Lis Frydenreich Hasholt

Lis Frydenreich Hasholt

Associate professor


  1. 2019
  2. Published

    Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease. / Rudenko, Olga; Springer, Cecilie; Skov, Louisa J.; Madsen, Andreas N.; Hasholt, Lis; Nørremølle, Anne; Holst, Birgitte.

    In: Journal of Neuroendocrinology, Vol. 31, No. 7 (SI), e12699, 2019.

    Research output: Contribution to journalConference articleResearchpeer-review

  3. 2018
  4. Published

    Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model. / Reynolds, Regina Hertfelder; Petersen, Maria Hvidberg; Willert, Cecilie Wennemoes; Heinrich, Marie; Nymann, Nynne; Dall, Morten; Treebak, Jonas T.; Björkqvist, Maria; Silahtaroglu, Asli; Hasholt, Lis; Nørremølle, Anne.

    In: Molecular and Cellular Neuroscience, Vol. 88, 2018, p. 118-129.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2017
  6. Published

    The D313Y variant in the GLA gene – no evidence of a pathogenic role in Fabry disease. / Hasholt, Lis; Ballegaard, Martin; Bundgaard, Henning; Christiansen, Michael; Law, Ian; Lund, Allan M.; Norremolle, Anne; Rasmussen, Ase Krogh; Ravn, Kirstine; Tumer, Zeynep; Wibrand, Flemming; Feldt-Rasmussen, Ulla.

    In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 77, No. 8, 2017, p. 617-621.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2016
  8. Published

    Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. / Hansen, Susanne Kofoed; Stummann, Tina C.; Madsen, Helena Borland; Hasholt, Lis Frydenreich; Tümer, Zeynep; Nielsen, Jørgen Erik; Rasmussen, Mikkel Aabech; Nielsen, Troels Tolstrup; Daechsel, Justus C. A.; Fog, Karina; Hyttel, Poul.

    In: Stem Cell Research, Vol. 17, No. 2, 09.2016, p. 306-317.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Seasonal difference in brain serotonin transporter binding predicts symptom severity in patients with seasonal affective disorder. / Mc Mahon, Brenda; Andersen, Sofie B.; Madsen, Martin K.; Hjordt, Liv V.; Pedersen, Ida Hageman; Dam, Henrik; Svarer, Claus; da Cunha-Bang, Sofi; Baare, William; Madsen, Jacob; Hasholt, Lis; Holst, Klaus; Frokjaer, Vibe G.; Knudsen, Gitte M.

    In: Brain, Vol. 139, 01.05.2016, p. 1605-1614.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11. / Hansen, Susanne Kofoed; Borland, Helena; Hasholt, Lis Frydenreich; Tümer, Zeynep; Nielsen, Jørgen Erik; Rasmussen, Mikkel A.; Nielsen, Troels Tolstrup; Stummann, Tina C.; Fog, Karina; Hyttel, Poul.

    In: Stem Cell Research, Vol. 16, No. 3, 05.2016, p. 553-556.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11. / Hansen, Susanne Kofoed; Borland, Helena; Hasholt, Lis Frydenreich; Tümer, Zeynep; Nielsen, Jørgen Erik; Rasmussen, Mikkel A.; Nielsen, Troels Tolstrup; Stummann, Tina C.; Fog, Karina; Hyttel, Poul.

    In: Stem Cell Research, Vol. 16, No. 3, 05.2016, p. 589-592.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Liver function in Huntington's disease assessed by blood biochemical analyses in a clinical setting. / Nielsen, Signe Marie Borch; Vinther-Jensen, Tua; Nielsen, Jørgen E.; Nørremølle, Anne; Hasholt, Lis; Hjermind, Lena E.; Josefsen, Knud.

    In: Journal of the Neurological Sciences, Vol. 362, 15.03.2016, p. 326-332.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Psychiatric and cognitive symptoms in Huntington's disease are modified by polymorphisms in catecholamine regulating enzyme genes. / Vinther-Jensen, T; Nielsen, Troels Tolstrup; Budtz-Jørgensen, E; Larsen, I U; Hansen, Mathias Melgaard; Hasholt, L; Hjermind, L E; Nielsen, J E; Nørremølle, A.

    In: Clinical Genetics, Vol. 89, No. 3, 03.2016, p. 320-327.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). / Rasmussen, Mikkel A.; Hjermind, Lena E.; Hasholt, Lis F.; Waldemar, Gunhild; Nielsen, Jorgen E.; Clausen, Christian; Hyttel, Poul; Holst, Bjørn.

    In: Stem Cell Research, Vol. 16, No. 1, 01.2016, p. 75-78.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT). / Rasmussen, Mikkel A.; Hjermind, Lena Elisabeth; Hasholt, Lis Frydenreich; Waldemar, Gunhild; Nielsen, Jørgen Erik; Clausen, Christian; Hyttel, Poul; Holst, Bjørn.

    In: Stem Cell Research, Vol. 16, No. 1, 2016, p. 70-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Induced pluripotent stem cells (iPSCs) derived from af pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia. / Rasmussen, Mikkel A.; Hjermind, Lena Elisabeth; Hasholt, Lis Frydenreich; Waldemar, Gunhild; Nielsen, Jørgen Erik; Clausen, Christian; Hyttel, Poul; Holst, Bjørn.

    In: Stem Cell Research, Vol. 16, No. 1, 2016, p. 105-109.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2015
  18. Published

    Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington's Disease Mouse Model R6/2. / Nielsen, Signe Marie Borch; Hasholt, Lis; Nørremølle, Anne; Josefsen, Knud Elnegaard.

    In: PLoS Currents, Vol. 7, 20.04.2015.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  19. 2014
  20. Published

    Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling. / Fisher, Patrick M; Madsen, Martin K; Mc Mahon, Brenda; Holst, Klaus K; Andersen, Sofie B; Laursen, Helle R; Hasholt, Lis Frydenreich; Siebner, Hartwig R; Knudsen, Karen Birgitte Moos.

    In: Biological Psychiatry, Vol. 76, No. 4, 15.08.2014, p. 332-339.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy. / Mosbech, Mai-Britt; Olsen, Anne S B; Neess, Ditte; Ben-David, Oshrit; Klitten, Laura L; Larsen, Jan; Sabers, Anne; Vissing, John; Nielsen, Jørgen E; Hasholt, Lis; Klein, Andres D; Tsoory, Michael M; Hjalgrim, Helle; Tommerup, Niels; Futerman, Anthony H; Møller, Rikke S; Færgeman, Nils J.

    In: Annals of Clinical and Translational Neurology, Vol. 1, No. 2, 28.02.2014, p. 88-98.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin. / Ehrnhoefer, Dagmar E; Skotte, Niels H; Ladha, Safia; Nguyen, Yen T N; Qiu, Xiaofan; Deng, Yu; Huynh, Khuong T; Engemann, Sabine; Nielsen, Signe M; Becanovic, Kristina; Leavitt, Blair R; Hasholt, Lis; Hayden, Michael R.

    In: Human Molecular Genetics, Vol. 23, No. 3, 01.02.2014, p. 717-29.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2013
  24. Published

    Localization of A11-reactive oligomeric species in prion diseases. / Aidt, Frederik H; Hasholt, Lis F; Christiansen, Michael; Laursen, Henning.

    In: Histopathology, Vol. 62, No. 7, 06.2013, p. 994-1001.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model. / Aidt, Frederik Heurlin; Nielsen, Signe Marie Borch; Kanters, Jørgen; Pesta, Dominik; Nielsen, Troels Tolstrup; Nørremølle, Anne; Hasholt, Lis; Christiansen, Michael; Hagen, Christian Munch.

    In: PLoS Currents, Vol. 5, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2012
  27. Published

    ATXN2 with intermediate-length CAG/CAA repeats does not seem to be a risk factor in hereditary spastic paraplegia. / Nielsen, Troels Tolstrup; Svenstrup, Kirsten; Budtz-Jørgensen, Esben; Eiberg, Hans; Hasholt, Lis; Nielsen, Jørgen E.

    In: Journal of the Neurological Sciences, Vol. 321, No. 1-2, 10.2012, p. 100-2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference. / Nielsen, Troels Tolstrup; Mizielinska, Sarah; Hasholt, Lis; Isaacs, Adrian M; Nielsen, Jørgen E; the FReJA Consortium.

    In: Journal of Gene Medicine, Vol. 14, No. 8, 08.2012, p. 521-529.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Three weeks of daily exposure to bright light does not alter striatal serotonin transporter binding in healthy Scandinavians. / Mc Mahon, Brenda; Andersen, Anne Sofie; Feng, Ling; Madsen, Martin Korsbak; Lehel, Szabolcs; Herth, Matthias Manfred; Iversen, Pernille; Hasholt, Lis; Knudsen, Gitte Moos.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, 08.2012, p. S79-S80.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. / Lee, J-M; Ramos, E M; Lee, J-H; Gillis, T; Mysore, J S; Hayden, M R; Warby, S C; Morrison, P; Nance, M; Ross, C A; Margolis, R L; Squitieri, F; Orobello, S; Di Donato, S; Gomez-Tortosa, E; Ayuso, C; Suchowersky, O; Trent, R J A; McCusker, E; Novelletto, A; Frontali, M; Jones, R; Ashizawa, T; Frank, S; Saint-Hilaire, M H; Hersch, S M; Rosas, H D; Lucente, D; Harrison, M B; Zanko, A; Abramson, R K; Marder, K; Sequeiros, J; Paulsen, J S; Landwehrmeyer, G B; Myers, R H; MacDonald, M E; Gusella, J F; Hasholt, Lis Frydenreich; Nørremølle, Anne; Nielsen, Jørgen Erik; PREDICT-HD study of the Huntington Study Group (HSG).

    In: Neurology, Vol. 78, No. 10, 03.2012, p. 690-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2011
  32. Published

    Discrepancies in reporting the CAG repeat lengths for Huntington's disease. / Quarrell, Oliver W; Handley, Olivia; O'Donovan, Kirsty; Dumoulin, Christine; Ramos-Arroyo, Maria; Biunno, Ida; Bauer, Peter; Kline, Margaret; Landwehrmeyer, G Bernhard; Hjermind, Lena Elisabeth; Hasholt, Lis Frydenreich; Nørremølle, Anne; Nielsen, Jørgen Erik; European Huntington’s Disease Network.

    In: European Journal of Human Genetics, Vol. 20, No. 1, 08.2011, p. 20-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The lrrk2 p.Gly2019Ser mutation is uncommon in a Danish cohort with various neurodegenerative disorders. / Bech, Sara; Nørremølle, Anne; Winge, Kristian; Hasholt, Lis; Tommerup, Niels; Svenstrup, Kirsten; Nielsen, Jørgen E; Hjermind, Lena E.

    In: Parkinsonism & Related Disorders, Vol. 17, No. 5, 01.06.2011, p. 398-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Diagnostic dilemma : a young woman with Fabry disease symptoms, no family history, and a "sequencing cryptic" a-galactosidase a large deletion. / Feldt-Rasmussen, Ulla; Dobrovolny, Robert; Nazarenko, Irina; Ballegaard, Martin; Hasholt, Lis; Rasmussen, Ase K; Christensen, Erik Ilsø; Sorensen, Soren S; Wibrand, Flemming; Desnick, Robert J.

    In: Molecular Genetics and Metabolism, Vol. 104, No. 3, 2011, p. 314-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

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