Michael Givskov

Michael Givskov

Professor

  • Bacteriology

    22, Building: 22.2.22

    2200 København N

    Phone: +45 35 32 78 55Mobile: +45 21 40 98 67

Introductory remarks on publicationslist

Publications and Citations

170 publications: 132 peer reviewed articles and 21 review articles (including 2 in Chinese journals), 6 patent applications (3 patents held) + 2 more pending in 2008, 10 book chapters, 1 book (editor), 3 reviews for public outreach activities. Sum of citations (December, 2008) 6.613, H-index 49. Current international citation rate ~ 90 citations per month.

Publication list

  • 1. Givskov, M., and Molin, S. (1984) Copy mutants of plasmid R1: Effects of base pair substitutions in the copA gene on the replica­tion control system. Mol Gen Genet. 194:286-292
  • 2. Molin, S., Givskov, M., and Riise, E. (1985) Bac­terial enzymes. Patent DK 2100/85.
  • 3. Givskov, M., Stougaard, P., Light, J., and Molin, S. (1987) Identi­fi­cation and characterization of muta­tions responsible for a runaway replication phenotype of plasmid R1. Gene 57:203-211.
  • 4. Givskov, M., Olsen, L., and Molin, S. (1988) Cloning and ex­pres­sion in Escherichia coli of the gene for an extracellular phospholi­pase from Serratia liquefaci­ens. J Bacteriol 170: 5855-5862.
  • 5. Molin, S., Givskov, M., Kristensen, C. S., Pej, A., and Eberl, L. (1992). A method of limiting the survival of genetically engine­ered microorga­nisms in their environment. USA Patent 07/863,2­61.
  • 6. Givskov, M., and Molin, S. (1992) Expression of extracellular phospholi­pase from Serratia liquefa­ci­ens is growth phase-depen­dent, catabolite repressed and regulated by anaerobio­sis. Molec Microbiol 6:1363-1374.
  • 7. Eberl. L., Givskov. M., and Schwab. H. (1992) The divergent pro­moters mediating transcription of the par locus of plasmid RP4 are subject to autoregula­tion. Molec Microbiol 6:1969-1979.
  • 8. Givskov, M., and Molin, S. (1993) Secretion of Serratia liquefa­ciens phospholipase from Escherichia coli. Molec Microbiol 8:229-242.
  • 9. Molin, S., Boe, L., Jensen, L. B., Kristensen, C. S., Givskov, M., Ramos, J.L., and Bej, A.K. (1993). Suicidal genetic elements and their use in biological containment of bacteria. Annu Rev Microbiol 47:139-166.
  • 10. Givskov, M., Eberl, L., Møller, S., Poulsen, L. K., and Molin. S (1994) Responses to nutri­ent starvation in Pseudo­monas putida KT2442: Analysis of general cross-protection, cell shape, and macromole­cular content. J Bacteriol 176:7-14.
  • 11. Givskov, M., Eberl, L., and Molin, S (1994) Responses to nutri­ent starvation in Pseudomonas putida KT2442: 2-Dimensio­nal electrofo­re­tic analysis of starvation and stress in­ducible proteins. J Bac­teriol 176:4816-4824.
  • 12. Eberl. L., Kristensen. C., Givskov. M., Grohmann. E., Gerlitz. M., and Schwab. H. (1994) Analysis of the multimer resolution system encoded by the parCBA operon of broad-host-range plasmid RP4. Molec Micro­biol 12:131-141.
  • 13. Ravn, P., Givskov, M., Eegholm, K. M., Madsen. S. M., and Boe. L. (1994). Observations on the formation of deletions on mono­meric and dimeric plasmids in Escherichia coli. Molec Microbiol 14:263-270.
  • 14. Givskov, M., Eberl, L., Christiansen, G., Benedik, M.J., and Molin, S. (1995). Induction of phospholi­pase- and fla­gellar synthe­sis in Serratia liquefaci­ens is con­trolled by expres­sion of the flagellar ma­ster operon flhD. Molec Microbi­ol 15:445-454
  • 15. Kristensen, C. S., Eberl, L., Sanchez-Romero, J. M., Givskov, M., Molin, S., and deLorenzo, V. (1995) Site-specific dele­tions of chromosomal DNA segments with the multimer resolu­tion system (mrs) of the broad-host-range plasmid RP4. J bacteri­ol 177:52­-58.
  • 16. van Overbeek,­ L.S., Eberl, L., Givskov, M., Molin, S., and van Elsas, J.D. (1995) Survival of, and induced stress resistance in, carbon-starved Pseudomonas fluores­cens cells residing in soil. Appl Environ Microbiol 61:4202-4208
  • 17. Kjelleberg, S., Steinberg, P., de Nys, R., Manefield, M., Givskov, M., and Gram, L. (1995) Microbiocide and microbial regulator. Australia patent application 94/450.
  • 18. Eberl, L., Givskov, M., Møller, S., Christiansen, G., and Molin, S. (1996) Responses to phosphate starvation in Pseudomo­nas putida KT2442. Microbiol 142:155-163
  • 19. Eberl, L., Christiansen, G., Molin, S., and Givskov, M.(1996) Differen­tiation of Serratia liquefaciens into swarm cells is controlled­ by the expression of the flhD master operon. J Bacteriol 178:554-559
  • 20. Eberl, L., Winson, M.K., Sternberg, C., Stewart, G. S. A. B., Christi­ansen, G., Chhabra, S.R., Daykin, M., Williams, P., Moli­n, S., and Giv­sk­ov, M. (19­96) In­vol­ve­ment of N-acyl-L-homoserine lactone autoinducers in control of multicellular behavior of Serra­tia liquefaciens. Molec Micro­biol 20:127-136.
  • 21. de Nys, R., M. Givskov, L. Gram, S. Kjelleberg, M. Manefield, R. Maximilien, and P. Steinberg 1996. Inhibiting microbial processes regulated by homoserine lactone - using furanone drivs., pref. from algae, e.g. to prevent motility, swarming and enzyme production in pathogenic bacteria. Patent WO9629392-A1.
  • 22. Givskov, M., de Nys, R., Manefield, M., Gram, L., Maximilien, R., Eberl, L., Molin, S., Steinberg, P. D., and Kjelleberg, S. (1996) Eukaryotic interfer­ence with homoserine lactone mediated procary­otic signalling. J Bacteriol 178:6618-6622.
  • 23. Gram, L., de Nys, R., Maximilien, R., Givskov, M., Steinberg, P. D., and Kjelleberg, S. (1996) Inhibitory effects of furanones from the red alga Delisea pulchra on swarming motility of Proteus mirabilis. Appl Environ Microbiol 62:4284-4287.
  • 24. Eberl, L., Givskov, M., Poulsen, L. K., and Molin, S. (1997) Use of biolumines­cence for monitoring the viability of individual Pseudo­monas putida KT2442 cells. FEMS Microbiol Lett 149:129-132.
  • 25. Givskov, M., Eberl, L., and Molin, S. (1997). Control of exoenzyme production, motility and cell differentiation in Serratia liquefaci­ens. FEMS Microbiol Lett 148:115-122 Review
  • 26. Kjelleberg, S. Steinberg, P. D., Givskov, M., Manefield, M., and de Nys, R. (1997). Do marine products interfere with procaryotic AHL regulatory systems? Review Aquat Microbiol Ecol 13:85-93.
  • 27. Givskov, M., Östling, J., Lindum, P. W., Eberl, L., Christiansen, G., Molin, S., and Kjelleberg, S. (1998). The participation of two seperate regulatory systems in controlling swarming motility of Serratia liquefaciens (J Bacteriol 180:742-745)
  • 28. Møller, S., Sternberg, C., Andersen, J. B., Christensen, B. B., Ramos, J. L., Givskov, M., and Molin, S. (1998). In situ gene expression in mixed culture biofilms: evidence of metabolic interactions between community members (Appl Environ Microbiol 64: 721-732)
  • 29. Andersen, J. B., Sternberg, C., Poulsen, L. K., Bjørn, S. P., Givskov, M., and Molin, S. (1998) New unstable variants of green fluorescent protein for studies of transient gene expression in Bacteria (Appl Environ Microbiol 64:2240-2246).
  • 30. Christensen, B. B., Sternberg, C., Andersen, J. B., Eberl, L., Møller, S., Givskov, M., and Molin, S. (1998) Establishment of new genetic traits in a model community for degradation of benzyl alchohol. Appl Environ Microbiol 64:2247-2255.
  • 31. Eberl, L., Ammendola, A., Geisenberger, O., Schulze, R., Givskov, M., Sternberg, C., Molin, S., and Schleifer, K. H. (1998) Use of green flourescent protein for online, single cell detection of bacteria introduced into activated sludge microcosms. Biofilm 3, 1
  • 32. Ammendola, A., Geisenberger, O., Andersen, J. B., Givskov, M., Schleifer, K. H., and Eberl, L. (1998) Serratia liquefaciens swarm cells exhibit enhanced resistance to predation by Tetrahymena sp. FEMS Microbiol Lett 164:69-75
  • 33. Maximilien, R., de Nys, R., Holmström, C., Gram, L., Givskov, M., Crass, K., Kjelleberg, S., and Steinberg, P. D. (1998) Chemical mediation of bacterial surface colonisation by secondary metabolites from the red alga Delisea pulchra. Aquat Microbiol Ecol 15:233-246.
  • 34. Hansen, M. C., Tolker-Nielsen, T., Givskov, M., and Molin, S (1998) Biased 16S rDNA PCR amplification caused by interference from DNA flanking the template region. FEMS Microbiol Lett 26:141-149
  • 35. Givskov, M., and Søgaard-Andersen, L. (1998) Kommunikation hos bakterier. Naturens verden 5:207-216. Review
  • 36. Lindum, P. W, U. Anthoni, C. Christoffersen, L. Eberl, S. Molin, and M. Givskov. (1998). N-acyl-L-homoserine lactone autoinducers control production of an extracellular surface active lipopeptide required for swarming motility of Serratia liquefaciens MG1. J Bacteriol 180: 6384-6388.
  • 37. Molin, S., Nielsen, A.T. Christensen, B.B., Andersen, J.B., Licht, T.R., Tolker-Nielsen,T., Sternberg, C., Hansen, M.C., Ramos, C., and Givskov, M. (1999). Molecular ecology of biofilms. In: Biofilms, 2nd edition (ed. James Bryers), J Wiley & Sons, Inc. BooK chapter.
  • 38. Manefield, M., DeNys, R., Kumar, N., Read, R., Givskov, M., Steinberg, P., and Kjellebjerg, S (1999) Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein Microbiology 145: 283-291
  • 39. Madsen, S., Arnau, J., Vrang, A., Givskov, M., and Israelsen, H. (1999) Molecular analysis and characterization of a pH and stationary phase inducible promoter, P170, from Lactococcus lactis Molec Microbiol 32:75-87.
  • 40. Christensen, BB., Sternberg, C., Andersen, JB., Palmer, RJ., Nielsen, AT., Givskov, M., and Molin, S (1999) Molecular tools in physiological studies of microbial biofilms. Meth Enzymol 310:20-42
  • 41. Eberl, L., Molin, S., and Givskov, M (1999). Surface motility in Serratia liquefaci­ens. J Bacteriol 181:1703-1712. Review
  • 42. Mathee, K., Ohman, D., E, Ciofu, O., Sternberg, C., Lindum, P., Campbell, J., Jensen, P., Givskov, M., Molin, S., Høiby, N., Kharazmi, A. (1999) Mucoid Conversion of Pseudomonas aeruginosa by Hydrogen Peroxide: A Potential Mechanism for Virulence Activation in the Cystic Fibrosis Lung Microbiology 145: 1349-1357.
  • 43. Gram, L., Christensen, A. B., Ravn, L., Molin, S., and Givskov, M. (1999) Production of acylated homoserine lactones by psychrotrophic Enterobacteriaceae isolated from foods. Appl. Envir. Microbiol. 65: 3458-3463
  • 44. Rice, S.A., Givskov, M, Steinberg, and Kjelleberg, S (1999) Bacterial signals and antagonists: The interaction between bacteria and higher organisms. J Mol Microbiol Biotechnol 1: 23-31.
  • 45. Molin, S., and Givskov, M (1999) Application of molecular tools for in situ monitoring of bacterial growth activity. Environ Microbiol 1:383-391.
  • 46. Sternberg, C., Christensen, BB., Johansen, T., Andersen, JB., Givskov, M., and Molin, S (1999) Distribution of bacterial growth activity in flow-chamber biofilms Appl Eviron Microbiol 65:4108-4117.
  • 47. Holden MT, Ram Chhabra S, De Nys R, Stead P, Bainton NJ, Hill PJ, Manefield M, Kumar N, Labatte M, England D, Rice S, Givskov M, Salmond GP, Stewart GS, Bycroft BW, Kjelleberg S, Williams P (1999) Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria. Molec Microbiol 33:1254-1266
  • 48. Givskov, M., Andersen, J. B., Henzer, M., Heidorn, A., Molin, S., Eberl, L., deNys, R., Manefield, M., Steinberg, P. D., Kjelleberg, S., Wu, H., Song, Z., and Høiby, N. (1999). Quorum sensing and eukaryote-prokaryote interactions. Clin Microbiol Infect 5:6-7 . Review
  • 49. Bees, M. A., Andresèn, P., Mosekilde, E., and Givskov, M. (2000) The interaction of thin-film flow, bacterial swarming and cell differentiation in colonies of Serratia liquefaciens. J Math Biology 40:27-63.
  • 50. Krogfelt, K. A., Hjulgaard, M., Sørensen, K., Cohen, S., and Givskov, M. (2000) Escherichia coli BJ4 colonization of the streptomycin-treated mouse large intestine is independent of rpoS-gene function. Infect and Immun 68: 2518-2524.
  • 51. Geisenberger, O., M. Givskov, K. Riedel, N. Høiby, B. Tümmler, and L. Eberl. (2000). Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS Microbiol. Lett. 184:273-277.
  • 52. Tolker-Nielsen, T., Christensen, A. B., Eberl, L., Rasmussen, T. B., Sternberg, C., Molin, S., and Givskov, M. (2000) Assessment of flhDC mRNA levels in individual Serratia liquefaciens swarm cells. J Bacteriol 182:2680-2686.
  • 53. Kjelleberg S, and Givskov M (2000) Communication systems as targets for biological control. Environ microbiol 2: 5-5
  • 54. Eberl, L., Ammendola, A., Rothballer, M. H., Givskov, M., Sternberg, C., Kilstrup, M., Schleifer, K-H., and Molin, S. (2000) Inactivation of gltB Abolishes Expression of the Assimilatory Nitrate Reductase Gene (nasB) in Pseudomonas putida KT2442J. Bacteriol. 182: 3368-3376
  • 55. Charlton, T. S., de Nys, R., Netting, A., Kumar, N., Hentzer, M., Givskov, M., Kjelleberg, S (2000) A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: Application to a model bacterial biofilm. Environ Microbiol, 2: 530-541 .
  • 56. Charlton, T., Givskov, M., deNys, R., Andersen, J. B., Hentzer, M., Rice, S., and Kjelleberg, S. (2000) Genetic and Chemical Tools for Investigating Signaling Processes in Biofilms (Methods in Enzymology 336:108-128).
  • 57. Heydorn, A., Nielsen, A. T., Hentzer, M., Sternberg, C., Givskov, M., Ersbøll, B. K., Molin, S. (2000). Quantification of biofilm structures by the novel computer program comstat Microbiology 146: 2395-2407.
  • 58. Heydorn, A., B. K. Ersboll, M. Hentzer, M. R. Parsek, M. Givskov & S. Molin. (2000). Experimental reproducibility in flow-chamber biofilms Microbiology; 146: 2409-2415.
  • 59. Wu, H., Song, Z., Henzer, M., Andersen, J. B, Heidorn, A., Mathee, K., Moser, C., Molin, S., Høiby, N., and Givskov, M. (2000). Detection of N-acyl-homoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiol 146: 2481-2493
  • 60. Rasmussen, T. B., Manefield, M., Andersen,J.B., Eberl, L., Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S., and Givskov, M. (2000). How Delisea pulchra furanones affect quorum-sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 146: 3237-3244.
  • 61. DeNys, R., Rice, S., Manefield, M., Srinivasan, S., McDougald, D., Loh, A., Lindum, P., Östling, J., Givskov, M., Steinberg, P. D., and Kjelleberg, S (2000) Cross-talk in bacterial extracellular systems. In: Microbial ecosystem: New Frontiers. Bell, C. R., Brylinsky, P., and Johnson, P (eds.). Atlantic Canada Society for Microbiology, Halifax. pp. 279-285.
  • 62. Andersen, J. B., Heydorn, A., Hentzer, M., Eberl, L., Geisenberger, O., Molin, S., and Givskov, M (2001) gfp based N-acyl-homoserine-lactone monitors for detection of bacterial communication. App Environ Microbiol, 67: 575-585.
  • 63. Riedel, K., Ohnesorg, T., Krogfelt, K. A., Hansen, T. S., Omori, K., Givskov, M., and Eberl, L. (2001). N-Acyl-L-homoserine lactone-mediated regulation of the Lip secretion system in Serratia liquefaciens MG1. J. Bacteriol 183: 1805-1809.
  • 64. Wu, H., Song, Z., Givskov, M., Doring, G., Mathee, K., Rygaard, J., and Høiby, N. (2001) Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection. Microbiology.147:1105-13.
  • 65. Gram, L., and Givskov, M (2001) Kommunikation hos bakterier - i mad og andre steder. Naturens Verden 84:18-25. Review.
  • 66. Ravn, L., A.B. Christensen, S. Molin, M. Givskov and L. Gram. (2001). Methods for identifying and quantifying acylated homoserine lactones produced by Gram-negative bacteria and their application in studies of AHL-production kinetics. J Microbiol Methods 44: 239-251.
  • 67. Huber, B., Riedel, K., Hentzer, M., Heydorn, A., Gotschlich, A., Givskov, M., Molin, S., and Eberl, L. (2001) The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility. Microbiol 147:2517-28.
  • 68. Hentzer, M., Teitzel, G., Balzer, G., Heydorn, A., Molin S., Givskov, M., and Parsek, M. R. (2001) Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function. J. Bacteriol 183:5395-401.
  • 69. Riedel, K., Hentzer, M., Geisenberger, O., Huber, B., Steidle, A., Wu, H., Høiby, N., Givskov, M., Molin, S., and Eberl, L. (2001). N-Acyl homoserinelactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiol 147:3249-62.
  • 70. Steidle, A., Sigl, K., Schuhegger, R., Ihring, A., Schmid, M., Stoffels, M., Riedel, K., Givskov, M., Hartmann, A., Langebartels, C., Eberl, L. (2001) Visualization of N-Acylhomoserine Lactone (AHL)-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere Appl. Environ. Microbiol. 67: 5761-5770
  • 71. Manefield, M., Welch, M., Givskov, M., Salmond, G. P. C., and Kjelleberg, S. (2001). Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. FEMS Microbiol Lett. 27 205:131-8.
  • 72. Olsen, J. A., R. Severinsen, T. B. Rasmussen, M. Hentzer, M. Givskov and J. Nielsen (2002) Synthesis of New 3- and 4-Substituted Analogs of Acyl Homoserine Lactone Quorum Sensing Autoinducers. Bioorg Med Chem Lett.12:325-8.
  • 73. Hentzer, M., K. Riedel, T. B. Rasmussen, A. Heydorn, J. B. Andersen, M. R. Parsek, S. Rice, L. Eberl, S. Molin, S., Høiby, N., Kjelleberg, and M. Givskov (2002). Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiol 148:87-102.
  • 74. Manefield, M., Rasmussen, T. B., Kumar, N., Hentzer, M., Andersen, J. B., Steinberg, P., Kjelleberg, S., and Givskov M (2002). Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiol 148, 1119-1127.
  • 75. Bees, M. A., Andrèsen, P., Mosekilde, E., and Givskov, M. (2002) Quantitative effects of medium hardness and nutrient availability on the swarming of Serratia liquefaciens. Bull Math Biol.64:565-87.
  • 76. Hentzer, M., Givskov, M., and Parsek, M. R. (2002) Targeting Quorum Sensing for Treatment of Chronic Bacterial Biofilm Infections. Lab Medicine 33:295-306.
  • 77. Gram, L., Ravn, L, Rasch, M., Bruhn, J.B., Christensen, A. B., and Givskov, M (2002) Food spoilage - interactions between food spoilage bacteria. International Journal of Food Microbiology 78: 79-97.
  • 78. Heydorn, A., Ersbøll, B., Kato, J., Hentzer, M., Parsek, M. R., Tolker-Nielsen, T., Givskov, M., and Molin, S. (2002) A Statistical Analysis of Pseudomonas aeruginosa Biofilm Development: Impact of Mutations in Genes Involved in Twitching Motility, Cell-to-cell Signaling and Stationary Phase Gene Expression. Appl Environ Microbiol.68:2008-17.
  • 79. Laux, D. C., Corson, J. M., Givskov, M., Hentzer, M., Møller, N., Olson, J. C., Krogfelt, K. A., Goldberg, J. B., and Cohen, P. S. (2002) Lysophosphatidic Acid Regulation of Pseudomonas aeruginosa Elastase and LasA. Microbiol 148: 1709-1723
  • 80. Schembri, M. A., Givskov, M., and Klemm, P (2002). An Attractive Surface: Gram-negative Bacterial Biofilms. Sci STKE. 14 (132):RE6. Review
  • 81. Koch, B., Nielsen, T. H., Sørensen, D., Andersen, J. B., Christophersen, C., Molin, S., Givskov, M., Sørensen, J., Nybroe, O. (2002) Lipopeptide production in Pseudomonas sp. strain DSS73 is regulated by components of sugarbeet seed exudate via the Gac two-component regulatory system. Appl Environ Microbiol 68:4509-16.
  • 82. Nielsen J and Givskov M (2002) Compounds and methods to control bacterial virulence. (PCT patent application).
  • 83. Givskov, M., Hentzer, M., Kjelleberg, S (2002) A method of causing sloughing (Australian patent application).
  • 84. Nielsen, T. H., D. Sørensen, C. Tobiasen, J. B. Andersen, P. S. Lübeck, B., C. Christophersen, S. Molin, M. Givskov, and J. Sørensen (2002). Antibiotic and biosurfactant properties of cyclic lipopeptides produced by soil fluorescent Pseudomonas spp. from two Danish agricultural soils. Appl Environ Microbiol.68:3416-23.
  • 85. Bagge N, Ciofu O, Hentzer M, Campbell JI, Givskov M, Hoiby N. (2002). Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD. Antimicrob Agents Chemother. 46(11):3406-11.
  • 86. Agersø, Y., Jensen, L. B., Givskov, M., and Roberts, M. C. (2002) The identification of the tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group. FEMS Microbiol Lett.214:251-6.
  • 87. Huber B, Riedel K, Köthe1 M, Givskov M, Molin S and Eberl L (2002) Genetic Analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111. Mol Microbiol. 46:411-26.
  • 88. Givskov, M., and Rasmussen, T. B. (2002) Quorum sensing hæmmere: en ny måde at bekæmpe bakterielle infektioner på. Dansk Kemi 83(11):32-36. Review
  • 89. Steidle A, Allesen-Holm M, Riedel K, Berg G, Givskov M, Molin S, Eberl L. (2002) Identification and Characterization of an N-Acylhomoserine Lactone-Dependent Quorum-Sensing System in Pseudomonas putida Strain IsoF. Appl Environ Microbiol. 68:6371-82.
  • 90. Christensen, A. B., Riedel, K., Eberl, L., Flodgaard, L, R., Molin, S., Gram, L., and Givskov, M. (2003) Quorum sensing directed protein expression in Serratia proteamaculans B5a. Microbiol 149:471-483.
  • 91. Andersen JB, Koch B, Nielsen TH, Sørensen D, Hansen M, Nybroe O, Christophersen C, Sørensen J, Molin S and Givskov, M (2003) Surface motility in Pseudomonas sp. DSS73 is required for efficient biological containment of the root pathogenic microfungi Rhizoctonia solani and Pythium ultimum. Microbiol 149(pt1):37-46.
  • 92. Hentzer, M., Eberl, L., Nielsen J., and Givskov, M (2003) Quorum sensing: a novel target for treatment of biofilm infections. Biodrugs 17(4):241-250. Review
  • 93. Hjemlmgaard, T., Persson, T., Rasmussen, T. B., Givskov, M., and J. Nielsen (2003) Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. Bioorg Med Chem 69(7):3261-3271
  • 94. M. Manefield, S. Kjelleberg, and M. Givskov. (2003) Controlling bacterial infection through AHL mediated gene expression. Curr Med Chemistry-Anti-Infect Agents. 2:213-218
  • 95. Hentzer, M., Wu, H., Andersen, J.B., Riedel, K., Rasmussen, T.B., Bagge, N., Kumar, N., Schembri, M., Song, Z., Kristoffersen, P., Manefield, M., Eberl, L., Costerton, J.W., Molin, S., Steinberg, P., Kjelleberg, S., Høiby, N., and Givskov M. (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 22(15):3803-3815
  • 96. Riedel, K., Talker-Huiber, D., Givskov, M., Schwab, H., Eberl, L. (2003) Identification and characterization of a GDSL esterase located proximal to the swr quorum-sensing system of Serratia liquefaciens MG1. Appl Environ Microbiol.69(7):3901-10.
  • 97. Wu, H., Song, Z., Hoiby, N., and Givskov, M (2003) Bacterial cell-cell communication - Gram negative bacterial quorum sensing systems. Prog Nat Sci (China) 13(7): 679-687. Review
  • 98. Webb, J.S., Thompson, L., James, S., Charlton, T., Tolker-Nielsen, T., Koch, B., Givskov, M., Kjelleberg, S. (2003). Cell death in Pseudomonas aeruginosa biofilm development. J Bacteriol 185(15):4585-92.
  • 99. Song, Z., Wu, H., Givskov, M., and Hoiby, N. (2003) Bacterial biofilms and antibiotic resistance. Prog in Nat Sci, China 13(10):1015-1021. Review
  • 100. Flodgaard RL, Christensen AB, Molin S, Givskov M, Gram L. 2003 Influence of food preservation parameters and associated microbiota on production rate, profile and stability of acylated homoserine lactones from food-derived Enterobacteriaceae. Int J Food Microbiol. 84(2):145-156
  • 101. Hentzer, M., and Givskov, M (2003) Pharmacological Inhibition of Quorum Sensing for Treatment of Chronic Bacterial Infections. J Clin Invest 112(9):1300-7. Review
  • 102. Labbate, M., Queck, S.Y., Rice, S. A., Givskov, M., and Kjelleberg, S. (2004) Quorum sensing controlled biofilm development in Serratia liquefaciens MG1. J Bacteriol 186(3): 692-698.
  • 103. Webb, J.S, Givskov M., Kjelleberg S (2003) Bacterial biofilms: prokaryotic adventures in multicellularity. Curr Opin Microbiol. 2003 Dec; 6(6):578-85. Review.
  • 104. Arevalo-Ferro C, Hentzer M, Reil G, Görg A, Kjelleberg S, Givskov M, Riedel K, Eberl L (2003) Identification of quorum sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics. Environ Microbiol.5(12):1350-1369.
  • 105. Rasch M, Buch C, Austin B, Slierendrecht W.J, Ekmann K.S, Larsen J.L, Johansen C, Riedel K, Eberl L, Givskov M and Gram L. (2004). An inhibitor of bacterial quorum sensing reduced mortalities caused by vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum) Syst. Appl. Microbiology 27: 350-359.
  • 106. Wu, H., Song, Z., Givskov, M and Hoiby, N. (2004). Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa. Microbes Infect. 6(1): 34-7.
  • 107. Bagge N, Hentzer M, Andersen, J.B, Ciofu O, Givskov M, and Hoiby N. (2004) Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.Antimicrob Agents Chemother. 48(4):1168-74.
  • 108. Bagge N, Schuster M, Hentzer M, Ciofu O, Petersen B. P., Duus J.Ø., Givskov M, Greenberg E.P., and Hoiby N. (2004). Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production. Antimicrob Agents Chemother. 48(4):1175-87.
  • 109. Wu H, Song Z, Hentzer M, Andersen J.B, Molin S, Givskov M, and Høiby N. 2004 Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. J Antimicrob Chemother. 53(6):1054-61
  • 110. Zhu, H., Bandara, R., Conibear, T. C., Thuruthyil, S.J., Rice, S.A., Kjelleberg, S., Givskov, S., and Willcox, M. D. (2004). Pseudomonas aeruginosa with LasI quorum-sensing deficiency during corneal infection. Invest Ophthalmol Vis Sci. 45(6):1897-903
  • 111. Hentzer, M., Eberl, L., and Givskov, M. (2004) Quorum sensing in Biofilms: Gossip in the slime world? pp 118-140. In Microbial biofilms, Eds M. Ghannoum & G.O'Toole, ASM Press, Washington, D.C.Book chapter.
  • 112. Givskov, M (2004) Intelligent bakteriebekæmpelse. Aktuel Naturvidenskab 2:25-27. Review
  • 113. Danhorn, T., Hentzer,M., Givskov,M., Parsek,M. R., Fuqua, C. (2004) Phosphorus Limitation Enhances Biofilm Formation of the Plant Pathogen Agrobacterium tumefaciens through the PhoR-PhoB Regulatory System J. Bacteriol. 186:1448-03
  • 114. Bruhn, J.B., Christensen, A.B., Flodgaard, L.R., Nielsen, K.F., Larsen, T.O., M. Givskov and Gram L. (2004). Presence of acylated homoserine lactones (AHLs) and AHL producing bacteria in meat and the potential role of AHL in spoilage of meat. Appl. Environ. Microbiol. 70:4293-4302
  • 115. Persson, T., Johansen, S.K., Martiny, L., Givskov, M., and Nielsen, J. (2004) Synthesis of carbon-14 labelled (5Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone: a potent quorum sensing inhibitor. J Label Compd Radiopharm. 47:627-634.
  • 116. Chhabra, S.R., Eberl, L., Givskov, M., Philip, B., Williams, P and Cámara, M. (2005) Extracellular communication in bacteria. Pheromones and other Semiochemicals Vol 2. (Ed. S.. Schulz) Springer-Verlag. Topics in Current Chemistry 240: 279-315. Book chapter.
  • 117. Rasmussen TB, Bjarnsholt T, Skindersoe ME, Hentzer M, Kristoffersen P, Köte M, Nielsen J, Eberl L, Givskov M. 2005. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J Bacteriol. 187(5):1799-814.
  • 118. Bjarnsholt T., Jensen P.Ø., Burmølle M., Hentzer M., Haagensen J.A., Hougen H.P., Calum H., Madsen K.G., Moser C., Molin S., Hoiby N., Givskov M. 2005. Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology.151:373-83.
  • 119. Persson T, Hansen TH, Rasmussen TB, Skinderso ME, Givskov M, Nielsen J. 2005 Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic. Org Biomol Chem. 21;3(2):253-62.
  • 120. Jelsbak L, Givskov M, Kaiser D. 2005 Enhancer-binding proteins with a forkhead-associated domain and the {sigma}54 regulon in Myxococcus xanthus fruiting body development. Proc Natl Acad Sci U S A. 22;102(8):3010-5.
  • 121. Hoffmann, N., Rasmussen, T.B., Jensen, P.Ø., Stub, C., Hentzer, M., Molin, S., Ciofu, O., Givskov, M., Johansen, H.K., Høiby, N. (2004). A Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis. Infection and Immunity 73(4):2504-14..
  • 122. Rasch, M., J.B. Andersen, K.F. Nielsen, L. R. Flodgaard, H. Christensen, M. Givskov and L. Gram 2005. Involvement of bacterial quorum sensing signals in spoilage of bean sprouts. Appl. Environ. Microbiol. 71(6):3321-30.
  • 123. Flodgaard, L.R., P. Dalgaard, J.B. Andersen, K.F. Nielsen, M. Givskov and L. Gram 2005. Non-bioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal 3-hydroxyl-octanoyl homoserine lactone. Appl. Environ. Microbiol. 71(4):2113-20.
  • 124. Hentzer,M., Eberl,L., Givskov,M. (2005) Transcriptome Analysis of Pseudomonas aeruginosa. Biofilms. 2(1): 37-61.
  • 125. Hentzer, M., and Givskov, M. (2005) Jamming bacterial communication: new strategies to combat bacterial infections and the development of biofilms. In Bacterial Cell-to-Cell Communication:Role in Virulence and Pathogenesis.Demuth DR, Lamont R(eds.), Cambridge UniversityPress, Cambridge, UK. Book chapter.
  • 126. Rasmussen, T.B., Skindersoe, M.E., Bjarnsholt, T., Phipps, R.K., Christensen, K.B., Andersen, J.B., Larsen, T.O., Hentzer, M., Eberl, L., and Givskov, M. (2005) Identity and Effects of Quorum Sensing Inhibitors Produced by Penicillium Species. Microbiol. 151 (5):1325-40.
  • 127. Bragonzi, A., Worlitzsch, D., Pier, G. B., Hentzer, M., Givskov, M., Conese, M., and Döhring, G (2005). Non-mucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a murine model. Journal Infectious Diseases 192(3):410-9.
  • 128. Koch,B., Liljefors, T., Persson, T., Nielsen,J., Kjelleberg, S., and Givskov, M. (2005) The LuxR receptor: the sites of interaction with quorum sensing signals and inhibitors. Microbiol. 151(Pt 11):3589-602.
  • 129. Bjarnsholt, T., Jensen, P. Ø., Rasmussen, T.B., Christophersen, L., Calum, H., Hentzer, M., Hougen, H-P., Rygaard, J., Moser, C., Eberl, L., Høiby, N., and Givskov, M. (2005). Garlic which blocks the Pseudomonas aeruginosa communication systems, promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiol. 151(Pt 12):3873-80.
  • 130. Persson T, Givskov M, Nielsen J. (2005) Quorum sensing inhibition: Targeting chemical communication in Gram-negative bacteria. Curr Med Chem. 12(26):3103-15.
  • 131. Rasmussen, T.B., Givskov, M. (2006) Quorum sensing Inhibitors as anti-pathogenic drugs. Int Journal Medical Microbiol. 296(2-3):149-61.
  • 132. Schreiber K, Boes N, Eschbach M, Jaensch L, Wehland J, Bjarnsholt T, Givskov M, Hentzer M, Schobert M. (2006). Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein. J Bacteriol. 188(2):659-68.
  • 133. Allesen-Holm M, Barken KB, Yang L, Klausen M, Webb JS, Kjelleberg S, Molin S, Givskov M, Tolker-Nielsen T. (2006) A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. Mol Microbiol. 59(4):1114-28.
  • 134. de Nys, R., M. Givskov, N. Kumar, S. Kjelleberg, P.D. Steinberg (2006). Furanones. Progress in Molecular and Subcellular Biology. 42:55-86. Subseries Marine Molecular Biotechnology. N. Fusetani, A.S. Clare (Eds.): Antifouling Compounds. Springer-Verlag Berlin Heidelberg 2006 ISBN 3-540-30014-7. Review.
  • 135. Rasmussen, T.B., and Givskov, M (2006) Quorum sensing inhibitors: a bargain of effects. Microbiol 152. 895-904. Review.
  • 136. Shrout, J. D., Chopp, D.L., Just, C.L., Hentzer, M., Givskov, M., and Parsek, M.R (2006) The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol. 2006 62(5):1264-77.
  • 137. Bjarnsholt, T., and Givskov, M (2007). The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa. Anal Bioanal Chem., 387, 2: 409-14.
  • 138. Kastbjerg VG, Nielsen KF, Dalsgaard I, Rasch M, Bruhn JB, Givskov M, Gram L.(2007) Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production. J Appl Microbiol. 102(2):363-74.
  • 139. Rasch, M., T.B. Rasmussen, J.B. Andersen, T. Persson, J. Nielsen, M. Givskov and L. Gram (2007). Well-known quorum sensing inhibitors do not affect bacterial quorum regulated bean sprout spoilage. J Appl Microbiol. 102(3):826-37
  • 140. Rasch, M., V.G. Kastbjerg, I. Dalsgaard, J.B. Bruhn, M. Givskov and L. Gram (2007). Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor. Dis Aquat Organ. 13;78(2):105-13.
  • 141. Hjelmgaard, T, Givskov, M and Nielsen, J (2007). Expedient synthesis of Pyrrothine natural products and analogs. Bioorg. Med. Chem. Jan 21;5(2):344-8.
  • 142. Fexby, F., Bjarnsholt, T., Jensen, P.Ø., Roos,V., Høiby,N., Givskov,M and Klemm, P. A (2007). Biological Trojan Horse: Antigen 43 Provides Specific Bacterial Uptake and Survival in Human Neutrophils. Infect Immun. 75(1):30-4.
  • 143. Labbate, M., Zhu, H., Thung, L., Bandara, R., Larsen, M.R., Willcox, M.D.P., Givskov, M., Rice, S.A., Kjelleberg, S. (2007) Quorum sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent. J. Bacteriol 189(7):2702-11
  • 144. Van Houdt R, Givskov M, Michiels CW. (2007) Quorum sensing in Serratia. FEMS Microbiol Rev. FEMS Microbiol Rev. 31(4):407-24. Review.
  • 145. Bjarnsholt, T., and Givskov, M (2007). Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Philos Trans R Soc Lond B Biol Sci. Jul 29;362(1483):1213-22. Review
  • 146. Yang L, Barken KB, Skindersoe ME, Christensen AB, Givskov M, Tolker-Nielsen T. (2007) Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa. Microbiology. 153(Pt 5):1318-28.
  • 147. Jensen PØ, Bjarnsholt T, Phipps R, Rasmussen TB, Calum H, Christoffersen L, Moser C, Williams P, Pressler T, Givskov M, Høiby N. 2007 Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology. 153(Pt 5):1329-38.
  • 148. Christensen, L. D., Moser, C., Jensen P.Ø., Rasmussen, T.B., Christophersen, L., Kjelleberg, S., Kumar, N., Høiby, N., Givskov, M and Bjarnsholt, T. (2007).The impact of Pseudomonas aeruginosa Quorum Sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. Microbiol. 153(Pt 7):2312-20.
  • 149. Bourne, D., Webster, N., Payne, M., Hoj, L., Skindersøe, M., Givskov, M. and Hall, M. (2007). Microbiological aspects of phyllosoma rearing of the ornate rock lobster Panulirus ornatus. Aquaculture. 268 (1-4): 274-287
  • 150. Kjelleberg, S., and Givskov, M (Eds) (2007). The Biofilm Mode of Life: Mechanisms and Adaptations. Horizon Bioscience, Norfolk NR18 0JA U.K. Book chapter
  • 151. Bjarnsholt, T., Kirketerp-Møller, K., Kristiansen, S., Phipps, R., Nielsen, A. K., Jensen, P.Ø., Høiby, N., and Givskov, M (2007) Silver against Pseudomonas aeruginosa biofilms. APMIS 115(8):921-8.
  • 152. Hoffmann N, Lee B, Hentzer M, Rasmussen TB, Song Z, Johansen HK, Givskov M, Hoiby N. 2007 Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary growth phase killing of P. aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr -/--mice. Antimicrob Agents Chemother. 51:3677-3687.
  • 153. Rice SA, McDougald D, Givskov M, Kjelleberg S. (2007) Detection and inhibition of bacterial cell-cell communication. Methods Mol Biol.431:55-68.
  • 154. Høiby N, Johansen HK, Ciofu O, Jensen PØ, Bjarnsholt T, Givskov M. 2007) Foreign body infections--biofilms and quorum sensing] Ugeskr Laeger. 26;169(48):4163-6. Review. Danish.
  • 155. Bjarnsholt, T., Kirketerp-Møller, K., Jensen, P.Ø., Madsen, K.G., Phipps, R., Krogfelt, K., Høiby, N., and Givskov, M (2008) Why chronic wounds won't heal: a novel hypothesis. Wound Repair Regen.16(1):2-10.
  • 156. Bjarnsholt, T and Givskov, M (2008) Quorum sensing inhibitory drugs as the next generation of anti-microbial compounds: Will it be worth the effort? Current Infectious Disease Reports. 10(1): 22-28. Review.
  • 157. Kjelleberg, S., McDougald, D., Rasmussen, T. B., Givskov, M Quorum-sensing inhibition. In Chemical communication among bacteria, eds S.C.Winans and B.J.Bassler 2008 ASM Press, Washington DC. Book chapter.
  • 158. Skindersoe, M. E., Epstein-Ettinger, P., Rasmussen, T.B., Bjarnsholt, T., de Nys, R., and Givskov, M. (2008) Quorum sensing antagonism from marine organisms. Mar Biotechnol (NY). 10(1):56-63.
  • 159. Niels Høiby, Helle Krogh Johansen, Oana Ciofu, Claus Moser, Peter Ø. Jensen, Thomas Bjarnsholt, Søren Molin, Michael Givskov (2008) The clinical impact of bacterial biofilms. Accepted for publication in Annals of medicine. Review.
  • 160. Balaban, N., Givskov, M Costerton, J.W, et al (2008). Control of Biofilm Infections by Signal Manipulation. Springer series on Biofilms ISSN 1863-9607. Springer-Verlag Berlin-Heidelberg. 4 Book chapters.
  • 161. ---+---
  • 162. ---+---
  • 163. ---+---
  • 164. Barken, K.B., Pamp, S.J., Yang, L., Gjermansen, M., Bertrand, J., Klausen, M., Givskov, M., Whitchurch, C., Engel, J., and Tolker-Nielsen, T. 2008 Roles of type IV pili, flagellum-mediated motility, and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms. ENVIRONMENTAL MICROBIOLOGY 10(9): 2331-2343.
  • 165. Søren Kristiansen, Thomas Bjarnsholt, Dinah Adeltoft, Peter Ifversen and Michael Givskov. 2008. The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the polyamine synthesis in human cells. APMIS 116 (5): 361-371
  • 166. Skindersoe, M. E., Phipps, R., Yang, L., Jensen, P.O., Rasmussen, T. B., Bjarnsholt, T., Høiby, N. and Givskov, M. (2008) Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 52(10): 3648-3663
  • 167. Willcox, M. D. P., Zhu, H., Conibear, T. C. R., Hume, E. B. H., Givskov, M. Kjelleberg, S., Rice, S. A. (2008). Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis. MICROBIOLOGY 154: 2184-2194
  • 168. Kirketerp-Moller, Klaus, Jensen, Peter O., Fazli, Mustafa, Madsen, Kit G., Pedersen, Jette, Moser, Claus, Tolker-Nielsen, Tim, Hoiby, Niels, Givskov, Michael, Bjarnsholt, Thomas (2008) Distribution, organization, and ecology of bacteria in chronic wounds. JOURNAL OF CLINICAL MICROBIOLOGY 46 (8): 2717-2722
  • 169. Matz C, Moreno AM, Alhede M, Manefield M, Hauser AR, Givskov M Kjelleberg S (2008) Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae. ISME JOURNAL 2 (8): 843-852.
  • 170. Claus Moser, Peter Østrup Jensen, Henrik Calum, Thomas Bjarnsholt, Hans Petter Hougen, Michael Givskov, Niels Høiby and Marie Johannesson; Female mice are more susceptible to chronic pseudomonas aeruginosa lung infection; Accapted for publication in APMIS.

  1. 2019
  2. Published

    Antibiotics inhibit tumor and disease activity in cutaneous T cell lymphoma. / Lindahl, Lise M; Willerslev-Olsen, Andreas; Gjerdrum, Lise M R; Nielsen, Pia R; Blümel, Edda; Rittig, Anne H; Celis, Pamela; Herpers, Bjorn; Becker, Jürgen C; Stausbøl-Grøn, Birgitte; Wasik, Mariusz A; Gluud, Maria; Fredholm, Simon; Buus, Terkild B; Johansen, Claus; Nastasi, Claudia; Peiffer, Lukas; Kubat, Linda; Bzorek, Michael; Eriksen, Jens O; Krejsgaard, Thorbjørn; Bonefeld, Charlotte M; Geisler, Carsten; Mustelin, Tomas; Langhoff, Erik; Givskov, Michael; Woetmann, Anders; Kilian, Mogens; Litman, Thomas; Iversen, Lars; Odum, Niels.

    In: Blood, Vol. 134, No. 13, 26.09.2019, p. 1072-1083.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content. / Almblad, Henrik; Rybtke, Morten; Hendiani, Saghar; Andersen, Jens Bo; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Microbiology, Vol. 165, No. 3, 03.2019, p. 324-333.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Key players and individualists of Cyclic-di-GMP signaling in burkholderia cenocepacia. / Richter, Anja M.; Fazli, Mustafa; Schmid, Nadine; Shilling, Rebecca; Suppiger, Angela; Givskov, Michael; Eberl, Leo; Tolker-Nielsen, Tim.

    In: Frontiers in Microbiology, Vol. 10, No. JAN, 3286, 01.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Inactivation of the pgmA Gene in Streptococcus mutans Significantly Decreases Biofilm-Associated Antimicrobial Tolerance. / Nilsson, Martin; Givskov, Michael; Twetman, Svante; Tolker-Nielsen, Tim.

    In: Microorganisms, Vol. 7, No. 9, 310, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells. / Teh, Wooi Keong; Dramsi, Shaynoor; Tolker-Nielsen, Tim; Yang, Liang; Givskov, Michael.

    In: Journal of Bacteriology, Vol. 201, No. 6, 2019, p. 1-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa. / Fong, July; Mortensen, Kim T.; Nørskov, Amalie; Qvortrup, Katrine; Yang, Liang; Tan, Choon Hong; Nielsen, Thomas E.; Givskov, Michael.

    In: Frontiers in Cellular and Infection Microbiology, Vol. 11, 433, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Key Players and Individualists of Cyclic-di-GMP Signaling in Burkholderia cenocepacia. / Richter, Anja M; Fazli, Mustafa; Schmid, Nadine; Shilling, Rebecca; Suppiger, Angela; Givskov, Michael; Eberl, Leo; Tolker-Nielsen, Tim.

    In: Frontiers in Microbiology, Vol. 9, 3286, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms. / Nilsson, Martin; Jakobsen, Tim Holm; Givskov, Michael; Twetman, Svante; Tolker-Nielsen, Tim.

    In: Microbiology-Sgm, Vol. 165, No. 3, 2019, p. 334-342.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Accepted/In press

    Reactivity and Synthetic Applications of Multicomponent Petasis Reactions. / Wu, Peng; Givskov, Michael; Nielsen, Thomas E.

    In: Chemical Reviews, 2019.

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    Transposon Mutagenesis in Streptococcus Species. / Nilsson, Martin; Givskov, Michael; Tolker-Nielsen, Tim.

    Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, 2019. p. 39-49 (Methods in Molecular Biology, Vol. 2016).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. Published

    Visualizing biofilm by targeting eDNA with long wavelength probe CDr15. / Kwon, Haw Young; Kim, Jun Young; Liu, Xiao; Lee, Jung Yeol; Yam, Joey Kuok Hoong; Dahl Hultqvist, Louise; Xu, Wang; Rybtke, Morten; Tolker-Nielsen, Tim; Heo, Wooseok; Kim, Jong Jin; Kang, Nam Young; Joo, Taiha; Yang, Liang; Park, Sung Jin; Givskov, Michael; Chang, Young Tae.

    In: Biomaterials Science, Vol. 7, No. 9, 2019, p. 3594-3598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2018
  14. Published

    CDy14 : A novel biofilm probe targeting exopolysaccharide Psl. / Kwon, Haw Young; Kim, Jun Young; Lee, Jung Yeol; Yam, Joey Kuok Hoong; Hultqvist, Louise Dahl; Xu, Wang; Rybtke, Morten; Tolker-Nielsen, Tim; Kim, Jong Jin; Kang, Nam Young; Yang, Liang; Park, Sung Jin; Givskov, Michael; Chang, Young Tae.

    In: Chemical Communications, Vol. 54, No. 84, 2018, p. 11865-11868.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul. / Ding, Yichen; Zwe, Ye Htut; Chin, Seow Fong; Kohli, Gurjeet S.; Drautz-Moses, Daniela I.; Givskov, Michael; Schlundt, Jorgen; Schuster, Stephan C.; Yuk, Hyun Gyun; Yang, Liang.

    In: Gut Pathogens, Vol. 10, 20, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa. / Fong, July; Zhang, Chaodong; Yang, Renliang; Boo, Zhao Zhi; Tan, Soon Keat; Nielsen, Thomas E.; Givskov, Michael; Liu, Xue-Wei; Bin, Wu; Su, Haibin; Yang, Liang.

    In: Scientific Reports, Vol. 8, 1155, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Imaging N-acyl homoserine lactone quorum sensing in vivo. / Hultqvist, Louise Dahl; Alhede, Maria; Jakobsen, Tim Holm; Givskov, Michael; Bjarnsholt, Thomas.

    Quorum Sensing: Methods and Protocols. ed. / Livia Leoni; Giordano Rampion. Vol. 1673 Humana Press, 2018. p. 203-212 (Methods in Molecular Biology; No. 1673).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  18. Published
  19. Published

    Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus. / Chew, Su Chuen; Yam, Joey Kuok Hoong; Matysik, Artur; Seng, Zi Jing; Klebensberger, Janosch; Givskov, Michael; Doyle, Patrick; Rice, Scott A.; Yang, Liang; Kjelleberg, Staffan.

    In: mBio, Vol. 9, No. 6, e00585-18, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro. / Jakobsen, Tim Holm; Alhede, Maria; Hultqvist, Louise Dahl; Bjarnsholt, Thomas; Givskov, Michael.

    Quorum Sensing: Methods and Protocols. Vol. 1673 Springer, 2018. p. 275-285 (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  21. Published

    Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents. / Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela I.; Hoong Yam, Joey Kuok; Aung, Thet Tun; Beuerman, Roger W.; Santillan Salido, May Margarette; Schuster, Stephan C.; Tan, Choon Hong; Givskov, Michael; Yang, Liang; Nielsen, Thomas E.

    In: Beilstein Journal of Organic Chemistry, Vol. 14, 2018, p. 3059-3069.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells. / Gall-Mas, Laura; Fabbri, Alessia; Namini, Martin R J; Givskov, Michael; Fiorentini, Carla; Krejsgaard, Thorbjørn.

    In: International Journal of Molecular Sciences , Vol. 19, No. 5, 1408, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2017
  24. Published

    A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors. / Bang, Claus G.; Jensen, Jakob F.; O'Hanlon Cohrt, Emil; Olsen, Lasse B.; Siyum, Saba G.; Mortensen, Kim T.; Skovgaard, Tine; Berthelsen, Jens; Yang, Liang; Givskov, Michael; Qvortrup, Katrine; Nielsen, Thomas E.

    In: ACS Combinatorial Science, Vol. 19, No. 10, 10.2017, p. 657-669.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes in Pseudomonas aeruginosa. / Chua, Song Lin; Liu, Yang; Li, Yingying; Ting, Hui Jun; Kohli, Gurjeet S.; Cai, Zhao; Suwanchaikasem, Pipob; Goh, Kelvin Kau Kit; Ng, Sean Pin; Tolker-Nielsen, Tim; Yang, Liang; Givskov, Michael.

    In: Frontiers in Cellular and Infection Microbiology, Vol. 7, 451, 10.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes. / Jakobsen, Tim Holm; Tolker-Nielsen, Tim; Givskov, Michael.

    In: International Journal of Molecular Sciences, Vol. 18, No. 9, 1970, 09.2017.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Cholesterol crystals enhance TLR2-and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis. / Køllgaard, Tania Maria Simonsen; Enevold, Christian; Bendtzen, Klaus; Hansen, Peter R.; Givskov, Michael; Holmstrup, Palle; Nielsen, Claus H.

    In: P L o S One, Vol. 12, No. 2, 0172773, 24.02.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa. / Fong, July; Yuan, Mingjun; Jakobsen, Tim Holm; Mortensen, Kim T.; Delos Santos, May Margarette Salido; Chua, Song Lin; Yang, Liang; Tan, Choon Hong; Nielsen, Thomas E.; Givskov, Michael.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 12.01.2017, p. 215-227.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Gauging and visualizing c-di-GMP levels in pseudomonas aeruginosa using fluorescence-based biosensors. / Rybtke, Morten; Chua, Song Lin; Yam, Joey Kuok Hoong; Givskov, Michael; Yang, Liang; Tolker-Nielsen, Tim.

    c-di-GMP Signaling: Methods and Protocols. ed. / Karin Sauer. Vol. 1657 Humana Press, 2017. p. 87-98 (Methods in Molecular Biology, Vol. 1657).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  30. Published

    High-throughput screening for compounds that modulate the cellular c-di-GMP level in bacteria. / Groizeleau, Julie; Andersen, Jens Bo; Givskov, Michael; Berthelsen, Jens; Tolker-Nielsen, Tim.

    c-di-GMP Signaling: Methods and Protocols. ed. / Karin Sauer. Vol. 1657 Humana Press, 2017. p. 455-470 (Methods in Molecular Biology, Vol. 1657).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  31. Published

    A broad range quorum sensing inhibitor working through sRNA inhibition. / Jakobsen, Tim H.; Warming, Anders N.; Vejborg, Rebecca M.; Moscoso, Joana A.; Stegger, Marc; Lorenzen, Frederik; Rybtke, Morten; Andersen, Jens B.; Petersen, Rico; Andersen, Paal Skytt; Nielsen, Thomas E.; Tolker-Nielsen, Tim; Filloux, Alain; Ingmer, Hanne; Givskov, Michael.

    In: Scientific Reports, Vol. 7, No. 1, 9857, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors. / Thanh Tung, Truong; Jakobsen, Tim Holm; Dao, Trong Tuan; Fuglsang, Anja Thoe; Givskov, Michael; Christensen, Søren Brøgger; Nielsen, John.

    In: European Journal of Medicinal Chemistry, Vol. 126, 2017, p. 1011-1020.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy. / Roizman, Dan; Vidaillac, Celine; Givskov, Michael; Yang, Liang.

    In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 10, e01088-17, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    In vitro and In vivo efficacy of an LpxC inhibitor, CHIR-090, alone or combined with colistin against Pseudomonas aeruginosa biofilm. / Tan, Jun Hou; Vidaillac, Celine; Yam, Joey Kuok Hoong; Chua, Song Lin; Givskov, Michael; Yang, Liang.

    In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 7, e02223-16, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries. / Belstrøm, Daniel; Constancias, Florentin; Liu, Yang; Yang, Liang; Drautz-Moses, Daniela I; Schuster, Stephan C; Kohli, Gurjeet Singh; Jakobsen, Tim Holm; Holmstrup, Palle; Givskov, Michael.

    In: NPJ biofilms and microbiomes, Vol. 3, 23, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB. / Fazli, Mustafa; Rybtke, Morten Levin; Steiner, Elisabeth; Weidel, Elisabeth; Berthelsen, Jens; Groizeleau, Julie Dora Dona; Bin, Wu; Zhi, Boo Zhao; Yaming, Zhang; Kaever, Volkhard; Givskov, Michael; Hartmann, Rolf W; Eberl, Leo; Tolker-Nielsen, Tim.

    In: MicrobiologyOpen, Vol. 6, No. 4, e00480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2016
  38. Published

    Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels. / Chua, Song Lin; Ding, Yichen; Liu, Yang; Cai, Zhao; Zhou, Jianuan; Swarup, Sanjay; Drautz-Moses, Daniela I.; Schuster, Stephan Christoph; Kjelleberg, Staffan; Givskov, Michael; Yang, Liang.

    In: Open Biology, Vol. 6, 160162, 11.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation. / Groizeleau, Julie; Rybtke, Morten; Andersen, Jens Bo; Berthelsen, Jens; Liu, Yang; Yang, Liang; Nielsen, Thomas E.; Kaever, Volkhard; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Microbiology, Vol. 162, No. 10, 01.10.2016, p. 1797-1807.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms. / Nilsson, Carl Martin Peter; Rybtke, Morten; Givskov, Michael; Høiby, Niels; Twetman, Svante; Tolker-Nielsen, Tim.

    In: International Journal of Antimicrobial Agents, Vol. 48, No. 3, 09.2016, p. 298–304.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11. / Kim, Jun Young; Sahu, Srikanta; Yau, Yin Hoe; Wang, Xu; Shochat, Susana Geifman; Nielsen, Per Halkjær; Dueholm, Morten Simonsen; Otzen, Daniel E.; Lee, Jungyeol; Delos Santos, May Margarette Salido; Yam, Joey Kuok Hoong; Kang, Nam Young; Park, Sung Jin; Kwon, Hawyoung; Seviour, Thomas; Yang, Liang; Givskov, Michael; Chang, Young Tae.

    In: Journal of the American Chemical Society, Vol. 138, No. 1, 13.01.2016, p. 402-407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction. / Hansen, Gorm Mørk; Belstrøm, Daniel; Nilsson, Carl Martin Peter; Helqvist, Steffen; Nielsen, Claus Henrik; Holmstrup, Palle; Tolker-Nielsen, Tim; Givskov, Michael; Hansen, Peter Riis.

    In: P L o S One, Vol. 11, No. 12, e0168771, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms. / Chua, Song Lin; Yam, Joey Kuok Hoong; Hao, Piliang; Adav, Sunil S; Salido, May Margarette; Liu, Yang; Givskov, Michael; Sze, Siu Kwan; Tolker-Nielsen, Tim; Yang, Liang.

    In: Nature Communications, Vol. 7, 10750, 2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2015
  45. Published

    RpoN Regulates Virulence Factors of Pseudomonas aeruginosa via Modulating the PqsR Quorum Sensing Regulator. / Cai, Zhao; Liu, Yang; Chen, Yicai; Yam, Joey Kuok Hoong; Chew, Su Chuen; Chua, Song Lin; Wang, Ke; Givskov, Michael; Yang, Liang.

    In: International Journal of Molecular Sciences, Vol. 16, No. 12, 12.2015, p. 28311-28319.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface. / Rybtke, Morten; Berthelsen, Jens; Yang, Liang; Høiby, Niels; Givskov, Michael; Tolker-Nielsen, Tim.

    In: MicrobiologyOpen, Vol. 4, No. 6, 12.2015, p. 917-930.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Pseudomonas aeruginosa Biofilm Infections : Community Structure, Antimicrobial Tolerance and Immune Response. / Rybtke, Morten; Hultqvist, Louise Dahl; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Journal of Molecular Biology, Vol. 427, No. 23, 20.11.2015, p. 3628-45.

    Research output: Contribution to journalReviewResearchpeer-review

  48. Published

    Spatially extensive microbial biogeography of the Indian Ocean provides insights into the unique community structure of a pristine coral atoll. / Jeffries, Thomas C.; Ostrowski, Martin; Williams, Rohan B.; Xie, Chao; Jensen, Rachelle M.; Grzymski, Joseph J.; Senstius, Svend Jacob; Givskov, Michael; Hoeke, Ron; Philip, Gayle K.; Neches, Russell Y.; Drautz-Moses, Daniela I.; Chenard, Caroline; Paulsen, Ian T.; Lauro, Federico M.

    In: Scientific Reports, Vol. 5, 15383 , 20.10.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species. / Thorsing, Mette; Bentin, Thomas; Givskov, Michael; Tolker-Nielsen, Tim; Goltermann, Lise.

    In: Microbiology, Vol. 161, No. 10, 10.2015, p. 1999-2007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation. / Chua, Song Lin; Hultqvist, Louise D; Yuan, Mingjun; Rybtke, Morten; Nielsen, Thomas Eiland; Givskov, Michael; Tolker-Nielsen, Tim; Yang, Liang.

    In: Nature Protocols (Print), Vol. 10, No. 8, 08.2015, p. 1165-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. / Sun, Jiadong; Marais, Jannie P J; Khoo, Christina; LaPlante, Kerry; Vejborg, Rebecca M; Givskov, Michael; Tolker-Nielsen, Tim; Seeram, Navindra P; Rowley, David C.

    In: Journal of Functional Foods, Vol. 17, 08.2015, p. 235-242.

    Research output: Contribution to journalLetterResearchpeer-review

  52. Published

    Erratum for Almblad et al., The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP. / Almblad, Henrik; Harrison, Joe J.; Rybtke, Morten; Groizeleau, Julie; Givskov, Michael; Parsek, Matthew R.; Tolker-Nielsen, Tim.

    In: Journal of Bacteriology, Vol. 197, No. 16, 08.2015, p. 2731.

    Research output: Contribution to journalComment/debateResearch

  53. Published

    The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP. / Almblad, Henrik; Harrison, Joe J; Rybtke, Morten; Groizeleau, Julie; Givskov, Michael; Parsek, Matthew R; Tolker-Nielsen, Tim.

    In: Journal of Bacteriology, Vol. 197, No. 13, 07.2015, p. 2190-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Antibiofilm Properties of Acetic Acid. / Bjarnsholt, Thomas; Alhede, Morten; Jensen, Peter Østrup; Nielsen, Anne Kirstine; Johansen, Helle Krogh; Homoe, Preben; Hoiby, Niels; Givskov, Michael; Kirketerp-Moller, Klaus.

    In: Advances in Wound Care, Vol. 4, No. 7, 06.2015, p. 363-372.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen Elizabethkingia anophelis in Response to Oxidative Stress. / Li, Yingying; Liu, Yang; Chew, Su Chuen; Tay, Martin; Salido, May Margarette Santillan; Teo, Jeanette; Lauro, Federico M.; Givskov, Michael; Yang, Liang.

    In: Genome Biology and Evolution, Vol. 7, No. 6, 06.2015, p. 1676-1685.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Synthesis of Substituted γ- and δ-Lactams through Mannich-Type Reactions of Solid-Supported N-Acyliminium Ions. / Komnatnyy, Vitaly V.; Taveras, Kennedy M.; Nandurkar, Nitin S.; Le Quement, Sebastian T.; Givskov, Michael; Nielsen, Thomas E.

    In: European Journal of Organic Chemistry, Vol. 2015, No. 16, 06.2015, p. 3524-3530.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Functional Amyloids Keep Quorum-sensing Molecules in Check. / Seviour, Thomas; Hansen, Susan Hove; Yang, Liang; Yau, Yin Hoe; Wang, Victor Bochuan; Stenvang, Marcel R.; Christiansen, Gunna; Marsili, Enrico; Givskov, Michael; Chen, Yicai; Otzen, Daniel E.; Nielsen, Per Halkjaer; Geifman-Shochat, Susana; Kjelleberg, Staffan; Dueholm, Morten S.

    In: Journal of Biological Chemistry, Vol. 290, No. 10, 06.03.2015, p. 6457-6469.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Combining the Petasis 3-Component Reaction with Multiple Modes of Cyclization : A Build/Couple/Pair Strategy for the Synthesis of Densely Functionalized Small Molecules. / Flagstad, Thomas; Hansen, Mette R.; Le Quementt, Sebastian T.; Givskov, Michael; Nielsen, Thomas E.

    In: A C S Combinatorial Science, Vol. 17, No. 1, 01.2015, p. 19-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients : Results with Use of a High Sensitivity Polymerase Chain Reaction Assay. / Hansen, Gorm Mørk; Nilsson, Martin; Nielsen, Claus Henrik; Holmstrup, Palle; Helqvist, Steffen; Tolker-Nielsen, Tim; Givskov, Michael; Hansen, Peter Riis.

    In: PloS one, Vol. 10, No. 12, e0145657, 2015, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Autofluorescence in samples obtained from chronic biofilm infections – “all that glitters is not gold”. / Eickhardt-Dalbøge, Steffen Robert; Kragh, Kasper N.; Schrøder, Stine; Poulsen, Steen Seier; Sillesen, Henrik; Givskov, Michael; Hoiby, Niels; Bjarnsholt, Thomas; Alhede, Morten.

    In: Pathogens and Disease, Vol. 73, No. 4, ftv012, 2015.

    Research output: Contribution to journalLetterResearchpeer-review

  61. Published

    C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. / Chua, Song Lin; Sivakumar, Krishnakumar; Rybtke, Morten Levin; Yuan, Mingjun; Andersen, Jens Bo; Nielsen, Thomas E.; Givskov, Michael; Tolker-Nielsen, Tim; Cao, Bin; Kjelleberg, Staffan; Yang, Liang.

    In: Scientific Reports, Vol. 5, 10052, 2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    In silico analyses of metagenomes from human atherosclerotic plaque samples. / Mitra, Suparna; Drautz-Moses, Daniela I; Alhede, Morten; Maw, Myat T; Liu, Yang; Purbojati, Rikky W; Yap, Zhei H; Kushwaha, Kavita K; Gheorghe, Alexandra G; Bjarnsholt, Thomas; Hansen, Gorm M; Sillesen, Henrik; Hougen, Hans P; Hansen, Peter R; Yang, Liang; Tolker-Nielsen, Tim; Schuster, Stephan C; Givskov, Michael.

    In: Microbiome, Vol. 3, 38, 2015, p. 1-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    In-frame and unmarked gene deletions in Burkholderia cenocepacia via an allelic exchange system compatible with gateway technology. / Fazli, Mustafa; Harrison, Joe J.; Gambino, Michela; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Applied and Environmental Microbiology, Vol. 81, No. 11, 2015, p. 3623-3630.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa. / Chen, Yicai; Yuan, Mingjun; Mohanty, Anee; Yam, Joey Kuok Hoong; Liu, Yang; Chua, Song Lin; Nielsen, Thomas E.; Tolker-Nielsen, Tim; Givskov, Michael; Cao, Bin; Yang, Liang.

    In: Environmental Microbiology Reports, Vol. 7, No. 3, 2015, p. 498-507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. / Hansen, Mette Reimert; Jakobsen, Tim Holm; Bang, Claus Gunnar; Cohrt, Anders Emil; Hansen, Casper Lykke; Clausen, Janie Regitse Waël; Le Quement, Sebastian Thordal; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 7, 2015, p. 1638-1650.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. 2014
  67. Published

    Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa. / Tan, Sean Yang-Yi; Liu, Yang; Chua, Song Lin; Vejborg, Rebecca Munk; Jakobsen, Tim Holm; Chew, Su Chuen; Li, Yingying; Nielsen, Thomas E.; Tolker-Nielsen, Tim; Yang, Liang; Givskov, Michael.

    In: Antimicrobial Agents and Chemotherapy, Vol. 58, No. 11, 11.2014, p. 6648-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier. / Tran, Cindy S; Rangel, Stephanie M; Almblad, Henrik; Kierbel, Arlinet; Givskov, Michael; Tolker-Nielsen, Tim; Hauser, Alan R; Engel, Joanne N.

    In: P L o S Pathogens, Vol. 10, No. 11, e1004479, 11.2014, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    A mariner transposon vector adapted for mutagenesis in oral streptococci. / Nilsson, Martin; Christiansen, Natalia; Høiby, Niels; Twetman, Svante; Givskov, Michael; Tolker-Nielsen, Tim.

    In: MicrobiologyOpen, Vol. 3, No. 3, 06.2014, p. 333-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Mulig sammenhæng mellem marginal parodontitis og iskæmisk hjertesygdom. / Hansen, Gorm Mørk; Holmstrup, Palle; Tolker-Nielsen, Tim; Køllgaard, Tania; Nielsen, Claus Henrik; Givskov, Michael; Hansen, Peter Riis.

    In: Ugeskrift for Laeger, Vol. 176, No. 18, 28.04.2014, p. 1752-1754.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Effects of Radix Ginseng on microbial infections : a narrative review. / Wu, Hong; Høiby, Niels; Yang, Liang; Givskov, Michael; Song, Zhijun.

    In: Journal of Traditional Chinese Medicine, Vol. 34, No. 2, 04.2014, p. 227-233.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators. / Hansen, Mette R; Le Quement, Sebastian T; Jakobsen, Tim H; Skovstrup, Søren; Taboureau, Olivier; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas E.

    In: ChemBioChem, Vol. 15, No. 3, 10.02.2014, p. 460-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Bacterial biofilm formation and treatment in soft tissue fillers. / Alhede, Morten; Er, Ozge; Eickhardt, Steffen; Kragh, Kasper; Alhede, Maria; Hultqvist, Louise Dahl; Poulsen, Steen Seier; Givskov, Michael; Christensen, Lise H; Høiby, Niels; Tvede, Michael; Bjarnsholt, Thomas.

    In: Pathogens and Disease, Vol. 70, 30.01.2014, p. 339-346.

    Research output: Contribution to journalJournal articleResearch

  74. Published

    Bacteria-triggered release of antimicrobial agents. / Komnatnyy, Vitaly V; Chiang, Wen-Chi; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas E.

    In: Angewandte Chemie (International ed. in English), Vol. 53, No. 2, 07.01.2014, p. 439-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles. / Chua, Song Lin; Liu, Yang; Yam, Joey Kuok Hoong; Chen, Yicai; Vejborg, Rebecca Munk; Tan, Bryan Giin Chyuan; Kjelleberg, Staffan; Tolker-Nielsen, Tim; Givskov, Michael; Yang, Liang.

    In: Nature Communications, Vol. 5, 4462, 2014, p. 1-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Draft Genome Sequence of the Model Naphthalene-Utilizing Organism Pseudomonas putida OUS82. / Tay, Martin; Roizman, Dan; Cohen, Yehuda; Tolker-Nielsen, Tim; Givskov, Michael; Yang, Liang.

    In: Genome Announcements, Vol. 2, No. 1, e01161-13, 2014, p. 1.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    PNA-based fluorescence in situ hybridization for identification of bacteria in clinical samples. / Fazli, Mustafa; Bjarnsholt, Thomas; Høiby, Niels; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Methods in Molecular Biology, Vol. 1211, 2014, p. 261-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Pseudomonas aeruginosa Biofilms : Mechanisms of Immune Evasion. / Alhede, Maria; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Morten.

    In: Advances in Applied Microbiology, Vol. 86, 2014, p. 1-40.

    Research output: Contribution to journalJournal articleResearch

  79. Published

    Regulation of biofilm formation in Pseudomonas and Burkholderia species. / Fazli, Mustafa; Almblad, Henrik; Rybtke, Morten Levin; Givskov, Michael; Eberl, Leo; Tolker-Nielsen, Tim.

    In: Environmental Microbiology, Vol. 16, No. 7, 2014, p. 1961-1981.

    Research output: Contribution to journalReviewResearchpeer-review

  80. 2013
  81. Published

    Applying insights from biofilm biology to drug development - can a new approach be developed? / Bjarnsholt, Thomas; Ciofu, Oana; Molin, Søren; Givskov, Michael; Høiby, Niels.

    In: Nature Reviews. Drug Discovery, Vol. 12, No. 10, 01.10.2013, p. 791-808.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria. / Hultqvist, Louise Dahl; van Gennip, Maria; Rybtke, Morten T; Wu, Hong; Chiang, Wen-Chi; Alhede, Morten; Høiby, Niels; Nielsen, Thomas; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Infection and Immunity, Vol. 81, No. 8, 08.2013, p. 2705-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Targeting quorum sensing in Pseudomonas aeruginosa biofilms : current and emerging inhibitors. / Jakobsen, Tim Holm; Bjarnsholt, Thomas; Jensen, Peter Østrup; Givskov, Michael; Høiby, Niels.

    In: Future Microbiology, Vol. 8, No. 7, 07.2013, p. 901-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms. / Chiang, Wen-Chi; Nilsson, Martin; Jensen, Peter Østrup; Høiby, Niels; Nielsen, Thomas; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 5, 05.2013, p. 2352-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa. / Pihl, Maria; Arvidsson, Anna; Skepö, Marie; Nilsson, Martin; Givskov, Michael; Tolker-Nielsen, Tim; Svensäter, Gunnel; Davies, Julia R.

    In: Pathogens and Disease, Vol. 67, No. 3, 04.2013, p. 192-198.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation. / Dueholm, Morten Simonsen; Søndergaard, Mads; Nilsson, Martin; Christiansen, Gunna; Stensballe, Allan; Overgaard, Michael Toft; Givskov, Michael; Tolker-Nielsen, Tim; Otzen, Daniel; Nielsen, Per H.

    In: MicrobiologyOpen, Vol. 2, 18.03.2013, p. 365-382.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349. / Fazli, Mustafa; McCarthy, Yvonne; Givskov, Michael; Ryan, Robert P; Tolker-Nielsen, Tim.

    In: MicrobiologyOpen, Vol. 2, No. 1, 02.2013, p. 105-122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    C-di-GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa. / Chua, Song Lin; Tan, Sean Yang-Yi; Rybtke, Morten Theil; Chen, Yicai; Rice, Scott A; Kjelleberg, Staffan; Tolker-Nielsen, Tim; Yang, Liang; Givskov, Michael.

    In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 5, 2013, p. 2066-2075.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes. / Jakobsen, Tim Holm; Hansen, Martin Asser; Jensen, Peter Østrup; Hansen, Lars; Riber, Leise; Cockburn, April Patricia Indera; Kolpen, Mette; Hansen, Christine Rønne; Ridderberg, Winnie; Eickhardt-Sørensen, Steffen Robert; Hansen, Marlene; Kerpedjiev, Peter; Alhede, Morten; Qvortrup, Klaus; Burmølle, Mette; Moser, Claus Ernst; Kühl, Michael; Ciofu, Oana; Givskov, Michael; Sørensen, Søren Johannes; Høiby, Niels; Bjarnsholt, Thomas.

    In: P L o S One, Vol. 8, No. 7, e68484, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells. / Wang, Victor Bochuan; Chua, Song-Lin; Cao, Bin; Seviour, Thomas; Nesatyy, Victor J; Marsili, Enrico; Kjelleberg, Staffan; Givskov, Michael; Tolker-Nielsen, Tim; Song, Hao; Loo, Joachim Say Chye; Yang, Liang.

    In: PLOS ONE, Vol. 8, No. 5, e63129, 2013, p. e63129.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts. / Schwager, Stephan; Agnoli, Kirsty; Köthe, Manuela; Feldmann, Friederike; Givskov, Michael; Carlier, Aurelien; Eberl, Leo.

    In: Infection and Immunity, Vol. 81, No. 1, 2013, p. 143-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Identification of LasR ligands through a virtual screening approach. / Skovstrup, Søren; Le Quement, Sebastian Thordal; Hansen, Thomas; Jakobsen, Tim Holm; Harmsen, Morten; Tolker-Nielsen, Tim; Nielsen, Thomas E; Givskov, Michael; Taboureau, Olivier.

    In: ChemMedChem, Vol. 8, No. 1, 2013, p. 157-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR. / Claussen, Anetta; Jakobsen, Tim Holm; Bjarnsholt, Thomas; Givskov, Michael; Welch, Martin; Ferkinghoff-Borg, Jesper; Sams, Thomas.

    In: International Journal of Molecular Sciences (Online), Vol. 14, No. 7, 2013, p. 13360-76.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Protoanemonin : a natural quorum sensing inhibitor that selectively activates iron starvation response. / Bobadilla Fazzini, Roberto A; Skindersoe, Mette E; Bielecki, Piotr; Puchalka, Jacek; Givskov, Michael; Martins sos Santos, Vitor A P.

    In: Environmental Microbiology Reports, Vol. 15, No. 1, 2013, p. 111-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators. / Stacy, Danielle M; Le Quement, Sebastian Thordal; Hansen, Casper; Clausen, Janie W; Tolker-Nielsen, Tim; Brummond, Jacob W; Givskov, Michael; Nielsen, Thomas E; Blackwell, Helen E.

    In: Organic & Biomolecular Chemistry, Vol. 11, No. 6, 2013, p. 938-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. 2012
  97. Published

    Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence. / Komnatnyy, Vitaly V.; Givskov, Michael; Nielsen, Thomas E.

    In: Chemistry. A European Journal, Vol. 18, No. 52, 12.2012, p. 16793-16800.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms. / Zhang, Lianbo; Chiang, Wen-Chi; Gao, Qingguo; Givskov, Michael; Tolker-Nielsen, Tim; Yang, Liang; Zhang, Guang.

    In: Microbiology, Vol. 158, No. 12, 12.2012, p. 3014-3019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo. / van Gennip, Maria; Hultqvist, Louise Dahl; Alhede, Morten; Qvortrup, Klaus; Jensen, Peter Østrup; Høiby, Niels; Givskov, Michael; Bjarnsholt, Thomas.

    In: Infection and Immunity, Vol. 80, No. 8, 08.2012, p. 2601-2607.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition. / Alhede, Morten; Qvortrup, Klaus; Liebrechts, Ramon; Høiby, Niels; Givskov, Michael; Bjarnsholt, Thomas.

    In: F E M S Immunology and Medical Microbiology, Vol. 65, No. 2, 07.2012, p. 335-342.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa. / Yang, Liang; Hengzhuang, Wang; Wu, Hong; Damkiaer, Søren; Jochumsen, Nicholas; Song, Zhijun; Givskov, Michael; Høiby, Niels; Molin, Søren.

    In: F E M S Immunology and Medical Microbiology, Vol. 65, No. 2, 07.2012, p. 366-376.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms. / Chiang, Wen-Chi; Pamp, Sünje Johanna; Nilsson, Carl Martin Peter; Givskov, Michael; Tolker-Nielsen, Tim.

    In: F E M S Immunology and Medical Microbiology, Vol. 65, No. 2, 07.2012, p. 245-256.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. Published

    Process for the manufacture of ajoene derivatives. / Bjarnsholt, Thomas (Inventor); Hoeiby, Niels (Inventor); Jensen, Peter Østrup (Inventor); Phipps, Richard (Inventor); Shanmugham, Meenakshi, Sundaram (Inventor); Alhede, Maria (Inventor); Hultqvist, Louise Dahl (Inventor); Jakobsen, Tim Holm (Inventor); Tanner, David (Inventor); Larsen, Thomas, Ostenfeld (Inventor); Givskov, Michael (Inventor).

    IPC No.: C07C 323/ 65 A I. Patent No.: WO2012076016.

    Research output: Patent

  104. Published

    Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. / Jakobsen, Tim Holm; van Gennip, Maria; Phipps, Richard Kerry; Shanmugham, Meenakshi Sundaram; Hultqvist, Louise Dahl; Alhede, Morten; Skindersoe, Mette Eline; Rasmussen, Thomas Bovbjerg; Friedrich, Karlheinz; Uthe, Friedrich; Jensen, Peter Østrup; Moser, Claus; Nielsen, Kristian Fog; Eberl, Leo; Larsen, Thomas Ostenfeld; Tanner, David Ackland; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Maria.

    In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 5, 05.2012, p. 2314-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. / Christensen, Louise; van Gennip, Maria; Jakobsen, Tim H; Alhede, Morten; Hougen, Hans Petter; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Maria.

    In: The Journal of antimicrobial chemotherapy, Vol. 67, No. 5, 05.2012, p. 1198-206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Beyond nutrition : health-promoting foods by quorum-sensing inhibition. / Givskov, Michael.

    In: Future Microbiology, Vol. 7, No. 9, 2012, p. 1025-1028.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Bursting the bubble on bacterial biofilms : a flow cell methodology. / Crusz, Shanika A; Popat, Roman; Rybtke, Morten Theil; Cámara, Miguel; Givskov, Michael; Tolker-Nielsen, Tim; Diggle, Stephen P; Williams, Paul.

    In: Biofouling, Vol. 28, No. 8, 2012, p. 835-842.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    Combating biofilms. / Yang, Liang; Liu, Yang; Wu, Hong; Song, Zhijun; Høiby, Niels; Molin, Søren; Givskov, Michael.

    In: F E M S Immunology and Medical Microbiology, Vol. 65, No. 2, 2012, p. 146–157.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. Published

    Fluorescence-based reporter for gauging cyclic di-GMP Levels in Pseudomonas aeruginosa. / Rybtke, Morten T; Borlee, Bradley R; Murakami, Keiji; Irie, Yasuhiko; Hentzer, Morten; Nielsen, Thomas E; Givskov, Michael; Parsek, Matthew R; Tolker-Nielsen, Tim.

    In: Applied and Environmental Microbiology, Vol. 78, No. 15, 2012, p. 5060-5069.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. Published

    Food as a source for quorum sensing inhibitors : iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. / Jakobsen, Tim Holm; Bragason, Steinn Kristinn; Phipps, Richard Kerry; Christensen, Louise Dahl; van Gennip, Maria; Alhede, Morten; Skindersoe, Mette; Larsen, Thomas Ostenfeld; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael.

    In: Applied and Environmental Microbiology, Vol. 78, No. 7, 2012, p. 2410-2421.

    Research output: Contribution to journalJournal articleResearchpeer-review

  111. Published

    Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones. / Le Quement, Sebastian T; Flagstad, Thomas; Mikkelsen, Remi J T; Hansen, Mette R; Givskov, Michael; Nielsen, Thomas E.

    In: Organic Letters, Vol. 14, No. 2, 2012, p. 640-643.

    Research output: Contribution to journalJournal articleResearchpeer-review

  112. Published

    Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. / Hultqvist, Louise Dahl; van Gennip, Maria; Jakobsen, Tim Holm; Alhede, Morten; Hougen, Hans Petter; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael.

    In: Journal of Antimicrobial Chemotherapy, Vol. 67, No. 5, 2012, p. 1198-1206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  113. 2011
  114. Published

    Novel and future treatment strategies. / Alhede, Morten; Jakobsen, Tim Holm; Givskov, Michael.

    Biofilm Infections. Springer, 2011. p. 231-249.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  115. Published

    The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients. / Rudkjøbing, Vibeke B; Thomsen, Trine R; Alhede, Morten; Kragh, Kasper N; Nielsen, Per H; Johansen, Ulla R; Givskov, Michael; Høiby, Niels; Bjarnsholt, Thomas.

    In: F E M S Immunology and Medical Microbiology, Vol. 65, No. 2, 07.2011, p. 236-244.

    Research output: Contribution to journalJournal articleResearchpeer-review

  116. Published

    Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation. / Wu, Hong; Lee, Baoleri; Yang, Liang; Wang, Hengzuang; Givskov, Michael; Molin, Søren; Høiby, Niels; Song, Zhijun.

    In: F E M S Immunology and Medical Microbiology, Vol. 62, No. 1, 01.06.2011, p. 49-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  117. Published

    The contribution of cell-cell signaling and motility to bacterial biofilm formation. / Shrout, Joshua D; Tolker-Nielsen, Tim; Givskov, Michael; Parsek, Matthew R.

    In: M R S Bulletin, Vol. 36, No. 5, 05.2011, p. 367-373.

    Research output: Contribution to journalJournal articleResearchpeer-review

  118. Published

    Imaging N-acyl homoserine lactone quorum sensing in vivo. / Christensen, Louise Dahl; van Gennip, Maria; Jakobsen, Tim Holm; Givskov, Michael; Bjarnsholt, Thomas.

    In: Methods in Molecular Biology, Vol. 692, No. 2, 01.01.2011, p. 147-157.

    Research output: Contribution to journalJournal articleResearchpeer-review

  119. Published

    Qualitative and quantitative determination of quorum sensing inhibition in vitro. / Jakobsen, Tim Holm; van Gennip, Maria; Christensen, Louise Dahl; Bjarnsholt, Thomas; Givskov, Michael.

    In: Methods in Molecular Biology, Vol. 692, No. 3, 01.01.2011, p. 253-263.

    Research output: Contribution to journalJournal articleResearchpeer-review

  120. Published

    Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability. / Nilsson, Martin; Chiang, Wen-Chi; Fazli, Mustafa; Gjermansen, Morten; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Environmental Microbiology, Vol. 13, No. 5, 2011, p. 1357-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  121. Published

    Interfering with bacterial gossip. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Givskov, Michael.

    Biofilm perspectives: Biofilm highlight. ed. / H-C Flemming; J Wingender; U Szewzyk. 1. ed. Berlin : Springer Publishing Company, 2011. p. 163-188 (Springer Series on Biofilms, Vol. 5).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  122. Published

    Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm. / Alhede, Morten; Kragh, Kasper Nørskov; Qvortrup, Klaus; Allesen-Holm, Marie; van Gennip, Maria; Christensen, Louise D; Jensen, Peter Østrup; Nielsen, Anne K; Parsek, Matt; Wozniak, Dan; Molin, Søren; Tolker-Nielsen, Tim; Høiby, Niels; Givskov, Michael; Bjarnsholt, Thomas.

    In: P L o S One, Vol. 6, No. 11, 2011, p. e27943.

    Research output: Contribution to journalJournal articleResearchpeer-review

  123. Published

    Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds. / Fazli, Mustafa; Bjarnsholt, Thomas; Kirketerp-Møller, Klaus; Jørgensen, Anne; Andersen, Claus Bøgelund; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Wound Repair and Regeneration, Vol. 19, No. 3, 2011, p. 387-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  124. Published

    Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the autoinducer synthase AsaI on bacterial virulence. / Schwenteit, Johanna; Gram, Lone; Nielsen, Kristian F; Fridjonsson, Olafur H; Bornscheuer, Uwe T; Givskov, Michael; Gudmundsdottir, Bjarnheidur K.

    In: Veterinary Microbiology, Vol. 147, No. 3-4, 2011, p. 389-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  125. Published

    Quorum sensing inhibitors disable bacterial biofilms. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Givskov, Michael.

    Emerging trends in in antibacterial discovery.. ed. / A.A. Miller; P.F. Miller. 1. ed. Norvich UK : HorizonBioscience, 2011. p. 211-224.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  126. Published

    The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia. / Fazli, Mustafa; O'Connell, Aileen; Nilsson, Martin; Niehaus, Karsten; Dow, J Maxwell; Givskov, Michael; Ryan, Robert P; Tolker-Nielsen, Tim.

    In: Molecular Microbiology, Vol. 82, No. 2, 2011, p. 327-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  127. Published

    The clinical impact of bacterial biofilms. / Høiby, Niels; Ciofu, Oana; Johansen, Helle Krogh; Song, Zhi-jun; Moser, Claus; Jensen, Peter Østrup; Molin, Søren; Givskov, Michael; Tolker-Nielsen, Tim; Bjarnsholt, Thomas.

    In: International Journal of Oral Science, Vol. 3, No. 2, 2011, p. 55-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  128. Published

    The implication of Pseudomonas aeruginosa biofilms in infections. / Rybtke, Morten T; Jensen, Peter Østrup; Høiby, Niels; Givskov, Michael; Tolker-Nielsen, Tim; Bjarnsholt, Thomas.

    In: Inflammation & Allergy - Drug Targets, Vol. 10, No. 2, 2011, p. 141-57.

    Research output: Contribution to journalJournal articleResearchpeer-review

  129. Published

    True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis. / Rudkjøbing, Vibeke Børsholt; Thomsen, Trine R; Alhede, Morten; Kragh, Kasper N; Nielsen, Per H; Johansen, Ulla; Givskov, Michael; Høiby, Niels; Bjarnsholt, Thomas.

    In: Journal of Clinical Microbiology, Vol. 49, No. 12, 2011, p. 4352-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  130. 2010
  131. Published

    Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening. / Marsden, David M; Nicholson, Rebecca L; Skindersoe, Mette E; Galloway, Warren R J D; Sore, Hannah F; Givskov, Michael; Salmond, George P C; Ladlow, Mark; Welch, Martin; Spring, David R.

    In: Organic & Biomolecular Chemistry, Vol. 8, No. 23, 07.12.2010, p. 5313-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  132. Published

    Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. / Koh, Andrew Y; Mikkelsen, Per J; Smith, Roger S; Coggshall, Kathleen T; Kamei, Akinobu; Givskov, Michael; Lory, Stephen; Pier, Gerald B.

    In: P L o S One, Vol. 5, No. 12, 01.12.2010, p. e15131.

    Research output: Contribution to journalJournal articleResearchpeer-review

  133. Published

    Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial. / Smyth, Alan R; Cifelli, Paramita M; Ortori, Catharine A; Righetti, Karima; Lewis, Sarah; Erskine, Penny; Holland, Elaine D; Givskov, Michael; Williams, Paul; Cámara, Miguel; Barrett, David A; Knox, Alan.

    In: Pediatric Pulmonology, Vol. 45, No. 4, 01.04.2010, p. 356-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  134. Published

    Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots. / Andersen, A S; Joergensen, B; Bjarnsholt, T; Johansen, H; Karlsmark, T; Givskov, M; Krogfelt, K A; Andersen, A S; Jørgensen, Bo; Bjarnsholt, T; Johansen, H; Karlsmark, Tonny; Givskov, Michael; Krogfelt, Karen Angeliki.

    In: Microbiology, Vol. 156, No. Pt 2, 01.02.2010, p. 400-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  135. Published

    Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis. / Kolpen, Mette; Hansen, C. R.; Bjarnsholt, Thomas; Moser, C; Hultqvist, Louise Dahl; van Gennip, M; Ciofu, O; Mandsberg, L; Kharazmi, A; Döring, G; Givskov, M; Høiby, N; Jensen, Peter Østrup.

    In: Thorax, Vol. 65, No. 1, 01.01.2010, p. 57-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  136. Published

    Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients. / Bjarnsholt, Thomas; Jensen, Peter Østrup; Jakobsen, Tim Holm; Phipps, Richard; Nielsen, Anne Kirstine; Rybtke, Morten Theil; Tolker-Nielsen, Tim; Givskov, Michael; Høiby, Niels; Ciofu, Oana; Scandinavian Cystic Fibrosis Study Consortium.

    In: PLoS ONE, Vol. 5, No. 4, 01.01.2010, p. e10115.

    Research output: Contribution to journalJournal articleResearchpeer-review

  137. Published

    Acetic acid and a buffer. / T, Bjarnsholt (Inventor); M, Givskov (Inventor); P, Homoe (Inventor); Høiby, Niels (Inventor); PO, Jensen (Inventor); HK, Johansen (Inventor); K, Kirketerp-Moller (Inventor).

    Patent No.: WO2009155931. Jan 30, 2010.

    Research output: Patent

  138. Published

    An in vitro model of bacterial infections in wounds and other soft tissues. / Werthén, Maria; Henriksson, Lina; Jensen, Peter Østrup; Sternberg, Claus; Givskov, Michael; Bjarnsholt, Thomas.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 118, No. 2, 2010, p. 156-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  139. Published

    Antibiotic resistance of bacterial biofilms. / Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael; Molin, Søren; Ciofu, Oana.

    In: International Journal of Antimicrobial Agents, Vol. 35, No. 4, 2010, p. 322-332.

    Research output: Contribution to journalReviewResearchpeer-review

  140. Published

    Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections. / Burmølle, Mette; Thomsen, Trine Rolighed; Fazli, Mustafa; Dige, Irene; Christensen, Lise; Homøe, Preben; Tvede, Michael; Nyvad, Bente; Tolker-Nielsen, Tim; Givskov, Michael; Moser, Claus Ernst; Kirketerp-Møller, Klaus; Johansen, Helle Krogh; Høiby, Niels; Jensen, Peter Østrup; Sørensen, Søren Johannes; Bjarnsholt, Thomas.

    In: FEMS Immunology and Medical Microbiology, Vol. 59, No. 3, 2010, p. 324-336.

    Research output: Contribution to journalReviewResearchpeer-review

  141. Published

    In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect. / Bjarnsholt, Thomas; van Gennip, Maria; Jakobsen, Tim H; Christensen, Louise D; Jensen, Peter Østrup; Givskov, Michael.

    In: Nature Protocols (Print Edition), Vol. 5, No. 2, 2010, p. 282-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  142. Published

    Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Høiby, Niels; Givskov, Michael.

    In: Expert Reviews in Molecular Medicine, Vol. 12, 2010, p. e11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  143. Published

    Quorum sensing regulation in Aeromonas hydrophila. / Garde, Christian; Bjarnsholt, Thomas; Givskov, Michael; Jakobsen, Tim Holm; Hentzer, Morten; Claussen, Anetta; Sneppen, Kim; Ferkinghoff-Borg, Jesper; Sams, Thomas.

    In: Journal of Molecular Biology, Vol. 396, No. 4, 2010, p. 849-57.

    Research output: Contribution to journalJournal articleResearchpeer-review

  144. Published

    The bacteriology of chronic venous leg ulcer examined by culture-independent molecular methods. / Thomsen, Trine R; Aasholm, Martin S; Rudkjøbing, Vibeke B; Saunders, Aaron M; Bjarnsholt, Thomas; Givskov, Michael; Kirketerp-Møller, Klaus; Nielsen, Per H.

    In: Wound Repair and Regeneration, Vol. 18, No. 1, 2010, p. 38-49.

    Research output: Contribution to journalJournal articleResearchpeer-review

  145. Published

    The immune system vs. Pseudomonas aeruginosa biofilms. / Jensen, Peter Østrup; Givskov, Michael; Bjarnsholt, Thomas; Moser, Claus.

    In: FEMS Immunology and Medical Microbiology, Vol. 59, No. 3, 2010, p. 292-305.

    Research output: Contribution to journalJournal articleResearchpeer-review

  146. 2009
  147. Published

    Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa. / van Gennip, Maria; Moser, Claus; Christensen, Louise D; Bjarnsholt, Thomas; Calum, Henrik; Jensen, Peter Østrup; Christophersen, Lars; Hougen, Hans Petter; Ciofu, Oana; Molin, Søren; Givskov, Michael; Høiby, Niels.

    In: Journal of Antimicrobial Chemotherapy, Vol. 64, No. 6, 01.12.2009, p. 1241-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  148. Published

    Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes. / Van Gennip, Maria; Christensen, Louise Dahl; Alhede, Morten; Phipps, Richard; Jensen, Peter Østrup; Christophersen, Lars; Pamp, Sünje Johanna; Moser, Claus; Mikkelsen, Per Jensen; Koh, Andrew Y; Tolker-Nielsen, Tim; Pier, Gerald B; Høiby, Niels; Givskov, Michael; Bjarnsholt, Thomas.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 117, No. 7, 01.07.2009, p. 537-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  149. Published

    Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. / Bjarnsholt, Thomas; Jensen, Peter Østrup; Fiandaca, Mark J; Pedersen, Jette; Hansen, Christine Rønne; Andersen, Claus Bøgelund; Pressler, Tacjana; Givskov, Michael; Høiby, Niels.

    In: Pediatric Pulmonology, Vol. 44, No. 6, 01.06.2009, p. 547-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

  150. Published

    Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis. / Moser, C.; Gennip, M. van; Bjarnsholt, T.; Jensen, Peter Østrup; Lee, B.; Hougen, H.P.; Calum, H.; Ciofu, O.; Givskov, M.; Molin, S.; Høiby, Niels.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 117, No. 2, 01.02.2009, p. 95-107.

    Research output: Contribution to journalJournal articleResearchpeer-review

  151. Published

    Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes. / Alhede, Morten; Bjarnsholt, Thomas; Jensen, Peter Østrup; Phipps, Richard Kerry; Moser, Claus; Christophersen, Lars; Hultqvist, Louise Dahl; van Gennip, Maria; Parsek, Matt; Høiby, Niels; Rasmussen, Thomas Bovbjerg; Givskov, Michael.

    In: Microbiology, Vol. 155, No. 11, 2009, p. 3500-3508.

    Research output: Contribution to journalJournal articleResearchpeer-review

  152. Published

    Biofilms and type III secretion are not mutually exclusive in Pseudomonas aeruginosa. / Mikkelsen, H; Bond, N J; Skindersoe, M E; Givskov, M; Lilley, K S; Welch, M.

    In: Microbiology, Vol. 155, No. Pt 3, 2009, p. 687-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  153. Published

    Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors. / Yang, Liang; Rybtke, Morten Theil; Jakobsen, Tim Holm; Hentzer, Morten; Bjarnsholt, Thomas; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 6, 2009, p. 2432-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  154. Published

    Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Givskov, Michael; Janssen, Martin; Christensen, Lise Hanne.

    In: Dermatologic Surgery, Vol. 35 Suppl 2, 2009, p. 1620-1624.

    Research output: Contribution to journalJournal articleResearchpeer-review

  155. Published

    Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds. / Fazli, Mustafa; Bjarnsholt, Thomas; Kirketerp-Møller, Klaus; Jørgensen, Bo; Andersen, Anders Schou; Krogfelt, Karen A; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Journal of Clinical Microbiology, Vol. 47, No. 12, 2009, p. 4084-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  156. Published

    Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis. / Moser, Claus Ernst; van Gennip, Maria; Bjarnsholt, Thomas; Jensen, P.Ø.; Lee, B.; Hougen, Hans Petter; Calum, Henrik Pierre; Ciofu, Oana; Givskov, Michael; Høiby, Niels.

    In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 117, 2009, p. 95-107.

    Research output: Contribution to journalJournal articleResearchpeer-review

  157. Published

    Pseudomonas aeruginosa quorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation. / Skindersoe, Mette E; Zeuthen, Louise H; Brix, Susanne; Fink, Lisbeth N; Lazenby, James; Whittall, Christine; Williams, Paul; Diggle, Stephen P; Froekiaer, Hanne; Cooley, Margaret; Givskov, Michael.

    In: FEMS Immunology and Medical Microbiology, Vol. 55, No. 3, 2009, p. 335-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  158. Published

    Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation. / Yang, Liang; Nilsson, Martin; Gjermansen, Morten; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Molecular Microbiology, Vol. 74, No. 6, 2009, p. 1380-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  159. 2008
  160. Published

    Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. / Skindersoe, Mette E; Alhede, Morten; Phipps, Richard; Yang, Liang; Jensen, Peter O; Rasmussen, Thomas B; Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Høiby, Niels; Givskov, Michael.

    In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 10, 01.10.2008, p. 3648-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  161. Published

    Distribution, organization, and ecology of bacteria in chronic wounds. / Kirketerp-Møller, Klaus; Jensen, Peter Østrup; Fazli, Mustafa; Madsen, Kit G; Pedersen, Jette; Moser, Claus; Tolker-Nielsen, Tim; Høiby, Niels; Givskov, Michael; Bjarnsholt, Thomas.

    In: Journal of Clinical Microbiology, Vol. 46, No. 8, 01.08.2008, p. 2717-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  162. Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae. / Matz, Carsten; Moreno, Ana Maria; Alhede, Morten; Manefield, Mike; Hauser, Alan R; Givskov, Michael; Kjelleberg, Staffan.

    In: ISME Journal, Vol. 2, No. 8, 2008, p. 843-852.

    Research output: Contribution to journalJournal articleResearchpeer-review

  163. Detection and inhibition of bacterial cell-cell communication. / Rice, Scott A; McDougald, Diane; Givskov, Michael; Kjelleberg, Staffan.

    In: Methods in Molecular Biology, Vol. 431, 2008, p. 55-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  164. Published

    Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort? / Bjarnsholt, Thomas; Givskov, M.

    In: Current Infectious Disease Reports, Vol. 10, No. 1, 2008, p. 22-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  165. Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis. / Willcox, M D P; Zhu, H; Conibear, T C R; Hume, E B H; Givskov, M; Kjelleberg, S; Rice, S A.

    In: Microbiology, Vol. 154, No. Pt 8, 2008, p. 2184-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  166. Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms. / Barken, Kim Bundvig; Pamp, Sünje Johanna; Yang, Liang; Gjermansen, Morten; Bertrand, Jacob J.; Klausen, Mikkel; Givskov, Michael; Whitchurch, Cynthia B.; Engel, Joanne N.; Tolker-Nielsen, Tim.

    In: Environmental Microbiology, Vol. 10, No. 9, 2008, p. 2331-2343.

    Research output: Contribution to journalJournal articleResearchpeer-review

  167. Published

    The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells. / Kristiansen, Søren; Bjarnsholt, Thomas; Adeltoft, Dinah; Ifversen, Peter; Givskov, Michael.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 116, No. 5, 2008, p. 361-371.

    Research output: Contribution to journalJournal articleResearchpeer-review

  168. Published

    Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection. / Calum, Henrik Pierre; Moser, Claus Ernst; Jensen, Peter Østrup; Christoffersen, L.; Damlund, Dina Silke Malling; Alhede, Maria; Bjarnsholt, Thomas; Hougen, Hans Petter; Givskov, Michael; Jacobsen, Grete Krag; Høiby, Niels.

    In: Clinical and Experimental Immunology, Vol. 156, No. 1, 2008, p. 102-110.

    Research output: Contribution to journalJournal articleResearchpeer-review

  169. Published

    Why chronic wounds will not heal: a novel hypothesis. / Bjarnsholt, Thomas; Kirketerp-Møller, Klaus; Jensen, Peter Østrup; Madsen, Kit G; Phipps, Richard Kerry; Krogfelt, Karen; Høiby, Niels; Givskov, Michael.

    In: Wound Repair and Regeneration, Vol. 16, No. 1, 2008, p. 2-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  170. 2007
  171. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice. / Hoffmann, Nadine; Lee, Baoleri; Hentzer, Morten; Rasmussen, Thomas Bovbjerg; Song, Zhijun; Johansen, Helle Krogh; Givskov, Michael; Høiby, Niels.

    In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 10, 2007, p. 3677-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  172. Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa. / Yang, Liang; Barken, Kim B; Skindersoe, Mette E; Christensen, Allan B; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Microbiology, Vol. 153, No. Pt 5, 2007, p. 1318-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  173. Published

    Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing. / Høiby, Niels; Johansen, Helle Krogh; Ciofu, Oana; Jensen, Peter Østrup; Bjarnsholt, Thomas; Givskov, Michael.

    In: Ugeskrift for læger, Vol. 169, No. 48, 2007, p. 4163-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  174. Published

    Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model. / Christensen, Louise Dahl; Moser, Claus; Jensen, Peter Østrup; Rasmussen, Thomas B; Christophersen, Lars; Kjelleberg, Staffan; Kumar, Naresh; Høiby, Niels; Givskov, Michael; Bjarnsholt, Thomas.

    In: Microbiology, Vol. 153, No. Pt 7, 2007, p. 2312-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  175. Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production. / Kastbjerg, V G; Nielsen, K F; Dalsgaard, I; Rasch, M; Bruhn, J B; Givskov, M; Gram, L.

    In: Journal of Applied Microbiology, Vol. 102, No. 2, 2007, p. 363-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  176. Quorum sensing antagonism from marine organisms. / Skindersoe, Mette Elena; Ettinger-Epstein, Piers; Rasmussen, Thomas Bovbjerg; Bjarnsholt, Thomas; de Nys, Rocky; Givskov, Michael.

    In: Marine Biotechnology, Vol. 10, No. 1, 2007, p. 56-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  177. Published

    Quorum sensing antagonism from marine organisms. / Skindersoe, Mette Elena; Ettinger-Epstein, Piers; Rasmussen, Thomas Bovbjerg; Bjarnsholt, Thomas; de Nys, Rocky; Givskov, Michael.

    In: Marine Biotechnology, Vol. 10, No. 1, 2007, p. 56-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  178. Quorum sensing in Serratia. / Van Houdt, Rob; Givskov, Michael; Michiels, Chris W.

    In: FEMS Microbiology Reviews, Vol. 31, No. 4, 2007, p. 407-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  179. Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor. / Rasch, Maria; Kastbjerg, Vicky Gaedt; Bruhn, Jesper Bartholin; Dalsgaard, Inger; Givskov, Michael; Gram, Lone.

    In: Diseases of Aquatic Organisms, Vol. 78, No. 2, 2007, p. 105-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  180. Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. / Bjarnsholt, Thomas; Givskov, Michael.

    In: Philosophical Transactions of the Royal Society of London. Biological Sciences, Vol. 362, No. 1483, 2007, p. 1213-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  181. Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent. / Labbate, Maurizio; Zhu, Hua; Thung, Leena; Bandara, Rani; Larsen, Martin R; Willcox, Mark D P; Givskov, Michael; Rice, Scott A; Kjelleberg, Staffan.

    In: Journal of Bacteriology, Vol. 189, No. 7, 2007, p. 2702-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  182. Published

    Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. / Jensen, Peter Østrup; Bjarnsholt, Thomas; Phipps, Richard; Rasmussen, Thomas B; Calum, Henrik; Christoffersen, Lars; Moser, Claus; Williams, Paul; Pressler, Tacjana; Givskov, Michael; Høiby, Niels.

    In: Microbiology, Vol. 153, No. Pt 5, 2007, p. 1329-38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  183. Published

    Silver against Pseudomonas aeruginosa biofilms. / Bjarnsholt, Thomas; Kirketerp-Møller, Klaus; Kristiansen, Søren; Phipps, Richard; Nielsen, Anne Kirstine; Jensen, Peter Østrup; Høiby, Niels; Givskov, Michael.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 115, No. 8, 2007, p. 921-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  184. Well-known quorum sensing inhibitors do not affect bacterial quorum sensing-regulated bean sprout spoilage. / Rasch, M; Rasmussen, T B; Andersen, J B; Persson, T; Nielsen, J; Givskov, M; Gram, L.

    In: Journal of Applied Microbiology, Vol. 102, No. 3, 2007, p. 826-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  185. 2006
  186. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. / Allesen-Holm, Marie; Barken, Kim Bundvig; Yang, Liang; Klausen, Mikkel; Webb, Jeremy S; Kjelleberg, Staffan; Molin, Søren; Givskov, Michael; Tolker-Nielsen, Tim.

    In: Molecular Microbiology, Vol. 59, No. 4, 2006, p. 1114-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  187. Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein. / Schreiber, Kerstin; Boes, Nelli; Eschbach, Martin; Jaensch, Lothar; Wehland, Juergen; Bjarnsholt, Thomas; Givskov, Michael; Hentzer, Morten; Schobert, Max.

    In: Journal of Bacteriology, Vol. 188, No. 2, 2006, p. 659-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  188. Published

    Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils. / Fexby, Sara; Bjarnsholt, Thomas; Jensen, Peter Østrup; Roos, Viktoria; Høiby, Niels; Givskov, Michael; Klemm, Per.

    In: Infection and Immunity, Vol. 75, No. 1, 2006, p. 30-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  189. Expedient total synthesis of pyrrothine natural products and analogs. / Hjelmgaard, Thomas; Givskov, Michael; Nielsen, John.

    In: Organic & Biomolecular Chemistry, Vol. 5, No. 2, 2006, p. 344-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  190. Furanones. / de Nys, R; Givskov, M; Kumar, N; Kjelleberg, S; Steinberg, P D.

    In: Progress in Molecular and Subcellular Biology, Vol. 42, 2006, p. 55-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  191. Quorum sensing inhibitors: a bargain of effects. / Rasmussen, Thomas B; Givskov, Michael.

    In: Microbiology, Vol. 152, No. Pt 4, 2006, p. 895-904.

    Research output: Contribution to journalJournal articleResearchpeer-review

  192. Quorum-sensing inhibitors as anti-pathogenic drugs. / Rasmussen, Thomas B; Givskov, Michael.

    In: International Journal of Medical Microbiology, Vol. 296, No. 2-3, 2006, p. 149-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  193. The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. / Shrout, Joshua D; Chopp, David L; Just, Collin L; Hentzer, Morten; Givskov, Michael; Parsek, Matthew R.

    In: Molecular Microbiology, Vol. 62, No. 5, 2006, p. 1264-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  194. 2005
  195. Published

    Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. / Bjarnsholt, Thomas; Jensen, Peter Østrup; Burmølle, Mette; Hentzer, Morten; Haagensen, Janus A J; Hougen, Hans Petter; Calum, Henrik; Madsen, Kit G; Moser, Claus; Molin, Søren; Høiby, Niels; Givskov, Michael.

    In: Microbiology, Vol. 151, No. Pt 2, 02.2005, p. 373-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  196. Enhancer-binding proteins with a forkhead-associated domain and the sigma54 regulon in Myxococcus xanthus fruiting body development. / Jelsbak, Lars; Givskov, Michael; Kaiser, Dale.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 102, No. 8, 2005, p. 3010-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  197. Published

    Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudo-monas aeruginosa infections. / Bjarnsholt, Thomas; Jensen, P.Ø.; Rasmussen, T.B.; Christoffersen, L.; Calum, Henrik Pierre; Hentzer, Morten; Hougen, Hans Petter; Rygaard, Jørgen; Moser, Claus Ernst; Eberl, Leo; Høiby, Niels; Givskov, Michael.

    In: F E M S Microbiology, Vol. 151, 2005, p. 3873-3880.

    Research output: Contribution to journalJournal articleResearchpeer-review

  198. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. / Bjarnsholt, Thomas; Jensen, Peter Østrup; Rasmussen, Thomas B; Christophersen, Lars; Calum, Henrik; Hentzer, Morten; Hougen, Hans-Petter; Rygaard, Jørgen; Moser, Claus; Eberl, Leo; Høiby, Niels; Givskov, Michael.

    In: Microbiology, Vol. 151, No. Pt 12, 2005, p. 3873-80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  199. Published

    Identity and effects of quorum-sensing inhibitors produced by Penicillium species. / Rasmussen, Thomas Bovbjerg; Skindersoe, Mette E; Bjarnsholt, Thomas; Phipps, Richard K; Christensen, Kathrine Bisgaard; Jensen, Peter Østrup; Andersen, Jens Bo; Koch, Birgit; Larsen, Thomas Ostenfeld; Hentzer, Morten; Eberl, Leo; Høiby, Niels; Givskov, Michael.

    In: Microbiology, Vol. 151, No. Pt 5, 2005, p. 1325-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  200. Published

    Involvement of bacterial quorum-sensing signals in spoilage of bean sprouts. / Rasch, Maria; Andersen, Jens Bo; Nielsen, Kristian Fog; Flodgaard, Lars Ravn; Christensen, Henrik; Givskov, Michael; Gram, Lone.

    In: Applied and Environmental Microbiology, Vol. 71, No. 6, 2005, p. 3321-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  201. Nonbioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-Hydroxyoctanoyl)homoserine lactone. / Flodgaard, L R; Dalgaard, P; Andersen, Jens Bo; Nielsen, K F; Givskov, M; Gram, L.

    In: Applied and Environmental Microbiology, Vol. 71, No. 4, 2005, p. 2113-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  202. Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model. / Bragonzi, Alessandra; Worlitzsch, Dieter; Pier, Gerald B; Timpert, Petra; Ulrich, Martina; Hentzer, Morten; Andersen, Jens Bo; Givskov, Michael; Conese, Massimo; Doring, Gerd.

    In: Journal of Infectious Diseases, Vol. 192, No. 3, 2005, p. 410-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  203. Published

    Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis. / Hoffmann, Nadine; Rasmussen, Thomas Bovbjerg; Jensen, Peter Østrup; Stub, Charlotte; Hentzer, Morten; Molin, Søren; Ciofu, Oana; Givskov, Michael; Johansen, Helle Krogh; Høiby, Niels.

    In: Infection and Immunity, Vol. 73, No. 4, 2005, p. 2504-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  204. Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria. / Persson, Tobias; Givskov, Michael; Nielsen, John.

    In: Current Medicinal Chemistry, Vol. 12, No. 26, 2005, p. 3103-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  205. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. / Rasmussen, Thomas Bovbjerg; Bjarnsholt, Thomas; Skindersoe, Mette Elena; Hentzer, Morten; Kristoffersen, Peter; Köte, Manuela; Nielsen, John; Eberl, Leo; Givskov, Michael.

    In: Journal of Bacteriology, Vol. 187, No. 5, 2005, p. 1799-814.

    Research output: Contribution to journalJournal articleResearchpeer-review

  206. The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors. / Koch, B; Liljefors, T; Persson, T; Nielsen, J; Kjelleberg, S; Givskov, M.

    In: Microbiology, Vol. 151, No. Pt 11, 2005, p. 3589-602.

    Research output: Contribution to journalJournal articleResearchpeer-review

  207. 2004
  208. An inhibitor of bacterial quorum sensing reduces mortalities caused by Vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum). / Rasch, Maria; Buch, Christiane; Austin, Brian; Slierendrecht, Wilhelmina J; Ekmann, Kim S; Larsen, Jens Laurits; Johansen, Charlotte; Riedel, Kathrin; Eberl, Leo; Givskov, Michael; Gram, Lone.

    In: Systematic and Applied Microbiology, Vol. 27, No. 3, 2004, p. 350-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  209. Published

    Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms. / Bagge, Niels; Hentzer, Morten; Andersen, Jens Bo; Ciofu, Oana; Givskov, Michael; Høiby, Niels.

    In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 4, 2004, p. 1168-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  210. Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa. / Wu, Hong; Song, Zhijun; Givskov, Michael; Høiby, Niels.

    In: Microbes and Infection, Vol. 6, No. 1, 2004, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  211. Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system. / Danhorn, Thomas; Hentzer, Morten; Givskov, Michael; Parsek, Matthew R; Fuqua, Clay.

    In: Journal of Bacteriology, Vol. 186, No. 14, 2004, p. 4492-501.

    Research output: Contribution to journalJournal articleResearchpeer-review

  212. Presence of acylated homoserine lactones (AHLs) and AHL-producing bacteria in meat and potential role of AHL in spoilage of meat. / Bruhn, Jesper Bartholin; Christensen, Allan Beck; Flodgaard, Lars Ravn; Nielsen, Kristian Fog; Larsen, Thomas Ostenfeld; Givskov, Michael; Gram, Lone.

    In: Applied and Environmental Microbiology, Vol. 70, No. 7, 2004, p. 4293-302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  213. Published

    Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production. / Bagge, Niels; Schuster, Martin; Hentzer, Morten; Ciofu, Oana; Givskov, Michael; Greenberg, Everett Peter; Høiby, Niels.

    In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 4, 2004, p. 1175-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  214. Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection. / Zhu, Hua; Bandara, Rani; Conibear, Tim C R; Thuruthyil, Sophy J; Rice, Scott A; Kjelleberg, Staffan; Givskov, Michael; Willcox, Mark D P.

    In: Investigative Ophthalmology & Visual Science, Vol. 45, No. 6, 2004, p. 1897-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  215. Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1. / Labbate, Maurizio; Queck, Shu Yeong; Koh, Kai Shyang; Rice, Scott A; Givskov, Michael; Kjelleberg, Staffan.

    In: Journal of Bacteriology, Vol. 186, No. 3, 2004, p. 692-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  216. Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic. / Persson, Tobias; Hansen, Thomas H; Rasmussen, Thomas B; Skindersø, Mette E; Givskov, Michael; Nielsen, John.

    In: Organic & Biomolecular Chemistry, Vol. 3, No. 2, 2004, p. 253-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  217. Published

    Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. / Wu, H; Song, Z; Hentzer, M; Andersen, Jens Bo; Molin, S; Givskov, M; Høiby, Niels.

    In: Journal of Antimicrobial Chemotherapy, Vol. 53, No. 6, 2004, p. 1054-61.

    Research output: Contribution to journalJournal articleResearchpeer-review

  218. 2003
  219. Published

    Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. / Hentzer, Morten; Wu, Hong; Andersen, Jens Bo; Riedel, Kathrin; Rasmussen, Thomas B; Bagge, Niels; Kumar, Naresh; Schembri, Mark A; Song, Zhijun; Kristoffersen, Peter; Manefield, Mike; Costerton, John W; Molin, Søren; Eberl, Leo; Steinberg, Peter; Kjelleberg, Staffan; Høiby, Niels; Givskov, Michael.

    In: EMBO Journal, Vol. 22, No. 15, 2003, p. 3803-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  220. Bacterial biofilms: prokaryotic adventures in multicellularity. / Webb, Jeremy S; Givskov, Michael; Kjelleberg, Staffan.

    In: Current Opinion in Microbiology, Vol. 6, No. 6, 2003, p. 578-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  221. Cell death in Pseudomonas aeruginosa biofilm development. / Webb, Jeremy S; Thompson, Lyndal S; James, Sally; Charlton, Tim; Tolker-Nielsen, Tim; Koch, Birgit; Givskov, Michael; Kjelleberg, Staffan.

    In: Journal of Bacteriology, Vol. 185, No. 15, 2003, p. 4585-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  222. Identification and characterization of a GDSL esterase gene located proximal to the swr quorum-sensing system of Serratia liquefaciens MG1. / Riedel, Kathrin; Talker-Huiber, Daniela; Givskov, Michael; Schwab, Helmut; Eberl, Leo.

    In: Applied and Environmental Microbiology, Vol. 69, No. 7, 2003, p. 3901-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  223. Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics. / Arevalo-Ferro, Catalina; Hentzer, Morten; Reil, Gerold; Görg, Angelika; Kjelleberg, Staffan; Givskov, Michael; Riedel, Kathrin; Eberl, Leo.

    In: Environmental Microbiology, Vol. 5, No. 12, 2003, p. 1350-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  224. Influence of food preservation parameters and associated microbiota on production rate, profile and stability of acylated homoserine lactones from food-derived Enterobacteriaceae. / Ravn Flodgaard, Lars; Christensen, Allan Beck; Molin, Søren; Givskov, Michael; Gram, Lone.

    In: International Journal of Food Microbiology, Vol. 84, No. 2, 2003, p. 145-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  225. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. / Hentzer, Morten; Givskov, Michael.

    In: Journal of Clinical Investigation, Vol. 112, No. 9, 2003, p. 1300-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  226. Quorum sensing : a novel target for the treatment of biofilm infections. / Hentzer, Morten; Eberl, Leo; Nielsen, John; Givskov, Michael.

    In: BioDrugs, Vol. 17, No. 4, 2003, p. 241-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  227. Quorum-sensing-directed protein expression in Serratia proteamaculans B5a. / Christensen, Allan B; Riedel, Kathrin; Eberl, Leo; Flodgaard, Lars R; Molin, Søren; Gram, Lone; Givskov, Michael.

    In: Microbiology, Vol. 149, No. Pt 2, 2003, p. 471-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  228. Published

    Surface motility in Pseudomonas sp. DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum. / Andersen, Jens Bo; Koch, Birgit; Nielsen, Tommy Harder; Sørensen, Dan; Hansen, Michael; Nybroe, Ole; Christophersen, Carsten; Sørensen, Jan; Molin, Søren; Givskov, Michael.

    In: Microbiology, Vol. 149, No. Pt 1, 2003, p. 37-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  229. Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. / Hjelmgaard, Thomas; Persson, Tobias; Rasmussen, Thomas B; Givskov, Michael; Nielsen, John.

    In: Bioorganic & Medicinal Chemistry, Vol. 11, No. 15, 2003, p. 3261-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  230. 2002
  231. Published

    Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers. / Olsen, J. A.; Severinsen, R.; Rasmussen, T. B.; Hentzer, M.; Givskov, M.; Nielsen, J.; Nielsen, John.

    In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 3, 11.02.2002, p. 325-328.

    Research output: Contribution to journalJournal articleResearchpeer-review

  232. An attractive surface : gram-negative bacterial biofilms. / Schembri, Mark; Givskov, Michael; Klemm, Per.

    In: Science Signaling, Vol. 2002, No. 132, 2002, p. re6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  233. Published

    Antibiotic and biosurfactant properties of cyclic lipopeptides produced by fluorescent Pseudomonas spp. from the sugar beet rhizosphere. / Nielsen, T H; Sørensen, D; Tobiasen, C; Andersen, Jens Bo; Christophersen, C; Givskov, M; Sørensen, J.

    In: Applied and Environmental Microbiology, Vol. 68, No. 7, 2002, p. 3416-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  234. Published

    Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD. / Bagge, Niels; Ciofu, Oana; Hentzer, Morten; Campbell, Joan I A; Givskov, Michael; Høiby, Niels.

    In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 11, 2002, p. 3406-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  235. Food spoilage--interactions between food spoilage bacteria. / Gram, Lone; Ravn, Lars; Rasch, Maria; Bruhn, Jesper Bartholin; Christensen, Allan B; Givskov, Michael.

    In: International Journal of Food Microbiology, Vol. 78, No. 1-2, 2002, p. 79-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  236. Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111. / Huber, Birgit; Riedel, Kathrin; Köthe, Manuela; Givskov, Michael; Molin, Søren; Eberl, Leo.

    In: Molecular Microbiology, Vol. 46, No. 2, 2002, p. 411-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  237. Published

    Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. / Manefield, Michael; Rasmussen, Thomas Bovbjerg; Henzter, Morten; Andersen, Jens Bo; Steinberg, Peter; Kjelleberg, Staffan; Givskov, Michael.

    In: Microbiology, Vol. 148, No. Pt 4, 2002, p. 1119-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  238. Identification and characterization of an N-acylhomoserine lactone-dependent quorum-sensing system in Pseudomonas putida strain IsoF. / Steidle, Anette; Allesen-Holm, Marie; Riedel, Kathrin; Berg, Gabriele; Givskov, Michael; Molin, Søren; Eberl, Leo.

    In: Applied and Environmental Microbiology, Vol. 68, No. 12, 2002, p. 6371-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  239. Published

    Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. / Hentzer, Morten; Riedel, Kathrin; Rasmussen, Thomas B; Heydorn, Arne; Andersen, Jens Bo; Parsek, Matthew R; Rice, Scott A; Eberl, Leo; Molin, Søren; Høiby, Niels; Kjelleberg, Staffan; Givskov, Michael.

    In: Microbiology, Vol. 148, No. Pt 1, 2002, p. 87-102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  240. Lipopeptide production in Pseudomonas sp. strain DSS73 is regulated by components of sugar beet seed exudate via the Gac two-component regulatory system. / Koch, Birgit; Nielsen, Tommy H; Sørensen, Dan; Andersen, Jens Bo; Christophersen, Carsten; Molin, Søren; Givskov, Michael; Sørensen, Jan; Nybroe, Ole.

    In: Applied and Environmental Microbiology, Vol. 68, No. 9, 2002, p. 4509-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  241. Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA. / Laux, David C; Corson, Joy M; Givskov, Michael; Hentzer, Morten; Møller, Annette; Wosencroft, Kathleen A; Olson, Joan C; Krogfelt, Karen A; Goldberg, Joanna B; Cohen, Paul.

    In: Microbiology, Vol. 148, No. Pt 6, 2002, p. 1709-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  242. Quantitative effects of medium hardness and nutrient availability on the swarming motility of Serratia liquefaciens. / Bees, M A; Andresén, P; Mosekilde, E; Givskov, M.

    In: Bulletin of Mathematical Biology, Vol. 64, No. 3, 2002, p. 565-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  243. Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers. / Olsen, J A; Severinsen, Rune Eg; Rasmussen, T B; Hentzer, Morten; Givskov, M; Nielsen, J.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 12, No. 3, 2002, p. 325-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  244. The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group. / Agersø, Yvonne; Jensen, Lars Bogø; Givskov, Michael; Roberts, Marilyn C.

    In: FEMS Microbiology Letters, Vol. 214, No. 2, 2002, p. 251-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  245. 2001
  246. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function. / Hentzer, Morten; Teitzel, G M; Balzer, G J; Heydorn, Arne; Molin, Søren; Givskov, M; Parsek, M R.

    In: Journal of Bacteriology, Vol. 183, No. 18, 2001, p. 5395-401.

    Research output: Contribution to journalJournal articleResearchpeer-review

  247. Genetic and chemical tools for investigating signaling processes in biofilms. / Charlton, T; Givskov, M; deNys, R; Andersen, Jens Bo; Hentzer, Morten; Rice, S; Kjelleberg, S.

    In: Methods in Enzymology, Vol. 336, 2001, p. 108-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  248. Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. / Manefield, M; Welch, M; Givskov, M; Salmond, G P; Kjelleberg, S.

    In: F E M S Microbiology Letters, Vol. 205, No. 1, 2001, p. 131-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  249. Methods for detecting acylated homoserine lactones produced by Gram-negative bacteria and their application in studies of AHL-production kinetics. / Ravn, L; Christensen, A B; Molin, Søren; Givskov, M; Gram, L.

    In: Journal of Microbiological Methods, Vol. 44, No. 3, 2001, p. 239-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  250. Published

    N-acyl homoserinelactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. / Riedel, K.; Mentzer, M.; Geisenberger, O.; Huber, B.; Steidle, A.; Wu, H.; Høiby, Niels; Givskov, Michael; Molin, S.; Eberl, L.

    In: Microbiology, No. 147, 2001, p. 3249-3262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  251. N-acyl-L-homoserine lactone-mediated regulation of the lip secretion system in Serratia liquefaciens MG1. / Riedel, K; Ohnesorg, T; Krogfelt, K A; Hansen, T S; Omori, K; Givskov, M; Eberl, Leo.

    In: Journal of Bacteriology, Vol. 183, No. 5, 2001, p. 1805-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  252. Published

    N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. / Riedel, K; Hentzer, Morten; Geisenberger, O; Huber, B; Steidle, A; Wu, H; Høiby, N; Givskov, M; Molin, Søren; Eberl, Leo.

    In: Microbiology, Vol. 147, No. Pt 12, 2001, p. 3249-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  253. Published

    Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection. / Wu, H; Song, Z; Givskov, Michael; Doring, G; Worlitzsch, D; Mathee, K; Rygaard, J; Høiby, N.

    In: Microbiology, Vol. 147, No. Pt 5, 2001, p. 1105-1113.

    Research output: Contribution to journalJournal articleResearchpeer-review

  254. The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility. / Huber, B; Riedel, K; Hentzer, Morten; Heydorn, Arne; Gotschlich, A; Givskov, M; Molin, Søren; Eberl, Leo.

    In: Microbiology, Vol. 147, No. Pt 9, 2001, p. 2517-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  255. Visualization of N-acylhomoserine lactone-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere. / Steidle, A; Sigl, K; Schuhegger, R; Ihring, A; Schmid, M; Gantner, S; Stoffels, M; Riedel, K; Givskov, M; Hartmann, A; Langebartels, C; Eberl, Leo.

    In: Applied and Environmental Microbiology, Vol. 67, No. 12, 2001, p. 5761-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  256. gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication. / Andersen, J B; Heydorn, Arne; Hentzer, Morten; Eberl, Leo; Geisenberger, O; Christensen, B B; Molin, Søren; Givskov, M.

    In: Applied and Environmental Microbiology, Vol. 67, No. 2, 2001, p. 575-85.

    Research output: Contribution to journalJournal articleResearchpeer-review

  257. 2000
  258. A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry : application to a model bacterial biofilm. / Charlton, T S; de Nys, R; Netting, A; Kumar, N; Hentzer, Morten; Givskov, M; Kjelleberg, S.

    In: Environmental Microbiology, Vol. 2, No. 5, 2000, p. 530-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  259. Published

    Detection of N-acyl-homoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. / Wu, H.; Song, Z.; Hentzer, M.; Andersen, J.B.; Heydorn, A.; Mathee, K.; Moser, C.; Eberl, L.; Molin, S.; Høiby, Niels; Givskov, Michael.

    In: Microbiology, No. 146, 2000, p. 2481-2493.

    Research output: Contribution to journalJournal articleResearchpeer-review

  260. Published

    Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. / Wu, H; Song, Z; Hentzer, Morten; Andersen, Jens Bo; Heydorn, Arne; Mathee, K; Moser, C; Eberl, Leo; Molin, Søren; Høiby, N; Givskov, M.

    In: Microbiology, Vol. 146 ( Pt 10), 2000, p. 2481-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  261. Experimental reproducibility in flow-chamber biofilms. / Heydorn, Arne; Ersbøll, Bjarne Kjær; Hentzer, Morten; Parsek, M R; Givskov, M; Molin, Søren.

    In: Microbiology, Vol. 146 ( Pt 10), 2000, p. 2409-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  262. Published

    How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. / Rasmussen, T B; Manefield, M; Andersen, Jens Bo; Eberl, Leo; Anthoni, U; Christophersen, C; Steinberg, P; Kjelleberg, S; Givskov, M.

    In: Microbiology, Vol. 146 Pt 12, 2000, p. 3237-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  263. Inactivation of gltB abolishes expression of the assimilatory nitrate reductase gene (nasB) in Pseudomonas putida KT2442. / Eberl, Leo; Ammendola, A; Rothballer, M H; Givskov, M; Sternberg, C; Kilstrup, M; Schleifer, K H; Molin, Søren.

    In: Journal of Bacteriology, Vol. 182, No. 12, 2000, p. 3368-76.

    Research output: Contribution to journalJournal articleResearchpeer-review

  264. Published

    Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. / Geisenberger, O; Givskov, M; Riedel, K; Høiby, N; Tümmler, B; Eberl, Leo.

    In: F E M S Microbiology Letters, Vol. 184, No. 2, 2000, p. 273-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  265. Published

    Production of N-acyl-L-homoserine lactones by Pseudomonas aeruginosa isolates from chronic lung infections associated with cystic fibrosis. / Geisenberger, O.; Givskov, Michael; Riedel, K.; Høiby, Niels; Tümmler, B.; Eberl, L.

    In: FEMS Microbiology Letters, No. 184, 2000, p. 273-278.

    Research output: Contribution to journalJournal articleResearchpeer-review

  266. Quantification of biofilm structures by the novel computer program COMSTAT. / Heydorn, Arne; Nielsen, A T; Hentzer, Morten; Sternberg, C; Givskov, M; Ersbøll, Bjarne Kjær; Molin, Søren.

    In: Microbiology, Vol. 146 ( Pt 10), 2000, p. 2395-407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  267. The interaction of thin-film flow, bacterial swarming and cell differentiation in colonies of Serratia liquefaciens. / Bees, Martin Alan; Andresén, P; Mosekilde, Erik; Givskov, M.

    In: Journal of Mathematical Biology, Vol. 40, No. 1, 2000, p. 27-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  268. rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine. / Krogfelt, K A; Hjulgaard, M; Sørensen, K; Cohen, Paul; Givskov, M.

    In: Infection and Immunity, Vol. 68, No. 5, 2000, p. 2518-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  269. 1999
  270. Application of molecular tools for in situ monitoring of bacterial growth activity. / Molin, Søren; Givskov, M.

    In: Environmental Microbiology, Vol. 1, No. 5, 1999, p. 383-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  271. Bacterial signals and antagonists : the interaction between bacteria and higher organisms. / Rice, S A; Givskov, M; Steinberg, P; Kjelleberg, S.

    In: Journal of Molecular Microbiology and Biotechnology, Vol. 1, No. 1, 1999, p. 23-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  272. Distribution of bacterial growth activity in flow-chamber biofilms. / Sternberg, C; Christensen, B B; Johansen, T; Toftgaard Nielsen, A; Andersen, J B; Givskov, M; Molin, Søren.

    In: Applied and Environmental Microbiology, Vol. 65, No. 9, 1999, p. 4108-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  273. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. / Manefield, M; de Nys, R; Kumar, N; Read, R; Givskov, M; Steinberg, P; Kjelleberg, S.

    In: Microbiology, Vol. 145 ( Pt 2), 1999, p. 283-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  274. Molecular characterization of the pH-inducible and growth phase-dependent promoter P170 of Lactococcus lactis. / Madsen, S M; Arnau, Jose; Vrang, Astrid; Givskov, M; Israelsen, Hans.

    In: Molecular Microbiology, Vol. 32, No. 1, 1999, p. 75-87.

    Research output: Contribution to journalJournal articleResearchpeer-review

  275. Molecular tools for study of biofilm physiology. / Christensen, B B; Sternberg, C; Andersen, J B; Palmer, R J; Nielsen, A T; Givskov, M; Molin, Søren.

    In: Methods in Enzymology, Vol. 310, 1999, p. 20-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  276. Published

    Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung. / Mathee, K; Ciofu, O; Sternberg, C; Lindum, P W; Campbell, J I; Jensen, P; Johnsen, A H; Givskov, M; Ohman, D E; Molin, S; Høiby, N; Kharazmi, A.

    In: Microbiology, Vol. 145 ( Pt 6), 1999, p. 1349-57.

    Research output: Contribution to journalJournal articleResearchpeer-review

  277. Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods. / Gram, L; Christensen, A B; Ravn, L; Molin, Søren; Givskov, M.

    In: Applied and Environmental Microbiology, Vol. 65, No. 8, 1999, p. 3458-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  278. Published

    Quorum sensing systems contribute to the severity of the lung infection of pseudomonas aeruginosa in rats. / Wu, H.; Song, Z.J.; Givskov, Michael; Mathee, K.; Rygaard, J.; Høiby, Niels.

    In: Pediatric Pulmonology, No. Suppl 19, 1999, p. 269-269.

    Research output: Contribution to journalJournal articleResearchpeer-review

  279. Quorum-sensing cross talk : isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria. / Holden, M T; Ram Chhabra, S; de Nys, R; Stead, P; Bainton, N J; Hill, P J; Manefield, M; Kumar, N; Labatte, M; England, D; Rice, S; Givskov, M; Salmond, G P; Stewart, G S; Bycroft, B W; Kjelleberg, S; Williams, Poul Frederick.

    In: Molecular Microbiology, Vol. 33, No. 6, 1999, p. 1254-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  280. Surface motility of serratia liquefaciens MG1. / Eberl, Leo; Molin, Søren; Givskov, M.

    In: Journal of Bacteriology, Vol. 181, No. 6, 1999, p. 1703-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  281. Published

    The N-acyl-homoserine lactones from Pseudomonas aeruginosa can be monitored by green flourescent protein in vivo. / Wu, H.; Song, Z.J.; Lindum, P.W.; Moser, C.; Givskov, Michael; Høiby, Niels.

    In: Netherlands Journal of Medicine, No. 54, 1999, p. 42-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  282. 1998
  283. Establishment of new genetic traits in a microbial biofilm community. / Christensen, B B; Sternberg, Claus; Andersen, J B; Eberl, Leo; Moller, S; Givskov, M; Molin, Søren.

    In: Applied and Environmental Microbiology, Vol. 64, No. 6, 1998, p. 2247-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  284. In situ gene expression in mixed-culture biofilms : evidence of metabolic interactions between community members. / Møller, S; Sternberg, Claus; Andersen, J B; Christensen, B B; Ramos, J L; Givskov, M; Molin, Søren.

    In: Applied and Environmental Microbiology, Vol. 64, No. 2, 1998, p. 721-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  285. Published

    N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1. / Lindum, Peter Wurtz; Anthoni, U; Christophersen, Carsten; Eberl, Leo; Molin, Søren; Givskov, M.

    In: Journal of Bacteriology, Vol. 180, No. 23, 1998, p. 6384-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  286. New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria. / Andersen, J B; Sternberg, C; Poulsen, L K; Bjorn, S P; Givskov, M; Molin, Søren.

    In: Applied and Environmental Microbiology, Vol. 64, No. 6, 1998, p. 2240-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  287. Serratia liquefaciens swarm cells exhibit enhanced resistance to predation by Tetrahymena sp. / Ammendola, A; Geisenberger, O; Andersen, J B; Givskov, M; Schleifer, K H; Eberl, Leo.

    In: F E M S Microbiology Letters, Vol. 164, No. 1, 1998, p. 69-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  288. Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1. / Givskov, M; Ostling, J; Eberl, Leo; Lindum, Peter Wurtz; Christensen, A B; Christiansen, G; Molin, Søren; Kjelleberg, S.

    In: Journal of Bacteriology, Vol. 180, No. 3, 1998, p. 742-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  289. 1996
  290. Differentiation of Serratia liquefaciens into swarm cells is controlled by the expression of the flhD master operon. / Eberl, Leo; Christiansen, G; Molin, Søren; Givskov, M.

    In: Journal of Bacteriology, Vol. 178, No. 2, 1996, p. 554-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  291. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. / Givskov, M; de Nys, R; Manefield, M; Gram, L; Maximilien, R; Eberl, Leo; Molin, Søren; Steinberg, P D; Kjelleberg, S.

    In: Journal of Bacteriology, Vol. 178, No. 22, 1996, p. 6618-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  292. Inhibitory Effects of Secondary Metabolites from the Red Alga Delisea pulchra on Swarming Motility of Proteus mirabilis. / Gram, L; de Nys, R; Maximilien, R; Givskov, M; Steinberg, P; Kjelleberg, S.

    In: Applied and Environmental Microbiology, Vol. 62, No. 11, 1996, p. 4284-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  293. Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens. / Eberl, Leo; Winson, M K; Sternberg, Claus; Stewart, G S; Christiansen, G; Chhabra, S R; Bycroft, B; Williams, Poul Frederick; Molin, Søren; Givskov, M.

    In: Molecular Microbiology, Vol. 20, No. 1, 1996, p. 127-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  294. 1995
  295. Induction of phospholipase- and flagellar synthesis in Serratia liquefaciens is controlled by expression of the flagellar master operon flhD. / Givskov, M; Eberl, Leo; Christiansen, G; Benedik, M J; Molin, Søren.

    In: Molecular Microbiology, Vol. 15, No. 3, 1995, p. 445-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  296. Site-specific deletions of chromosomally located DNA segments with the multimer resolution system of broad-host-range plasmid RP4. / Kristensen, C S; Eberl, Leo; Sanchez-Romero, J M; Givskov, M; Molin, Søren; De Lorenzo, V.

    In: Journal of Bacteriology, Vol. 177, No. 1, 1995, p. 52-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  297. Survival of, and induced stress resistance in, carbon-starved Pseudomonas fluorescens cells residing in soil. / van Overbeek, L S; Eberl, Leo; Givskov, M; Molin, Søren; van Elsas, J D.

    In: Applied and Environmental Microbiology, Vol. 61, No. 12, 1995, p. 4202-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  298. 1994
  299. Analysis of the multimer resolution system encoded by the parCBA operon of broad-host-range plasmid RP4. / Eberl, Leo; Kristensen, C S; Givskov, M; Grohmann, E; Gerlitz, M; Schwab, H.

    In: Molecular Microbiology, Vol. 12, No. 1, 1994, p. 131-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  300. Observations on the formation of deletions on monomeric and dimeric plasmids in Escherichia coli. / Ravn, P; Givskov, M; Eegholm, K M; Madsen, S M; Boe, Lars.

    In: Molecular Microbiology, Vol. 14, No. 2, 1994, p. 263-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  301. Responses to nutrient starvation in Pseudomonas putida KT2442 : analysis of general cross-protection, cell shape, and macromolecular content. / Givskov, M; Eberl, Leo; Møller, S; Poulsen, L K; Molin, Søren.

    In: Journal of Bacteriology, Vol. 176, No. 1, 1994, p. 7-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  302. 1993
  303. Secretion of Serratia liquefaciens phospholipase from Escherichia coli. / Givskov, M; Molin, Søren.

    In: Molecular Microbiology, Vol. 8, No. 2, 1993, p. 229-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  304. Suicidal genetic elements and their use in biological containment of bacteria. / Molin, Søren; Boe, Lars; Jensen, L B; Kristensen, C S; Givskov, M; Ramos, J L; Bej, A K.

    In: Annual Review of Microbiology, Vol. 47, 1993, p. 139-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  305. 1992
  306. Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed and regulated by anaerobiosis. / Givskov, M; Molin, Søren.

    In: Molecular Microbiology, Vol. 6, No. 10, 1992, p. 1363-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  307. The divergent promoters mediating transcription of the par locus of plasmid RP4 are subject to autoregulation. / Eberl, Leo; Givskov, M; Schwab, H.

    In: Molecular Microbiology, Vol. 6, No. 14, 1992, p. 1969-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  308. 1988
  309. Cloning and expression in Escherichia coli of the gene for extracellular phospholipase A1 from Serratia liquefaciens. / Givskov, M; Olsen, L; Molin, Søren.

    In: Journal of Bacteriology, Vol. 170, No. 12, 1988, p. 5855-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  310. 1987
  311. Identification and characterization of mutations responsible for a runaway replication phenotype of plasmid R1. / Givskov, M; Stougaard, P; Light, J; Molin, Søren.

    In: Gene, Vol. 57, No. 2-3, 1987, p. 203-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  312. 1984
  313. Copy mutants of plasmid R1 : effects of base pair substitutions in the copA gene on the replication control system. / Givskov, M; Molin, Søren.

    In: Molecular and General Genetics MGG, Vol. 194, No. 1-2, 1984, p. 286-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5838523