Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor


  1. Published

    High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles : quality by design optimization and characterization. / Cun, Dongmei; Jensen, Ditte Marie Krohn; Maltesen, Morten Jonas; Bunker, Matthew; Whitside, Paul ; Scurr, David; Foged, Camilla; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 77, No. 1, 2011, p. 26-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Polymeric nanocarriers for siRNA delivery : challenges and future prospects. / Cun, Dongmei; Jensen, Linda Boye; Nielsen, Hanne Mørck; Moghimi, Seyed Moien; Foged, Camilla.

    In: Journal of Biomedical Nanotechnology, Vol. 4, No. 3, 2008, p. 258-275.

    Research output: Contribution to journalReviewResearch

  3. High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles : quality by design optimization and characterization. / Cun, Dongmei; Jensen, Ditte Marie Krohn; Maltesen, Morten Jonas; Bunker, Matthew; Whitside, Paul; Scurr, David; Foged, Camilla; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 77, No. 1, 2011, p. 26-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Preparation and characterization of poly (DL-lactide-co-glycolide) nanoparticles for siRNA delivery. / Cun, Dongmei; Foged, Camilla; Yang, Mingshi; Frøkjær, Sven; Nielsen, Hanne Mørck.

    In: Internation Journal of Pharmaceutics, Vol. 390, No. 1, 2010, p. 70-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles. / Colombo, Stefano; Cun, Dongmei; Remaut, Katrien; Bunker, Matt; Zhang, Jianxin; Martin-Bertelsen, Birte; Yaghmur, Anan; Braeckmans, Kevin; Nielsen, Hanne M; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 201, 10.03.2015, p. 22-31.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Evaluation of carrier-mediated siRNA delivery : lessons for the design of a stem-loop qPCR-based approach for quantification of intracellular full-length siRNA. / Colombo, Stefano; Nielsen, Hanne Mørck; Foged, Camilla.

    In: Journal of Controlled Release, Vol. 166, No. 3, 11.01.2013, p. 220-226.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Solid-phase route to Fmoc-protected cationic amino acid building blocks. / Clausen, Jacob Dahlqvist; Linderoth, Lars; Nielsen, Hanne Mørck; Franzyk, Henrik.

    In: Amino Acids, Vol. 43, No. 4, 2012, p. 1633-41.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis. / Christophersen, Philip Carsten B; Zhang, L.; Yang, M; Nielsen, H Mørck; Müllertz, A; Mu, H.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 3, part A, 02.08.2013, p. 473-480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation. / Christophersen, Philip Carsten; Zhang, Long; Müllertz, Anette; Nielsen, Hanne Mørck; Yang, Mingshi; Mu, Huiling.

    In: Pharmaceutical Research, Vol. 31, No. 9, 13.03.2014, p. 2420-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs. / Christophersen, Philip Carsten; Fano, Mathias; Saaby, Lasse; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    In: Current Pharmaceutical Design, Vol. 21, No. 19, 2015, p. 2611-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. / Christophersen, Philip C.; Birch, Ditlev; Saarinen, Jukka; Isomäki, Antti; Nielsen, Hanne M.; Yang, Mingshi; Strachan, Clare J.; Mu, Huiling.

    In: Journal of Controlled Release, Vol. 197, 10.01.2015, p. 111-120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin. / Christophersen, Philip C; Vaghela, Dimple; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne M; Mu, Huiling.

    In: A A P S Journal, Vol. 16, No. 4, 07.2014, p. 875-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles. / Christophersen, P.; Vaghela, D.; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    2014. Abstract from 41st Controlled Release Society (CRS) Annual Meeting, Chicago, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  14. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles. / Christophersen, P.; Vaghela, D.; Müllertz, Anette; Yang, Mingshi; Nielsen, Hanne Mørck; Mu, Huiling.

    2014. Abstract from 41st Controlled Release Society (CRS) Annual Meeting, Chicago, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  15. Published

    19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR. / Christensen, Malene Vinther; Kongstad, Kenneth Thermann; Sondergaard, Teis Esben; Stærk, Dan; Nielsen, Hanne Mørck; Franzyk, Henrik; Wimmer, Reinhard.

    In: Journal of Biomolecular N M R, Vol. 73, 2019, p. 167-182.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations. / Christensen, Dennis; Foged, Camilla; Rosenkrands, Ida; Lundberg, Carina Vingsbo; Andersen, Peter; Agger, Else Marie; Nielsen, Hanne Mørck.

    In: Internation Journal of Pharmaceutics, Vol. 390, 2010, p. 19-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    a, a´- trehalose 6,6´- dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying. / Christensen, Dennis; Kirby, Daniel; Foged, Camilla; Agger, Else Marie; Andersen, Peter; Perrie, Yvonne; Nielsen, Hanne Mørck.

    In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1778, No. 5, 2008, p. 1365-1373.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01. / Christensen, Dennis; Allesø, Morten; Rosenkrands, Ida; Rantanen, Jukka Tapio; Foged, Camilla; Agger, Else Marie; Andersen, Peter; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 70, No. 3, 2008, p. 914-920.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01. / Christensen, Dennis; Allesø, Morten; Rosenkrands, Ida; Rantanen, Jukka Tapio; Foged, Camilla; Agger, Else Marie; Andersen, Peter; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 70, No. 3, 2008, p. 914-920.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations. / Christensen, Dennis; Foged, Camilla; Rosenkrands, Ida; Lundberg, Carina Vingsbo; Andersen, Peter; Agger, Else Marie; Nielsen, Hanne Mørck.

    In: Internation Journal of Pharmaceutics, Vol. 390, 2010, p. 19-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying. / Christensen, Dennis; Foged, Camilla; Rosenkrands, Ida; Nielsen, Hanne Mørck; Andersen, Peter; Agger, Else Marie.

    In: BBA General Subjects, Vol. 1768, No. 9, 2007, p. 2120-2129.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    In vitro placental model optimization for nanoparticle transport studies. / Cartwright, Laura; Poulsen, Marie Sønnegaard; Nielsen, Hanne Mørck; Pojana, Giulio; Knudsen, Lisbeth E.; Saunders, Margaret; Rytting, Erik.

    In: International Journal of Nanomedicine (Online), Vol. 7, 2012, p. 497-510.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    In vitro placental model optimization for nanoparticle transport studies. / Cartwright, Laura; Poulsen, Marie Sønnegaard; Nielsen, Hanne Mørck; Pojana, Giulio; Knudsen, Lisbeth E.; Saunders, Margaret; Rytting, Erik.

    In: International Journal of Nanomedicine (Print), Vol. 7, 2012, p. 497-510.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Mucosal drug delivery : barriers, in vitro models and formulation strategies. / Bøgh, Marie; Foged, Camilla; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: Journal of Drug Delivery Science and Technology, Vol. 23, No. 4, 2013, p. 383-391.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Development and rheological profiling of biosimilar mucus. / Bøgh, Marie; Baldursdottir, Stefania G.; Nielsen, Maja H.; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: Nordic Rheology Society Annual Transactions, Vol. 21, 2013, p. 233-240.

    Research output: Contribution to journalConference articleResearchpeer-review

  26. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption. / Bøgh, Marie; Baldursdóttir, Stefania G; Müllertz, Anette; Nielsen, Hanne M.

    In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 87, 08.01.2014, p. 227-235.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Mucus as a Barrier to Drug Delivery : Understanding and Mimicking the Barrier Properties. / Bøgh, Marie; Nielsen, Hanne Mørck.

    In: Basic & Clinical Pharmacology & Toxicology, Vol. 116, No. 3, 03.2015, p. 179-186.

    Research output: Contribution to journalReviewResearchpeer-review

  28. Published

    Mucosal drug delivery : barriers, in vitro models and formulation strategies. / Bøgh, Marie; Foged, Camilla; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: Journal of Drug Delivery Science and Technology, Vol. 23, No. 4, 2013, p. 383-391.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Development and rheological profiling of biosimilar mucus. / Bøgh, Marie; Baldursdottir, Stefania G.; Nielsen, Maja H.; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: Nordic Rheology Society Annual Transactions, Vol. 21, 2013, p. 233-240.

    Research output: Contribution to journalConference articleResearchpeer-review

  30. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation. / Bøgh, Marie; García-Díaz, María; Müllertz, Anette; Nielsen, Hanne Mørck.

    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, No. Part A, 09.2015, p. 136–143.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  32. Published

    Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium. / Birch, Ditlev; Diedrichsen, Ragna G; Christophersen, Philip C; Mu, Huiling; Nielsen, Hanne M.

    In: European Journal of Pharmaceutical Sciences, Vol. 118, 06.2018, p. 144-153.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  34. Published

    Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Biochemical Journal, Vol. 475, No. 10, 24.05.2018, p. 1773-1788.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Intact penetratin metabolite permeates across Caco-2 monolayers. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2015. Poster session presented at Annual Meeting of the American Association of Pharmaceutical Sciences, Orlando, Florida, United States.

    Research output: Contribution to conferencePosterResearch

  36. Published

    Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability. / Birch, Ditlev; Christensen, Malene Vinther; Stærk, Dan; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: B B A - Biomembranes, Vol. 1859, No. 12, 2017, p. 2483-2494.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens. / Baker, Kristin Renee; Jana, Bimal; Nielsen, Hanne Mørck; Franzyk, Henrik; Guardabassi, Luca.

    2017. Abstract from ASM Microbe 2017, New Orleans, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  38. Published

    Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics. / Baker, Kristin R.; Jana, Bimal; Hansen, Anna Mette; Nielsen, Hanne Morck; Franzyk, Henrik; Guardabassi, Luca.

    In: Frontiers in Cellular and Infection Microbiology, Vol. 9, 02.07.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. / Baker, Kristin R; Jana, Bimal; Hansen, Anna Mette; Vissing, Karina Juul; Nielsen, Hanne Mørck; Franzyk, Henrik; Guardabassi, Luca.

    In: International Journal of Antimicrobial Agents, Vol. 53, 2019, p. 868-872.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analogues. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2012. Poster session presented at Zing Peptide Therapeutics Conference, 2012, Lanzarote, Spain.

    Research output: Contribution to conferencePosterResearch

  41. Published

    The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analogues. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Nielsen, Hanne Mørck.

    2012. Poster session presented at Zing Peptide Therapeutics Conference, 2012, Lanzarote, Spain.

    Research output: Contribution to conferencePosterResearch

  42. Published

    Antimicrobial and cell-penetrating properties of penetratin analogs : effect of sequence and secondary structure. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne; Nielsen, Hanne Mørck.

    In: B B A - Biomembranes, Vol. 1828, No. 2, 2013, p. 223-232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Cell-penetrating Peptides Targeting Intracellular Infections. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  44. Cell-penetrating Peptides Targeting Intracellular Infections. / Bahnsen, Jesper Søborg; Franzyk, Henrik; Sandberg-Schaal, Anne; Nielsen, Hanne Mørck.

    2013. Poster session presented at Controlled Release Society Meeting 2013, Honolulu, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  45. Published

    Håb om at ramme latente bakterier i deres skjul. / Bahnsen, Jesper Søborg; Water, Jorrit Jeroen; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning 2012, Vol. 2012, 2012, p. 12-14.

    Research output: Contribution to journalJournal articleResearch

  46. Håb om at ramme latente bakterier i deres skjul. / Bahnsen, Jesper Søborg; Water, Jorrit Jeroen; Foged, Camilla; Franzyk, Henrik; Nielsen, Hanne Mørck.

    In: Lægemiddelforskning 2012, Vol. 2012, 2012, p. 12-14.

    Research output: Contribution to journalJournal articleResearch

  47. Published

    Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. / Bahnsen, Jesper S; Franzyk, Henrik; Sayers, Edward J; Jones, Arwyn T; Nielsen, Hanne M.

    In: Pharmaceutical Research, Vol. 32, No. 5, 2015, p. 1546-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1299091