Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor


  1. 2018
  2. Published

    Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction. / Hedegaard, Sofie Fogh; Derbas, Mohammed Sobhi; Lind, Tania Kjellerup; Kasimova, Marina Robertnova; Christensen, Malene Vinther; Michaelsen, Maria Høtoft; Campbell, Richard A; Jorgensen, Lene; Franzyk, Henrik; Cárdenas, Marité; Nielsen, Hanne Mørck.

    In: Scientific Reports, Vol. 8, No. 1, 6327, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. / Thanki, Kaushik; Thakur, Aneesh; de Groot, A. M.; Geyer, A.; Fraire, Juan; Falkenberg, Emily; Van Eygen, Hannelore; Putteman, Emma; Van Bijnen, Djai C. J.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Broere, Femke; van Eden, Willem; Sijts, Alice J A M; Ogris, M.; Nielsen, Hanne Mørck; Braeckmans, Kevin; Foged, Camilla.

    2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  4. 2017
  5. Published

    Animal models for evaluation of oral delivery of biopharmaceuticals. / Harloff-Helleberg, Stine; Nielsen, Line Hagner; Nielsen, Hanne Mørck.

    In: Journal of Controlled Release, Vol. 268, 12.2017, p. 57-71.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles. / Liu, Jingying; Christophersen, Philip C; Yang, Mingshi; Nielsen, Hanne M; Mu, Huiling.

    In: Drug Development and Industrial Pharmacy, Vol. 43, No. 12, 12.2017, p. 2032-2042.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach. / Thanki, Kaushik; Zeng, Xianghui; Justesen, Sarah; Tejlmann, Sarah; Falkenberg, Emily; Van Driessche, Elize; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 120, 11.2017, p. 22-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA. / Foged, Camilla (Inventor); Franzyk, Henrik (Inventor); Zeng, Xianghui (Inventor); Nielsen, Hanne Mørck (Inventor); Thanki, Kaushik (Inventor).

    IPC No.: A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00. Patent No.: WO2017158093-A1. Mar 16, 2017.

    Research output: PatentResearch

  9. Published

    Innovative Methods and Applications in Mucoadhesion Research. / Mackie, Alan R; Goycoolea, Francisco M; Menchicchi, Bianca; Caramella, Carla Marcella; Saporito, Francesca; Lee, Seunghwan; Stephansen, Karen; Chronakis, Ioannis S; Hiorth, Marianne; Adamczak, Malgorzata; Waldner, Max; Nielsen, Hanne Mørck; Marcelloni, Luciano.

    In: Macromolecular Bioscience, Vol. 17, No. 8, 1600534, 08.2017.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    Assessment of mucoadhesion using small deformation rheology revisited. / Harloff-Helleberg, Stine; Vissing, Karina Juul; Nielsen, Hanne Mørck.

    In: Nordic Rheology Society Annual Transactions, Vol. 25, 04.2017, p. 63.

    Research output: Contribution to journalConference articleResearchpeer-review

  11. Published

    An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens. / Baker, Kristin Renee; Jana, Bimal; Nielsen, Hanne Mørck; Franzyk, Henrik; Guardabassi, Luca.

    2017. Abstract from ASM Microbe 2017, New Orleans, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  12. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs. / Thanki, Kaushik; Zeng, Xianghui; Justesen, Sarah; Tejlmann, Sarah; Falkenberg, Emily; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Poster session presented at 6th FIP Pharmaceutical Sciences World Congress (PSWC), Stockholm, Sweden.

    Research output: Contribution to conferencePosterResearch

  13. Published

    Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: B B A - Biomembranes, Vol. 1859, No. 12, 2017, p. 2483-2494.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA. / Zeng, Xianghui; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Abstract from 2nd Gazi Pharma Symposium Series, Ankara, Turkey.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  16. Published

    Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy. / Falkenberg, Emily; de Groot, Anne Marit; Sijts, Alice J A M; Thanki, Kaushik; Zeng, Xianghui; Nielsen, Hanne Mørck; Franzyk, Henrik; Foged, Camilla.

    2017. Poster session presented at 10th European Workshop on Particulate Systems (EWPS), Copenhagen, Denmark.

    Research output: Contribution to conferencePosterResearch

  17. 2016
  18. Published

    Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients : Challenges and Drug Delivery Approaches. / Klodzinska, Sylvia Natalie; Priemel, Petra Alexandra; Rades, Thomas; Mørck Nielsen, Hanne.

    In: International Journal of Molecular Sciences , Vol. 17, No. 10, 1688, 09.10.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers. / Li, Ping; Nielsen, Hanne Mørck; Müllertz, Anette.

    In: Journal of Pharmaceutical Sciences, Vol. 105, No. 9, 09.2016, p. 2743-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System. / Jing, Xiaona; Foged, Camilla; Martin-Bertelsen, Birte; Yaghmur, Anan; Knapp, Kolja Michael; Malmsten, Martin; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Molecular Pharmaceutics, Vol. 13, No. 6, 06.06.2016, p. 1739-1749.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Issues in development of biodrug delivery systems. / Jørgensen, Lene; Frokjaer, Sven; Nielsen, Hanne Mørck.

    Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. CRC Press, 2016. p. 13-25.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  22. Published

    Interactions between Surfactants in Solution and Electrospun Protein Fibers : Effects on Release Behavior and Fiber Properties. / Stephansen, Karen; García-Díaz, María; Jessen, Flemming; Chronakis, Ioannis S; Nielsen, Hanne M.

    In: Molecular Pharmaceutics, Vol. 13, No. 3, 07.03.2016, p. 748-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Cell-Penetrating Peptides as Carriers for Oral Delivery of Biopharmaceuticals. / Kristensen, Mie; Nielsen, Hanne Mørck.

    In: Basic & Clinical Pharmacology & Toxicology Online, Vol. 118, No. 2, 02.2016, p. 99-106.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos. / Kristensen, Mie; Birch, Ditlev; Mørck Nielsen, Hanne.

    In: International Journal of Molecular Sciences , Vol. 17, No. 2, 185, 30.01.2016, p. 1-17.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. / Kristensen, Mie; Nielsen, Hanne Mørck.

    In: Tissue Barriers, Vol. 4, No. 2, e1178369, 2016.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S. ; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  27. Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking. / Thanki, Kaushik; Geyer, A.; Zeng, Xianghui; Sami, H.; Gehrig, S.; Justesen, Sarah; Franzyk, Henrik; Ogris, M.; Nielsen, Hanne Mørck; Foged, Camilla.

    2016. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences (AAPS) 2016, Denver, United States.

    Research output: Contribution to conferencePosterResearch

  28. Published

    Large-scale biophysical evaluation of protein PEGylation effects : in vitro properties of 61 protein entities. / Vernet, Erik; Popa, Gina; Pozdnyakova, Irina; Rasmussen, Jakob Ewald; Grohganz, Holger; Giehm, Lise; Jensen, Malene Hillerup; Wang, Huabing; Plesner, Bitten; Nielsen, Hanne Mørck; Jensen, Knud Jørgen; Berthelsen, Jens; Sundström, Michael; van de Weert, Marco.

    In: Molecular Pharmaceutics, Vol. 13, No. 5, 2016, p. 1587-1598.

    Research output: Contribution to journalJournal articleResearchpeer-review

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