas; Vissing, John; Schwartz, Marianne.

    In: European Journal of Human Genetics, Vol. 12, No. 9, 2004, p. 738-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Does KCNE5 play a role in long QT syndrome? / Hofman-Bang, Jacob; Jespersen, Thomas; Grunnet, Morten; Larsen, Lars Allan; Andersen, Paal Skytt; Kanters, Jørgen Kim; Kjeldsen, Keld; Christiansen, Michael.

    In: Clinica Chimica Acta, Vol. 345, No. 1-2, 2004, p. 49-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog. / Grunnet, Morten; Jespersen, Thomas; Perrier, Jean-Francois Marie.

    In: Journal of Neuroscience Research, No. 78, 2004, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. 2003
  103. Published

    A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1. / Angelo, Kamilla; Korolkova, Yuliya V; Grunnet, Morten; Grishin, Eugene V; Pluzhnikov, Kirill A; Klaerke, Dan A; Knaus, Hans-Günther; Møller, Morten; Olesen, Søren-Peter.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 447, No. 1, 2003, p. 55-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton. / Jorgensen, Nanna K; Pedersen, Stine F; Rasmussen, Hanne B; Grunnet, Morten; Klaerke, Dan A; Olesen, Søren-Peter.

    In: BBA General Subjects, Vol. 1615, No. 1-2, 2003, p. 115-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis. / Nørremølle, Anne; Grunnet, Morten; Hasholt, Lis; Sørensen, Sven Asger.

    In: Journal of Neuroscience Research, Vol. 71, No. 1, 2003, p. 132-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Characterization of two new dominant ClC-1 channel mutations associated with myotonia. / Grunnet, Morten; Jespersen, Thomas; Colding-Jørgensen, Eskild; Schwartz, Marianne; Klaerke, Dan A; Vissing, John; Olesen, Søren-Peter; Dunø, Morten.

    In: Muscle & Nerve, Vol. 28, No. 6, 2003, p. 722-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels. / Ljungstrom, Trine; Grunnet, Morten; Jensen, Bo Skaaning; Olesen, Søren-Peter.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 446, No. 6, 2003, p. 684-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. / Grunnet, Morten; Rasmussen, Hannne B; Hay-Schmidt, Anders; Rosenstierne, Maiken; Klaerke, Dan A; Olesen, Søren-Peter; Jespersen, Thomas.

    In: Biophysical Journal, Vol. 85, No. 3, 2003, p. 1525-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. Published

    KCNQ1 channels sense small changes in cell volume. / Grunnet, Morten; Jespersen, Thomas; MacAulay, Nanna; Jørgensen, Nanna K; Schmitt, Nicole; Pongs, Olaf; Olesen, Søren-Peter; Klærke, Dan Arne.

    In: Journal of Physiology, Vol. 549, No. Pt 2, 2003, p. 419-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. Published

    Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon. / Hay-Schmidt, Anders; Grunnet, Morten; Abrahamse, Salomon L; Knaus, Hans-Günther; Klaerke, Dan A.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 446, No. 1, 2003, p. 61-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  111. Published

    Pharmacological investigation of the role of ion channels in salivary secretion. / Stummann, Tina C; Poulsen, Jørgen H; Hay-Schmidt, Anders; Grunnet, Morten; Klaerke, Dan A; Rasmussen, Hanne B; Olesen, Søren-Peter; Jorgensen, Nanna K.

    In: Pflügers Archiv: European Journal of Physiology, Vol. 446, No. 1, 2003, p. 78-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  112. Published

    Solid-phase synthesis and biological activity of a thioether analogue of conotoxin G1. / Bondebjerg, Jon; Grunnet, Morten; Jespersen, Thomas; Meldal, Morten.

    In: ChemBioChem, Vol. 4, No. 2-3, 2003, p. 186-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  113. Published

    The role og K+ and C1- channels in salivary secretion. / Stummann, T.C.; Poulsen, Jørgen Hedemark; Hay-Schmidt, Anders; Grunnet, Morten; Klærke, Dan Arne; Olesen, Søren-Peter; Jørgensen, Nanna Koschmieder.

    In: Pflügers Archiv: European Journal of Physiology, No. 446, 2003, p. 78-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  114. Published

    The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia. / Grunnet, Morten; Rasmussen, Hanne B; Hay-Schmidt, Anders; Klaerke, Dan A.

    In: BBA General Subjects, Vol. 1616, No. 1, 2003, p. 85-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  115. 2002
  116. Published

    Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. / Jespersen, Thomas; Grunnet, M; Angelo, K; Klaerke, D A; Olesen, S P.

    In: BioTechniques, Vol. 32, No. 3, 01.03.2002, p. 536-8, 540.

    Research output: Contribution to journalJournal articleResearchpeer-review

  117. Published

    KCNE4 is an inhibitory subunit to the KCNQ1 channel. / Grunnet, Morten; Jespersen, Thomas; Rasmussen, Hanne Borger; Ljungstrøm, Trine; Jorgensen, Nanna K; Olesen, Søren-Peter; Klaerke, Dan A.

    In: Journal of Physiology, Vol. 542, No. Pt 1, 2002, p. 119-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  118. Published

    KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. / Angelo, Kamilla; Jespersen, Thomas; Grunnet, Morten; Nielsen, Morten Schak; Klaerke, Dan A; Olesen, Søren-Peter.

    In: Biophysical Journal, Vol. 83, No. 4, 2002, p. 1997-2006.

    Research output: Contribution to journalJournal articleResearchpeer-review

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