Jens Juul Holst

Jens Juul Holst

Professor


  1. Published

    Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. / Vestergaard, Esben Thyssen; Hjelholt, Astrid Johanneson; Kuhre, Rune E; Møller, Niels; Larraufie, Pierre; Gribble, Fiona M; Reimann, Frank; Jessen, Niels; Holst, Jens Juul; Jørgensen, Jens Otto Lunde.

    In: The Journal of clinical endocrinology and metabolism, Vol. 104, No. 7, 2019, p. 2581-2592.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Gastric emptying, glucose metabolism and gut hormones : evaluation of a common preoperative carbohydrate beverage. / Vermeulen, Mechteld A R; Richir, Milan C; Garretsen, Martijn K; van Schie, Annelies; Ghatei, Mohammed A; Holst, Jens Juul; Heijboer, Annemieke C; Uitdehaag, Bernard M J; Diamant, Michaela; Eekhoff, E Marelise W; van Leeuwen, Paul A M; Ligthart-Melis, Gerdien C.

    In: Nutrition, Vol. 27, No. 9, 09.2011, p. 897-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The role of postprandial releases of insulin and incretin hormones in meal-induced satiety - effect of obesity and weight reduction. / Verdich, C.; Toubro, S.; Buemann, B.; Holst, J.J.

    In: International Journal of Obesity, No. 25, 2001, p. 1206-1214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus). / Verbrugghe, A; Hesta, M; Daminet, S; Polis, I; Holst, Jens Juul; Buyse, J; Wuyts, B; Janssens, G P J.

    In: Journal of Animal Physiology and Animal Nutrition (Online), Vol. 96, No. 6, 12.2012, p. 1054-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Effect of glucagon-like peptide-1-(7,36)-amide on glucose effectiveness and insulin action in people with type 2 diabetes mellitus. / Vella, A.; Shah, P.; Basu, R.; Basu, A.; Holst, J.J.; Rizza, R.A.

    In: Diabetes, No. 49, 2000, p. 611-617.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Effect of glucagon-like peptide- 1 (7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes. / Vella, A.; Shah, P.; Basu, R.; Holst, J.J.

    In: Diabetes, No. 50, 2001, p. 565-572.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. / Vegge, Andreas; Thymann, Thomas; Lund, Pernille; Stoll, Barbara; Bering, Stine Brandt; Hartmann, Bolette; Jelsing, Jacob; Qvist, Niels; Burrin, Douglas G; Jeppesen, Palle Bekker; Holst, Jens Juul; Sangild, Per T.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 305, No. 4, 2013, p. G277-G285.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men. / Veedfald, Simon; Wu, Tongzhi; Bound, Michelle; Grivell, Jacqueline; Hartmann, Bolette; Rehfeld, Jens F.; Deacon, Carolyn F.; Horowitz, Michael; Holst, Jens J.; Rayner, Christopher K.

    In: Journal of Clinical Endocrinology & Metabolism, Vol. 103, No. 12, 2018, p. 4409-4418.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs. / Veedfald, Simon; Hansen, Marie; Christensen, Louise Wulff; Larsen, Sara Agnete Hjort; Hjøllund, Karina Rahr; Plamboeck, Astrid; Hartmann, Bolette; Deacon, Carolyn F; Holst, Jens Juul.

    In: Experimental Physiology, Vol. 101, No. 7, 30.03.2016, p. 895-912.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Pancreatic polypeptide responses to isoglycemic oral and intravenous glucose in humans with and without intact vagal innervation. / Veedfald, Simon; Plamboeck, Astrid; Hartmann, Bolette; Svendsen, Lars B; Vilsbøll, Tina; Knop, Filip K; Holst, Jens J.

    In: Peptides, Vol. 71, 09.2015, p. 229-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. / Veedfald, Simon; Plamboeck, Astrid; Deacon, Carolyn F; Hartmann, Bolette; Knop, Filip K; Lauritsen, Tina Vilsbøll; Holst, Jens J.

    In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 310, No. 1, 01.01.2016, p. G43-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Ghrelin secretion in humans - a role for the vagus nerve? / Veedfald, S; Plamboeck, A; Hartmann, B; Vilsbøll, T; Knop, F K; Deacon, C F; Svendsen, L B; Holst, J J.

    In: Neurogastroenterology and Motility, Vol. 30, No. 6, e13295, 06.2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Major rapid weight loss induces changes in cardiac repolarization. / Vedel-Larsen, Esben; Iepsen, Eva Pers Winning; Lundgren, Julie; Graff, Claus; Struijk, Johannes J; Hansen, Torben; Holst, Jens Juul; Madsbad, Sten; Torekov, Signe; Kanters, Jørgen K.

    In: Journal of Electrocardiology, Vol. 49, No. 3, 10.02.2016, p. 467-472.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose. / Vardarli, Irfan; Arndt, Elisabeth; Deacon, Carolyn F; Holst, Jens Juul; Nauck, Michael A.

    In: Diabetes, Vol. 63, No. 2, 02.2014, p. 663-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes. / Vardarli, Irfan; Nauck, Michael A; Köthe, Lars D; Deacon, Carolyn F; Holst, Jens Juul; Schweizer, Anja; Foley, James E.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 4, 2011, p. 945-954.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption. / Valeur, Jørgen; Øines, Eliann; Morken, Mette Helvik; Holst, Jens Juul; Berstad, Arnold.

    In: Scandinavian Journal of Gastroenterology, Vol. 43, No. 10, 2008, p. 1212-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. / Utzschneider, Kristina M; Tong, Jenny; Montgomery, Brenda; Udayasankar, Jayalakshmi; Gerchman, Fernando; Marcovina, Santica M; Watson, Catherine E; Ligueros-Saylan, Monica A; Foley, James E; Holst, Jens J; Deacon, Carolyn F; Kahn, Steven E.

    In: Diabetes Care, Vol. 31, No. 1, 2007, p. 108-113.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Gastric emptying of orally administered glucose solutions and incretin hormone responses are unaffected by laparoscopic adjustable gastric banding. / Usinger, Lotte; Hansen, Katrine B; Kristiansen, Viggo B; Larsen, Steen; Holst, Jens Juul; Knop, Filip K.

    In: Obesity Surgery, Vol. 21, No. 5, 2011, p. 625-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. / Ugleholdt, Randi; Zhu, Xiaorong; Deacon, Carolyn F; Ørskov, Cathrine; Steiner, Donald F; Holst, Jens J.

    In: Endocrinology, Vol. 145, No. 3, 2003, p. 1349-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. / Ugleholdt, Randi; Pedersen, Jens; Bassi, Maria Rosaria; Füchtbauer, Ernst-Martin; Jørgensen, Signe Marie; Kissow, Hannelouise; Nytofte, Nikolaj; Poulsen, Steen Seier; Rosenkilde, Mette Marie; Seino, Yutaka; Thams, Peter; Holst, Peter Johannes; Holst, Jens Juul.

    In: The Journal of Biological Chemistry, Vol. 286, No. 52, 12.2011, p. 44632-44645.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. / Ugleholdt, Randi; Poulsen, Marie-Louise H; Holst, Peter J; Irminger, Jean-Claude; Orskov, Cathrine; Pedersen, Jens; Rosenkilde, Mette M; Zhu, Xiaorong; Steiner, Donald F; Holst, Jens Juul.

    In: Journal of Biological Chemistry, Vol. 281, No. 16, 2006, p. 11050-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response. / Tura, A.; Bagger, J. I.; Ferrannini, E.; Holst, J. J.; Knop, F. K.; Vilsbøll, T.; Mari, A.

    In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 27, No. 12, 12.2017, p. 1123-1129.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs. / Trebbien, Ramona; Klarskov, Letty; Olesen, Mette; Holst, Jens J; Carr, Richard D; Deacon, Carolyn F.

    In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 287, No. 3, 2004, p. E431-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans. / Toräng, Signe; Bojsen-Møller, Kirstine N; Svane, Maria S; Hartmann, Bolette; Rosenkilde, Mette Marie; Madsbad, Sten; Holst, Jens Juul.

    In: A J P: Regulatory, Integrative and Comparative Physiology (Online), Vol. 310, No. 1, 27.01.2016, p. R866-R874.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo. / Toräng, Signe; Veedfald, Simon; Rosenkilde, Mette Marie; Hartmann, Bolette; Holst, Jens Juul.

    In: Physiological Reports, Vol. 3, No. 7, e12455, 20.07.2015, p. 1-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    PACAP 1-38 as neurotransmitter in porcine adrenal glands. / Tornøe, K.; Hannibal, J.; Rickelt, L.F.; Bolding Jensen, M.; Børglum, J.T.; Fahrenkrug, Jan; Holst, J.J.

    In: American Journal of Physiology: Endocrinology and Metabolism, No. 279, 2000, p. E1412-E1425.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    PACAP 1-38 as neurotransmitter in the pig pancreas: PACAP-receptor activation revealed by the antagonist PACAP 6-38. / Tornøe, K.; Hannibal, J.; Fahrenkrug, Jan; Holst, J.J.

    In: Am. J. Physiol., No. 273, 1997, p. G436-G446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    PACAP 1-38 as neurotransmitter in the porcine antrum. / Tornoe, K.; Hannibal, J.; Georg, Birgitte; Holst, J.J.

    In: Regulatory Peptides, No. 101, 2001, p. 109-121.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Dose response of subcutaneous GLP-1 infusion in patients with type 2 diabetes. / Torekov, Signe Sørensen; Kipnes, M S; Harley, R E; Holst, J J; Ehlers, M R.

    In: Diabetes, Obesity and Metabolism, Vol. 13, No. 7, 2011, p. 639-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Dose response of continuous subcutaneous infusion of recombinant glucagon-like peptide-1 in combination with metformin and sulphonylurea over 12 weeks in patients with type 2 diabetes mellitus. / Torekov, Signe Sørensen; Holst, J J; Ehlers, M R.

    In: Diabetes, Obesity and Metabolism, Vol. 16, No. 5, 05.2014, p. 451-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk. / Torekov, Signe Sørensen; Harsløf, T; Rejnmark, L; Eiken, P; Jensen, J B; Herman, A P; Hansen, T; Pedersen, O; Holst, J J; Langdahl, B L.

    In: The Journal of clinical endocrinology and metabolism, Vol. 99, No. 4, 04.2014, p. E729-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    KCNQ1 Long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia. / Torekov, Signe S; Iepsen, Eva; Christiansen, Michael; Linneberg, Allan; Pedersen, Oluf; Holst, Jens J; Kanters, Jørgen K.; Hansen, Torben.

    In: Diabetes, Vol. 63, No. 4, 04.2014, p. 1315-1325.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. / Torekov, Signe S; Larsen, Lesli H; Glümer, Charlotte; Borch-Johnsen, Knut; Jørgensen, Torben; Holst, Jens J; Madsen, Ole D; Hansen, Torben; Pedersen, Oluf.

    In: Diabetes, Vol. 54, No. 7, 2005, p. 2261-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Evidence of an association between the Arg72-allele of the peptide YY (PYY) and increased risk of type 2 diabetes. / Torekov, S.S.; Larsen, L.H.; Glümer, C.; Borch-Johnsen, K.; Jørgensen, T.; Holst, Jens Juul; Madsen, O.D.; Hansen, T.; Pedersen, O.

    In: Diabetes, No. 54, 2005, p. 2261-2265.

    Research output: Contribution to journalJournal articleResearch

  35. Published

    Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1. / Torekov, S S; Ma, L; Grarup, N; Hartmann, B; Hainerová, I A; Kielgast, U; Kissow, H; Rosenkilde, M; Lebl, J; Witte, D R; Jørgensen, T; Sandbaek, A; Lauritzen, T; Madsen, O D; Wang, J; Linneberg, A; Madsbad, S; Holst, J J; Hansen, T; Pedersen, O; GIANT Consortium.

    In: Diabetologia, Vol. 54, No. 11, 2011, p. 2820-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential. / Torekov, S S; Madsbad, S; Holst, Jens Juul.

    In: Obesity Reviews, Vol. 12, No. 8, 2011, p. 593-601.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: Effect mediated through central or enteric nervous mechanisms. / Tolessa, T.; Gutniak, M.K.; Holst, J.J.; Efendic, S.; Hellstrom, P.M.

    In: Dig. Dis. Sci., No. 43, 1998, p. 2284-2290.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin. / Tolessa, T.; Gutniak, M.K.; Holst, J.J.; Efendic, S.; Hellstrom, P.M.

    In: J. Clin. Invest., No. 102, 1998, p. 764-774.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Determinants of the effectiveness of glucagon-like peptide- 1 in type 2 diabetes. / Toft-Nielsen, M.B.; Madsbad, S.; Holst, J.J.

    In: J Clin Endocr Metab, No. 86, 2001, p. 3853-3860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Continuous subcutaneous infusion of Glucagon-like Peptide-1 (GLP-1) lowers plasma glucose and reduces appetite in type II diabetic patients. / Toft-Nielsen, M.B.; Madsbad, S.; Holst, J.J.

    In: Diabetes Care, No. 22, 1999, p. 1137-1143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. / Toft-Nielsen, M B; Damholt, M B; Madsbad, Sten; Hilsted, L M; Hughes, T E; Michelsen, B K; Holst, Jens Juul.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 8, 2001, p. 3717-3723.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia. / Toft-Nielsen, M; Madsbad, Sten; Holst, Jens Juul.

    In: Diabetologia, Vol. 41, No. 10, 1998, p. 1180-1186.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study. / Tischmann, Lea; Drummen, Mathijs; Gatta-Cherifi, Blandine; Raben, Anne; Fogelholm, Mikael; Hartmann, Bolette; Holst, Jens Juul; Matias, Isabelle; Cota, Daniela; Mensink, Ronald P; Peters, Joris; Westerterp-Plantenga, Margriet S; Adam, Tanja C.

    In: Nutrients, Vol. 11, 2269, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning. / Thymann, Thomas; Le Huërou-Luron, I; Petersen, Y M; Hedemann, Mette Skou; Elinf, J; Jensen, B B; Holst, Jens Juul; Hartmann, Bolette; Sangild, Per Torp.

    In: Journal of Animal Science, Vol. 92, No. 5, 2014, p. 2070-2079.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Glucagon-like peptide 2 (Glp-2) stimulates intestinal function during weaning. / Thymann, Thomas; Huërou-Luron, I. Le; Petersen, Y.M.; Hedemann, Mette Skou; Elnif, Jan; Jensen, B.B.; Hartmann, Bolette; Holst, Jens Juul; Sangild, Per Torp.

    44th annual meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, 2011: programme and abstract booklet. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), 2011. p. 202.

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearch

  46. Published

    Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal-jejunal transposition or small bowel resection. / Thulesen, Jesper; Hartmann, B.; Kissow, H.; Jeppesen, P.B.; Ørskov, C.; Holst, J.J.; Poulsen, Steen Seier.

    In: Digestive Diseases and Sciences, No. 46 (2), 2001, p. 379-388.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist. / Thulesen, Jesper; Knudsen, Lotte Bjerre; Hartmann, Bolette; Hastrup, Sven; Kissow, Hannelouise; Jeppesen, Palle Bekker; Ørskov, Cathrine; Holst, Jens Juul; Poulsen, Steen Seier.

    In: Regulatory Peptides, Vol. 103, No. 1, 2002, p. 9-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Potential targets for glucagon-like peptide 2 (GLP-2) in the rat: distribution and binding of i.v. injected (125)I-GLP-2. / Thulesen, Jesper; Hartmann, Bolette; Ørskov, C.; Jeppesen, P.B.; Holst, J.J.; Poulsen, Steen Seier.

    In: Peptides, No. 10, 2000, p. 1511-1517.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Short term insulin treatment prevents the diabetogenic action of streptozotocin in rats. / Thulesen, Jesper; Ørskov, Cathrine; Holst, Jens Juul; Poulsen, Steen Seier.

    In: Endokrinologiya, No. Vol. 138, No. 1, 1997, p. 62-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Diabetic Intestinal Growth Adaptation and glucagon-like peptide 2 (GLP-2) in the rat. Effect of dietary fibres. / Thulesen, J.; Hartmann, B.; Nielsen, C.; Holst, J.J.; Poulsen, S.S.

    In: Gut, No. 45, 1999, p. 672-678.

    Research output: Contribution to journalJournal articleResearchpeer-review

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